Practical conversations about software development.
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Welcome to LEPHT HAND — a channel for immersive philosophy, psychology, and politics. Created by Sereptie (Craig) from the Acid Horizon podcast, this channel is your gateway to informative essays, thought-provoking videos, and exclusive content from Sereptie's interdisciplinary coursework . Thank you for subscribing.
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Join host, Doug Madenford, as he welcomes guests onto his front porch for some good old-fashioned conversation. New episodes air on the 1st of each month.
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Data in Biotech is a fortnightly podcast exploring how companies leverage data to drive innovation in life sciences. Every two weeks, Ross Katz, Principal and Data Science Lead at CorrDyn, sits down with an expert from the world of biotechnology to understand how they use data science to solve technical challenges, streamline operations, and further innovation in their business. You can learn more about CorrDyn - an enterprise data specialist that enables excellent companies to make smarter ...
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Solving Chronic Disease with Life Insurance and Data Featuring Jeremy Shane
1:00:25
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1:00:25Venture Partner Jeremy Shane joins host Ross Katz to discuss Life for Health, a revolutionary framework aiming to tackle chronic disease through the integration of life insurance, longitudinal data, and preventative care. From drug discovery feedback loops to outcomes-based pricing, Shane outlines a bold new path for biotech and healthcare converge…
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Individuation Explained: Gilbert Simondon, Carl Jung & the Evolution of Form in Philosophy and Depth Psychology with Timothy Jackson
1:29:30
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1:29:30Support the Vintagia campaign before it is too late! https://www.kickstarter.com/projects/acidhorizon/vintagia-i-ching-oracle-for-psychogeographers-and-creatives What if the self isn’t a fixed unity, but a process unfolding through tension, relation, and transformation? In this episode of LEPHT HAND, Sereptie speaks with evolutionary biologist and …
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Yahoo! Throw your straw hats up in the air because we are celebrating. This episode marks the 100th episode of Doug's Front Porch. For such an event, I felt obliged to turn the interview table around and instead of asking the questions, I would answer them. A special thanks goes out to Kevin Shock for interviewing me and Dustin Shirk for asking me …
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How Etiome Is Redefining Preemptive Medicine with Scott Lipnick
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58:54In this episode of Data in Biotech, host Ross Katz sits down with Scott Lipnick, Co-Founder and President of Etiome, to explore how preemptive medicine is changing the way biotech approaches therapeutic modeling and intervention. Discover how Etiome’s recently launched, AI-driven platform is built to detect disease earlier, identify precise biomark…
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Transforming Houseplants with Synthetic Biology with Patrick Torbey
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47:17In this episode of Data in Biotech, host Ross Katz speaks with Patrick Torbey, CEO and Co-Founder of Neoplants, about using genetic engineering and microbiome innovation to tackle indoor air pollution. Patrick explains how Neoplants is turning everyday houseplants into powerful air purifiers using synthetic biology, offering insights into VOC degra…
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Play, Sovereignty, and the Refusal of Work: Bataille’s Challenge to Modern Thought
54:53
54:53
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54:53Support Vintagia: https://www.kickstarter.com/projects/acidhorizon/vintagia-i-ching-oracle-for-psychogeographers-and-creatives In this monologue, we reflect on Georges Bataille’s essay “Are We Here to Play or Be Serious?”—recorded off-grid during a spring power outage! The discussion explores Bataille’s critique of work, the concept of sovereignty,…
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This month I continue the tradition of sitting down with some of my graduating seniors. This year I welcome Avah Rafter, Michael Britten, Victoria Guthrie, and Ricky Fantaski onto the Front Porch. They discuss what they did in high school, what they are feeling as they prepare to graduate, what they are afraid of, what they are proud of, and what t…
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How Phage Therapy is Scaling to Meet Antibiotic Resistance with Jessica Sacher
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59:02Phage therapy is stepping into the spotlight as antibiotic resistance rises - and Jessica Sacher is helping lead the charge. In this episode, Ross Katz speaks with Jessica, Co-Founder of Phage Directory and Staff Scientist at Stanford, about sourcing phages, operationalizing therapy, and predicting efficacy through data. This conversation explores …
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Mysticism Without Transcendence? Laruelle’s 'Vision-in-One' with Jeremy R. Smith
1:10:00
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1:10:00Follow Vintagia: https://www.kickstarter.com/projects/acidhorizon/vintagia-i-ching-oracle-for-psychogeographers-and-creatives In this special crossover episode of LEPHT HAND and Acid Horizon, we explore the radical mysticism of François Laruelle through his essay Vision-in-One or Unlearned Knowing. Laruelle proposes a mysticism stripped of transcen…
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Targeting Transcription Factors with AI, featuring Will Fondrie from Talus Bio
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46:54How do you drug the undruggable? In this episode of Data in Biotech, Ross Katz sits down with Will Fondrie, Head of Data Science and Engineering at Talus Bio, to explore how machine learning, mass spectrometry, and innovative computational models are transforming drug discovery. Learn how Talus Bio is targeting transcription factors—once considered…
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Brandon Liu is an open source developer and creator of the Protomaps basemap project. We talk about how static maps help developers build sites that last, the PMTiles file format, the role of OpenStreetMap, and his experience funding and running an open source project full time. Protomaps Protomaps PMTiles (File format used by Protomaps) Self-hoste…
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Decoding the Dark Proteome: Biological Insights for Pharma with Dr. Jonathan Usuka from Sapient
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46:45In this episode of the Data and Biotech Podcast, host Ross Katz sits down with Dr. Jonathan Usuka to discuss Usuka’s extensive background in bioinformatics and genomics, leading to his current role as CEO of Sapient. The conversation dives into the importance of deep molecular characterization of diseases, the role of proteomics and metabolomics in…
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The Image of Soul in Post-Jungian Thought: Giegerich, Deleuze, and Beyond
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1:01:51Sereptie's recent blog piece: https://splitinfinities.substack.com/p/crossing-the-line-the-repeater-books In this episode of LEPHT HAND, Sereptie is joined by Christian McMillan from the University of Essex to explore Wolfgang Giegerich’s provocative essay Why Jung?. Together, they investigate the image of soul as a conceptual battleground in post-…
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In this episode I welcome Lara Thomas on to the Front Porch. We discuss Lara's childhood, being the daughter of two educators and a mother who instilled a love of genealogy in her. We also discuss Lara's work with the Berks County Association for Graveyard Preservation. Lara tells us about the great things that they do and what she has learned and …
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Schreber’s Paranoia: Madness, Power and the Politics of Psychosis with Devin Gouré
1:10:43
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1:10:43In this LEPHT HAND interview, I am joined by Devin Gouré of Moral Minority for a deep descent into the world of Daniel Paul Schreber's Memoirs of My Nervous Illness. Together, they explore Schreber’s cosmic visions, divine persecution, and the "unmanning" at the heart of his psychosis—not merely as symptoms of mental illness, but as portals into th…
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How AI Can Increase Clinical Trial Efficiency with Patrick Leung from Faro Health
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39:02How can AI improve clinical trials and accelerate drug development? In this episode of Data in Biotech, Ross Katz sits down with Patrick Leung, CTO of Faro Health, to explore how AI-driven tools are reshaping clinical trial design. Patrick shares insights into document generation, patient burden analysis, and AI governance in biotech. Learn how Far…
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Organoids and Active Learning for Chronic Disease with Naren Tallapragada
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50:25In this episode of Data In Biotech, Ross Katz interviews Naren Tallapragada, CEO and Co-founder of Tessel Bio, about his background in electrical engineering and physics and how personal circumstances led to him pivoting his focus to enter biotech and start Tessel Bio. Naren breaks down Tessel Bio’s unique approach to drug discovery, which involves…
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Dionysus in Exile: Nietzsche, the Dionysian, and the Modern World with Keegan Kjeldsen
1:42:45
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1:42:45Sereptie is joined by Keegan Kjeldsen of The Nietzsche Podcast to explore the exile of Dionysus in the modern world. They discuss the Dionysian as a force of ecstasy, self-forgetting, and excess, tracing its decline from ancient Greek rituals to the rationalized, surveilled, and moralized structures of today. Touching on Nietzsche, Bataille, and Or…
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In this episode we welcome Dr. Francis (Frank) Redmon on to the Front Porch. Frank is currently the superintendent of schools for the Keystone Central School District in Mill Hall, PA...and my boss. We discuss his childhood growing up the son of a Marine father and all of the many places that he moved to and lived in. We also discuss his path to be…
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Hong Minhee is an open source developer and the creator of the Fedify ActivityPub server framework. We talk about how applications like Mastodon and Misskey communicate with one another using ActivityPub. This includes discussions on built-in activites, extending the specification in a backwards compatible way, difficulties implementing JSON-LD, th…
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Dionysus Decoded: Nietzsche, Deleuze & Depth Psychology Reimagine Myth
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56:33In this monologue, we explore the many faces of Dionysus, from mythology to depth psychology and continental philosophy. Drawing on Dionysus in Exile, the discussion highlights his paradoxical nature—not just a god of excess but also of stillness and transformation. Nietzsche and Deleuze provide insight into Dionysian becoming, especially through A…
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Prefetcher on Building PinkSea on the AT Protocol
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1:13:14Kacper "prefetcher" Staroń created the PinkSea oekaki BBS on top of the AT Protocol. He also made the online multiplayer game MicroWorks with Noam "noam 2000" Rubin. He's currently studying Computer Science at the Lublin University of Technology. We discuss the appeal of oekaki BBSs, why and how PinkSea was created, web design o…
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How Alex Junge from amass is Speeding Up Scientific Breakthroughs with AI
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52:25In this episode of the Data and Biotech Podcast, host Ross Katz sits down with Alexander Junge, Co-Founder and CTO of amass, to break down how AI is reshaping scientific research in life sciences. Alex walks us through how his platform is creating professional tools for researchers, biotech companies, and venture firms to navigate the (rapidly!) gr…
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Advancing Therapeutic Design in Gene and Cell Therapy with Dipen Sangurdekar
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40:34In this episode of Data in Biotech, Ross sits down with Dipen Sangurdekar, VP of Data Sciences at KSQ Therapeutics, to discuss the role of data-driven approaches in therapeutic design and development. The conversation explores the intersection of computational biology, machine learning, and bioinformatics in advancing personalized medicine and impr…
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Tom MacWright on Shutting down Placemark
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1:02:17Tom MacWright is a prolific contributor in the geospatial open source community. He made geojson.io, Mapbox Studio, and was the lead developer on the OpenStreetMap editor. He's currently on the team at Val Town. In 2021 he bootstrapped a solo business and created the Placemark mapping application. He acquired customers and found steady growth but a…
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In this episode I welcome Scott Reagan onto the Front Porch. We discuss his childhood that was immersed in all kinds of music, his undergrad work in German and his graduate work in ethnomusicology. We also discuss his current work at Martin Guitar and writing and performing traditional and original PA Dutch language folk music. We close the intervi…
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Lacanian Psychoanalysis and Zen Buddhism: What's the Connection? with Raul Moncoya
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1:01:06Contact Raul and discover his work here: https://www.raulmoncayophd.com/ Buy the book: https://www.routledge.com/Lacan-and-Chan-Buddhist-Thought-Reflections-on-Buddhism-in-Lacans-Seminar-X-and-Beyond/Moncayo-Yu/p/book/9781032056975?srsltid=AfmBOooucogAZl7Z8szfzd1l8OhR8pTYQ0_F3vnxUL2G6Qw1TezclrYa In this episode we explore the intersection of Lacani…
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Democratizing Therapeutic Discovery for Neglected Diseases using AI with Timothy Jenkins of DTU Bioengineering
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50:39This week on Data in Biotech, we welcome Timothy Jenkins, the Head of Data Science and Associate Professor at DTU Bioengineering, a leading scientific community dedicated to advancing areas of biotechnology, food technology, and health through innovative teaching and research. Timothy starts the conversation by walking us through his background and…
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On Melancholy and Mania: James Hillman and Gilles Deleuze meet Nosferatu
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35:52In this installment of LEPHT HAND, we delve into the James Hillman Uniform Edition on On Melancholy and Depression, exploring his archetypal approach to melancholy as a cosmic force and its critique of modern life under capitalism. Drawing connections to Robert Eggers’ Nosferatu, we examine how longing and melancholy transcend individual experience…
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Paul Frazee is the CTO of Bluesky. He previously worked on the Beaker browser and the peer-to-peer social media protocol Secure Scuttlebutt. Paul discusses how Bluesky and ATProto got started, scaling up a social media site, what makes ATProto decentralized, lessons ATProto learned from previous peer-to-peer projects, and the challenges of content …
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Revolutionizing Drug Discovery with AI: Fred Manby of Iambic Therapeutics
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38:19In this episode, Ross Katz sits down with Fred Manby, Co-Founder and Chief Technology Officer of Iambic Therapeutics, to explore how cutting-edge AI technologies are reshaping the landscape of drug discovery. From building advanced machine learning platforms to designing user-friendly interfaces for scientists, Fred shares insights into the company…
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In this episode we welcome 2025 in by taking a short journey through my trusty Baer's Agricultural Almanac. We take a look at long range forecasts for the year, major anniversaries happening, and some humorous stories as well. Get your own copy of Baer's Almanac! Get your Front Porch Merch! Become a Patron! Support the show…
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What is Freud's Metapsychology? with Taylor Adkins
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1:34:28Support LEPHT HAND in 2025: https://www.patreon.com/LEPHTHAND In this episode, Taylor joins Sereptie to discuss Freud’s Metapsychology, exploring the conceptual underpinnings of psychoanalysis. From the topographical model of the mind to the dynamics of repression, we unpack the key essays that form Freud’s theory of psychic structures and drives. …
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Jung and Spinoza: Passage Through the Blessed Self with Dr. Robert Langan
1:19:33
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1:19:33Jung and Spinoza: Passage Through the Blessed Self: https://www.routledge.com/Jung-and-Spinoza-Passage-Through-The-Blessed-Self/Langan/p/book/9781032851853 In this episode of LEPHT HAND, host Serpetie aka Craig is joined by Dr. Robert Langan, author of Jung and Spinoza: Passage Through the Blessed Self, to explore the intersections between Carl Jun…
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Unlocking the Power of AI in Microscopy with Ilya Goldberg and Reese Findley
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47:32In this episode of Data in Biotech, Ross Katz explores the transformative role of AI in microscopic imaging and life sciences with Ilya Goldberg, Chief Science Officer, and Reese Findley, an AI Data Scientist at ViQi. They discuss the cutting-edge applications of AI in automating high-content screening (HCS), enabling more efficient drug discovery,…
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In this episode I welcome Eve Allen on to the front porch. Eve is the program director for the Northeast Bioregion at the Ecological Health Network. We discuss her work on improving the supply of native seeds and plants to support ecological restoration, her travels, and the importance of the human connection to our ecosystem. To learn more: Ecolog…
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Reflections & Predictions: One Year of Data in Biotech with Ross Katz
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39:42In this episode of Data in Biotech, Ross Katz reflects on what he’s learned from one year of hosting the podcast. Diving deep into the intersection of data science and biotechnology, this episode covers topics like: The need for predictive models in biotech that are grounded in real-world experimentation. The challenges of biases in model evaluatio…
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The Active Imagination of Henry Corbin, Carl Jung, and James Hillman with Tom Cheetham
1:27:49
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1:27:49Help fund the Kickstarter campaign now: https://www.kickstarter.com/projects/acephalous/acephalous-the-erotic-tarot-of-georges-bataille Tom's Substack: https://substack.com/@tomcheetham2 In this episode of LEPHT HAND, we sit down with Tom Cheetham, author and expert on the intersections of imagination, spirituality, and psychology, to explore the c…
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Deleuze, Symbols, and Sorcery: Synthesizing Insights on Deleuze's Hermeticism
1:20:44
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1:20:44The Kickstarter link: https://www.kickstarter.com/projects/acephalous/acephalous-the-erotic-tarot-of-georges-bataille In this interview, I am joined by c_o_L_L_a_g_e, a friend and colleague from our research community at Acid Horizon. Together, we explore the intersection of Deleuze's philosophy and the role of symbols within the hermetic tradition…
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We go international this month as we welcome my good friend, Norman Jung, from Steinbach am Glan, Germany, on to the Front Porch. We discuss the wisdom and life lessons instilled in Norman by his grandparents, his study abroad in Arizona, and his work with the Pennsylvania Dutch culture from his side of the Atlantic. We end with our classic 10 quic…
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From Moderna to Dash Bio - Revolutionizing Drug Development with Dave Johnson
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32:54In this episode of Data in Biotech, Ross Katz sits down with Dave Johnson, CEO and co-founder of Dash Bio, a next-gen drug development services company with a mission to revolutionize clinical bioanalysis and streamline drug development. Dave begins the episode by taking us back to the early research days in Moderna, where he helped lay the groundw…
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Destituent Power and the Reclamation of the Imagination with Serene Richards
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47:54Support the Kickstarter: https://www.kickstarter.com/projects/acephalous/acephalous-the-erotic-tarot-of-georges-bataille Biopolitics as a System of Thought: https://www.bloomsbury.com/us/biopolitics-as-a-system-of-thought-9781350412095/ In this LEPHT HAND interview, we explore the themes of destituent power and political imagination in Serene Richa…
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Chitrang Dave on Harnessing Real-Time Data to Transform MedTech and Healthcare
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29:10This week, Chitrang Dave, Global Head of Enterprise Data & Analytics at Edwards Lifesciences, joins us to discuss the transformative power of real-time data, AI, and collaboration in medical device manufacturing and support. He and host, Ross Katz, dive into how real-time data from IoT devices is reshaping quality assurance in medtech and what the …
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Bataille on War and the "Acéphalous" Project
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1:02:33The Kickstarter campaign: https://www.kickstarter.com/projects/acephalous/acephalous-the-erotic-tarot-of-georges-bataille In this episode, Adam C. Jones of Acid Horizon joins a recent livestream with Sereptie to dive into Georges Bataille’s complex relationship with war, exploring his shift from insurrectionary fervor to an uneasy advocacy for peac…
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Automating Bioprocessing to Speed up Workflows with Invert
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36:41This week on Data in Biotech, we’re joined by Martin Permin, the co-founder of Invert, a company that builds software that automates bioprocessing. Martin talks us through his own unique journey into biotech - starting from a role at Airbnb - through to co-founding Invert. Invert helps users grab data from their instruments, map out their individua…
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In this episode I invite award winning chef, Jeremy Nolen onto the front porch. We discuss his lifelong affair with food and his particular love of German cuisine. We also discuss his newest endeavor of offering tours to germanic Europe that are all food and drink focused. He also offers some advice for all of you foodies and home cooks out there! …
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From Bataille to Blanchot: The Negative Community and the Death of the Other
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48:50Support LEPHT HAND: https://www.patreon.com/LEPHTHAND 🔮 Introducing 'Acéphalous: The Erotic Tarot of Georges Bataille' 🔮 - Uncover the raw, provocative fusion of Bataille's philosophy and tarot in this daring new deck. Pre-launch is live—discover more and join us in this journey: https://www.kickstarter.com/projects/acephalous/acephalous-the-erotic…
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The Evolution of Genomic Analysis with Sapient
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43:15This week on Data in Biotech, we’re joined by Mo Jain, the Founder and CEO of Sapient, a biomarker discovery organization that enables biopharma sponsors to go beyond the genome to accelerate precision drug development. Mo talks us through his personal journey into the world of science, from school to working in academia to founding his business, S…
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The Thought and Life of Simone Weil with Kenny Novis
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1:07:10Join the Patreon for early access to all new releases: https://www.patreon.com/LEPHTHAND In this LEPHT HAND interview, Sereptie speaks with philosopher and researcher Kenny Novis about the complex and often contentious ideas of Simone Weil. The conversation explores the controversies surrounding Weil's life and work, while Kenny offers valuable ins…
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In this episode I welcome Tyler Barth, Principal of Robb Elementary School in Lock Haven, PA, on to the front porch. We discuss his childhood that was heavily influenced by both his parents and his grandparents. We also discuss why he went into education, his transition from the classroom to the principal's office, and how he builds and maintains a…
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