Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Lung Cancer, a leading cause of cancer-related mortality worldwide. We explore the pathophysiology, risk factors, and key differences between non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) to help you master this complex topic. Our di…

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Myelodysplastic Syndrome (MDS), a group of hematologic disorders characterized by ineffective hematopoiesis and a risk of progression to acute myeloid leukemia (AML). We also discuss the pathophysiology of MDS, highlighting the clonal stem cell mutations t…

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Breast Cancer's pathogenesis, risk factors, and the latest advancements in screening, diagnosis, and treatment. We break down the molecular subtypes of breast cancer, including hormone receptor-positive, HER2-positive, and triple-negative disease, and disc…

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Amyloidosis, a complex disorder characterized by the misfolding and deposition of insoluble amyloid fibrils in tissues. We break down the different subtypes, including AL (light chain), AA (secondary), ATTR (transthyretin), and Aβ2M (β2 microglobulin), hig…

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive deep into Lymphoma, breaking down its pathogenesis, clinical presentation, and the latest advancements in treatment. We explore the key differences between Hodgkin and Non-Hodgkin Lymphoma, examining the role of Reed-Sternberg cells, CD markers, and genetic m…

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Chronic Leukemias, focusing on their pathogenesis, clinical features, and modern treatment strategies. We compare Chronic Myeloid Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL), discussing the role of BCR-ABL in CML and the implications of smudge ce…

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive deep into Acute Leukemias, breaking down their pathophysiology, clinical presentation, and management. We explore the key differences between Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL), focusing on the genetic mutations, risk factors,…

Ninja Nerds! Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Myeloproliferative Neoplasms, covering their pathophysiology, clinical presentation, and management. We discuss Polycythemia Vera, Essential Thrombocythemia, Chronic Myeloid Leukemia, and Primary Myelofibrosis, focusing on key mutations like JAK2, CALR, an…

Ninja Nerds! Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we take a closer look at Plasma Cell Disorders, focusing on their pathophysiology, clinical features, and management. Topics include the mechanisms behind multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), and Waldenström macroglobulinemia, …

Ninja Nerds! Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Antiplatelets, Anticoagulants, and Thrombolytics, focusing on their mechanisms and clinical uses. Topics include the pharmacology of antiplatelet agents such as aspirin and P2Y12 inhibitors, the role of anticoagulants like heparins, direct oral anticoagula…

Ninja Nerds! Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Hypercoagulable States, covering key disorders and their clinical significance. Topics include Antiphospholipid Syndrome (APLS), its role in thrombosis and pregnancy loss; Factor V Leiden Mutation, the most common inherited thrombophilia; and Prothrombin G…

Ninja Nerds! Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Coagulopathy, focusing on key bleeding and clotting disorders. Topics include Hemophilia A and B, their genetic causes, and modern treatments; Von Willebrand Disease (vWD), the most common inherited bleeding disorder; and Heparin-Induced Coagulopathy, with…

Ninja Nerds! Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Platelet Disorders, breaking down the essential concepts and clinical applications. We will discuss Heparin-Induced Thrombocytopenia (HIT), focusing on its pathophysiology and management. Learn about Antiphospholipid Syndrome (APLS) and its role in thrombo…

Ninja Nerds! Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive into blood transfusions, breaking down the essential components and clinical uses. We will discuss packed red blood cell transfusions (PRBC) for anemia management, platelet transfusions for thrombocytopenia and bleeding risk, and the role of Fresh Frozen Plas…

Ninja Nerds! Welcome to the Ninja Nerd Podcast with Zach and Rob! This episode dives into Macrocytic Anemia. During this discussion, we will review B12 Deficiency Anemia, Folate Deficiency Anemia, and Non-Megaloblastic Anemia. We have three cases we will be working through, so please listen along and see if you can figure out these cases. Enjoy the…

Ninja Nerds! Welcome to the Ninja Nerd Podcast with Zach and Rob! This episode dives into Normocytic Anemia, exploring the primary types, including Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria (PNH), G6PDH Deficiency, Hereditary Spherocytosis, Autoimmune Hemolytic Anemia (AIHA), Sickle Cell Anemia, Microangiopathic Hemolytic Anemia (MAHA), …

Ninja Nerds! Welcome to the Ninja Nerd Podcast with Zach and Rob! This episode is on Microcytic Anemia, covering the major types such as iron deficiency anemia, thalassemia, anemia of chronic disease, and sideroblastic anemia. Enjoy the podcast and support us below! Ninja Nerd Website | https://ninjanerd.org Ninja Nerd Podcast | https://podcast.nin…

Premium Member Resources: https://ninjanerd.org Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Vasculitis. You'll learn about the causes, symptoms, and treatment options for Large, Medium, and Small Vessel Vasculitis. We'll discuss clinical cases to highlight critical diagnostic and management strategies for diseas…

Premium Member Resources: https://ninjanerd.org Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Nephrolithiasis. You'll learn about the causes, symptoms, and treatment options for Nephrolithiasis. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepared f…

Premium Member Resources: https://ninjanerd.org Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Diuretics. You'll learn about the causes, symptoms, and treatment options for Diuretics. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepared for your exam…

Premium Member Resources: https://ninjanerd.org Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss IV Fluids. You'll learn about the causes, symptoms, and treatment options for IV Fluids. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepared for your exam…

Premium Member Resources: https://ninjanerd.org Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss the Approach to Hematuria. You'll learn about the causes, symptoms, and treatment options for Hematuria. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepar…

Premium Member Resources: https://ninjanerd.org Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Cystic Kidney Disease. You'll learn about the causes, symptoms, and treatment options for Cystic Kidney Disease. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're wel…

Premium Member Resources: https://ninjanerd.org Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Glomerular Diseases, including Nephrotic and Nephritic Syndrome. You'll learn about the causes, symptoms, and treatment options for Glomerular Diseases. We'll discuss clinical cases to highlight critical diagnostic and ma…

Premium Member Resources: https://ninjanerd.org Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Chronic Kidney Disease (CKD). You'll learn about the causes, symptoms, and treatment options for CKD. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're well-prepared …

Premium Member Resources: https://ninjanerd.org Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Acute Kidney Injury (AKI). You'll learn about the causes, symptoms, and treatment options for Prerenal, Intrarenal, and Postrenal AKI. We'll discuss three clinical cases to highlight critical diagnostic and management str…

Premium Member Resources: https://ninjanerd.org Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Calcium Disorders. You'll learn about the causes, symptoms, and treatment options for Hypocalcemia and Hypercalcemia. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you'r…

Premium Member Resources: https://ninjanerd.org Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Potassium Disorders. You'll learn about the causes, symptoms, and treatment options for Hypokalemia and Hyperkalemia. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you'r…

Premium Member Resources: https://ninjanerd.org Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Sodium Disorders. You'll learn about the causes, symptoms, and treatment options for Hyponatremia and Hypernatremia. We'll discuss clinical cases to highlight critical diagnostic and management strategies, ensuring you're…

Premium Member Resources: https://ninjanerd.org Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Acid-Base Disorders. You'll learn about the causes, symptoms, and treatment options for Metabolic Acidosis, Metabolic Alkalosis, Respiratory Acidosis, and Respiratory Alkalosis. We'll discuss clinical cases to highlight c…

Premium Member Resources: https://ninjanerd.org Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore the intricacies of hypovolemia and hypervolemia. You'll learn about the causes, symptoms, and treatment options for both conditions. We'll discuss clinical cases to highlight key diagnostic and management strategies, ensu…

This week, Rob and Zach will be talking about Hyperaldosteronism. We will be discussing the following topics within this episode on Hyperaldosteronism! The Aldosterone Pathway and Normal Physiology Aldosterone Target Organs & Effects Causes of High Aldosterone Diagnostic Workup Treatment To follow along with Notes & Illustrations for our podcasts p…

This week, Rob and Zach will be talking about Cushing's Syndrome. We will be discussing the following topics within this episode on Cushing's Syndrome! The Cortisol Pathway and Normal Physiology Cortisol Target Organs & Effects Causes of High Cortisol Diagnostic Workup Treatment To follow along with Notes & Illustrations for our podcasts please bec…

This week, Rob and Zach will be talking about Anxiolytic & Hypnotic Drugs. We will be discussing the following topics within this episode on Anxiolytic & Hypnotic Drugs! Pathophysiology Anxiety Insomnia Mechanism of Action Anxiolytics Hypnotics Treatment Approach Anxiety Insomnia Adverse Drug Reactions Anxiolytics Hypnotics To follow along with Not…

This week, Rob and Zach will be talking about Drugs for Epilepsy. We will be discussing the following topics within this episode on Drugs for Epilepsy! Classification between Seizures & Epilepsy Causes / Pathophysiology Mechanism of Anti Epileptic Drugs (AEDs) Clinical Approach to Epilepsy Adverse Drug Reactions & Systematic Involvement To follow a…

This week, Rob and Zach will be talking about Parkinson's Disease (PD) Drugs We will be discussing the following topics within this episode on Parkinson's Disease (PD) Drugs! Anatomy of Basal Ganglia Direct vs. Indirect Pathway Pathophysiology and Mechanism of Action of PD Drugs PD Drug Categories L-dopa & Carbidopa Dopamine Agonists COMT-Inhibitor…

This week, Rob and Zach will be talking about Hypernatremia. We will be discussing the following topics within this episode on Hypernatremia! Introduction to Hypernatremia Causes / Pathophysiology Clinical Features Physical Exam Findings Diagnosis Treatment To follow along with Notes & Illustrations for our podcasts please become a member on our we…

This week, Rob and Zach will be talking about Hyponatremia. We will be discussing the following topics within this episode on Hyponatremia! Introduction to Hyponatremia Causes / Pathophysiology Clinical Features Physical Exam Findings Diagnosis Treatment To follow along with Notes & Illustrations for our podcasts please become a member on our websi…

This week, Rob and Zach will be talking about Muscarinic Antagonists within our short four part series on Autonomic Pharmacology We will be discussing the following topics within this episode on Muscarinic Antagonists! To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org/podcas…

This week, Rob and Zach will be talking about Cholinergic Agonists within our short four part series on Autonomic Pharmacology We will be discussing the following topics within this episode on Cholinergic Agonists! To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org/podcast/au…

This week, Rob and Zach will be talking about Adrenergic Antagonists within our short four part series on Autonomic Pharmacology We will be discussing the following topics within this episode on Adrenergic Antagonists! To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org Follow…

This week, Rob and Zach will be talking about Adrenergic Agonists within our short four part series on Autonomic Pharmacology We will be discussing the following topics within this episode on Adrenergic Agonists! To follow along with Notes & Illustrations for our podcasts please become a member on our website! https://www.ninjanerd.org/podcast/auto…

This week, Rob and Zach will be talking about Anticoagulants, Thrombolytics, and Antiplatelet Agents We will be discussing the following topics within this episode on Anticoagulants, Thrombolytics, and Antiplatelet Agents! Hemostasis: Coagulation Cascade, Extrinsic + Intrinsic Pathway Anticoagulants: Heparin UFH LMWH Fondaparinux Direct Factor Inhi…

This week, Rob and Zach will be talking about Diuretics We will be discussing the following topics within this episode on Diuretics! Defining a Diuretic Diuretics Drug Categories: Osmotic Diuretics Carbonic Anhydrase Inhibitors Loop Diuretics Thiazide Diuretics Potassium Sparing Diuretics Diuretics MOA Therapeutic Indications Adverse Drug Reactions…

This week, Rob and Zach will be talking about Antiarrhythmic Drugs We will be discussing the following topics within this episode on Antiarrhythmic Drugs! Defining an Arrhythmia Pathophysiology of an Arrhythmia: Abnormal Automaticity Increased Triggered Activity Re-Entrant Circuits Antiarrhythmic Drug Categories: Class I: Sodium Channel Blockers (T…

This week, Rob and Zach will be talking about Drugs for Treating Heart Failure - Let's master this topic together, Ninja Nerds! We will be discussing the following topics within this episode on Drugs for Heart Failure! Defining Congestive Heart Failure (CHF) Pathophysiology of CHF Drug Categories used to Treat Heart Failure: Beta Blockers ACE Inhib…

This week, Rob and Zach will be talking about Drugs for Treating Hyperlipidemia. Make sure you stick around for the entire episode, this one is a beauty, unlike my coronary vessels... We will be discussing the following topics within this episode on Hyperlipidemia Drugs! Defining Hyperlipidemia Pathophysiology & Complications of Hyperlipidemia Drug…

This week, Rob and Zach will be talking about Antianginal Drugs. We will be discussing the following topics within this episode on Antianginal Drugs! Defining Angina Pathophysiology of Angina Mechanism of Antianginal Drugs Indications and Adverse Drug Reactions of Antianginal Drugs Drug Categories of Antianginal Agents will include: Beta Blockers C…

This week, Rob and Zach will be talking about Antihypertensive Drugs to supplement our YouTube lecture on Antihypertensive Drugs. We will be discussing the following topics within this episode on Antihypertensive Drugs! Defining Hypertension Mechanism of Hypertension Mechanisms of Antihypertensive Agents Indications and Adverse Drug Reactions of An…

This week, Rob and Zach will be talking about Tuberculosis. We will be discussing the following topics within this episode on Tuberculosis! Introduction to Tuberculosis Causes / Pathophysiology Clinical Features Physical Exam Findings Diagnosis Treatment To follow along with Notes & Illustrations for our podcasts please become a member on our websi…