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The Lancet Respiratory Medicine

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The Lancet Respiratory Medicine publishes a range of article types in respiratory medicine and critical care. These include Original Research, Reviews, Personal Views, Comments, and News articles. Topics include but are not limited to asthma, COPD, tobacco control, critical care, lung cancer, cystic fibrosis, pneumonia, sarcoidosis, mesothelioma, sleep medicine, and respiratory infections.
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Editors at The Lancet Respiratory Medicine, in conversation with the journal’s authors, explore their latest research and its impact on people’s health, healthcare, and health policy. A monthly audio companion to the journal, this podcast covers a broad range of topics, from long COIVD outcomes to tobacco control, the management of uncontrolled asthma to intensive care medicine, and more.
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Last Week in Medicine

Stephen Jenkins, MD, Austin Rupp, MD

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Wouldn't it be nice if someone reviewed all the latest internal medicine literature and distilled it into a brief podcast you could listen to on your way to work? Get updates from the New England Journal of Medicine, JAMA Network, Annals of Internal Medicine, Journal of Hospital Medicine, Journal of General Internal Medicine, Lancet and more.
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Bianca Brandon, Senior Editor at The Lancet Respiratory Medicine, is joined by Professor Hjalmar Bouma to discuss a new review on sepsis in immunocompromised patients, exploring the diagnostic challenges, complexities of immune status, and future directions for targeted therapies. The episode also analyses the increased vulnerability of specific pa…
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What do you do when most trials suggest benefit for an intervention, but then a new trial suggests harm? We thought steroids in pneumonia was a settled question, but REMAP-CAP had other plans! We also review a new RCT for BP targets in patients with hypertension and diabetes, a new aldosterone synthase inhibitor for hypertension, and reduced dose a…
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Deputy Editor of The Lancet Respiratory Medicine Ari Colosio discusses the critical findings of a new epidemiological study on pulmonary embolism in children and adolescents with Simon Wolf from the University Hospital of Zurich. This episode delves into the prevalence, risk factors, and clinical implications of this rare but serious condition, hig…
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For this episode we are joined by EBM guru, Dr. Brian Locke, who deftly breaks down all of our statistics questions. Is half dose DOAC as good as full dose DOAC for preventing VTE, and does it reduce bleeding risk? Can procalcitonin reduce duration of antibiotics for infections without compromising mortality rates? Can LLMs like GPT-4 help physicia…
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Dr Sandeep Sahay and Professor Franck Rahaghi discuss their Personal View on future treatment paradigms in pulmonary arterial hypertension. Read the full paper, Future treatment paradigms in pulmonary arterial hypertension: a personal view from physicians, health authorities, and patients, here: https://www.thelancet.com/journals/lanres/article/PII…
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We're back, after a brief hiatus! Today we talk about duration of therapy for bacteremia, Factor XI inhibition for atrial fibrillation, whether to stop ACEi or ARB before elective surgery, and whether GLP-1 agonists are beneficial in heart failure with preserved ejection fraction. Go to minute 7:30 to skip the banter. 7 vs 14 Days of Antibiotics fo…
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Il Professor Sergio Harari commenta i risultati di un trial clinico di fase 2 volto a valutare l’attivita’ e la sicurezza del farmaco nintedanib come trattamento in pazienti affetti da linfangioleiomiomatosi (LAM). Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https:/…
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Professor Sergio Harari joins us to discuss the results of a phase 2 clinical trial evaluating activity and safety of nintedanib in people with lymphangioleiomyomatosis (LAM). Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal h…
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Dr Robert Kullberg joins us to discuss his Viewpoint on empiric antibiotic therapy for sepsis and the importance of reducing unnecessary use of anti-anaerobic antibiotics. Read the full article: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00257-1/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanres Continue this conversation …
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It's been a long time, but we are back! Apologies on the audio quality from Dr. Jenkins. Apparently he was recording from inside a cardboard box. Today we talk about important, practice changing studies in internal medicine from the last several months. What's the best anticoagulant in patients with cirrhosis and atrial fibrillation? Why do doctors…
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Professor Heather Zar joins The Lancet Respiratory Medicine to discuss early-life RSV disease and long-term respiratory health. This topic will be covered in one of four Series papers in a cross-journal Series with The Lancet. You can read the Series of papers at: https://www.thelancet.com/series/respiratory-syncytial-virus?dgcid=buzzsprout_icw_pod…
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Dr Margaux Mesle discusses estimates of lives directly saved by COVID-19 vaccination programs in the WHO European Region in the period from 2020 to 2023 and public health implications. Read the full article: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00179-6?dgcid=buzzsprout_icw_podcast_generic_lanres Continue this conversat…
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Professor James Hull joins us to discuss his recent Spotlight on protecting the respiratory health of athletes ahead of the Summer Olympics and Paralympics. Read the full article: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00183-8?dgcid=buzzsprout_icw_podcast_generic_lanres Continue this conversation on social! Follow us tod…
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Professor Eric Lim discusses the outcomes after extended pleurectomy decortication plus chemotherapy versus chemotherapy alone for pleural mesothelioma. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/com…
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Dr Anne Chang discusses the burden of chronic respiratory diseases in Indigenous people. Read the full article: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00008-0/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanres Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.c…
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Professor Daniel Steinfort and Professor Shankar Siva discuss the effect of systematic endoscopic mediastinal staging on radiotherapy field planning in patients with locally advanced non-small-cell lung cancer. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://fac…
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Prof Daniel Prieto-Alhambra, Dr Annika Jödicke, and Dr Martí Català discuss the effectiveness of COVID-19 vaccines to prevent Long COVID, estimated to affect up to 20% of those infected with SARS-CoV-2. Read the full article: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00414-9/fulltext?dgcid=buzzsprout_icw_podcast_generic_lan…
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Dr Tim Nicholson and Dr Sarah Gorst discuss the development of an international Delphi consensus study on a core outcome measurement set for long COVID and how it will be used to inform future research and clinical care. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup h…
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Dr Betty Raman discusses multiorgan MRI findings in patients after hospitalisation with COVID-19. Read the full article: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00262-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanres Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://in…
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Dr Keith Chappell discusses the bivalent recombinant vaccine for COVID-19 following the study by Dayan and colleagues, with focus on vaccine access, variants and boosters, tolerability and side effects, as well as hopes for future trials. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.co…
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Today we are joined by Dr. Brian Locke, recently graduated pulmonary-critical care fellow, who takes us on a journey of avoiding statistical fallacies. Does metformin reduce the likelihood of long COVID? Should we give platelet transfusions to thrombocytopenic patients before central line placement? Did the CANVAS trial change practice in cancer as…
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Today we have a special guest, Dr. Joel Topf, board-certified nephrologist and medical educator extraordinaire. Our listeners will likely recognize Dr. Topf from his prolific tweeting @Kidney_boy, as well as his numerous appearances on the Curbsiders podcast. He is a co-founder of the NephJC on Twitter, and host and founder of the NephJC podcast Fr…
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This week we have special guest, Dr. Adam Spivak, to talk about the new study on doxycycline post-exposure prophylaxis for STIs. Dr. Spivak is an infectious disease expert and works in both an HIV clinic and a free PrEP clinic. I also review the latest COVID-19 anticoagulation trial and a paper looking at rates of fracture non-union in people who r…
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Prof. James Chalmers discusses the characteristics of patients with bronchiectasis across Europe, the differences between countries, and possible differences in clinical outcomes, based on data from the EMBARC registry. Read the full article: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00093-0/fulltext?dgcid=buzzsprout_tlv_ep…
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Today we have special guest, Dr. Sarah Gilligan, a nephrologist, to talk about the new study of thiazides for kidney stones. We all learn in medical school that thiazides reduce urinary excretion of calcium, but does that really translate to fewer kidney stones? We also have Dr. Brian Locke on to talk about the CAPE COD trial, a big new critical ca…
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Prof Richard Costello discusses the use of digital measurements of medication adherence and lung function to guide management of uncontrolled asthma. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/compan…
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Dr Keiju Aokage discusses segmentectomy for ground-glass-dominant lung cancer with a tumour diameter of 3 cm or less. Read the full article: Segmentectomy for ground-glass-dominant lung cancer with a tumour diameter of 3 cm or less including ground-glass opacity (JCOG1211): a multicentre, single-arm, confirmatory, phase 3 trial Continue this conver…
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Today we welcome special guest and fellow EBM lover Dr. Mita Hoppenfeld to talk about a new randomized controlled trial evaluating the best duration of antibiotics for febrile UTI in men. Is 7 days as good as 14 days? We also review the latest guidelines for lower GI bleeding and a new retrospective study on renal outcomes in patients with AKI who …
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Carol Hodgson discusses recent advances in our understanding of in-hospital and post-discharge outcomes in critically ill patients who receive ECMO. Read the full article: Comparative outcomes of extracorporeal membrane oxygenation for COVID-19 delivered in experienced European centres during successive SARS-CoV-2 variant outbreaks (ECMO-SURGES) Co…
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We're back with Season 4! Sorry for the unplanned hiatus. Today we talk about the CLOVERS trial, which tested the hypothesis that early vasopressors and restrictive fluid would be superior to liberal fluids plus rescue vasopressors. We also looked at the TRANSFORM-HF study, which compared torsemide and furosemide in congestive heart failure, the PR…
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