Best Mark Ebell Podcasts (2025)

1
Episode 179: novel migraine tx, safety of albuterol in infants, new UTI antibiotic, and vitamin K2 for leg cramps 32:06

5d ago32:06

32:06

This week join our intrepid primary care physicians Kate, Gary, Henry and Mark as they discuss 4 new studies: an experimental treatment for chronic migraines, safety of albuterol in wheezy kids under 2, oral gepotidacin for uncomplicated UTI, and vitamin K2 and Leg Cramps. Here are the links: Lukas' Fund supporting the Piedmont Athens and Grady Atl…

1
Episode 178: tapering benzos, neuro testing for athletes, vonoprazan for PUD, and zoster-dementia link 34:24

18d ago34:24

34:24

This week Kate, Gary, Mark and Henry discuss discontinuation of benzodiazepines and treatment of insomnia, the value of baseline cognitive testing of college athletes, vonoprazan vs PPI for preventing and treating ulcers, and whether herpes zoster vaccine reduces dementia risk. Show links: Essential Evidence Plus: www.essentialevidenceplus.com Tape…

1
Episode 177: steroids and CV risk, dementia guideline, fezolinetant for VMS, and osteoporosis screening 31:11

1M ago31:11

31:11

This week Gary, Mark, Kate and Henry discuss: adverse effects from inhaled steroids in asthma, Italian dementia guideline, fezolinetant for treatment of vasomotor symptoms, and updated USPSTF recommendations for osteoporosis screening. Show notes and links: Asthma and risk of CV events: https://pubmed.ncbi.nlm.nih.gov/39088770/ GINA 2024 guidelines…

1
Episode 176: bright lights, fever in kids, new anticoagulant for AF, and antibiotics for appendicitis 28:15

2M ago28:15

28:15

Join Kate, Gary, Mark and Henry as they discuss 4 new POEMs relevant to primary care: bright light therapy for non-seasonal depression, fever control in children, abelacimab for atrial fibrillation, antibiotics vs surgery in children with nonperforated appendicitis. Get all of the POEMs (a new one every day) by going to Essential Evidence Plus and …

1
Episode 175: RSV monoclonals, acupuncture for sciatica, zoledronate in low risk women, and measuring BP at home. 32:41

2M ago32:41

32:41

This week, Gary, Kate, Henry and Mark discuss 4 new studies relevant to primary care practice: the effectiveness of RSV monoclonals in infants, acupuncture for sciatica associated with disk herniation, zoledronate every 5 years for low risk women, and the effect of arm position on blood pressure readings. Plus a quiz! Please see below for show note…

1
Episode 174: sexual dysfunction, GLP-1 benefits, surveillance for DCIS, episodic migraine prevention 31:12

2M ago31:12

31:12

Join Kate, Mark, Gary and Henry as they discuss 4 new POEMs on treatment of sexual dysfunction, the benefits and harms of GLP-1 agonists, active surveillance vs usual care for ductal carcinoma in situ, and medications to prevent episodic migraine headache. Henry mentioned AAFP's uncensored resources: www.aafp.org/family-physician/patient-care/clini…

1
Episode 173: prenatal cannabis use, fluids in sickle crisis, single or dual tx for AF plus CAD, and exercise for weight loss. 29:02

3M ago29:02

29:02

This week, join Kate, Mark, Gary and Henry as they discuss 4 new studies: prenatal cannabis exposure, fluid resuscitation during acute sickle crises, edoxaban or edoxaban + ASA for afib with CAD, and the impact of aerobic exercise on weight loss in adults

1
Episode 172: mindfulness for pain, methotrexate and resveratrol for OA, and eradicating HP 23:55

3M ago23:55

23:55

Join Henry, Kate, Mark and Gary as they discuss 4 new POEMs: an RCT of mindfulness for chronic pain, use of methotrexate (huh?) for pain relief in adults with knee DJD, a new way to eradicate H., and oral resveratrol for adults with painful DJD of the knee (you know, the stuff from red wine). And a quiz: what actually are the benefits of lower BP t…

1
Episode 171: obesity in babies, DOACs after stroke, semaglutide for OA, and thunderclap headaches 28:12

4M ago28:12

28:12

This week join our intrepid team of skeptical primary care doctors as Kate, Mark, Henry and Gary discuss a web- and text-based intervention to prevent obesity in babies, the best timing of DOAC initiation after ischemic stroke in adults with atrial fibrillation, using semaglutide for knee osteoarthritis, and the differential diagnosis of thundercla…

1
Episode 170: yoga for incontinence, muscle relaxants for pain, maternal cannabis use, and GLP-1 v. surgery 29:24

4M ago29:24

29:24

This month Kate, Mark, Gary and Henry discuss yoga for treating urinary incontinence in older women, benefits and harms of muscle relaxants for adults with chronic pain, maternal prenatal cannabis use and developmental delays, and bariatric surgery vs. glucagon-like peptide 1 receptor agonists in obese adults with T2DM. Links: Yoga for incontinence…

1
Episode 169: migraine, plantar fasciitis, beta-blocker duration and prostate cancer 28:37

5M ago28:37

28:37

This week Mark, Kate, Gary and Henry talk about the comparative effectiveness of migraine medications, strategies for adults with plantar fascia pain, whether to continue beta-blocker use after acute MI, and the outcomes of 5-alpha reductase inhibitor use prior to prostate cancer diagnosis. Links Migraine: https://www.bmj.com/content/386/bmj-2024-0…

1
Episode 168: RSV med, colonoscopy by PCP, hair loss drug, and AI for ECGs 24:25

5M ago24:25

24:25

This week listen in as Kate, Mark, Gary and Henry discuss antiviral treatment for infant RSV, colonoscopy competence by specialty, oral minoxidil for hair loss in men, and artificial intelligence performance on interpreting electrocardiograms . RSV medication: https://www.nejm.org/doi/full/10.1056/NEJMoa2313551#ap2 and https://pubmed.ncbi.nlm.nih.g…

1
Episode 167: laughter, HP eradication, antibiotics for delirium, and MRIs of the knee 27:49

6M ago27:49

27:49

Join Kate, Gary, Henry and Mark as they discuss a new therapy for dry eye syndrome, antibiotics for suspected UTI in adults with delirium, a new ACG guideline for treating H pylori, and the prevalence of knee pathology in asymptomatic adults. See below for links to the articles and other stuff: Dry eye treatment BMJ: https://www.bmj.com/content/386…

1
Episode 166: vaping cessation, BP meds and dementia, SGLT-2's, and AI for melanoma 29:20

6M ago29:20

29:20

Join Gary, Kate, Mark and Henry as they discuss text messages for adolescent vaping cessation, stopping BP meds in nursing home residents with dementia, the benefits of SGLT-2 inhibitors, and mobile phone app–based artificial intelligence for diagnosing melanoma. Click here for transcript, notes and links for this episode.…

1
Episode 165: psychedelics for depression, preventing and treating influenza, and GLP-2 for...sleep apnea? 34:15

7M ago34:15

34:15

It's biscuit week, oops, I mean flu week here on the Great Primary Care Update. Join our bakers, I mean POETs, as they discuss preventing influenza, treating severe influenza, psychedelics for depression, and GLP-1 agonists to treat sleep apnea of all things.

1
Episode 164: HTN in kids, steroids for hip OA, drugs for T2DM, and AI to develop guidelines 32:38

7M ago32:38

32:38

This week, Gary, Henry, Kate and Mark discuss CV events in children with hypertension, intra-articular steroid injections in adults with hip DJD, the best drug classes for treating adults with T2DM, and AI supported development of practice guideline questions. And a quiz, and two sports stories from Henry!…

1
Episode 163: salt substitutes, VR apps for pain, multivitamins, and vitamin D 29:24

8M ago29:24

29:24

This week join Kate, Mark, Henry and Gary for a discussion of the cardiovascular benefits of salt substitutes, using virtual reality for cancer-related pain, whether multivitamins reduce mortality, and if and when to recommend vitamin D supplements.

1
Episode 162: PREVENT risk score, UTI prognosis, sinusitis treatment, and biomarkers for SDAT 33:53

8M ago33:53

33:53

This week, Kate, Mark, Gary and Henry tackle 4 new studies: the updated PREVENT cardiovascular disease risk calculators from the AHA, long-term consequences of UTIs in children, antibiotics for sinusitis in kids, and biomarkers to diagnose Alzheimer’s disease

1
Episode 161: Antibiotics for CAP, melatonin for delirium, screening for lung disease, and seizures after COVID vaccine 30:53

8M ago30:53

30:53

This week, join Kate, Gary, Mark and Henry as they discuss screening asymptomatic people for COPD and asthma, the rate of new onset seizures after COVID vaccination, choosing the best oral antibiotic for mild to moderate CAP, and a trail of melatonin for delirium in older, hospitalized adults

1
Episode 160: prostate meds and dementia, umbilical hernias, mortality for infections, and AF detection 26:21

9M ago26:21

26:21

This week, Kate, Mark, Henry and Gary tackle the association between prostate medications and lower dementia risk, the natural history of umbilical hernias in children, differential mortality for flu, RSV and COVID, and what to do about device-detected atrial fibrillation.

1
Episode 159: DAPT duration, starting contraception, krill oil for OA, and misdiagnosis of CAP 29:58

9M ago29:58

29:58

This week, join Kate, Henry, Gary and Mark as they discuss same-day start contraception, krill oil for adults with knee DJD, misdiagnosis of community-acquired pneumonia, and ticagrelor + placebo VS ticagrelor + ASA after PCI. Plus some book recommendations: Whalefall, The Demon of Unrest, and the Commissario Brunetti novels by Donna Leon…

1
Episode 158: dequalinium for BV, mammography, weight loss drugs, and tirzepatide for OSA 28:39

10M ago28:39

28:39

Happy 4th of July! This week Kate, Gary, Henry and Mark celebrate by talking about dequalinium for bacterial vaginosis, the comparative effectiveness of weight loss drugs, the new USPSTF mammography recommendation, and tirzepatide for adults with sleep apnea.

1
Episode 157: Bleeding risk with AF, treating minor ischemic stroke, and beta-blockers after AMI 27:21

10M ago27:21

27:21

It's cardiovascular day at Primary Care Update as Kate, Mark and Henry discuss bleeding risk with diltiazem in treatment for atrial fibrillation, whether alteplase improves outcomes in patients with minor ischemic stroke, and whether to continue beta-blockers long-term after acute MI with preserved ejection fraction.…

1
Episode 156: APAP in pregnancy, AI for AOM, current use of Paxlovid, and CGM for T2DM 35:34

11M ago35:34

35:34

This week, Kate, Gary, Mark and Henry discuss 4 new studies that answer some important questions: Does acetaminophen in pregnancy and neurodevelopmental outcomes in offspring? Can AI accurately diagnose otitis media in children? Is nirmatrelvir-ritonavir (Paxlovid) still an effective treatment for outpatients with mild to moderate COVID? And finall…

1
Episode 155: wrist imaging, opioids post-op, rate vs rhythm control, and updated Cologuard, 31:00

11M ago31:00

31:00

This week, Kate, Gary, Henry and Mark discuss 4 new studies: a decision support tool for imaging wrist injuries, how many opioids should be dispensed after ACL reconstruction, an updated fecal DNA + FIT test for colon cancer screening, and rate vs. rhythm control and the risk of dementia/cognitive decline. And a quiz about...cicadas! Bzzzz.…

1
Episode 154: triptans and CV risk, urate levels and flares, tests for acute diverticulitis, and APOE4 30:57

12M ago30:57

30:57

Quite a diversity of topics this week, as Gary, Henry, Kate and Mark talk about: CV risk with triptans, baseline urate levels and risk of acute flairs in adults with gout, primary care feasible tests for acute diverticulitis, and how APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease.…

1
Episode 153: gabapentinoids and COPD, shoulder dislocations, and older Alzheimer's drugs 30:08

1y ago30:08

30:08

This week, Mark is taking a break so Kate, Henry and Gary will discuss gabapentinoids and the risk of severe COPD, rehab after an initial anterior shoulder dislocation, and cognitive enhancers for patients with Alzheimer’s dementia

1
Episode 152: SGLT2's for heart failure, bariatric surgery outcomes, UTI in kids, and lung screening outcomes. 29:02

1y ago29:02

29:02

Join Kate, Gary, Mark and Henry (who went to the eclipse!) as they discuss SGLT2 inhibitors for older adults and frail adults with heart failure, the long term outcomes of bariatric surgery in adults with T2DM, the best duration of antibiotics for febrile UTI in kids, and real world outcomes of lung cancer screening.…

1
Episode 151: SSRIs and mania, oseltamivir, exercise and BP, and HPV vaccine preventing cancer. 30:52

1y ago30:52

30:52

Join us today as Gary, Kate, Mark and Henry discuss risks of SSRIs provoking mania in adolescents, real world effectiveness of HPV vaccination for preventing cervical cancer, whether tamiflu reduces hospitalization in adults with flu, and the effects of exercise on BP.

1
Episode 150: EXXUA for depression, ubrogepant for migraine, PCI for stable angina, and a simple way to communications 30:37

1y ago30:37

30:37

This week, Gary, Kate, Henry and Mark discuss a newly approved medication for major depression in adults, initiation of abortive therapy using ubrogepant during migraine prodrome, the value of PCI for patients with stable angina, and a simple intervention to improve communication with hospitalized patients. And a quiz!…

1
Episode 149: afib risk scores, tai chi and cognition, flu vax, and managing gallstones 32:58

1y ago32:58

32:58

This week join us as Kate, Mark, Henry and Gary discuss clinical prediction tool for patients using DOACs for atrial fibrillation, the benefits of cognitively enhanced tai chi, whether high dose recombinant flu vaccine is useful in adults 50-64, and watching patients with symptomatic gallstone disease.…

1
Episode 148: meds for alcohol withdrawal, opioids and stimulants, and treating agitation in AD 23:19

1y ago23:19

23:19

This week, Kate, Henry and Mark discuss pharmacotherapy for alcohol use disorder, using opioids in adults with cancer pain who also use non-medical stimulants, and brexpiprazole for agitation in patients with Alzheimer's dementia.

1
Episode 147: TENS for post-op pain, Alzheimer's meds, and delivering bad news 32:37

1y ago32:37

32:37

Join Kate, Mark, Henry and Gary as they talk about: TENS for pain after cesarean delivery, cholinesterase inhibitors and risk of falls, a meta-analysis of the new Alzheimer’s drugs, and telephone delivery of bad news

1
Episode 146: nasal suction for infants, amitriptyline for IBS, aspirin to prevent CRC, and talking about hard things 31:58

1+ y ago31:58

31:58

This week, join Henry, Kate, Gary and Mark as they discuss 4 great studies: home suction devices for infants with bronchiolitis, amitriptyline for adults with irritable bowel, high-dose aspirin for preventing colorectal cancer, and communicating about serious illness and end of life.

1
Episode 145: DAPT for dementia, BP control post-stroke, managing CHD, and probiotics for IBS 36:07

1+ y ago36:07

36:07

This week, Kate, Henry, Mark and Gary discuss antiplatelet medications to prevent dementia, post-stroke blood pressure control, the latest guideline for managing patients with chronic cardiac disease, and probiotics for patients with irritable bowel syndrome.

1
Episode 144: cellulitis prognosis, chronic migraine tx, long COVID tx, and drugs for lipids 30:23

1+ y ago30:23

30:23

This week Kate, Mark, Henry and Gary talk about how long it takes for lower extremity cellulitis to improve, how long it takes for CGRP monoclonal antibodies to take effect in adults with chronic migraine, whether CBT is effective for fatigue in patients with long COVID, and outcome data for various lipid lowering therapies. Plus a painful quiz, an…

1
Episode 143: sponges for acne, renal colic, breast CA overdiagnosis, BP cuff size 26:36

1+ y ago26:36

26:36

This week, Kate, Mark, Gary and Henry will discuss a possible new agent for acne, analgesia in adults with renal colic, breast cancer overdiagnosis in older women, and the importance of BP cuff size. Plus a Dickensian quiz.

1
Episode 142: Tdap in pregnancy, atogepant for migraine, POCUS for SBO and gastroparesis 30:11

1+ y ago30:11

30:11

This week, join Kate, Mark, Henry and Gary (from his carport) as they discuss third trimester Tdap for prevention of infant pertussis, atogepant for preventing migraines, POCUS for diagnosing small bowel obstruction, and whether any medications work for treating gastroparesis

1
Episode 141: an app to reduce drinking, e-cigs to quit smoking, and does ADHD lead to substance use 24:59

1+ y ago24:59

24:59

This week, we give Henry the day off, leaving Kate, Mark and Gary to discuss a new app to reduce unhealthy alcohol use, whether e-cigarettes can help you quit smoking, and whether taking stimulant meds for ADHD increases the risk of substance use down the road. And the quiz, and a book recommendation ("A Voyage for Madmen").…

1
Episode 140: Mg+ for CP, amox challenge, ACP guidelines, and carotid surgery 30:41

1+ y ago30:41

30:41

This week Kate, Mark, Gary and Henry discuss magnesium to prevent cerebral palsy, amoxicillin challenge in the primary care clinic for suspectec PCN non-allergy, new ACP guidance on colorectal cancer screening, and surgery for carotid disease.

1
Episode 139: U=U, tetracyclines and teeth staining, metformin to prevent long COVID and the best med for onychomycosis 27:05

1+ y ago27:05

27:05

This week, Kate, Mark, Gary and Henry discuss viral loads and risk of HIV transmission, tetracyclines and dental staining in kids, metformin to prevent long COVID in obese and overweight adults, and the effectiveness of terbinafine pulse therapy for ugly toenails

1
Episode 138: Deprescribing, meds for neuropsych symptoms in dementia, and lowering BP too much 30:37

1+ y ago30:37

30:37

While Mark is biking, Kate, Henry and Gary talk about a deprescribing intervention for older adults in the hospital, medications for managing neuropsychiatric symptoms in adults with dementia, and harms associated with aggressive BP lowering in hospitalized older adults.

1
Episode 137: amox/mono, hearing aids, stem cells for knee OA, and preventing T2DM 29:56

1+ y ago29:56

29:56

This week, Kate, Mark, Henry and Gary talk about whether amoxicillin really causes a rash in kids with mono, whether hearing aids improve cognition in the elderly, stem cell injections and knee OA, and nonpharmacologic approaches to preventing type 2 DM.

1
Episode 136: Beers, testosterone harms, opioids for back and neck pain, and SDOH 34:40

1+ y ago34:40

34:40

This week, join Mark, Kate, Henry and Gary as they discuss screening for social determinants of health, the updated Beers List of naughty medications, the value of opioids for acute back and neck pain, and testosterone and adverse events.

1
Episode 135: osteoporosis treatment, evolocumab, mifepristone for adenomyosis, and ambulatory BP 32:33

1+ y ago32:33

32:33

This week, Kate, Gary, Mark and Henry discuss treatments for osteoporosis in post-menopausal women, the effect of adding evolocumab to a statin - a reanalysis of the FOURIER trial, using mifepristone for painful adenomyosis, and real world data comparing 24-hour ambulatory BP with clinic readings.

1
Primary Care Update Episode 134 28:11

1+ y ago28:11

28:11

This week, Kate, Gary, Henry and Mark discuss some fun throwbacks to 2003, the new first line medications for treating T2DM, whether you can take a diuretic at bedtime, and how to manage perioperative antihypertensive medications. And a quiz. Get CME credit at iafp.com just for listening, go to their education Web page.…

1
Episode 133: bilirubin in infants, rest after concussion, child abuse, and why words matter 25:29

2y ago25:29

25:29

This week, join Kate, Henry, Gary and Mark as they discuss point of care bilirubin tests for neonatal jaundice, guideline for evaluating children in close contact with abused children, early return to activity after concussion, and terminology preferences by patients being treated for substance use disorder.…

1
Episode 132: new drug for hot flushes, screening for autism, and steroids for pneumonia 28:59

2y ago28:59

28:59

This week, Kate, Henry and Mark discuss a new drug therapy for vasomotor symptoms of menopause, the accuracy of the M-CHAT tool for autism, and the value of steroids for severe community-acquired pneumonia. And Henry tells a joke about hot air balloons. And the quiz.

1
Episode 131: non-STEMI management in frail elderly, diagnosing secondary HTN in kids, and RSV vaccine for pregnant women 25:03

2y ago25:03

25:03

This week, while Gary tries to learn French in of all places France, Kate, Mark and Henry discuss management of non-STEMI in frail older adults, identifying children with secondary hypertension, and RSV vaccination in pregnant women

1
Episode 130: bempedoic acid, polypills and dementia, prophylaxis for STIs, and interpreting asymptomatic CAD 34:55

2y ago34:55

34:55

This week Kate, Gary, Henry and Mark talk about bempedoic acid for the prevention of ASCVD, the polypill and cognitive decline in the elderly, post-exposure prophylaxis in persons at high risk of STIs, asymptomatic CAD and subsequent AMI risk. And do you know how long ankle arthroplasties last?

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Mark Ebell Podcasts

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