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“Two Guys Talking $#it” is a podcast where two Gastroenterologists break down complex topics into engaging, educational, and occasionally humorous conversations. From liver health to gut microbiota and everything in between, A/Professor Jonathan Segal and Dr James Haridy deliver insights, share the latest research, and discuss clinical pearls with the odd guest in tow. Comments, suggestions, questions please contact us on twitter @2guystalkingit or leave a comment below..
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Gut Podcast

BMJ Group

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The Gut Podcast is your go-to source for the latest discussions in gastroenterology and hepatology. Each month Dr. Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, dives into key issues in the field by discussing articles with their authors. Gut - gut.bmj.com - is an international journal from BMJ Group and the British Society of Gastroenterology (BSG) publishing research and review articles in gastroenterology and ...
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“Got Knowledge Doc” Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Eac ...
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Hugh Thomas, Deputy Editor at The Lancet Gastroenterology & Hepatology, in conversation with the journal’s authors, explores their latest research and its impact on people’s health, healthcare, and health policy. A monthly audio companion to the journal, this podcast covers a broad range of topics, from predicting clinical outcomes in NAFLD to immunosuppressant withdrawal in patients with Crohn’s disease, the primary antibiotic resistance of Helicobacter pylori to surgical versus non-surgica ...
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Welcome to Guts & Glory, hosted by SingHealth Internal Medicine residents Dillon and Ching Han, together with consultant gastroenterologist Dr Andrew Ong! Each episode, we hope to bring you guys the latest in gastroenterology and hepatology approaches, updates, and discussions that you can tune into anytime. Join us, whether you're on your way to pre-round at 5 am, typing your 7th discharge summary of the day, or going home after reviewing your blue letters at 10 pm. This podcast is meant fo ...
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Vision To Prevent and Cure Liver Disease Mission To advance and disseminate the science and practice of hepatology, and to promote liver health and quality patient care AASLD is the leading organization of scientists and healthcare professionals committed to preventing and curing liver disease. AASLD was founded in 1950 by a small group of leading liver specialists (including Hans Popper, Leon Schiff, Fred Hoffbauer, Cecil Watson, Jesse Bollman, and Sheila Sherlock, to name a few) to bring t ...
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FG Podcast

BMJ Group

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The Frontline Gastroenterology (FG) podcast offers in-depth interviews with renowned authors and leading experts in gastroenterology, hepatology and clinical nutrition delving into the best practices in the field. FG - fg.bmj.com - is an esteemed international journal from the BMJ Group and the British Society of Gastroenterology (BSG). Elevate your practice by subscribing to the FG podcast.
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Back Bay Life Science Report

Jonathan P. Gertler and Peter Bak

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Back Bay Life Science Advisors brings you expert insights from our advisors and investment bankers in the world of BioPharma & MedTech. On this podcast, you’ll hear from our experts in life science development, commercialization, and investment banking, scientific investigators, biotech and medtech executives, physicians, and strategists who excel at guiding global life sciences companies and their investors through complex decisions. Join us for insights generated from in-depth scientific, ...
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Today we had the privilege of talking to a true superstar in the world of Hepatology. Elliot B. Tapper MD is an Associate Professor in the Division of Gastroenterology and Hepatology at the University of Michigan. He is Academic Chief of Hepatology. His primary goal is to empower patients to enjoy a high quality of life. He is an expert in the mana…
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🚨 New Insights in Heart Failure Care! 🫀💉 A landmark meta-analysis in Nature Medicine shows that intravenous iron therapy significantly reduces heart failure hospitalizations and cardiovascular deaths — especially in the first year of treatment. 📉💪 With over 7,000 patients across 6 RCTs, this study reinforces IV iron as a safe, outcome-improving the…
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🚨 Spotlight on Medieval Thought! 🧠📜 Explore the legacy of Anselm of Canterbury—father of Scholasticism and originator of the Ontological Argument for God’s existence. His fusion of faith 🙏 and reason 🧩 shaped Western theology. 🎓 #Philosophy #MedievalStudies #Anselm #TheologyBy MasterMedFacts LLC
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Tropical cyclones don’t just shake buildings — they shake hearts too. A powerful multicountry study in Science Advances links 🌊 storm exposure to a 13% rise in cardiovascular hospitalizations, especially ischemic heart disease and stroke. Vulnerable groups? Men, adults aged 20–59, and socioeconomically deprived communities. 🧠 The risk peaks ~2 mont…
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🚗 42,939 lives lost in 2021 — the U.S. motor vehicle fatality rate remains far higher than other high-income nations. The NEJM review on Motor Vehicle Crash Prevention highlights the Safe System Approach: 🛣️ Safer roads 🚘 Safer vehicles 👥 Safer people ⚡ Safer speeds 🚑 Better postcrash care 🔍 From graduated driver licensing to automated emergency br…
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In today's episode, we'll be diving into the world of colorectal health, breaking down both functional conditions like pelvic floor disorders and chronic constipation, and biological conditions such as colorectal cancer, inflammatory bowel disease, and more. Dr Chris Gillespie shares his personal journey into the field of colorectal surgery, and we…
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🎙️ New Podcast Episode! “Hole in the Heart, Stroke on the Brain, Science at the Core” 🧠❤️🔬 Discover how a tiny opening—present in 1 in 4 adults—can lead to devastating strokes 🩺⚠️. We unpack the latest JAMA review on PFO, cryptogenic stroke, and how RoPE and PASCAL scores guide who benefits from closure. 🎯💉 🔗 Tune in to learn about cutting-edge tri…
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🧬 Just explored the largest GWAS on stuttering—over 1 million participants! 🎵 Fascinating link uncovered between impaired rhythm and speech disfluency, supporting the Atypical Rhythm Risk Hypothesis. 🧠 Genes like VRK2 and FANCL connect beat synchronization and stuttering risk. 🚀 A big step toward precision care in developmental speech disorders. #G…
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🎙️ From MRAs to ASIs: Rewriting Heart Failure’s Aldosterone Story 🚨 New Episode Alert! 🎧 Title: From MRAs to ASIs: Rewriting Heart Failure’s Aldosterone Story 💔🧬💊 In this episode of Got Knowledge Doc, we unpack the double-edged role of aldosterone in heart failure and kidney disease—from its genomic mischief to its nongenomic chaos via GPER. We div…
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🚫💊➡️⚖️ The GLP-1 Comeback: Weight Regain After the Stop” 📊 Based on the 2025 BMC Medicine meta-analysis, we explore what happens after stopping anti-obesity meds like GLP-1 receptor agonists. 👀 Key takeaways: – Weight regain begins as early as 8 weeks after stopping – GLP-1 drugs show the highest rebound 📈 – Lifestyle changes alone may not prevent …
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🚨 Podcast Alert: “Move. Breathe. Beat AF 🏃‍♂️🫀💥” The latest Cochrane systematic review + meta-analysis shows that exercise-based cardiac rehabilitation (ExCR) meaningfully reduces: ✅ AF recurrence ✅ Symptom severity ✅ AF burden and frequency ✅ And improves VO₂ peak & mental health—all without increased serious events. 📢 Time to rethink rhythm contr…
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Titrate, Train, Triumph 🧬🏋️‍♀️🎯” Obesity medications like semaglutide and tirzepatide are game-changers—but managing GI side effects, sarcopenia risk, and long-term adherence requires nuance, nutrition, and teamwork. 💡 From nausea to nutrition, and from missed doses to muscle mass—this episode offers practical, evidence-based strategies to optimize…
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Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Tao Zuo from the Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, Guangdong, China, on the paper "Diet…
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🔬 New Insights in Lipidology! 🫀 A landmark study in European Heart Journal (2025) shows that Apolipoprotein B (ApoB) particle count is a more powerful predictor of coronary artery disease than traditional LDL cholesterol. While VLDL particles are more atherogenic per unit, LDL dominates by count — making total ApoB count + Lipoprotein(a) the gold s…
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🧠✨ Just read a thought-provoking article in JAMA on the US POINTER trial! Structured lifestyle changes (think 🏃‍♀️🥗🧩) showed modest but real gains in cognition for older adults at risk of dementia. But here’s the twist: even light-touch self-guided changes yielded nearly similar benefits. 🤯 So… 💬 Is intensity always worth the investment? Or can sim…
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🔬 New Review Alert! 🫀 South Asians face one of the highest global burdens of premature heart disease — and Lp(a) may be the silent culprit. 📈 In a comprehensive JAHA 2025 review, researchers reveal how 25% of South Asians have dangerously elevated Lp(a) levels, doubling their risk of myocardial infarction. 🧬💥 Key takeaways: ✅ Lp(a) is genetically d…
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📢 New insights on education & brain aging! 🧠📉 A mega-analysis across 33 countries (170K+ participants, 15K+ MRIs) shows 📚 higher education boosts baseline memory—but doesn’t slow brain aging or cognitive decline over time. ❌🧓 ✅ Early-life traits (like childhood cognition & environment) drive the advantage. 🔗 Education matters—but not in the way we …
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🧬 Just dropped: our latest podcast episode 🎙️ dives into Lipoprotein(a) and its powerful role in predicting vascular disease beyond the heart 🫀—including PAD 🦵 and stroke 🧠. 📊 Based on a massive UK Biobank study (n=460K+), high Lp(a) levels (≥150 nmol/L) were linked to: • 18% ↑ risk of PAD • 17% ↑ risk of carotid stenosis • 60% ↑ risk of major limb…
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🧠✨ Dive into the mind of Avicenna (Ibn Sina) — the Persian polymath who shaped medicine, metaphysics, and logic for centuries. From the Canon of Medicine to the Book of Healing, his legacy lives on in modern science and thought. 🎓📚 #Philosophy #Medicine #AvicennaBy MasterMedFacts LLC
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📢 New Data Drop! 🫀💥 South Asian adults in the U.S. have an earlier and sharper rise in coronary artery calcium (CAC) — a silent marker of heart disease risk! 🇮🇳📊 In a first-of-its-kind study combining MASALA & DILWALE cohorts (n=2,743), 65% of South Asian men and 30% of women had CAC >0 by age 55 — and women catch up fast after menopause. 🚹➡️🚺 📌 Se…
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🚨 New Insights from Nature Medicine 🧠🍕 Can cookies and chips hijack your brain like cocaine? A compelling new article argues that ultra-processed food addiction mirrors classic substance use disorders — down to the cravings, compulsive use, and reward circuit disruption. With GLP-1 drugs bridging obesity and addiction treatment, is it time the DSM-…
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In this episode of Bowel Sounds Summer School, hosts Drs. Temara Hajjat and Jason Silverman have taken highlights from past episodes on inflammatory bowel disease (IBD) and put them into a special episode jam-packed with clinical pearls. Former expert guests explain how to manage patients with IBD. Our Bowel Sounds Summer School series will include…
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In this episode of The Talking Gut Podcast, we’re joined by Professor Doug Drossman and Johannah Ruddy to discuss their two powerful books, Gut Feelings. We explore the history of mind-body medicine, the importance of the doctor–patient relationship, and the emotional and clinical complexity of disorders of gut-brain interaction (DGBI). A must-list…
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🧠🏃‍♂️ Can running rewire the Alzheimer’s brain? New study in Nature Neuroscience shows how exercise transforms cell-specific gene expression in the dentate gyrus of AD mice! Using single-nucleus RNA-seq, researchers found that voluntary running reversed transcriptional dysregulation in key cell types—especially immature neurons, astrocytes, and mic…
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🚨 Statins & Diabetes: Dose Matters, But So Does Perspective 💊📉 A 2024 CTT Collaboration meta-analysis of 154,664 participants confirms: ✅ Statins modestly increase risk of diabetes (10% with moderate, 36% with high-intensity) 📈 Small upticks in HbA1c and glucose 🧪 But most new cases were already teetering near the threshold 🩺 Bottom line? Cardiovas…
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🧬 Just explored a groundbreaking 50-year proteomic atlas that charts how our proteins evolve with age across 13 human tissues! 🧠 Key insights? Aging inflection around 50, transcriptome-proteome decoupling, amyloid buildup, and senoproteins like GAS6 & GPNMB driving vascular & systemic aging. 📊 Proteomic clocks, plasma biomarkers, and tissue-specifi…
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🧬 New findings from Science Signaling reveal that deleting PTP1B in cardiomyocytes protects the heart from high-fat diet–induced cardiomyopathy! 🛡️❤️ This elegant study shows how **metabolic rewiring—boosting fatty acid oxidation, enhancing AMPK, and preserving mitochondria—**prevents cardiac hypertrophy and dysfunction. 🚫🍔➡️💪💓 Could targeting the …
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🚨 Just in: The 2024 KDIGO guidelines are here to delay CKD progression! 🩺💡 With updated insights on protein intake, SGLT2 inhibitors, and BP targets, this is a must-read for every internist and nephrologist. 🚱💊 Highlights include use of finerenone, combo therapies, and emerging role of GLP-1RAs. 🧬📉 🔗 Dive into the new JAMA summary and elevate your …
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🚶‍♀️ How many steps a day keep the doctor away? 📉🧠 A sweeping meta-analysis in The Lancet Public Health reveals that just 7000 steps/day (not 10,000!) can reduce the risk of death, cardiovascular disease, cancer, dementia, diabetes, depression, and falls—with benefits starting as low as 4000 steps. 🩺👟 Every step counts. 🔗 Read more. #PublicHealth #…
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🔬 Just explored a brilliant review in Nature Reviews Cancer on how ageing shapes cancer evolution 🧓🧬 From clonal expansions and inflamm-ageing to cutting-edge models like GEMMs, CRISPR, and epithelioids, this article reframes how we study cancer through the lens of time ⏳ 🎧 Check out our latest podcast: “Mutations, Microenvironments & Mortality” — …
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🚨 New Podcast Alert! 🎙️ 🧬 “Genes, Hearts, and Hope: Precision Therapies for Cardiomyopathy” is LIVE! From sarcomeres to splicing, from fibrosis to fixable mutations—this episode unpacks cutting-edge treatments like myosin modulators 🧪, gene therapy 🧠, and antisense oligonucleotides 💉. If you’re a cardiologist, geneticist, or just curious about the …
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📢 Just read a landmark study in Nature Medicine—over 5 million participants across ancestries! 🧬 The new multi-ancestry polygenic risk score (PRS-CSx) predicts BMI & obesity from early life to adulthood 🌍👶📈. Strong implications for personalized prevention, though disparities persist in African ancestry populations ⚖️. Precision meets public health—…
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Welcome back to another episode of Talking Gut! Today, we’re joined once again by the legendary Professor Doug Drossman, a pioneer in the field of disorders of gut-brain interaction (DGBI), such as IBS. You may remember Dr. Drossman from Episode 13, where we explored the biopsychosocial model of care, and Episode 18, where we discussed communicatio…
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🔬🫀 When Troponin Lies: A Case of Macrotroponin 🧪❗ We’ve all seen elevated troponins trigger cath lab calls—but what if the numbers don’t add up? This fascinating case from EHJ Case Reports reveals how an IgG–troponin T complex (macrotroponin) mimicked an acute coronary syndrome in a patient with a structurally normal heart and clean coronaries. 📈 P…
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🎓 Dive into the profound legacy of Abu Nasr al-Farabi—the “Second Master” after Aristotle 🧠🎼 From logic to music, metaphysics to political philosophy, his thought shaped both East & West. 🕌🌍 #Philosophy #IslamicPhilosophy #AlFarabi #Neoplatonism #KnowledgeIsPower #WisdomWednesday ✨📚By MasterMedFacts LLC
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🚨 New Advances in Heart Transplantation! 🫀✨ Curious about how we’re expanding the donor pool and saving more lives? 🌍 Learn the differences between DCD (Donation after Circulatory Death) and DBD (Donation after Brain Death)—from ethics and outcomes to innovation and global trends. 💡 Techniques like REUP and on-table reanimation are reshaping what’s…
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🚨 New Study Alert! 🧠🧪 How does your brain handle a blocked drain — and does age make it worse? 🤔💧 This podcast dives into how chronic impairment of deep cervical lymphatic drainage affects brain fluid dynamics and triggers low-grade neuroinflammation — all in an age-dependent manner. 🧓⚖️👶 🔍 Using DCE-MRI, proteomics, and metabolomics, we found that…
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After a brief break, Talking Gut is back and better than ever. Hosted by Clinical Psychologist Dr. Jim Kantidakis, this podcast dives deep into the fascinating world of gut health, the gut-brain connection, and everything in between. Expect insightful conversations with leading experts, real stories, and evidence-based discussions on topics like IB…
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🚨 New Podcast Episode! 🎙️ “🦵 Swell, Strain, Support: Tackling Chronic Venous Insufficiency” Millions silently suffer from leg swelling, fatigue, and ulcers — but did you know most cases don’t need surgery? 🧦💡 We unpack the latest NEJM insights on functional vs. structural CVI, the underrated power of calf pumps 💪, compression therapy 🧘‍♀️, and when…
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New Study Alert! 🧠💉📉 Exciting real-world evidence shows that GLP-1 receptor agonists—semaglutide and tirzepatide—not only help with type 2 diabetes and obesity but may also reduce the risk of dementia, stroke, and all-cause mortality! 🙌📊 In a cohort of over 60,000 patients, these agents delivered neuroprotective and cerebrovascular benefits beyond …
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🧬 New Insights into Gut–Heart Axis 🫀💡 Groundbreaking research published in Nature shows that Imidazole propionate (ImP)—a metabolite produced by gut bacteria—drives atherosclerosis by hijacking immune pathways in myeloid cells via the I1R–mTORC1 axis 🔥🧫. 📈 Elevated ImP levels predicted subclinical atherosclerosis independently of cholesterol in two…
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🚨 New Podcast Alert! 🎙️🧬 Curious about how modern medicine is tackling devastating mitochondrial DNA diseases like MELAS, LHON, and NARP? Our latest podcast dives into four landmark NEJM articles covering cutting-edge advances—from embryo screening (PGT) to groundbreaking mitochondrial replacement therapy (MRT). 🧪👶 Join us as we explore science, et…
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🚨 AI meets ECG 🧠⚡ New insights show that a simple ECG — when powered by deep learning — can detect structural heart diseases like LV systolic dysfunction, HCM, and aortic stenosis with AUROCs >0.90! 🫀📈 📊 Sample size: 54,000+ | NPV >98% | p < 0.001 ✅ Low-cost, non-invasive, high-accuracy screening? Yes, please. 🧠 Time to rethink the ECG as a frontli…
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New Podcast Episode Alert! 🎙️ “💧Block, Burst, or Both?💥 Understanding Male LUTS” Up to 40% of men over 50 face lower urinary tract symptoms—from weak stream to nocturia. This week, we unpack the landmark JAMA 2025 review by Drs. Wei, Dauw, and Brodsky. 🧠💊 Tune in as we explore: 🔹 BPH vs Overactive Bladder 🔹 When to treat—and how 🔹 Meds, muscles, an…
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