Updates on new data and best practices in the care of patients with cancer across a wide variety of solid tumors and hematologic malignancies from Clinical Care Options. Gain practical clinical insights and strategies and earn CME/CE credit for selected episodes.
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A strategic podcast where Amy Ledin talks about the main F’s that have influenced her life and have helped her in creating her best self. She covers areas in faith, family, forgiveness, food, fitness, and formula. She will deep dive into how placing her baby for adoption at 18, losing almost 100 pounds, facing her marriage-ending affair, and battling stage 4 cancer for almost 7 years, has only made her stronger. Join Amy as she takes you through her story, her life-changing struggles, and sh ...
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Role of the Multidisciplinary Team in Achieving Comprehensive and Individualized Care of Patients with HR-positive/HER2-negative Metastatic Breast Cancer and Preexisting Comorbidities
35:15
35:15
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35:15In this podcast episode, Sara A. Hurvitz, MD, FACP, La-Urshalar B. Brock, FNP-BC, CNM, and Jordan Hill, PharmD, BCOP, discuss the important role of the multidisciplinary team in achieving comprehensive and individualized care of patients with HR-positive/HER2-negative metastatic breast cancer and preexisting comorbidities, including: Key Comorbidit…
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Uncovering Safety and Signposts to the Future: AEs With HER2-Targeted ADCs and Future Applications
21:54
21:54
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21:54In this episode, Catherine Fahey, MD, PhD; Alexandra Leary, MD, PhD; Funda Meric-Bernstam, MD; and Zev A. Wainberg, MD, discuss the evolving safety considerations and future directions of HER2-targeted antibody–drug conjugates (ADCs) across genitourinary, gastrointestinal, and gynecologic cancers. Toxicity Profiles of HER2-Targeted ADCs: Common and…
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Taking a New Path: Evaluating Clinical Data With HER2-Targeted ADCs in Genitourinary, Gastrointestinal, and Gynecological Malignancies
29:36
29:36
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29:36In this episode, Catherine Fahey, MD, PhD; Alexandra Leary, MD, PhD; Funda Meric-Bernstam, MD; and Zev A. Wainberg, MD, explore the mechanisms of HER2-targeted antibody–drug conjugates (ADCs) and emerging clinical data with these agents across genitourinary, gastrointestinal, and gynecologic cancers. Mechanisms of action of ADCs: how ADCs selective…
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The Latest Evidence on Targeting B7-H3 in Small Cell Lung Cancer
18:34
18:34
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18:34In this episode, hear Lauren Byers, MD and Christine Hann, MD share their insights on the latest data regarding new therapies targeting B7-H3 in small cell lung cancer including: Rationale for targeting B7-H3 Overview of the structure of antibody-drug conjugates (ADCs) Results from the phase I/II IDeate-PanTumor01 trial of ifinatamab deruxtecan (I-…
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The Lay of the Land: Overview of Biology of HER2 in Genitourinary, Gastrointestinal, and Gynecologic Malignancies
14:09
14:09
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14:09In this episode, Zev A. Wainberg, MD; Funda Meric-Bernstam, MD; Alexandra Leary, MD, PhD; and Catherine Fahey, MD, PhD, explore testing for HER2 alterations and the incidence of HER2-positive disease in the treatment of genitourinary, gastrointestinal, and gynecologic malignancies. HER2 Testing in Advanced Cancers: Recommendations for when and how …
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Oncologist On-Call: Thoughts on the Current Treatment Landscape for First-line Management of HER2-Positive mBC
14:42
14:42
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14:42In this episode, listen to Stephanie L. Graff, MD, FACP, FASCO; and Laura M. Spring, MD, share their clinical insights and takeaways regarding the current treatment landscape for first-line treatment of patients with HER2-positive metastatic breast cancer including: Data from multicenter, single-arm, phase IIIb/IV DESTINY-Breast12 evaluating trastu…
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Expert Insights and FAQs on CDK4/6 Inhibitors in the Care of Today’s Patients With HR-Positive/HER2-Negative Breast Cancer
45:08
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45:08In this episode, Jame Abraham, MD, FACP; William J. Gradishar, MD, FACP, FASCO; and Laura Spring, MD, review key insights and frequently asked questions related to the CDK4/6 inhibitors used to treat patients with early and metastatic hormone receptor (HR)–positive/HER2-negative breast cancer from a live program held in January 2025. Key clinical p…
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Bispecific Antibody Therapy in Relapsed/Refractory Multiple Myeloma: Key Updates From the Annual Hematology Meeting
20:01
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20:01In this episode, Shaji K. Kumar, MD, reviews key data on bispecific antibodies used to treat patients with relapsed/refractory multiple myeloma recently presented at the 2024 annual American Society of Hematology meeting, including: Early results with teclistamab combined with anti-CD38 therapy Real-world data with teclistamab including its use aft…
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Clinical Highlights: Oral SERDs for Patients With HR+/HER2- ESR1-Mutated Advanced Breast Cancer
36:04
36:04
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36:04In this episode, listen to Virginia Kaklamani, MD, DSc; Erica L. Mayer, MD, MPH; and Laura M. Spring, MD, share their clinical insights and takeaways from a live symposium, including from key abstracts presented at the 2024 San Antonio Breast Cancer Symposium: Estrogen receptor mutations in patients With HR-positive/HER2-negative advanced breast ca…
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Relapsed/Refractory Multiple Myeloma: Role and Safety of Bispecific Antibodies
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20:40
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20:40In this episode, Caitlin Costello, MD, discusses important topics related to relapsed/refractory (R/R) multiple myeloma (MM), including: 3 bispecific antibodies approved for the treatment of R/R MM that target BCMA or GPRC5D The role of bispecific antibodies in R/R MM Safety considerations for patients while receiving a bispecific antibody Emerging…
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Gastroenteropancreatic Neuroendocrine Tumors: Diagnosis, Findings, and Recommendations
28:28
28:28
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28:28In this episode, Thor R. Halfdanarson, MD, and Jonathan Strosberg, MD, discuss important topics related to gastroenteropancreatic neuroendocrine tumors (GEP-NETs), including: The diagnosis and typical presenting symptoms of GEP-NETs Findings from recent key phase III studies including NETTER-2 and CABINET Recommendations for treatment sequencing No…
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ESMO 2024 Congress Highlights in Gynecologic Cancer: New Data Informing Treatment of Ovarian, Endometrial, and Cervical Cancers
30:45
30:45
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30:45In this episode, listen to Ana Oaknin, MD, PhD and Alexandra Leary, MD, PhD, share their clinical insights and takeaways on key updates and new data presented for ovarian, endometrial, and cervical cancer at the ESMO 2024 annual congress including: Phase III PRIMA/ENGOT-OV26/GOG-3012 Final OS Results: Niraparib as First-Line Maintenance in Advanced…
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A Cancer Conversation: Optimizing the Care of Patients With CLL Through a Deeper Understanding of BTK Inhibitor Resistance
32:48
32:48
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32:48In this episode, listen to Matthew S. Davids, MD, MMSc, and Lindsey Roeker, MD, discuss BTK inhibitor resistance and how it shapes treatment choices for patients with CLL, including: Contemporary treatment paradigms for patients with CLL Safety and efficacy of current regimens Molecular testing, including when and how to test for BTK inhibitor res…
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Available and Emerging Therapies for Progressive/Recurrent ROS1-Altered Advanced NSCLC
13:53
13:53
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13:53In this episode, listen to Alice T. Shaw, MD, PhD, and Jessica J. Lin, MD, share their thoughts on the available and emerging clinical data for second-line and beyond treatments in patients with recurrent ROS1-altered advanced NSCLC including: Assessing ROS1-TKI resistance mutations with tumor and liquid biopsies in patients with ROS1-altered advan…
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Available Clinical Data and Approved First-line Treatments for ROS1-Altered Advanced NSCLC
13:46
13:46
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13:46In this episode, listen to Alice T. Shaw, MD, PhD, and Jessica J. Lin, MD, share their thoughts on the available clinical data in support of frontline treatments for ROS1-altered NSCLC including: Efficacy and safety data for crizotinib, entrectinib, and repotrectinib in patients with ROS1-altered advanced NSCLC Long-term safety observations for cri…
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ROS1-Alterations and Molecular Testing in Advanced NSCLC
16:28
16:28
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16:28In this episode, listen to Alice T. Shaw, MD, PhD, and Jessica J. Lin, MD, share their thoughts on the current understanding of ROS1 rearrangements in non-small-cell lung cancer tumor biology and its implications for molecular testing and treatment selection including: ROS1-gene fusions in advanced lung cancer ROS1 testing recommendations with DNA …
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Midyear Highlights of Key Data From 2024 Gynecologic Cancer Conferences Informing Treatment of Ovarian, Endometrial, and Cervical Cancers
49:32
49:32
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49:32In this episode, listen to Floor J. Backes, MD, and Angeles Alvarez Secord, MD, MHSc, share their clinical insights and takeaways on new data presented for endometrial, ovarian, and cervical cancers presented at the 2024 annual meetings of the Society of Gynecologic Oncology and American Society of Clinical Oncology including: RUBY Part 1 Subgroup …
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Next-Generation Therapeutics for HR+/HER2- Breast Cancer: Spotlight on SERDs
34:45
34:45
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34:45In this episode, Dr Virginia Kaklamani moderates a discussion with Dr Aditya Bardia and Dr Sarah Sammons answering audience questions on the latest data on the use of oral SERDs therapy, including how to incorporate this new class of therapy into treatment plans for patients with HR+/HER2- breast cancer. Presenters: Virginia Kaklamani, MD, DSc Prof…
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Current Clinical Practice and NCCN Guidelines for CLL/SLL
31:33
31:33
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31:33In this podcast episode, Farrukh Awan, MD, Jeremy S. Abramson, MD, MMSc, and Shuo Ma, MD, PhD, discuss real-world patient cases and how to align current clinical practice with the NCCN guidelines for CLL/SLL, including: Prognostic variables when deciding between regimens Role of MRD in CLL Results from the phase II CAPTIVATE trial Choosing among th…
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Congress to Clinic: Expert Takeaways on Emerging Data for MPNs
28:35
28:35
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28:35In this episode, listen to Dr Brady L. Stein share his clinical insights and takeaways on new data for myeloproliferative neoplasms (MPNs) presented at the 2024 ASCO Annual Meeting and the EHA 2024 Congress including: Long-term survival adjusted for treatment crossover in patients with myelofibrosis (MF) treated with momelotinib vs danazol in the M…
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CELMoDs: Spotlight on Therapeutic Approaches Targeting Protein Degradation Pathways
24:23
24:23
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24:23In this podcast episode, Julio C. Chavez, MD, MS, and Alan Skarbnik, MD, discuss the emerging role of CELMoDs in NHL care, including: Rationale for targeting CELMoDs in NHL Mechanism of action of CELMoDs Key studies and available efficacy and safety data with investigational CELMoDs in NHL Key ongoing clinical trials of CELMoDs in NHL Strategies to…
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Experts Discuss the Role of CDK4/6 Inhibitors in HR+/HER2- Breast Cancer
24:30
24:30
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24:30In this episode, Dr Joyce O’Shaughnessy moderates a discussion with Dr Sara Hurvitz and Dr Erica Mayer answering audience questions on the latest data on incorporating CDK4/6 inhibitors into treatment plans for patients with HR+/HER2- breast cancer. Topics in this podcast include: Evidence from the monarchE and NATALEE trials of adjuvant abemacicli…
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Congress to Clinic: Expert Takeaways on Emerging Data for AML
25:21
25:21
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25:21In this episode, listen to Professor Eunice S. Wang, MD, share her clinical insights and takeaways on new data for acute myeloid leukemia (AML) presented at the 2024 ASCO annual meeting and the EHA 2024 Congress including: Data from the prospective, single-center phase Ib/II study of FLAG-IDA plus venetoclax in newly diagnosed or relapsed/refractor…
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Congress to Clinic: Expert Takeaways on Emerging Data for MDS
19:19
19:19
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19:19In this episode, listen to Professor Courtney DiNardo, MD, MSCE, share her clinical highlights and clinical takeaways on new data for myelodysplastic syndromes (MDS) presented at the 2024 ASCO annual meeting and the EHA 2024 Congress including: COMMANDS trial of luspatercept in transfusion-dependent, erythropoietin stimulating agent–naive, very low…
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205 - Empowerment in Midlife: Revealing Your Potential with Joe Hoye
26:09
26:09
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26:09Explore the key components of designing your ideal life. Host Amy Ledin introduces Joe Hoye, a renowned fitness expert spearheading a summit on perimenopause, menopause, and overall well-being. Joe shares his transformative journey, ignited at age 13 by his mother's introduction to the gym, propelling him into a career in surgical technology with a…
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204 - Six Reasons You Should Rehearse Your Day
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13:54
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13:54Discover how a simple five-minute nightly routine can transform your day with reduced stress and heightened efficiency. Host Amy Ledin shares personal insights and actionable strategies for implementing this practice, emphasizing the benefits of detailed planning for daily tasks and nutrition. She explains how mentally rehearsing your day can help …
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Experiences With Oral SERDs for HR+/HER2- Metastatic Breast Cancer
25:55
25:55
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25:55In this episode, Manali Bhave, MD; Annalise Labatut, PharmD, BCOP; and nurse practitioner Jamie L. Carroll, CNP, APRN, MSN, begin by discussing the landmark EMERALD study that led to FDA approval of elacestrant, the first oral selective estrogen receptor degrader (SERD) for treatment of hormone receptor–positive/HER2-negative metastatic breast canc…
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Applying the Latest Evidence and NCCN Guideline Recommendations in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
47:23
47:23
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47:23In this episode, Danielle M. Brander, MD; Deborah Stephens, DO; and Brian Hill, MD, PhD, discuss key aspects of the NCCN CLL guidelines and share strategies for applying these recommendations in your clinical practice to optimize treatment and outcomes. The greater discussion addresses: Optimal selection of therapy for treatment-naive CLL, includin…
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Embark on a journey of understanding, solace, and resilience as we explore grief, faith, and the human spirit. Host Amy Ledin graciously welcomes Sarah Prebianca to the podcast. Together, they have unraveled Sarah's remarkable story—a testament to resilience in the face of unimaginable loss, her daughter Georgia taken by a rare disease. Through Sar…
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Forget about the generic "What I Eat in a Day" posts flooding your social media feeds. Amy Ledin breaks away from the norm, revealing the intricacies of her weekly meal plans, complete with recipes, grocery lists, and strategic advice. Amy delves into the significance of meal timings, managing portions, and embracing mindful eating, giving you a pe…
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201 - Managing Stress and Leveraging the Body's Energy for Healing With Isaac Ho
59:08
59:08
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59:08In this enlightening episode, Amy Ledin welcomes back Isaac Ho for a deep dive into understanding the intricate relationship between our emotions, physical health, and overall well-being. Isaac, with 20 years of experience as a trainer and therapist, shares his journey and insights into how our bodies respond to stress and the significance of tunin…
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200 - Overcoming Emotional Immaturity with Dr. Nicole LePera (The Holistic Psychologist)
1:06:47
1:06:47
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1:06:47Host Amy Ledin delves into the transformative power of emotional maturity with Dr. Nicole LePera, the Holistic Psychologist. This insightful episode explores the impact of childhood experiences, the significance of self-care in managing triggers, the effectiveness of future self-journaling for rewiring habits, and the profound benefits of community…
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Homologous Recombination Repair (HRR) Testing and Targeted Therapy in Prostate Cancer
48:15
48:15
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48:15In this episode, Colin C. Pritchard, MD, PhD, a pathologist, and Heather H. Cheng, MD, PhD, a medical oncologist, discuss optimal biomarker testing to guide treatment decisions in advanced prostate cancer, with topics including: Rationale for targeting PARP in prostate cancer with ARI combinations Study design nuances and findings from key randomiz…
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199 - The Slow Identity Killer and How to Fix That Today
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22:43
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22:43Explore the journey of self-recovery with Amy Ledin in 'The Slow Identity Killer,' where she tackles the challenges of losing one's sense of self through life's unpredictability's. She reveals her personal struggle through a season of upheaval, including a significant loss—leading to a disruption of routine and confidence. Discover Amy's raw insigh…
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198 - Proven Mindset to Transforming Fitness From Within With Jared Hamilton
38:05
38:05
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38:05Challenge conventional wisdom on fat loss with a fresh perspective that prioritizes mental and emotional health as the foundation for physical change. This episode Amy discusses with Jared the critical role of addressing underlying issues like binge eating, emotional eating, and self-sabotage before embarking on a weight loss journey. Learn about t…
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Real-world Perspectives on Novel HER2-Targeted and TROP-2–Directed Therapies in Advanced Breast Cancer
36:29
36:29
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36:29In this podcast episode, Sara M. Tolaney, MD, MPH, and Melinda Telli, MD, delve into the critical aspects of the current therapeutic landscape for patients with unresectable or metastatic HER2-low, hormone receptor–positive, and triple-negative breast cancer, including: Challenges with the pathologic testing for HER2-low expression Optimal treatmen…
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197 - How To Keep Your Diet On Track Anywhere with Sara Frenza
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39:05
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39:05Learn how to navigate the challenges of staying healthy while traveling. Amy and Sara, both fitness coaches, discuss the nuances of traveling without compromising on their health goals. They cover practical advice on planning, restraint, and making informed choices. This episode is packed with real-world strategies for anyone looking to maintain th…
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196 - Plastic Surgery: I Got My Implants Put Back In
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20:23
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20:23Amy revisits her journey with breast implants, sharing the unexpected turn of deciding to have them reinserted after previous removal due to concerns about breast implant illness. With raw honesty, she explores the intricate balance between physical appearance and mental health, offering a nuanced perspective on cosmetic surgery. This episode unpac…
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195 - How Emotional Energy Affects Your Health
1:05:25
1:05:25
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1:05:25Coach and Therapist, Isaac Ho shares the journey of uncovering the hidden links between past traumas and physical health issues. Through personal experiences and professional insights, this episode sheds light on how unresolved emotional pain can manifest in the body. It delves into the transformative power of holistic healing practices, emphasizin…
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Amy Ledin raises an intriguing question at the heart of today's discussion: 'What new habits are now a part of your daily life that weren't here before?' In this thought-provoking episode, Amy discusses the journey of evolving one's identity to foster a healthier, more fulfilling life. She shares insights into the psychological shifts necessary for…
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193 - New Season, New Chapter - Back in Canada
13:56
13:56
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13:56Amy Ledin delves into the complexities of her family's significant move back to Canada, shedding light on the emotional and logistical challenges faced together. From tackling immigration hurdles to confronting the difficulties of reuniting their family across borders, Amy shares the story of their journey with honesty and vulnerability. This episo…
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Current Considerations for Adverse Event Management With HER3-Directed Agents
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12:33
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12:33The third and final episode in a 3-part series covers the safety profile of and considerations for managing adverse events associated with HER3-targeted antibody–drug conjugates, including patritumab deruxtecan (HER3-DXd) and others, in the setting of lung cancer. Presenters in this series include: Rebecca S. Heist, MD, MPH Associate Professor of M…
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Unpacking the Potential of HER3-Targeted Therapy in NSCLC
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15:24
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15:24This second episode in a 3-part series on HER3-targeted agents in NSCLC covers current clinical trials with HER3-targeted therapy, including: Recent data on patritumab deruxtecan (HER3-DXd) in the HERTHENA-Lung01 trial The EGFRxHER3 bispecific antibodies BL-B01D1 and izalontamab The HER2xHER3 bispecific antibody zenocutuzumab The HER3-targeted anti…
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Recent Advances in ADCs and Rationale for HER3 as a Target in Lung Cancer
8:54
8:54
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8:54This first episode in a 3-part series tackles the role of HER3 in cancer, specifically in NSCLC, and how HER3 can be effectively targeted with ADCs. Presenters in this series include: Rebecca S. Heist, MD, MPH Associate Professor of Medicine Harvard Medical School Medical Oncology Massachusetts General Hospital Boston, Massachusetts Helena Yu, MD A…
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Expert Insight on Seminal New Clinical Trial Data Presented at the 2023 IGCS Conference Informing Treatment for Endometrial, Ovarian, and Cervical Cancers
30:29
30:29
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30:29In this episode, Brian Slomovitz, MD, MS, FACOG, and Keiichi Fujiwara, MD, PhD, share their thoughts and opinions on seminal data presented at the 2023 IGCS annual meeting for endometrial, ovarian, and cervical cancers, including: Phase III NRG GY018 trial of carboplatin and paclitaxel with or without pembrolizumab followed by pembrolizumab or plac…
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Novel Emerging Investigational Treatment Strategies for Patients With Myelofibrosis
19:33
19:33
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19:33In this episode, Jacqueline S. Garcia, MD, discusses novel agents and strategies in clinical trial development for treating patients with myelofibrosis, including: Navitoclax (BCL-XL/BCL-2 inhibitor) Pelabresib (BET inhibitor) Imetelstat (telomerase inhibitor) Luspatercept (erythroid maturation agent) Additional strategies Presenter: Jacqueline S. …
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A Year in Review and a Look to the Future: BTKi in CLL and MCL
27:33
27:33
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27:33In this episode, Ana Marin-Niebla, MD, PhD, and Stephan Stilgenbauer, MD, discuss key trial data on the use of BTK inhibitors in CLL and MCL throughout the past year, how these studies have impacted their practice, and what data they are looking forward to in the near future. The discussion includes analyses of: SHINE: First-Line Ibrutinib + Bendam…
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Expert Insight on Key Updates and New Clinical Trial Data From the ESMO 2023 Congress Informing Treatment for Endometrial, Ovarian, and Cervical Cancers
33:18
33:18
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33:18In this episode, Isabelle Ray-Coquard, MD, PhD, and Ana Oaknin, MD, PhD, provide expert insights on new clinical trial data presented at the 2023 ESMO annual congress for endometrial, ovarian, and cervical cancers, including: Results from the double-blind, randomized, placebo-controlled phase III AtTEnd trial of atezolizumab plus carboplatin/paclit…
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Expert Insights and Considerations for Precision Care With HER3-Targeted Agents in NSCLC and Breast Cancer
38:51
38:51
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38:51In this episode, Aakash Desai, MD; Narjust Florez, MD; and Paolo Tarantino, MD, discuss the biologic rationale and clinical development of agents targeting HER3 for the treatment of breast and lung cancers. The potential niche for HER3-targeted agents in these treatment landscapes is considered, with consideration of acquired resistance to previous…
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Improving Care for Black Patients With Endometrial Cancer
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26:58
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26:58In this episode, Dr Leslie Boyd and Adrienne Moore, a patient advocate and endometrial cancer survivor, discuss how healthcare professionals can partner with Black patients to improve the diagnosis and management of endometrial cancer (EC). Topics include: Data on racial disparities in EC survival Importance of listening to Black patients to better…
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