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This Week in Startups

Jason Calacanis

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Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.
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Take it off! See. Love. Grow.

Joshua Fields & Jeremy Rubin

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An unfulfilled life has less to do with what it is - and more with how you see it. Your fulfillment is often on the other side of a tough decision or conversation. It is in the resolving of conflict and the releasing of self-judgment that we grow the most. So, if you feel stuck in your career, relationships, or how you think about yourself, it’s time to “TAKE IT OFF” and show up as your authentic self. Joshua A. Fields and Jeremy Rubin co-host the “Take it Off” Podcast. As a master practitio ...
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The official podcast of the Netflix film, “The Trial of the Chicago 7,” written and directed by Aaron Sorkin, is hosted and narrated by Krista Smith. The series features conversations devoted to the significance of events in 1968 and the trial, and the parallels with what’s happening in America today, as well as discussions with Sorkin and the actors and creative minds that realized the world of the film.
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The 007 Files

David Leigh, Bill Koenig, Javi Trujillo

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The 007 Files podcast dives deep into the world of James Bond, blending expert analysis with casual conversation. Co-hosted by David Leigh, author of The Complete Guide to the Drinks of James Bond and founder of The James Bond Dossier, Bill Koenig of The Spy Command and Javi Trujillo, the podcast explores Bond's films, books, and cultural impact. Stay tuned for everything from in-depth reviews to Bond 26 updates and discussions of all things 007. Perfect for lifelong fans and new recruits alike!
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Today’s show: Microsoft lays off 6,000 employees despite record profits, signaling a ruthless new phase in big tech. Jason, Lon, and Alex discuss what it means for the talent market, why tightening U.S. immigration could cripple startup innovation, and whether AI startup Windsurf is selling too early as OpenAI circles. Plus, Klarna’s AI customer se…
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Today’s show: Chime is finally going public with strong financials and a shot at matching its $25B 2021 valuation, signaling real momentum in the IPO market. Databricks just made a $1B bet on agentic AI by acquiring Neon, a Postgres-as-a-service startup riding the new database wave. Then, Dave Rubin joins to share how he built and sold Locals, his …
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Today’s show: Alex interviews founders from two frontier technologies reshaping our world. First, ZioSec is tackling the cybersecurity risks of AI agents with continuous adversarial testing before real attacks happen. Then, Terabase shows how mobile robotic factories are transforming solar energy deployment, assembling massive solar farms directly …
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Today’s show: Jason, Lon & Alex are back with a spicy Monday episode of This Week in Startups. Jason goes off on unions vs capitalism, we dig into why fewer seed startups are making it to Series A, and look at OpenAI’s quiet copyright land grab. Plus: YC says Google should be broken up (then kind of walks it back), Perplexity’s wild $14B valuation,…
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In this episode of The 007 Files, Bill Koenig and Javier Trujillo and David Leigh sit down with author and researcher Jeremy Duns to explore two little-known chapters in Bond lore. First, Jeremy delves into the early attempts to adapt Casino Royale for the screen, revealing the strange paths the story might have taken. Then, we discuss his recent r…
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Today’s show: Jason, Alex, and Lon break down OpenAI’s latest power move: hiring Instacart CEO Fidji Simo to lead its consumer apps. They also dive into the ethical storm brewing around an AI-generated victim statement used in court — is this the future of legal testimony? Plus, they explore how late-stage funding rounds like a “Series G” don’t aut…
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Today’s show: Jason, Lon & Alex discuss the day’s hottest tech and startup news. Zoox’s robotaxi crash and voluntary recall, COATUE’s innovative open-ended venture fund that could democratize private tech investing, the NSO Group's massive $167M fine for spyware abuse, Uber’s record-setting earnings and in-person work push, and a candid AI wake-up …
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Today’s show: Cursor’s explosive growth, hitting $200M in ARR and a massive $9B valuation. They also explore the buzz around Magical Toys’ new AI-powered dinosaur, where LLMs meet playtime. The conversation turns to “vibe coding” and how AI dev tools are changing the way product teams build. Plus, Jason shares stories from his Formula 1 poker table…
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In this episode of The 007 Files, Scott and Cam from SpyHards podcast join Bill Koenig to explore the wider world of spy fiction—and how James Bond sits squarely at its centre. The trio discuss why the spy genre offers so much more than just 007, while recognising how deeply the Bond franchise owes its DNA to earlier classics like North by Northwes…
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Today’s show: Jason, Lon, and Alex break down a loaded week in tech: Apple’s 27% App Store “link-out” fee gets shut down by a judge—unlocking margin for startups and slashing CAC; AI bots on Reddit’s r/ChangeMyView are now 6x more effective than humans at changing minds, signaling a seismic shift in online discourse; and Beehiiv CEO Tyler Denk join…
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In this episode of AI Basics, Jason sits down with Amin Vahdat, VP of ML at Google Cloud, to unpack the mind-blowing infrastructure behind modern AI. They dive into how Google’s TPUs power massive queries, why 2025 is the “Year of Inference,” and how startups can now build what once felt impossible. From real-time agents to exponential speed gains,…
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Today’s show: Jason, Alex, Lon and Special Guest Mark Jeffrey of Hash Rate, cover the explosive rise of Bittensor, a decentralized AI compute network some are calling the “third great coin” after Bitcoin and Ethereum, explore Meta’s bold move to host its open-source LLaMA models via partnerships with Groq and Cerebras—potentially setting the stage …
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Today’s show: we break down the wild story behind Meta’s AI chatbots going completely off the rails — including a bombshell WSJ exposé about bots flirting with minors. Then they cover Palo Alto Networks’ huge $500M+ acquisition of Protect AI, and sit down with the founder of Formulate, who’s building a robotic kitchen for chemicals and cosmetics. P…
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Today’s show: Jason, Alex, and Lon break down today’s top tech and startup stories — from Slate Auto’s customizable $25K EV truck to Discord’s major leadership shakeup ahead of a potential IPO. They also cover Uber’s self-driving push with Volkswagen, Perplexity AI’s aggressive growth moves, and why value-driven products are winning in a tough econ…
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Today’s show: Jason, Alex and Lon unpack the FTC’s lawsuit against Uber and what it could mean for subscription UX, break down how AI startup Cursor is growing faster than almost any SaaS company in history, and discuss how dark patterns, consumer trust, and regulatory scrutiny are reshaping product design. They also touch on the future of big tech…
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Today’s show: Jason and Lon break down the biggest stories in tech and startups this week: OpenAI’s new models are powerful but glitchy, Meta’s internal docs hint that Zuck knows the Facebook friends graph is toast, and fintech startup TapCheck might actually be doing some good. Plus, robot lifeguards and humanoid races — the wildest videos of the …
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Today’s show: Jason, Alex, and Lon discuss the rise of LMArena as it spins out into a full-fledged startup, what that means for AI benchmarking, and how it could monetize its growing community. They also dive into the emerging value of application-layer AI startups and why OpenAI’s acquisition spree is just beginning. Plus, branding expert Scott Ba…
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In this episode of AI Basics, Jason sits down with CapitalG partner Jill Chase to break down how AI is reshaping the startup ecosystem — from founders to investors to incumbents. They cover how CapitalG (Alphabet’s independent growth fund) thinks about the AI stack, why speed alone isn’t enough for startups today, and how to build durable advantage…
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Today’s show: Jason, Alex, and Lon discuss Figma’s surprise IPO filing following its $1B breakup from Adobe, OpenAI’s quiet push into social networking through a Sora image-sharing feed, and how sweeping new China tariffs are wreaking havoc on ecommerce companies—impacting jobs, supply chains, and pricing. Plus: the Substack vs. Patreon battle heat…
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Today’s show: Alex interviews founders from Abacus and Synthesia—two companies leading the charge in vertical AI. Abacus is deploying on-prem LLMs to banks and insurers with a focus on data control, accuracy, and integration with legacy infrastructure. Synthesia just hit $100M ARR by helping 70% of the Fortune 100 turn internal documents into scala…
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Javi Trujillo, Bill Koenig and David Leigh get together once again for a wide-ranging discussion on the new producers taking the helm of the James Bond franchise at Amazon MGM Studios. We explore who they are, what their backgrounds might reveal, and how their influence could shape the future of 007 on screen. Before we get into that, we talk about…
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Today’s show: In this episode, Jason, Alex, and Lon dive into Blue Origin’s all-female celeb spaceflight (yes, Katy Perry sang on reentry), Hugging Face’s unexpected move into robotics, and Jack Dorsey’s wild take that we should “delete all IP law.” Plus, they break down Figure AI’s eye-popping $39B valuation, the risks of SPVs, and what founders a…
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Today’s show: We dive into the latest tech and startup news — including Palantir’s bold new fellowship program that challenges the traditional college path, and DoorDash’s rollout of burrito-delivering Coco robots in LA and Chicago. We debut our new segment “Tips from the Trenches,” focused on how to land your first customers, and wrap up with two …
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Today’s show: Jason, Alex, and Lon talk about stories reshaping the startup world: 70mph drone deliveries are officially live in Dallas, with Zipline and Walmart promising groceries “as the crow flies” in under 5 minutes. Meanwhile, Trump slaps a 125% tariff on China and hints at a global economic shakeup — Jason warns founders to brace for layoffs…
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Today’s show: Jason and Alex unpack a wild week in tech and the markets — including a fake tweet that moved $4 trillion and Trump’s latest tariff talk. Lon jumps in for another round of Founder Fridays Pitch Madness, where four early-stage startups compete for a spot in the Elite Eight. Plus, Alex chats with Sunny Khamkar, CEO of MenuData, about ho…
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Today’s show: Jason and Alex dive into the startup world’s latest chaos — from Nasdaq’s slide and Trump’s tariffs to Klarna’s IPO pause and Rippling’s $16B target. They break down what founders really need to know: tightening CIO budgets, longer sales cycles, but easier hiring. Plus, TikTok’s ban gets another delay (with Bezos possibly lurking?). I…
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This Week in Startups is brought to you by… Kyte - TWIST Listeners: Go to https://kyte.com/ and download the Kyte app today. Use code JASON to save 10% on your first rental. Atlassian - Head to https://www.atlassian.com/startups/twist to see if you qualify for 50 free seats for 12 months. Lemon.io - Get 15% off your first 4 weeks of developer time …
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Today’s show: Circle gears up for its IPO and the stablecoin wars heat up, Palantir’s meme stock status gets a reality check, and they riff on a possible Uber + DoorDash merger and whether AI should train on Substack content. They react to Sequoia partner Andrew Reed’s inside take on fund dynamics, laugh at a brutal VC meme, and wrap with “Office H…
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In this episode, Bill Koenig and Javi Trujillo are joined by author and Bond historian Steven Jay Rubin for a revealing conversation centred on The James Bond Films: A Behind the Scenes History. Rubin shares how the book first came about and the incredible access he had in the late 1970s—including an unforgettable screening of an early cut of The S…
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Today’s show: Jason, Alex, and Lon cover everything from wild political headlines to big moves in AI and venture. They kick things off with the surprising Trump pardon of Trevor Milton, the disgraced Nikola founder, and break down CoreWeave’s rocky IPO debut. Then, Jason and Alex sit down with Mariano Apodaca, founder of Prosperous AI, to talk abou…
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Today’s show: In this episode, Alex and Lon kick things off with the latest tech news — including 23andMe’s dramatic collapse, MicroStrategy’s half-million Bitcoin haul, and whether we’re finally seeing a rebound in startup M&A. Then they sit down with three standout founders building the future across AI chips, data privacy, and healthcare. First …
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Today’s show: Jason, Alex, and Lon break down a subreddit question: A founder builds 100% of the product, is promised equity—and now he’s being pushed out. We break down exactly what he should do next. Plus, YouTuber Mark Rober’s viral Tesla test gets fact-checked by a small creator, and the results don’t look great for Mark. Finally, TechCrunch ge…
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Today’s show: Tesla FSD drama, Google’s massive $32B cybersecurity bet, and XRP’s SEC victory. Jason, Lon, and Alex break down the internet firestorm over Mark Rober’s viral Tesla test, why Google’s Wiz acquisition could spark a new M&A wave, and what the SEC dropping its case against XRP means for crypto’s future. Timestamps: (0:00) Episode Teaser…
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Today’s show: Alex interviews two incredible founders from the TWIST 500! First, Replit CEO Amjad Masad breaks down how AI-powered coding is changing software development and what the future of agents looks like. Then, Starfish Space co-founder Austin Link explains how they’re building a satellite towing service to extend missions and clean up orbi…
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Today’s show: Jason, Alex, and Lon break down a wild viral test on self-driving cars— will FSD see through fog, or does LiDAR win? Plus, Klarna is finally going public… but is "buy now, pay later" still the future or just a debt trap? And Netflix drops $300M on a Russo Brothers sci-fi blockbuster—critics hate it, but audiences love it. Was it worth…
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This Week in Startups is brought to you by… Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST CLA. Get started with CLA's CPAs, consultants, and wealth advisors now at https://claconn…
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Today’s show: Europe wants to keep its founders from fleeing, AI is growing at breakneck speed, and Nick Denton is back with a spicy Twitter storm—so we had to talk about it. Jason, Alex, and Lon break down Project Europe, a new $10M fund aimed at stopping the European startup brain drain. Plus, Anthropic’s revenue just jumped 40% in a single quart…
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In this episode of AI Basics, Jason sits down with Jia Li from LiveX AI to explore how human-like AI agents are changing the game for businesses. Instead of clunky bots, these AI agents engage customers in real-time, helping with onboarding, support, and even stopping them from leaving before they churn. We’ll break down how they work, why they fee…
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Timestamps: (0:00) Roy Lee's hack and Amazon's reaction (3:03) MicroStrategy's Bitcoin strategy(4:29) Market reactions to Trump's policies(6:33) Creating value in current market conditions(8:00) South by Southwest highlights (10:19) Coda. Empower your startup with Coda’s Team plan for free—get 6 months at https://www.Coda.io/twist (12:03) The $20,0…
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Special guest Kyle Barbeau joins Javi Trujillo, Bill Koenig, and David Leigh as we continue our deep dive into The World Is Not Enough for its 25th anniversary. In this episode, we examine the lasting influence of screenwriters Neal Purvis and Robert Wade, whose contributions have shaped the Bond series for over two decades. We also discuss the evo…
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Today’s show: AI is evolving at lightning speed—smarter assistants, faster models, and now, the massive energy demands that come with it. In this episode, Alex dives into two cutting-edge companies from the TWIST 500 that are shaping AI’s future in very different ways. First, Alex interviews Zap Energy, where CEO Benj Conway explains how their brea…
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This Week in Startups is brought to you by… Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today! Lemon.io. Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist Horatio. Visit htt…
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In this episode: Jason sits down with Harrison Chase, CEO of LangChain, to explore how AI-powered agents are transforming the way startups operate. They discuss the shift from traditional entry-level roles to AI-driven automation, the importance of human-in-the-loop systems, and the future of AI-powered assistants in business. Harrison shares insig…
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Today’s show: Trump just floated the idea of a U.S. Crypto Reserve, suggesting a 10 bips transaction tax and naming unexpected altcoins like XRP, Solana, and Cardano. Jason and Alex break down what this means for crypto markets, regulation, and startups—plus the legal and political fallout. Is this a game-changer or just another pump-and-dump contr…
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Hosts Javi Trujillo, Bill Koenig, and David Leigh are joined by special guest Kyle Barbeau to mark the 25th anniversary of The World Is Not Enough. We revisit our memories of its release, debate where it ranks among the 25 Bond films, and break down the explosive (and unusually long) pre-title sequence. We also reflect on Desmond Llewelyn’s final t…
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Today’s show: Jason and Alex break down the latest head-scratching SEC ruling on meme coins—did they just legalize pump-and-dumps to protect Trump’s token? Plus, they dive into why venture debt can destroy startups, the rise of AI-driven companies, and how Tesla is gearing up to challenge Waymo in the self-driving car race. Then, Brandon Brown from…
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Today’s show: Jason interviews Rahul Vohra, CEO and founder of Superhuman, and Vlad Tenev, CEO and co-founder of Robinhood. This is a packed episode featuring founder tips, fun stories about how Superhuman and Robinhood got their start and much more! Timestamps: (0:00) Episode teaser(2:13) Product market fit and founder journeys(3:25) Jason's inves…
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Today’s show: Jason and Lon break down the latest trends shaping AI training, the evolving job market, and the shifting landscape of social media. A tribute to Steve Jobs on what would have been his 70th birthday explores his lasting impact, Apple’s massive $500 billion AI investment, and the future of US manufacturing. The conversation dives into …
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This Week in Startups is brought to you by… Squarespace. Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST LinkedIn Jobs. Post your first job for free at https://www.linkedin.com/twist AdQuick. Visit https://adquick.com/twist and mention TWIST to get $1000 off your first campaign. T…
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