This podcast focuses on explaining the fascinating ways that science and engineering change the world around us. In each episode, we talk to leading engineers from elite-level sports like cycling and Formula 1 to some of world's top academics to understand how fluid dynamics, machine learning & supercomputing are bringing in a new era of discovery. We also hear life stories, career advice and lessons they've learnt along the way that will help you to pursue a career in science and engineering.
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Welcome to The Computational Multiphase Physics Lab (CoMPhy-Lab)’s Public Podcast. We are part of the Physics of Fluids Department at the University of Twente, where we study non-Newtonian free-surface flows and soft matter singularities using a synergy of continuum simulations, theoretical analysis, and collaborative experiments. Our episodes delve into droplet impact, bubble bursting, and sheet fragmentation, unraveling universal mechanisms that shape both fundamental science and real-worl ...
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FOX6 Investigative reporters Bryan Polcyn, Jenna Sachs and Amanda St. Hilaire break down the big stories and what it took to get them. "Open Record" takes you behind the scenes of the investigative reporting unit in Milwaukee, Wisconsin. It's the details the reporters couldn't tell you on T.V.
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Join Dean Regas, astronomer, author, and space expert on a journey through the stars! Guests from all over the globe bring their knowledge and passion about today’s latest scientific discoveries and advancements. From eclipses to supernovas, from rockets to rovers; there’s a whole universe to explore! Dean is the author of “How to Teach Grown-Ups About Pluto” and “100 Things to See in the Night Sky” and was the longtime host of PBS' Stargazers television program. Looking Up is a production o ...
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The Fluid State of Mobile App Development
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Nodycast is a lively podcast discussing the theory, techniques and latest innovations in nonlinear dynamics, and its applications to systems of all kinds. This includes almost everything under the sun such as mechanical, structural, electrical, chemical, thermo-fluid, ecological, economic, epidemiological, biological and chemical systems. It is hosted by Dr. 'Nat' C. Nataraj, Moritz Professor at Villanova University and Senior Editor for Nonlinear Dynamics, a Springer-Nature journal.
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Teachers and students, got something to say? Put on your headphones and get ready to hit record! The folks behind NPR's Student Podcast Challenge made this handy guide on how to make a podcast in the classroom. We'll talk about how to gather good sound, ask great questions and conduct smart interviews. Plus, we'll hear from the contest's judges, last year's winners and feature some pretty inspiring stories of students and teachers. It's everything you need to make an amazing podcast!
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Talking to people who use maths in their work. Aiming to encourage further uptake of maths at A-level and beyond. Hosted by Peter Rowlett and Katie Steckles.
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Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.
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S3 EP3 - Professor Johannes Brandstetter on AI for Computational Fluid Dynamics
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1:18:02In this conversation, Neil Ashton interviews Prof. Johannes Brandstetter, a physicist turned machine learning expert, about his journey from academia to industry, focusing on the application of machine learning in engineering and computational fluid dynamics (CFD). They discuss the Aurora project, the challenges of integrating machine learning with…
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The Human Computer Who Changed Fluid Dynamics (with Anne Saker)
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16:56Science journalist Anne Saker describes the Chandrasekhar Limit as a range of possibility where if a planet has enough stability in its magnetic force and its gravitational force, it can sustain life. This Nobel Prize winning discovery changed the field of fluid dynamics. Though it was named after theoretical physicist Dr. Subrahmanyan Chandrasekha…
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114: One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique
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16:31️ Episode 114: One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique In this episode of PaperCast Base by Base, we explore the development of a rapid and affordable HPV DNA test designed for cervical cancer screening in low-resource settings. The study introduces a one-hour, ex…
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The Milwaukee Brewers are bringing the energy and keeping the momentum going as they gear up for playoffs. Packers training camp is off and running as the team looks to the start of the season, which is just weeks away. In this episode of Open Record, FOX6 Investigator Bryan Polcyn invites FOX6 Sports Director Tim Van Vooren and FOX6 anchor Ted Per…
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113: Joint, Multifaceted Genomic Analysis Enables Diagnosis of Ultra-Rare Monogenic Presentations
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22:08️ Episode 113: Joint, Multifaceted Genomic Analysis Enables Diagnosis of Ultra-Rare Monogenic Presentations In this episode of PaperCast Base by Base, we explore how the Undiagnosed Diseases Network (UDN) applied whole‑genome sequencing and new, well‑calibrated statistics to jointly analyze diverse, ultra‑rare monogenic cases across the consortium,…
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112: Local Genetic Sex Differences in Quantitative Traits
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21:16️ Episode 112: Local Genetic Sex Differences in Quantitative Traits In this episode of PaperCast Base by Base, we explore how genetic differences between males and females are distributed across the genome, moving beyond global averages of heritability and correlation. The study introduces a fine-scale approach using LAVA to examine local genetic s…
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111: A Multimodal Dataset for Precision Oncology in Head and Neck Cancer
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17:06️ Episode 111: A Multimodal Dataset for Precision Oncology in Head and Neck Cancer In this episode of PaperCast Base by Base, we explore the creation of HANCOCK, a comprehensive multimodal dataset designed to advance precision oncology in head and neck cancer. The study addresses the urgent need for large, publicly available datasets to improve bio…
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110: Whole-exome sequencing identifies new schizophrenia risk genes
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20:31️ Episode 110: Whole-exome sequencing identifies new schizophrenia risk genes In this episode of PaperCast Base by Base, we explore a landmark whole-exome sequencing study that expands our understanding of the rare genetic variants contributing to schizophrenia risk. By combining newly sequenced samples with large-scale published datasets, research…
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109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality
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18:10️ Episode 109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality In this episode of PaperCast Base by Base, we explore how loss of the RNA editor ADAR1 becomes lethal to BRCA1/2‑mutant cancer cells through a tumor‑cell‑autonomous interferon response, outlining a biomarker‑guided path to ADAR1‑targeted therapy. Study Highlights: A focus…
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108: Epigenome Editing Reverses HBG Silencing
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20:53️ Episode 108: Epigenome Editing Reverses HBG Silencing In this episode of PaperCast Base by Base, we explore how targeted removal of CpG methylation at the HBG promoters causally reactivates fetal hemoglobin (HbF) without cutting DNA, revealing a precise path to treat β‑hemoglobinopathies. Study Highlights: A forward CRISPR screen in adult‑type er…
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Shh... Astronomers are Sleeping! (with Vannessa Gressieux)
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17:38You might have to watch the sunrise by yourself at Kitt Peak Observatory. At night, astronomers and technicians conduct research and lead tours for the public. But as the sun starts to peek over the Quinlan Mountains, everyone is still asleep. Dean Regas chats with Vannessa Gressieux, the docent and guide coordinator at Kitt Peak National Observato…
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107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical Diseases
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19:07Episode 107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical Diseases In this episode of PaperCast Base by Base, we explore a large-scale genome-wide association study investigating the genetic underpinnings of pulpal and apical diseases. Using Finnish health registry data from over 485,000 individuals in the FinnGen cohort…
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Thousands in southeast Wisconsin are grappling with flooded businesses, homes, basements, garages, and cars. This, after torrential rainfall pummeled the Milwaukee area. In this episode of Open Record, FOX6 Investigator Bryan Polcyn explores the so-called 'Thousand Year' flood to hit the area. FOX6 Chief Meteorologist Tom Wachs explains what happen…
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106: Decoding Brain Maps for Pharmacotranscriptomics
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19:25️ Episode 106: Decoding Brain Maps for Pharmacotranscriptomics In this episode of PaperCast Base by Base, we explore a Nature Communications study, that introduces a fast, surface-based framework to decode imaging-derived brain phenotypes by aligning high-resolution cortical gene-expression maps with PET targets and structural MRI patterns. The wor…
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105: Genome-level Selection as a Universal Marker of Cancer Therapy Resistance
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18:28️ Episode 105: Genome-level Selection as a Universal Marker of Cancer Therapy Resistance In this episode of PaperCast Base by Base, we explore groundbreaking research revealing how the evolutionary dynamics of tumor genomes can serve as a universal marker of resistance to cancer therapy. By analyzing whole-exome sequencing data from multiple cancer…
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104: Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation
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16:56Episode 104: Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation In this episode of PaperCast Base by Base, we explore a large cross-ancestry study that integrates genome-wide association results with plasma proteomics to map genetic architecture, nominate causal pathways and proteins, and boost…
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103: Genome Sequencing Forecasts Outcomes After Congenital Cardiac Surgery
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17:56️ Episode 103: Genome Sequencing Forecasts Outcomes After Congenital Cardiac Surgery In this episode of PaperCast Base by Base, we explore how large-scale exome sequencing combined with explainable AI can predict adverse outcomes after surgery for congenital heart defects. Using a prospective cohort from the Pediatric Cardiac Genomics Consortium, t…
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102: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort
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14:38Episode 102: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort In this episode of PaperCast Base by Base, we explore how large-scale pharmacogenomics translates to real-world care using data from the Taiwan Precision Medicine Initiative. We follow a Nature Communications study that analyzes gene–drug interactions across 486…
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101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis
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18:25️Episode 101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis In this episode of PaperCast Base by Base, we explore how JAK2 inhibition with ruxolitinib can reshape clonal architecture in myeloproliferative neoplasms (MPN), favoring outgrowth of RAS‑pathway mutant subclones and altering patient outcomes. We situate these findings within …
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️ 100: Epigenomic Diagnosis and Prognosis of Acute Myeloid Leukemia
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14:44️ Episode 100: Epigenomic Diagnosis and Prognosis of Acute Myeloid Leukemia In this episode of PaperCast Base by Base, we explore a groundbreaking study that maps the epigenomic landscape of Acute Myeloid Leukemia (AML) and develops powerful diagnostic and prognostic tools for clinical use. The research introduces the Acute Leukemia Methylome Atlas…
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Parts of southeast Wisconsin have spent days under an air quality alert this summer, due to wildfire smoke creating unhealthy air quality. In this episode of Open Record, FOX6 Investigator Bryan Polcyn invites FOX6 Chief Meteorologist Rob Haswell on to talk about the Canadian wildfires. You'll learn why all that smoke is coming to Wisconsin, how we…
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️ 99: NXT2: A Testis-Specific RNA Export Factor Essential for Spermatogenesis
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14:36️ Episode 99: NXT2: A Testis-Specific RNA Export Factor Essential for Spermatogenesis In this episode of PaperCast Base by Base, we explore how the testis-enriched paralog NXT2 orchestrates nucleocytoplasmic mRNA export in human germ cells and its critical role in male infertility. Study Highlights: Proteomic analyses of human testicular tissue unc…
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️ 98: Cell Marker Accordion: Interpretable Single-Cell and Spatial Omics Annotation in Health and Disease
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19:20️ Episode 98: Cell Marker Accordion: Interpretable Single-Cell and Spatial Omics Annotation in Health and Disease In this episode of PaperCast Base by Base, we explore a user-friendly platform developed by Busarello et al. that integrates and standardizes over 23 human and murine gene-marker databases into a weighted resource for robust annotation …
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️ 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial
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21:43️ Episode 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial In this episode of PaperCast Base by Base, we explore how integrated whole genome and transcriptome sequencing uncovers clinically relevant subtypes and molecular features in advanced pancreatic ductal adenocarcinoma (PDAC). Study Highlights: The COMPASS trial profiled 268 ad…
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S3 EP2 - Prof. Russell Cummings - World leader in Aerospace Engineering and Hypersonics
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1:43:14In this episode of the Neil Ashton podcast, Professor Russell Cummings shares his extensive journey through the fields of aerodynamics, computational fluid dynamics and hypersonics. He discusses his early inspirations, his early days at University and the Hughes Aircraft Company - a key time during this life. He also talks about the cyclical nature…
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️ 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease
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16:39️ Episode 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease In this episode of PaperCast Base by Base, we explore a large-scale proteomic study comparing cerebrospinal fluid (CSF) profiles in individuals with Down Syndrome (DS), late-onset Alzheimer’s disease (LOAD), and autosomal dominant Alzheimer’s disease …
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️ 95: Mitochondria on the Move: Biotechnological Strategies for Transfer and Transplantation
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19:10️ Episode 95: Mitochondria on the Move: Biotechnological Strategies for Transfer and Transplantation In this episode of PaperCast Base by Base, we explore recent advances in biotechnological methods for mitochondria transfer and transplantation aimed at restoring cellular function in diseases driven by mitochondrial dysfunction. Study Highlights: T…
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️ 94: Intraindividual Epigenetic Heterogeneity in Advanced Prostate Cancer
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20:29️ Episode 94: Intraindividual Epigenetic Heterogeneity in Advanced Prostate Cancer In this episode of PaperCast Base by Base, we explore how integrated DNA methylation, RNA sequencing, and histone modification profiling across metastatic lesions reveal intraindividual epigenetic diversity underlying phenotypic subtypes of castration-resistant prost…
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️ 93: Neuroinvasive and Pulmonary Virulence of H5N1 Clade 2.3.4.4b Genotype B3.13
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19:01️ Episode 93: Neuroinvasive and Pulmonary Virulence of H5N1 Clade 2.3.4.4b Genotype B3.13 In this episode of PaperCast Base by Base, we explore how a bovine-derived H5N1 virus from clade 2.3.4.4b genotype B3.13 exhibits enhanced pulmonary and neurovirulent properties in mouse models, highlighting its potential implications for zoonotic transmission…
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In this episode of Open Record, FOX6 Investigator Bryan Polcyn explores the seismic shift from the No. 1 source of public funds for animal research and the undercover investigation that shows what they're trying to stop. Learn more about your ad choices. Visit podcastchoices.com/adchoicesBy © FOX6 Milwaukee
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️ 92: Genetic Loss of CFHR5 Function Protects Against Age-Related Macular Degeneration
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16:49️ Episode 92: Genetic Loss of CFHR5 Function Protects Against Age-Related Macular Degeneration In this episode of PaperCast Base by Base, we explore a genome‑wide association and fine‑mapping study in a Finnish cohort that identifies CFHR5 loss‑of‑function variants as independent protective factors against age‑related macular degeneration and inves…
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️ 91: Genome-wide Association of Plasma N-Glycome Reveals Links to Liver Disease and Anti-Inflammatory Proteins
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17:42️ Episode 91: Genome-wide Association of Plasma N-Glycome Reveals Links to Liver Disease and Anti-Inflammatory Proteins In this episode of PaperCast Base by Base, we explore a large-scale genome-wide association study that uncovers novel genetic regulators of plasma protein N-glycosylation and their connections to liver function and inflammatory pa…
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️ 90: Variable and Interactive Effects of Sex, APOE ε4 and TREM2 on Tau Deposition
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15:57️ Episode 90: Variable and Interactive Effects of Sex, APOE ε4 and TREM2 on Tau Deposition In this episode of PaperCast Base by Base, we explore how genetic factors—including sex differences, Apolipoprotein E ε4 allele dosage, and rare TREM2 risk variants—shape the accumulation and spread of tau pathology in Alzheimer’s disease using multimodal ima…
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️ 89: Decoding the Genetics of Smell: Sex-Specific Variants in Olfactory Identification
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20:28️ Episode 89: Decoding the Genetics of Smell: Sex-Specific Variants in Olfactory Identification In this episode of PaperCast Base by Base, we explore how a genome-wide association meta-analysis of olfactory identification across 21,495 individuals reveals novel genetic loci underlying human smell perception. Study Highlights: Using the Sniffin’ Sti…
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️ 88: Stable Heritability of Type 1 Diabetes Over Three Decades in Sweden
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18:28️ Episode 88: Stable Heritability of Type 1 Diabetes Over Three Decades in Sweden In this episode of PaperCast Base by Base, we explore a Swedish nationwide register-based study that assesses whether the heritability of childhood-onset type 1 diabetes has changed from 1982 to 2010 and how environmental factors have contributed to the rising inciden…
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️ 87: Circulating cfDNA Methylation Reveals Allograft Injury Sources after Liver Transplant
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20:20️ Episode 87: Circulating cfDNA Methylation Reveals Allograft Injury Sources after Liver Transplant In this episode of PaperCast Base by Base, we explore how sequence-based analysis of cell-free DNA methylation patterns can non-invasively monitor and differentiate cellular sources of allograft injury in liver transplant patients within the first po…
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️ 86: Variable Penetrance in Monogenic Traits — How Genetic Background Modulates Disease Severity
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19:27️ Episode 86: Variable Penetrance in Monogenic Traits — How Genetic Background Modulates Disease Severity In this episode of PaperCast Base by Base, we explore a landmark study that unravels why carriers of the same pathogenic variant often present with very different clinical outcomes, providing new insights into gene–disease association, variant …
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A 7-year-old boy is abducted in broad daylight. Prosecutors say the kidnappers planned to rob a drug dealer, but ended up holding her child for ransom. In this episode of Open Record, how a search for a boy led to gunshots and why experts say this dramatic abduction is unlike almost any other. FOX6 Investigator Bryan Polcyn invites FOX6 reporter Br…
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️ 85: Genomic landscape of virus-associated cancers
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23:15️ Episode 85: Genomic landscape of virus-associated cancers In this episode of PaperCast Base by Base, we explore the comparative genomic analysis of virus-positive and virus-negative tumors across nine cancer types linked to five oncogenic viruses uncovering epidemiological patterns, mutational signatures, and therapeutic implications. Study Highl…
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️ 84: Variants in NR6A1 cause a novel oculo-vertebral-renal syndrome
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17:12️ Episode 84: Variants in NR6A1 cause a novel oculo-vertebral-renal syndrome In this episode of PaperCast Base by Base, we explore the discovery of rare variants in the orphan nuclear receptor gene NR6A1 as the genetic cause of a newly described autosomal dominant oculo-vertebral-renal (OVR) syndrome characterized by colobomatous microphthalmia, ve…
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️ 83: Single-cell Analysis of dup15q Syndrome Illuminates Autism Mechanisms
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25:47️ Episode 83: Single-cell Analysis of dup15q Syndrome Illuminates Autism Mechanisms In this episode of PaperCast Base by Base, we explore how single-cell RNA sequencing of patient-derived cortical organoids and postmortem brain tissue uncovers developmental and postnatal molecular changes in duplication 15q syndrome, a major genetic cause of autism…
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S3 EP1 - Prof. Mike Giles - A CFD and Computational Finance Pioneer
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2:07:11In this episode of the Neil Ashton podcast, Professor Mike Giles shares his extensive journey through the fields of computational fluid dynamics (CFD), computational finance and HPC. He discusses his early academic influences, his early days at Cambridge, internships at Rolls-Royce, his transition to MIT and Oxford where he made significant contrib…
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️ 82: JAK2 Inhibition Drives RAS Pathway Mutant Clonal Selection in Myeloproliferative Neoplasms
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19:07️ Episode 82: JAK2 Inhibition Drives RAS Pathway Mutant Clonal Selection in Myeloproliferative Neoplasms In this episode of PaperCast Base by Base, we explore how JAK2 inhibition by ruxolitinib reshapes clonal dynamics in myelofibrosis by mediating the expansion of RAS pathway-mutated clones in myeloproliferative neoplasms. Study Highlights: We con…
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️ 81: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort
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21:10️ Episode 81: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort In this episode of PaperCast Base by Base, we explore a retrospective analysis of genetic and clinical data from the Taiwan Precision Medicine Initiative cohort to assess how actionable pharmacogenetic variants influence drug response and adverse events in near…
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️ 80: Genomic Forecasting of Postoperative Outcomes in Congenital Cardiac Surgery
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16:15️ Episode 80: Genomic Forecasting of Postoperative Outcomes in Congenital Cardiac Surgery In this episode of PaperCast Base by Base, we explore the use of artificial intelligence–driven genome sequencing to predict clinical outcomes following surgery for congenital heart defects. Study Highlights: The authors conducted a prospective observational c…
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️ 79: Cross-Population GWAS and Proteomic Insights in Atrial Fibrillation
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17:17️ Episode 79: Cross-Population GWAS and Proteomic Insights in Atrial Fibrillation In this episode of PaperCast Base by Base, we explore a cross-population genome-wide meta-analysis combined with proteomic profiling to enhance risk prediction and uncover molecular mechanisms underlying atrial fibrillation. Study Highlights: The authors conducted a m…
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On each shift, police officers face a threat they may never see coming. On this episode of Open Record, FOX6 Investigator Bryan Polcyn invites FOX6 reporter and anchor Sam Kraemer on to talk about ambushes and unprovoked attacks. They discuss what goes into the research and training aimed at protecting the people who protect us. Learn more about yo…
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️ 78: Interactions between TTYH2 and APOE Facilitate Endosomal Lipid Transfer
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14:53️ Episode 78: Interactions between TTYH2 and APOE Facilitate Endosomal Lipid Transfer In this episode of PaperCast Base by Base, we explore the discovery and characterization of the interaction between the membrane protein TTYH2 and apolipoprotein E (APOE), and how this partnership drives lipid transfer within endosomal compartments. Study Highligh…
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️ 77: Range Extender: Unlocking Long-Distance Enhancer Activity
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16:31️ Episode 77: Range Extender: Unlocking Long-Distance Enhancer Activity In this episode of PaperCast Base by Base, we explore the discovery and functional characterization of a novel cis-acting element, termed REX, that mediates megabase-scale enhancer–promoter interactions and enables remote gene activation during limb development. Study Highlight…
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️ 76: Whole-genome Ancestry of an Old Kingdom Egyptian
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13:22️ Episode 76: Whole-genome Ancestry of an Old Kingdom Egyptian In this episode of PaperCast Base by Base, we explore the first 2× coverage whole-genome sequence recovered from a high-status individual of the Old Kingdom excavated at the Nuwayrat necropolis and examine the evidence for multi-regional ancestry during early Dynastic Egypt. Study Highl…
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