Making Blood Vessels in a Factory

What's Your Problem?

#Tech #Business #Entrepreneur #iHeartPodcasts and Pushkin Industries #Pushkin Industries #Founder CEO

52:22

Season 3 of the smash hit FX/Hulu show “The Bear” roared to life just days ago, but Will Poulter (the actor who plays fan-favorite Luca) and 2014 F&W Best New Chef Dave Beran had been prepping for weeks. Poulter — like his co-star Jeremy Allen White — staged with Beran at his Santa Monica restaurant Pasjoli to learn how to accurately portray a professional chef onscreen. The lessons went so well, Beran says he’d hire Poulter as a cook — even despite a messy mishap with a pastry bag. The two dished all about getting kitchen culture right on and offscreen, what it takes to be at the top of your craft, and the pure magic of a great restaurant service. Learn more about your ad choices. Visit podcastchoices.com/adchoices…

about a year ago 42:06

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Laura Niklason is the co-founder and CEO of Humacyte. Laura's problem is this: How can you use human cells to create blood vessels that surgeons can pull out of a bag and implant into patients? Although still awaiting FDA approval in the U.S., Humacyte's vessels have already been used to treat wounded soldiers in Ukraine.

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161 episodes

Making Blood Vessels in a Factory

What's Your Problem?

12 subscribers

published about a year ago

MP3•Episode home

See omnystudio.com/listener for privacy information.

161 episodes

#Tech #Business #Entrepreneur #iHeartPodcasts and Pushkin Industries #Pushkin Industries #Founder CEO

All episodes

1
Inside the Mind of an AI Model 43:28

2 days ago43:28

43:28

AI might be the most consequential advancement in the world right now. But – astonishingly – no one fully understands what’s going on inside AI models. Josh Batson is a research scientist at Anthropic, the AI company behind Claude, one of the world’s leading language models. Josh’s problem is this: How do we learn how AI works? Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm . Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkin Subscribe on Pushkin: pushkin.com/plus See omnystudio.com/listener for privacy information.…

1
Teaching Robots How to Do Everything 37:18

9 days ago37:18

37:18

AI is better than humans at a lot of things, but physical tasks – even seemingly simple ones like folding a shirt – routinely stump AI-powered robots. Chelsea Finn is a professor at Stanford and the co-founder of Physical Intelligence. Chelsea's problem is this: Can you build an AI model that can teach any robot to do any task, anywhere? Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm . Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkin Subscribe on Pushkin: pushkin.com/plus See omnystudio.com/listener for privacy information.…

1
Making a Universal Flu Vaccine 38:19

16 days ago38:19

38:19

Jacob Glanville is the founder and CEO of Centivax. Jacob’s problem is this: Can you create a vaccine that protects people against almost all strains of flu – even strains that haven’t evolved yet? Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm . Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkin Subscribe on Pushkin: pushkin.com/plus See omnystudio.com/listener for privacy information.…

1
Teaching Computers to Smell 36:16

23 days ago36:16

36:16

Alex Wiltschko got obsessed with perfume when he was 12 years old. He grew up to be an AI researcher at Google. Then he started Osmo, a company that fused his job at Google with his childhood obsession: Osmo is using AI to teach computers to smell. The company is getting into the perfume business, and it plans eventually to use scent to diagnose disease and detect security risks. Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm . Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkin Subscribe on Pushkin: pushkin.com/plus See omnystudio.com/listener for privacy information.…

1
Can a Chatbot Treat Depression? 45:42

7 weeks ago45:42

45:42

Nick Jacobson and his team at Dartmouth medical school spent over 100,000 hours trying to build an AI chatbot that can serve as a safe, effective therapist. After a few false starts, they seem to be on to something. Note: This episode contains references to self harm. Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm . Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkin Subscribe on Pushkin: pushkin.com/plus See omnystudio.com/listener for privacy information.…

1
Will AI Radically Change the World by 2027?... from Risky Business 47:03

7 weeks ago47:03

47:03

This week, Nate and Maria discuss AI 2027, a new report from the AI Futures Project that lays out some pretty doom-y scenarios for our near-term AI future. They talk about how likely humans are to be misled by rogue AI, and whether current conflicts between the US and China will affect the way this all unfolds. Plus, Nate talks about the feedback he gave the AI 2027 writers after reading an early draft of their forecast, and reveals what he sees as the report’s central flaw. Enjoy this episode from Risky Business , another Pushkin podcast. The AI Futures Project’s AI 2027 scenario: https://ai-2027.com/ Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm . Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkin Subscribe on Pushkin: pushkin.com/plus See omnystudio.com/listener for privacy information.…

1
Is the Future of Flight Supersonic? 41:17

8 weeks ago41:17

41:17

Blake Scholl is the founder and CEO of Boom Supersonic. Blake's problem is this: Can you build a commercial airplane that flies faster than the speed of sound – and that makes economic sense? Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm . Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkin Subscribe on Pushkin: pushkin.com/plus See omnystudio.com/listener for privacy information.…

1
The Secrets of Silk 25:20

9 weeks ago25:20

25:20

Fiorenzo Omenetto is a professor of biomedical engineering at Tufts University and the director of Silklab. Fiorenzo's problem is this: How do you turn a material people have been using for thousands of years into useful, cutting edge tools that improve everything from vaccine delivery to food waste? Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm . Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkin Subscribe on Pushkin: pushkin.com/plus See omnystudio.com/listener for privacy information.…

1
Infiltrating an International Ransomware Gang 33:14

10 weeks ago33:14

33:14

A few years ago, a ransomware gang called LockBit rose from obscurity to extort over $100 million from organizations around the world. A security strategist named Jon DiMaggio wanted to understand how the organization worked. So he used the techniques of World War II-era spycraft to make contact with the hackers. On today’s show, Jon tells the story of LockBit – from the way it borrowed techniques from mainstream companies to market itself and attract talent, to the response from international governments that used the gang’s own tactics against it. And he talks about how he got the hackers to talk to him. Jon described the rise and fall of the company in a series of posts he called the Ransomware Diaries. You can read those here: https://analyst1.com/ransomware-diaries-volume-1/ Note: This bonus episode of What’s Your Problem? is sponsored by Microsoft. See omnystudio.com/listener for privacy information.…

1
Preparing for the Future of War 55:09

10 weeks ago55:09

55:09

Christopher Kirchhoff helped launch a Defense Department office that aimed to bring Silicon Valley technology to the US military. Christopher’s problem is this: How can the giant bureaucracy that is the US military keep up with technological change? Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm . Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkin Subscribe on Pushkin: pushkin.com/plus See omnystudio.com/listener for privacy information.…

1
Stopping HIV Without a Vaccine 27:56

13 weeks ago27:56

27:56

Jared Baeten is senior vice president in virology at Gilead Sciences. Jared's problem is this: In a world without a vaccine, how do you make a medicine that people will actually take to help prevent HIV? There’s already a daily pill that reduces the risk of getting HIV, but a majority of people who are at high risk are unwilling or unable to take it. So Jared and his colleagues are developing a new drug, lenacapivir, designed to be given as a shot once every six months. Note: The views and opinions expressed in this episode are those of the guest and do not necessarily reflect the views or positions of any entities they represent. Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm . Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkin Subscribe on Pushkin: pushkin.com/plus See omnystudio.com/listener for privacy information.…

1
Harnessing the Heat Deep Beneath Our Feet 49:26

14 weeks ago49:26

49:26

Carlos Araque is the co-founder and CEO of Quaise Energy. Carlos' problem is this: How do you make drilling for geothermal energy as routine, widespread, and profitable as drilling for oil or gas? The answer involves digging deeper into the Earth than anyone has ever dug before. See omnystudio.com/listener for privacy information.…

1
The Brain Implant That Could Change Medicine 29:11

15 weeks ago29:11

29:11

Ben Rapoport is the co-founder and CSO of Precision Neuroscience. Ben's problem is this: Can you build a device that allows a paralyzed person to use a computer with only their thoughts – without damaging their brain? See omnystudio.com/listener for privacy information.

1
Building a Mass Market Robot 45:24

16 weeks ago45:24

45:24

Jeff Cardenas is the co-founder and CEO of Apptronik. Jeff's problem is this: Can you make a safe, reliable humanoid robot – for less than $50,000? In the short term, Apptronik’s robots will work in factories. But Jeff’s long-term goal – based on the experience of his own grandparents – is to build robots that can help care for the elderly. See omnystudio.com/listener for privacy information.…

1
Solving Solar’s Biggest Problem 43:35

17 weeks ago43:35

43:35

We need better, cheaper ways to store solar and wind energy when it’s dark out and the wind isn’t blowing. One option: Compressing air in underground caverns when energy is abundant, then blowing it back out to create energy when you need it. It’s an old idea, but it has some fundamental problems. Curtis VanWalleghem, the co-founder and CEO of Hydrostor, thinks his company has solved those problems with a new approach. If he’s right, his firm will help fix the biggest bottleneck slowing down the adoption of solar and wind power. See omnystudio.com/listener for privacy information.…

What's Your Problem?

1
How Bubbles Power Breakthroughs 54:43

18 weeks ago54:43

54:43

There are moments in history when people make huge technological advances all of a sudden. Think of the Manhattan Project, the Apollo missions, or, more recently, generative AI. But what do these moments have in common? Is there some set of conditions that lead to massive technological leaps? Byrne Hobart is the author of a finance newsletter called The Diff, and the co-author of Boom: Bubbles and the End of Stagnation. In the book, Bryne makes the case for one thing that is really helpful if you want to make a wild technological leap: a bubble. See omnystudio.com/listener for privacy information.…

What's Your Problem?

1
Teaching AI to Build Stuff in the Physical World 51:24

19 weeks ago51:24

51:24

AI works well in the virtual world. That’s partly because the internet provides so much data to train AI models. But there’s no analogous data set for the physical world – and as a result, AI doesn’t work as well there… yet. Edward Mehr is the co-founder and CEO of Machina Labs. Edward's problem is this: How can you use AI to turn robots from dumb, inflexible machines into skilled, versatile craftsmen? See omnystudio.com/listener for privacy information.…

What's Your Problem?

1
NVIDIA: At the Heart of the AI Boom 44:24

20 weeks ago44:24

44:24

In the past few years, NVIDIA has become one of the most valuable and important companies in the world by making GPUs, the chips powering the AI boom. But where did the company come from, and why are NVIDIA chips the ones that dominate AI? Tae Kim is the author of a new book called The Nvidia Way. In his book, he tells the story of how NVIDIA’s founder and CEO, Jensen Huang, set NVIDIA on the path to becoming what it is today. See omnystudio.com/listener for privacy information.…

What's Your Problem?

1
What Claude Shannon Figured Out 42:05

21 weeks ago42:05

42:05

Claude Shannon is a major figure in the history of technology. Known as the father of information theory, Shannon spent decades at Bell Labs and MIT. But what exactly did Claude Shannon figure out, and why is it so important? To answer that question, Jacob talked with David Tse, a professor of electrical engineering at Stanford who studied under one of Shannon’s students, and who teaches Shannon to his own students today. David used Shannon's work to make a breakthrough in wireless communication that underpins every phone call we make today. See omnystudio.com/listener for privacy information.…

What's Your Problem?

1
Measles: The Cancer Killer?... from Incubation 30:30

25 weeks ago30:30

30:30

We thought we knew everything there was to know about measles. But in recent years, new research has revealed that the virus attacks the immune system and creates effects far more dramatic than a rash and fever. For this episode we’re joined by Michael Mina, a former Harvard epidemiologist now at eMed, who helped discover how measles was causing “immune amnesia.” Our second guest is Stephen Russell, a former Mayo Clinic researcher who co-founded a company called Vyriad. Russell is trying to use the measles virus to treat cancer. Enjoy this episode from Incubation , another Pushkin podcast. See omnystudio.com/listener for privacy information.…

What's Your Problem?

1
RoboPod and the Perpetual Money Machine – Cautionary Questions 2… from Cautionary Tales 43:20

26 weeks ago43:20

43:20

What really drove the 2008 financial crash? What’s a shadow bank? And what’s the connection between NIMBYs and BANANAs? Tim Harford and Jacob Goldstein answer more of your questions. Enjoy this episode from Cautionary Tales , another Pushkin Podcast. See omnystudio.com/listener for privacy information.…

What's Your Problem?

1
Turning Solar Energy Into Fuel (The Solar Era, Part 3) 50:38

28 weeks ago50:38

50:38

Solar power and batteries are becoming cheap and ubiquitous. Great. But there are problems batteries can’t solve – like fueling ships and planes. One way to solve those problems: Use solar power to create hydrogen, and turn that hydrogen into fuel. Today’s guest is Raffi Garabedian, the co-founder and CEO of Electric Hydrogen. Raffi’s problem is this: How do you turn solar and wind energy into clean hydrogen that’s cheap enough to compete with fossil fuel? This is the last of three episodes we’re doing about the solar-power revolution. Listen to the previous episodes on your podcast player or at our website: https://www.pushkin.fm/podcasts/whats-your-problem See omnystudio.com/listener for privacy information.…

What's Your Problem?

1
Get Happier, Help Others: Some Good Ideas About Giving 51:09

28 weeks ago51:09

51:09

It's the season of giving: colorful paper and shiny bows, sure, and charitable giving, too. In this special episode, Jacob Goldstein, the host of What's Your Problem , gets smart about donating. Did you know that spending money on others makes you happier than spending money on yourself? Or that altruistic nerds have discovered four of the most impactful charities in the world (per dollar spent)? Have you ever wondered how poker players think about giving? Dr. Laurie Santos from The Happiness Lab, Elie Hassenfeld of GiveWell, and Nate Silver and Maria Konnikova from Risky Business talk about how to maximize your giving – and why you’ll be happy you did. Link to donate: https://givingmultiplier.org/happinesslab Listen to The Happiness Lab with Dr. Laurie Santos Listen to Risky Business See omnystudio.com/listener for privacy information.…

What's Your Problem?

1
Can Hot Bricks Save the World? (The Solar Era, Part 2) 31:17

28 weeks ago31:17

31:17

This is the second of three episodes about the solar-power revolution. Last week, we talked about how solar power got so cheap. This week, we’re talking with someone who is building giant plants around the world to take advantage of all that cheap, intermittent energy. John O'Donnell is the co-founder of Rondo Energy. John’s problem is this: How do you turn intermittent energy into the cheap, reliable, intense heat that companies around the world need to make everything from steel beams to t-shirts? See omnystudio.com/listener for privacy information.…

What's Your Problem?

1
How the Sun Won (The Solar Era, Part 1) 44:08

29 weeks ago44:08

44:08

In the past 20 years, the price of solar panels has fallen by more than 97 percent. This extraordinary decline is good news for the world – and it’s transforming the way energy is produced and consumed. For the next few episodes, we’ll be talking to people who are in the middle of this solar power revolution to find out how it happened, and what it will mean for the world. Today, Jenny Chase, the author of Solar Power Finance Without the Jargon, tells the story of how solar power got so cheap and where it’s exploding today, and she explains what problems we still need to solve to pull off a worldwide energy transition. See omnystudio.com/listener for privacy information.…

What's Your Problem?

1
Drugs in Space 31:54

30 weeks ago31:54

31:54

Paul Reichert is a research scientist at Merck, working on improvements to how we administer drugs to patients. Paul's problem is this: How can you run experiments in space to learn how to make better drugs on Earth? See omnystudio.com/listener for privacy information.

What's Your Problem?

1
The World Is Getting Better (Really) 44:32

31 weeks ago44:32

44:32

Hannah Ritchie is a data scientist and the deputy editor of Our World in Data. She is also the author of Not the End of the World: How We Can Be the First Generation to Build a Sustainable Planet. Hannah’s problem is this: How do you use data to get past the doomsday headlines and solve big problems to achieve sustainability? Check out Our World in Data: https://ourworldindata.org/ See omnystudio.com/listener for privacy information.…

What's Your Problem?

1
Rabies: When Monsters are Real…from Incubation 28:32

32 weeks ago28:32

28:32

Why has rabies invaded our nightmares for centuries? Author and veterinarian Monica Murphy tells us about the cultural history of rabies (which involves vampires and werewolves!) and how our long nightmare with the disease came to an end. Then, wildlife biologist Kathy Nelson tells us about a surprising program that works to control raccoon rabies… from the sky. Enjoy this episode from Incubation , another Pushkin podcast. See omnystudio.com/listener for privacy information.…

What's Your Problem?

1
Using Gene Therapy to Help the Blind See 36:26

34 weeks ago36:26

36:26

After decades of research, gene therapy is starting to work. Shannon Boye is a professor of cellular and molecular therapeutics at the University of Florida. She is also the co-founder and chief scientific officer of Atsena Therapeutics. Shannon’s problem is this: How do you use gene therapy to cure certain forms of blindness? See omnystudio.com/listener for privacy information.…

What's Your Problem?

1
Bringing Back Mammoths and Dodos* 40:03

35 weeks ago40:03