Lauren Jatt is an infectious diseases fellow at the University of Washington. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. L.P. Jatt and Others. An HIV Vaccine in the Era of Twice-Yearly Lenacapavir for PrEP — Essential or Irrelevant? N Engl J Med 2025;392:1561-1563.…

Featuring articles on bronchiectasis, influenza, clonal hematopoiesis of indeterminate potential, and metachromatic leukodystrophy; a review article on biology of the Fc neonatal receptor; a case report of a woman with sore throat and rash; and Perspectives on HIV preexposure prophylaxis, on fossil fuels, and on Medicaid’s mandate for children and …

How good are we at preventing HIV? How do efficacy and effectiveness differ? We journey from oral pre-exposure prophylaxis (PrEP) to long-acting injectables, and then to the PURPOSE trials, which look at the use of long-acting lenacapavir as PrEP — a potential game-changer in the field of HIV. Listen to this latest episode of Beyond Journal Club, a…

Welcome to Simulcast! In this special episode, Victoria Brazil is joined by Hege Ersdal and Benjamin Kamala, the joint first authors of a ground-breaking study just published in the New England Journal of Medicine. Their program aimed to reduce birth-related mortality in Tanzania, with spectacular success. The Safer Births Bundle integrated key ele…

Join us for the April edition of the Simulcast Journal Club, hosted by Vic Brazil and Ben Symon, In this episode: Self-led debriefings, measuring team cognition, simulation as a basic computational mechanism in the brain, and picto-dictionaries. The papers Kumar P, Harrison NM, McAleer K, Khan I, Somerville SG. Exploring the role of self-led debrie…

In this NEJM Outbreaks Update, Editor-in-Chief Eric Rubin and Deputy Editor Lindsey Baden are joined by Indiana Commissioner of Public Health Lindsay Weaver to discuss the current state of avian influenza in Indiana. Eric Rubin is the Editor-in-Chief of the Journal. Lindsey Baden is a Deputy Editor of the Journal. Lindsay Weaver is the Indiana Comm…

Patricia Zettler is a professor of law at The Ohio State University Moritz College of Law. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. P.J. Zettler, T.L. Wagener, and M.L. Berman. What’s Next for Nicotine? The Coming Legal and Political Battles over an FDA Proposal. N Engl J Med 2025;392:1461-1463.…

Featuring articles on obinutuzumab in active lupus nephritis, tecovirimat for mpox, treatments for paroxysmal atrial fibrillation, and gene therapy for hemophilia B; a review article on enteral nutrition in hospitalized adults; a case report of a woman with cough and weight loss; and Perspectives on withdrawal of the United States from the WHO, on …

John Patrick Co is vice president of education at Mass General Brigham and an associate professor of pediatrics at Harvard Medical School. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. D.F. Weinstein, E. Olson, and J.P.T. Co. Addressing Socioeconomic Barriers to Residency Choice. N Engl J Med 2025;392:1353-135…

Featuring articles on cancer-associated venous thromboembolism, endovascular treatment for stroke, dapagliflozin in patients undergoing TAVI, screening for prostate cancer, and extrachromosomal DNA; a review article on otitis media in young children; a case report of a woman with flank pain, fever, and hypoxemia; and Perspectives on some efforts to…

How can the partnership and collaboration of multiple health care organizations attack the challenges of rural health care?By Dan Liljenquist, James N. Weinstein, Thomas H. Lee

Featuring articles on HIV prevention, left atrial appendage closure after ablation for atrial fibrillation, timing of thrombolysis for stroke, congenital diarrhea and enteropathy, and the association between wealth and mortality in the United States and Europe; a review article on malaria; a Clinical Problem-Solving describing a “hot” cardiomyopath…

What does Lipoprotein(a) tell us that a standard lipid panel doesn’t? Should we be testing everyone for it? Dive into the genetics, clinical implications, and evolving management strategies for Lp(a). Learn how to interpret results, counsel patients, and navigate topics with limited data like aspirin and PCSK9 inhibitors in treatment. 🔹 Sponsor: Fr…

Join us for the March edition of the Simulcast Journal Club, hosted by Vic Brazil and Ben Symon, In this episode: Integrating electronic medical records into simulations, learning from reluctant participants in paediatric simulation training, using tabletop sandbox simulations to understand emergency department care coordination, and quality in sim…

Rochelle Walensky is the Bayer fellow in health and biotech at the American Academy in Berlin, a senior fellow at the Harvard Kennedy School, and an executive fellow at Harvard Business School. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. R.P. Walensky and L.D. Walensky. Application Overload — A Call to Reduc…

Erin Fuse Brown is a professor of health services, policy, and practice at the Brown University School of Public Health and a member of the Journal’s Perspective Advisory Board. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. E.C. Fuse Brown, O.J. Wouters, and A. Mehrotra. Partnerships between Pharmaceutical and…

Featuring articles on intensive blood-pressure control in patients with diabetes, IgG4-related disease, severe chronic rhinosinusitis, advanced breast cancer, and vaccinating against C. difficile infection; a review article on chronic cough in adults; a case report of a man with hepatocellular carcinoma; an editorial on order out of chaos; and Pers…

This is our 200th episode of Simulcast. To mark the occasion, Vic, Ben. Jess and Jesse all shared some thoughts on what we think we’ve achieved, the impacts that Simulcast has had on us, and ventured some highlights We reflected on our first episode in 2016, and our review of Davis Gaba’s Future vision of simulation in healthcare. Ben ventured that…

A new way to think of clots beyond provoked vs. unprovoked: Learn all about how important it is to think about reversibility! What patient states affect the inherited thrombophilia testing? Learn the nuances and practical approaches! 🔹 Sponsor: Freed is an AI scribe that listens and writes your note in < 30 seconds. Freed learns your style over tim…

Alex Keuroghlian is an associate professor of psychiatry at Harvard Medical School and the director of the Division of Public and Community Psychiatry at Massachusetts General Hospital. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. D.R.A. Coelho, A.L. Chen, and A.S. Keuroghlian. Advancing Transgender Health am…

Featuring articles on breast cancer, bloodstream infection, subarachnoid hemorrhage, scrub typhus, and birth-related mortality; a review article on the evaluation and treatment of infertility; a case report of a woman with altered mental status and acidemia; and Perspectives on advancing transgender health amid policy threats, on evidence-based wor…

In this audio interview, Editor-in-Chief Eric Rubin and Deputy Editor Lindsey Baden are joined by state public health leaders Robbie Goldstein and Jennifer Shuford to discuss action against H5N1 in Massachusetts and Texas and across the nation. Eric Rubin is the Editor-in-Chief of the Journal. Lindsey Baden is a Deputy Editor of the Journal. Robert…

Sara Gerkeis an associate professor of law at the University of Illinois Urbana-Champaign. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. S. Gerke, M.B. Jacoby, and I.G. Cohen. Bankruptcy, Genetic Information, and Privacy — Selling Personal Information. N Engl J Med 2025;392:937-939.…

Featuring articles on bacterial vaginosis, diabetes prevention, Danon disease, chronic spontaneous urticaria, and VITT-like monoclonal gammopathy of thrombotic significance; a review article on micronutrients; a Clinical Problem-Solving on unveiling the unforeseen; and Perspectives on bankruptcy and genetic information, on drug development for rare…

What is the impact of microplastics on human health? How can we use observational data to support the argument that microplastics may lead to poor health outcomes? Join us as we tackle these questions and discuss the APAChE study on microplastics and cardiovascular disease on this episode of Beyond Journal Club, a series brought to you by Core IM i…

In this NEJM Outbreaks Update, Editor-in-Chief Eric Rubin and Deputy Editor Lindsey Baden are joined by veterinarian and virologist Yoshihiro Kawaoka to discuss avian influenza and its current impact on chickens, cows, cats, and humans. Eric Rubin is the Editor-in-Chief of the Journal. Lindsey Baden is a Deputy Editor of the Journal. Yoshihiro Kawa…

What is the last sense to go? How can music create connection, ease anxiety, and help process emotions at the end of life? Join Dr. Jafar Al-Mondhiry, Dr. Harry Han, and music therapist Bryanna Tobin as they explore the power of music therapy in hospice care, sharing moving stories and clinical insights. 🔹 This episode is also sponsored by Factor! …

John Kelly is the director of the Recovery Research Institute at Massachusetts General Hospital and a professor of psychiatry in addiction medicine at Harvard Medical School. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J.F. Kelly, N.D. Volkow, and H.K. Koh. The Changing Approach to Addiction — From Incarcera…