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Welcome to The AI Native Developer, hosted by Guy Podjarny and Simon Maple. Join us as we explore and help shape the future of software development through the lens of AI. In this new paradigm of AI Native Software Development, we delve into how AI is transforming the way we build software, from tools and practices to the very structure of development teams. Our target audience includes developers and development leaders eager to stay ahead of the curve. If you're passionate about the future ...
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A series of episodes that look at databases and the world from a data professional's viewpoint. Written and recorded by Steve Jones, editor of SQLServerCentral and The Voice of the DBA.
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Talk Python To Me

Michael Kennedy

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Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from the leaders. And if you've been Pythoning for years, you'll learn about your favorite packages and the hot new ones coming out of open source.
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For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™. You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance ...
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What if a laser could help a child speak for the first time—or reverse an “incurable” brain condition? In this episode of The Human Upgrade, Dave Asprey talks with Dr. Brandon Crawford, a leading neurotherapist and founder of 528 Innovations, about the emerging science of laser therapy for the brain and body. You’ll learn how light—when precisely p…
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When is the last time you interviewed for a new position? It could have been at a new company, or maybe you had an interview was for a different position inside your existing company. Perhaps you needed to talk to a manager internally for a new project. I've tried to treat all my one-on-one meetings or reviews as interviews since I'm usually trying…
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In this episode, Simon Maple converses with Gal Kleinman, co-founder of Traceloop, to delve into the realm of LLM observability. Kleinman shares his expertise on constructing evaluation suites and overcoming the challenges associated with LLM applications. Learn about innovative solutions like Open LLMetry and gain insights into best practices for …
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What if mitochondria weren’t just energy engines — but conscious beings guiding your survival and evolution? In this episode, Dave Asprey sits down with Zach Bush, MD, to uncover a radical new science of cellular intelligence. Together, they reveal how your mitochondria, microbiome, and genetic memory do far more than support survival—they actively…
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Pandas is at a the core of virtually all data science done in Python, that is virtually all data science. Since it's beginning, Pandas has been based upon numpy. But changes are afoot to update those internals and you can now optionally use PyArrow. PyArrow comes with a ton of benefits including it's columnar format which makes answering analytical…
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I heard Brent Ozar recently talked a bit about the SQL Server platform and its future. He also mentioned that Fabric has distracted the data platform team and it isn't a great product. I tend to agree, and I see too many bugs, holes, and problems. However at the end of this short snippet, he talks about SQL Server with an interesting comment. Is SQ…
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You’ve probably heard of HIIT—but have you heard of “REHIT?” This isn’t just another workout trend...it’s a new science-backed way to train with maximum efficiency and zero wasted time. If you’re still jogging, you’re wasting hours for minimal results. In this episode of The Human Upgrade, Dave Asprey sits down with Ulrich Dempfle, German-trained e…
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I get the Gates Notes email periodically and I always find it interesting to read. Like Bill Gates or not, he is a very smart individual and has thoughtful things to say. Even when I don't always agree with him, I enjoy hearing his view and have enjoyed seeing him deliver presentations. In fact, one of my career highlights was at SQL Saturday #175 …
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Your bloodwork looks normal. Your doctor says you’re fine. But you still feel exhausted, inflamed, anxious—or worse. In this episode, Dave Asprey talks with Dr. Daniel Pompa, a leading voice in cellular detox and root-cause healing, to expose the hidden stressors hijacking your energy, hormones, and metabolism—even when your labs say you’re healthy…
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At the end of last year, I ran into a friend I hadn't seen in a long time. We were chatting and this person mentioned that they were looking for a new job. They had been laid off and needed something. This is someone with a lot of experience and skill, so I wasn't worried for their career or future. At the time, they mentioned they had gotten an in…
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In this episode, host Simon Maple engages in a compelling discussion with Annie Vella, a skilled software engineer and manager, about the integration of AI into software development. Annie shares her insights on how AI tools are reshaping coding practices, the challenges engineers face in transitioning to management roles, and the skills required t…
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Most people run from stress. The world’s highest performers run toward it. Sébastien Page manages over $500 billion in global assets. He’s the CIO of one of the world’s largest investment firms, and he wrote The Psychology of Leadership while living under relentless pressure. His secret? He doesn’t avoid stress—he uses it as a tool for performance,…
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Do you or your company need accounting software? Well, there are plenty of SaaS products out there that you can give your data to. but maybe you also really like Django and would rather have a foundation to build your own accounting system exactly as you need for your company or your product. On this episode, we're diving into Django Ledger, create…
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The revolution with GenAI has been quite the ride since 2023 and quite a few people have been concerned that their employment status might be in jeopardy. I can certainly understand that, especially in light of the tight budgets, widespread layoffs, and executive views on AI technologies. There was an article recently talking about AI taking over s…
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Your DNA, health data, and digital identity are encrypted, monetized, and weaponized against you. But what if there was a way to take it back… and hack the system? In this mind-expanding episode, Dave sits down with two elite hacker-founders—Michael Tiffany, CEO of Fulcra.ai, and Vishakh, founder of Monadic DNA—to explore a radical shift in the way…
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One of the challenges in software development is coordinating database and application changes when one depends on the other. I find many software development teams struggle with this, especially in today's environments when no one wants to take a system offline. While some companies can stage and manage deployments, many of us find our systems nee…
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In this episode, Guy Podjarny sits down with Tom Hulme to discuss the transformative shift from a code-centric to a spec-centric approach in software development. They explore the advantages of cloud-native practices, the evolving tool ecosystem, and the future role of AI and LLMs. Gain expert insights into the trends that are shaping the future of…
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If your brain feels foggy, your mood swings like a pendulum, or your cravings seem to control you—this episode will flip what you think you know about your body and your mind. Because what if your thoughts… aren’t really yours? In this mind-altering episode of The Human Upgrade, Dr. Steven Gundry reveals a startling new theory: your gut microbiome …
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Have you ever spent an afternoon wrestling with a Jupyter notebook, hoping that you ran the cells in just the right order, only to realize your outputs were completely out of sync? Today's guest has a fresh take on solving that exact problem. Akshay Agrawal is here to introduce Marimo, a reactive Python notebook that ensures your code and outputs a…
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I saw an article recently that a quarter of the Y Combinator startups have 95% of the code in their repos being AI generated. The article notes that if no other startups had any AI generated code (no idea the likelihood here, then about 24% of their code for startups is GenAI written. 24% Is that high or low? If you think about all the code you've …
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If your hair is thinning, shedding, or simply not what it used to be—and nothing seems to work—this episode is for you. Because what if the story you’ve been told about balding… is wrong? For decades, hair loss has felt like fate: genetic, inevitable, untouchable. But science is catching up to something deeper—something root-level. What if the real…
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What if you could rewrite the code of your personality—on command? Not just cope with anxiety, overthinking, or social exhaustion… but delete the traits holding you back and install better ones? This episode challenges everything you’ve been told about identity. Dave dives deep into the science of personality change to reveal why your habits, moods…
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We're sitting down with Eric Matthes, the educator, author, and developer behind Django Simple Deploy. If you've ever struggled with taking that final step of getting your Django app onto a live server (without spending days wrestling with DevOps complexities), then give Django Simple Deploy a look. Eric shares how Django Simple Deploy automates aw…
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In this episode, Alex Komoroske delves into the transformative role of AI in the tech industry. As an expert in web platform development, Alex discusses AI's potential to redefine technology and creativity. Gain insights into how AI serves as a disruptive innovation and explore its implications for developers. Subscribe to the AI Native Developer p…
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Some of you reading this are database administrators (DBAs) who manage systems as their full-time job. Others of you might be developers, analytics people, or someone else who has another job, but you get stuck with managing the database somehow. I've seen a receptionist and a dental hygienist act in this role. We may call you the accidental DBAs, …
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Your brain isn’t broken—it’s underpowered. Energy crashes, poor sleep, brain fog, and emotional reactivity don’t just happen. You’re running on low voltage, and your mind pays the price. In this episode, Dave sits down with Dr. Patrick Porter, founder of BrainTap, to reveal how to reprogram your brain using light, sound, and guided visualization—no…
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The use of feature flags in software development has become more and more prevalent over time, especially as teams move to DevOps-style development with frequent releases. I've often thought that using feature flags allows technical people to separate out the deployment of some feature or change from the release of that to users. There are a number…
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A domain is a set of possible values (among other definitions). I use this word a lot in my work, often with a problem domain (the thing you're trying to solve) or the domain of possible values (like the US States and Territories list). That last one is interesting, as this is often the set of data we stick in some reference or lookup table to use …
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You think you’re helping your kid. You clear the path. You smooth the bumps. You make sure they never feel too sad, too bored, too uncomfortable. It feels like love. But what if it’s making them weak? In this episode, Dave Asprey sits down with bestselling author, TED speaker, and resilience expert Jennifer Cohen to reveal how today’s parenting nor…
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The DORA organization is dedicated to helping others build software better and faster, at a higher quality, and in a way that is more efficient. They continue to compile and publish the Accelerate State of DevOps report every year, which is a fascinating read. As a part of the report, they have identified four key metrics that identify high perform…
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Join Guy Podjarny as he hosts Olivier Pomel, CEO of Datadog, in a compelling discussion on the evolution of observability and AI's role in modern technology. Olivier offers his expertise on AI-powered applications, the security challenges they face, and the future of AI interactions. This episode provides crucial insights for tech professionals and…
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For decades, gut health was reduced to yogurt commercials and vague promises from probiotics that barely worked. But what if we’ve been targeting the wrong bugs, using the wrong delivery, and ignoring the true source of chronic inflammation and accelerated aging? In this thought-provoking episode, Dave sits down with Hannah Kleinfeld, a leader in m…
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This episode is all about Beeware, the project that working towards true native apps built on Python, especially for iOS and Android. Russell's been at this for more than a decade, and the progress is now hitting critical mass. We'll talk about the Toga GUI toolkit, building and shipping your apps with Briefcase, the newly official support for iOS …
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If you're a fan, no. You're chomping at the bit, waiting to get everyone using GenAI models in their work. If you're skeptical, then you might think it's never coming to take your job, be a personal assistant, help you with coding, etc. Pick the task it won't help you with. A more nuanced view, which is similar to mine, is from Kendra Little, in wh…
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For nearly a century, scientists believed we had discovered ALL of the essential fatty acids the human body needs. But what if they were wrong? Stephanie Venn-Watson, a veterinary epidemiologist and longevity researcher, joins Dave to reveal a groundbreaking discovery—a newly identified essential fatty acid, C15, that may hold the key to healthier …
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In this episode of the Tessl podcast, hosts Patrick Debois and Simon Maple explore the transformative landscape of software development practices. Join them as they discuss emerging patterns that are reshaping the industry. Patrick, a DevOps pioneer, shares valuable insights on aligning development work with business intents, while Simon brings his…
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