The Lancet Gastroenterology & Hepatology is a monthly journal that considers original research, reviews, and personal views in gastroenterology and hepatology from around the world. In the monthly podcasts, editors of the journal discuss highlights of the current issue.
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Hugh Thomas, Deputy Editor at The Lancet Gastroenterology & Hepatology, in conversation with the journal’s authors, explores their latest research and its impact on people’s health, healthcare, and health policy. A monthly audio companion to the journal, this podcast covers a broad range of topics, from predicting clinical outcomes in NAFLD to immunosuppressant withdrawal in patients with Crohn’s disease, the primary antibiotic resistance of Helicobacter pylori to surgical versus non-surgica ...
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How does acute kidney injury presentation and management differ globally for patients hospitalised with cirrhosis? We spoke to Salvatore Piano, corresponding author of the landmark International Club of Ascites GLOBAL AKI study, about new data on regional variations in severity, phenotype, treatment, and outcomes across 5 continents.…
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Salvatore Piano on the global epidemiology of acute kidney injury in hospitalised patients with decompensated cirrhosis
19:05
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19:05How does acute kidney injury presentation and management differ globally for patients hospitalised with cirrhosis? We spoke to Salvatore Piano, corresponding author of the landmark International Club of Ascites GLOBAL AKI study, about new data on regional variations in severity, phenotype, treatment, and outcomes across 5 continents. Read the full …
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John Chia on the ASCOLT trial of adjuvant aspirin for colorectal cancer
13:29
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13:29John Chia discusses the results of the ASCOLT trial, which explored the effect of aspirin after completion of standard adjuvant therapy for patients with colorectal cancer. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00387-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation…
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John Chia discusses the results of the ASCOLT trial, which explored the effect of aspirin after completion of standard adjuvant therapy for patients with colorectal cancer.By The Lancet
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Hannes Hagström discusses a study investigating the feasibility of screening for advanced liver fibrosis alongside retina scanning in people with type 2 diabetes.By The Lancet
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Hannes Hagström on screening for advanced liver fibrosis alongside retina scanning in people with type 2 diabetes
21:23
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21:23Hannes Hagström discusses a study investigating the feasibility of screening for advanced liver fibrosis alongside retina scanning in people with type 2 diabetes. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00313-3/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social…
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Cathy Lu (University of Calgary) discusses a consensus statement on the use of intestinal ultrasound for assessing and monitoring small bowel strictures in Crohn's disease.By The Lancet
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Cathy Lu on intestinal ultrasound for assessing and monitoring Crohn's disease small bowel strictures
11:15
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11:15Cathy Lu (University of Calgary) discusses a consensus statement on the use of intestinal ultrasound for assessing and monitoring small bowel strictures in Crohn's disease. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00265-6/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation…
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Peter De Cruz on the PREDICT-UC trial of intensified versus standard dose infliximab for steroid-refractory acute severe ulcerative colitis
14:42
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14:42Peter De Cruz (University of Melbourne) discusses the PREDICT-UC trial of intensified versus standard dose infliximab induction therapy for steroid-refractory acute severe ulcerative colitis. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00200-0?dgcid=buzzsprout_icw_podcast_generic_langas Continue this co…
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Peter De Cruz (University of Melbourne) discusses the PREDICT-UC trial of intensified versus standard dose infliximab induction therapy for steroid-refractory acute severe ulcerative colitis.By The Lancet
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Shahida Din and Beatriz Gros on the harms associated with receiving placebo in trials of drugs for inflammatory bowel disease
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34:15Shahida Din (Western General Hospital, Edinburgh) and Beatriz Gros (Reina Sofía University Hospital, Cordoba) discuss two new papers on the harms associated with receiving placebo in induction and maintenance trials of biological therapies and small molecules in inflammatory bowel disease. Read the full articles: https://www.thelancet.com/journals/…
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In conversation with... Shahida Din and Beatriz Gros
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34:15Shahida Din (Western General Hospital, Edinburgh) and Beatriz Gros (Reina Sofía University Hospital, Cordoba) discuss two new papers on the harms associated with receiving placebo in induction and maintenance trials of biological therapies and small molecules in inflammatory bowel disease.By The Lancet
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Arndt Vogel (Toronto General Hospital) discusses the NALIRICC trial of nanoliposomal irinotecan added to fluorouracil plus leucovorin in patients with cholangiocarcinoma and gallbladder carcinoma previously treated with gemcitabine-based therapies.By The Lancet
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Arndt Vogel on the NALIRICC trial of nanoliposomal irinotecan in pretreated advanced biliary tract cancer
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18:23Arndt Vogel (Toronto General Hospital) discusses the NALIRICC trial of nanoliposomal irinotecan added to fluorouracil plus leucovorin in patients with cholangiocarcinoma and gallbladder carcinoma previously treated with gemcitabine-based therapies. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00119-5?dgc…
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Nancy Baxter (University of Melbourne) discusses a population-based study on the duration of risk reduction in colorectal cancer incidence and mortality after a complete colonoscopy.By The Lancet
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Nancy Baxter on the duration of colorectal cancer risk reduction with a complete colonoscopy
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25:05Nancy Baxter (University of Melbourne) discusses a population-based study on the duration of risk reduction in colorectal cancer incidence and mortality after a complete colonoscopy. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00084-0?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversatio…
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In conversation with... Sanna Nybacka and Magnus Simrén
23:16
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23:16Sanna Nybacka and Magnus Simrén (University of Gothenburg) discuss the CARIBS randomised controlled trial of a low FODMAP diet versus a low-carbohydrate diet versus pharmacological treatment in IBS.By The Lancet
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Sanna Nybacka and Magnus Simrén on a trial of low FODMAP diets versus low carbohydrate diets in IBS
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23:16Sanna Nybacka and Magnus Simrén (University of Gothenburg) discuss the CARIBS randomised controlled trial of a low FODMAP diet versus a low-carbohydrate diet versus pharmacological treatment in IBS. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00045-1/fulltext?dgcid=buzzsprout_tlv_podcast_generic_langas …
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Nuru Noor (University of Cambridge) discusses the PROFILE trial of biomarker-stratified treatment strategies in people with newly diagnosed Crohn's disease.By The Lancet
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Nuru Noor on the PROFILE trial of biomarker-stratified treatment in newly diagnosed Crohn's disease
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19:55Nuru Noor (University of Cambridge) discusses the PROFILE trial of biomarker-stratified treatment strategies in people with newly diagnosed Crohn's disease. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00034-7/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social! Foll…
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Yusuke Shimakawa (Institut Pasteur) discusses the development and evaluation of a simple score for hepatitis B treatment eligibility in Africa.By The Lancet
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Yusuke Shimakawa on a simple score for hepatitis B treatment eligibility in Africa
20:54
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20:54Yusuke Shimakawa (Institut Pasteur) discusses the development and evaluation of a simple score for hepatitis B treatment eligibility in Africa. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00449-1?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on social! Follow us today at... http…
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Mads Israelsen on validating the new steatotic liver disease nomenclature in people with excessive alcohol intake
16:39
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16:39Mads Israelsen (Odense University Hospital) discusses a study to validate the new nomenclature of steatotic liver disease in patients with a history of excessive alcohol intake. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00443-0/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this convers…
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Mads Israelsen (Odense University Hospital) discusses a study to validate the new nomenclature of steatotic liver disease in patients with a history of excessive alcohol intake.By The Lancet
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Louise Dye on the role of expectancy and gluten in non-coeliac gluten sensitivity
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23:19Louise Dye (University of Leeds) discusses a trial exploring the role of expectancy and gluten ingestion on symptoms in people with non-coeliac gluten sensitivity. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00317-5/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversation on socia…
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Louise Dye (University of Leeds) discusses a trial exploring the role of expectancy and gluten ingestion on symptoms in people with non-coeliac gluten sensitivity.By The Lancet
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Tzu-Chan Hong (National Taiwan University Cancer Centre) discusses a systematic review and meta-analysis on primary antibiotic resistance of Helicobacter pylori between 1990 and 2022 in the Asia-Pacific region.By The Lancet
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Tzu-Chan Hong on the primary antibiotic resistance of Helicobacter pylori in the Asia-Pacific region
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14:40Tzu-Chan Hong (National Taiwan University Cancer Centre) discusses a systematic review and meta-analysis on primary antibiotic resistance of Helicobacter pylori between 1990 and 2022 in the Asia-Pacific region. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00281-9/fulltext?dgcid=buzzsprout_icw_podcast_gen…
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Sarah Moen on metachronous colorectal cancer risk according to Lynch syndrome pathogenic variant after colectomy
14:45
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14:45Sarah Moen (Erasmus University Medical Center) discusses a retrospective cohort study examining the risk of metachronous colorectal cancer after partial or extensive colectomy in carriers of different pathogenic Lynch syndrome variants. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00228-5/fulltext?dgcid=…
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Sarah Moen (Erasmus University Medical Center) discusses a retrospective cohort study examining the risk of metachronous colorectal cancer after partial or extensive colectomy in carriers of different pathogenic Lynch syndrome variants.By The Lancet
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Anna Emilie Kann (Zealand University Hospital, Denmark) discusses a population-based study done in Denmark exploring the causes of mortality in patients with alcohol-related liver disease.By The Lancet
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Anna Emilie Kann on the causes of mortality in patients with alcohol-related liver disease
16:19
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16:19Anna Emilie Kann (Zealand University Hospital, Denmark) discusses a population-based study done in Denmark exploring the causes of mortality in patients with alcohol-related liver disease. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00192-9/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue t…
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Robert Krouse on surgical versus non-surgical management of malignant bowel obstruction
16:31
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16:31Robert Krouse (University of Pennsylvania) discusses the pragmatic S1316 trial of surgical versus non-surgical management for patients with malignant small bowel obstruction. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00191-7/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this conversati…
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Robert Krouse (University of Pennsylvania) discusses the pragmatic S1316 trial of surgical versus non-surgical management for patients with malignant small bowel obstruction.By The Lancet
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Marc Rothenberg on a trial of benralizumab in eosinophilic gastritis
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14:29Marc Rothenberg (University of Cincinnati College of Medicine) discusses a new trial assessing the efficacy and safety of benralizumab in patients with eosinophilic gastritis, and how the surprising findings might change our understanding of eosinophilic gastrointestinal diseases. Read the full article: https://www.thelancet.com/journals/langas/art…
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Marc Rothenberg (University of Cincinnati College of Medicine) discusses a new trial assessing the efficacy and safety of benralizumab in patients with eosinophilic gastritis, and how the surprising findings might change our understanding of eosinophilic gastrointestinal diseases.By The Lancet
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Michael Pavlides (University of Oxford) discusses work by the LITMUS Consortium on the prognostic performance of non-invasive tests in patients with non-alcoholic fatty liver disease.By The Lancet
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Michael Pavlides on non-invasive tests for predicting clinical outcomes in non-alcoholic fatty liver disease
17:41
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17:41Michael Pavlides (University of Oxford) discusses work by the LITMUS Consortium on the prognostic performance of non-invasive tests in patients with non-alcoholic fatty liver disease. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00017-1/fulltext?dgcid=buzzsprout_icw_podcast_generic_langas Continue this c…
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Jasmohan Bajaj on global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis
12:48
12:48
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12:48Jasmohan Bajaj (Virginia Commonwealth University and Central Virginia Veterans Healthcare System, Richmond, VA, USA), on behalf of the CLEARED Consortium, discusses a prospective observational cohort study examining global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis. Read the full article: https://www.…
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Jasmohan Bajaj (Virginia Commonwealth University and Central Virginia Veterans Healthcare System, Richmond, VA, USA), on behalf of the CLEARED Consortium, discusses a prospective observational cohort study examining global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis.…
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Adelina Artenie (University of Bristol, UK) discusses a systematic review and meta-analysis exploring the incidence of HIV and HCV among people who inject drugs, and associations with age and sex or gender.By The Lancet
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Adelina Artenie on the incidence of HIV and HCV in people who inject drugs
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17:15Adelina Artenie (University of Bristol, UK) discusses a systematic review and meta-analysis exploring the incidence of HIV and HCV among people who inject drugs, and associations with age and sex or gender. Read the full article: https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00018-3/fulltext?dgcid=buzzsprout_icw_podcast_langas_…
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Johan Burisch (Copenhagen University Hospital, Denmark) discusses the findings and recommendations of The Lancet Gastroenterology & Hepatology Commission on the cost of inflammatory bowel disease in high-income settings.By The Lancet
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Johan Burisch on the costs of inflammatory bowel disease in high-income settings
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20:00Johan Burisch (Copenhagen University Hospital, Denmark) discusses the findings and recommendations of The Lancet Gastroenterology & Hepatology Commission on the cost of inflammatory bowel disease in high-income settings. Read the Commission here: The cost of inflammatory bowel disease in high-income settings Continue this conversation on social! Fo…
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Edouard Louis (University Hospital CHU of Liège) discusses the SPARE randomised controlled trial of infliximab or concomitant immunosuppressant withdrawal in patients with Crohn’s disease.By The Lancet
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Edouard Louis on the SPARE trial of infliximab or immunosuppressant withdrawal in Crohn’s disease
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21:30Edouard Louis (University Hospital CHU of Liège) discusses the SPARE randomised controlled trial of infliximab or concomitant immunosuppressant withdrawal in patients with Crohn’s disease. Read the full article: Withdrawal of infliximab or concomitant immunosuppressant therapy in patients with Crohn's disease on combination therapy (SPARE) Continue…
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Paula Ghaneh (University of Liverpool) discusses the ESPAC5 randomised controlled trial of short-course neoadjuvant therapy compared with immediate surgery for patients with borderline resectable pancreatic ductal adenocarcinoma.By The Lancet
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Paula Ghaneh on the ESPAC5 trial of neoadjuvant therapy in borderline resectable pancreatic cancer
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20:20Paula Ghaneh (University of Liverpool) discusses the ESPAC5 randomised controlled trial of short-course neoadjuvant therapy compared with immediate surgery for patients with borderline resectable pancreatic ductal adenocarcinoma. Read the full article: Immediate surgery compared with short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINO…
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Dan Turner (Shaare Zedek Medical Center) discusses the VEDOKIDS study on the safety, effectiveness, and dosing of vedolizumab in children with IBD.By The Lancet
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Dan Turner on vedolizumab in children with IBD
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14:51Dan Turner (Shaare Zedek Medical Center) discusses the VEDOKIDS study on the safety, effectiveness, and dosing of vedolizumab in children with IBD. Read the full article: Outcomes, dosing, and predictors of vedolizumab treatment in children with inflammatory bowel disease (VEDOKIDS) Continue this conversation on social! Follow us today at... https:…
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