Reversing cancer mechanisms to fight back against solid tumors

Beyond Biotech - the podcast from Labiotech

CatalYm is preparing to initiate its broad phase 2b clinical development program for visugromab to tackle multiple solid tumor indications.

Visugromab is a monoclonal antibody that neutralizes the tumor-derived growth differentiation factor-15 (GDF-15), a locally acting immunosuppressant fostering immunotherapy resistance.

Neutralizing GDF-15 with visugromab reverses key cancer resistance mechanisms to reinstate an efficient anti-tumor response by reenabling immune cell activation, proliferation and Interferon-γ signature induction.

Visugromab has demonstrated a good safety profile and potent and durable anti-tumor efficacy in combination with anti-PD-1 treatment in advanced cancer patients, as highlighted in its recent Nature publication and interim clinical data.

This week we have a conversation with Eugen Leo, chief medical officer at CatalYm.

01:30-03:38: About CatalYm
03:38-06:59: Solid tumors and also why they are hard to treat
06:59-09:04: Current treatments for solid tumors
09:04-10:47: What is immunotherapy resistance?
10:47-12:23: What is visugromab?
12:23-13:32: CatalYm’s clinical development program
13:32-15:12: What represents success for patients using visugromab?
15:12-17:50: Other treatment options being developed
17:50-19:50: CatalYm’s pipeline and the future

This week’s podcast was sponsored by TCR Solutions.

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Chapters

1. Reversing cancer mechanisms to fight back against solid tumors (00:00:00)

2. About CatalYm (00:01:30)

3. Solid tumors and also why they are hard to treat
 (00:03:38)

4. Current treatments for solid tumors
 (00:06:59)

5. What is immunotherapy resistance?
 (00:09:04)

6. What is visugromab?
 (00:10:47)

7. CatalYm’s clinical development program
 (00:12:23)

8. What represents success for patients using visugromab?
 (00:13:32)

9. Other treatment options being developed
 (00:15:12)

10. CatalYm’s pipeline and the future (00:17:50)