A Look Back on Design of Experiments

Data in Biotech

#Science #Tech #Biology #CorrDyn

16:32

You’re busy—but are you actually growing? In this episode, Nata Salvatori exposes a trap that’s costing service providers time, money, and sanity: chasing busywork that feels productive but doesn’t move the needle. She walks through a clear, five-step growth path—from clarifying your offer, validating through real sales, delivering sustainably, building repeatable systems, to scaling confidently. You’ll learn: How to spot and ditch “fake work” Why clarity beats complexity every time How to use real feedback to validate your offers Delivery tips that prevent burnout System creation that enables scaling How to honor your current phase of growth 📌 Ready to stop spinning your wheels and make real moves? Map your phase, pick your next action, and don’t be afraid to ask for help: 👉 accidentalceo.co/coaching Support the show…

about a year ago 55:57

MP3•Episode home

It's a holiday week here in the U.S., and the CorrDyn team is currently getting together for our annual company retreat. So, we decided to do something a little different this week.

We're re-releasing abridged versions of two of our most popular episodes.

These are dedicated to a critical workflow at the intersection of data and scientific research - Design of Experiments.

Across these interviews, we brought together two leading experts to give you a comprehensive overview of how best-practice DOE works in the biotech industry - Wolfgang Halter from Merck Life Sciences and Markus Gershater from Synthace.

48 episodes

A Look Back on Design of Experiments

Data in Biotech

published about a year ago

MP3•Episode home

It's a holiday week here in the U.S., and the CorrDyn team is currently getting together for our annual company retreat. So, we decided to do something a little different this week.

We're re-releasing abridged versions of two of our most popular episodes.

These are dedicated to a critical workflow at the intersection of data and scientific research - Design of Experiments.

48 episodes

#Science #Tech #Biology #CorrDyn

All episodes

Data in Biotech

1
Modernizing Clinical Data Analysis with Jesse Paquette 45:17

13 days ago45:17

45:17

In this episode of Data in Biotech, Jesse Paquette, co-founder and Chief Science Officer of Tag.bio, joins Ross Katz to explore how data mesh architecture and FAIR data principles are transforming clinical and research workflows in life sciences. From harmonizing legacy systems to enabling AI-readiness, Jesse shares how Tag.bio empowers domain experts to make data-driven decisions faster and more effectively. What You'll Learn in This Episode: >> How Tag.bio leverages data mesh and FAIR principles to democratize biomedical data access. >> The challenges biotech firms face with legacy infrastructure and clinical trial data. >> The importance of harmonized, version-controlled data products in AI-driven research. >> Why smaller pharma and life sciences firms benefit most from Tag.bio’s agile platform. Meet Our Guest Jesse Paquette is the co-founder and Chief Science Officer of Tag.bio, where he leads scientific strategy for AI-powered analytics. With over two decades in life sciences, he specializes in building tools that help researchers interpret complex biomedical data independently. About The Host Ross Katz is Principal and Data Science Lead at CorrDyn. Ross specializes in building intelligent data systems that empower biotech and healthcare organizations to extract insights and drive innovation. Connect with Our Guest: Sponsor: CorrDyn, a data consultancy Find out more about Tag.bio Connect with Jesse Parquette on LinkedIn Connect with Us: Follow the podcast for more insightful discussions on the latest in biotech and data science. Subscribe and leave a review if you enjoyed this episode! Connect with Ross Katz on LinkedIn Sponsored by… This episode is brought to you by CorrDyn, the leader in data-driven solutions for biotech and healthcare. Discover how CorrDyn is helping organizations turn data into breakthroughs at CorrDyn .…

Data in Biotech

1
Building Scalable Data Platforms for Spatial Biology with Kenny Workman of LatchBio 55:17

29 days ago55:17

55:17

In this episode of Data in Biotech, Ross Katz sits down with Kenny Workman, co-founder and CTO of LatchBio, to unpack how biotech’s data infrastructure must evolve to meet the demands of next-gen assays. From scalable workflows to high-performance visualization tools, Kenny breaks down the shift from traditional biotech to a future defined by data-driven research and agile cloud platforms. What You'll Learn in This Episode: Why spatial biology and high-throughput assays require new data infrastructure strategies How LatchBio’s five core components streamline molecular data processing The challenges of selling into biotech vs. solution providers and the strategic pivot LatchBio made to address this How large language models are revolutionizing public data curation for biotechs Why scientific innovation demands better tech adoption across the industry Meet Our Guest Kenny Workman is co-founder and CTO of LatchBio, a company transforming biological data infrastructure. A UC Berkeley alum, Kenny brings deep expertise in bioengineering, machine learning, and cloud systems. He was named to Forbes' 2023 "30 Under 30" list for his contributions to computational biology. About The Host Ross Katz is Principal and Data Science Lead at CorrDyn. Ross specializes in building intelligent data systems that empower biotech and healthcare organizations to extract insights and drive innovation. Connect with Our Guest: Sponsor: CorrDyn, a data consultancy Find out more about Latch Bio Connect with Kenny Workman on LinkedIn Connect with Us: Follow the podcast for more insightful discussions on the latest in biotech and data science. Subscribe and leave a review if you enjoyed this episode! Connect with Ross Katz on LinkedIn Sponsored by… This episode is brought to you by CorrDyn, the leader in data-driven solutions for biotech and healthcare. Discover how CorrDyn is helping organizations turn data into breakthroughs at CorrDyn .…

Data in Biotech

1
Solving Chronic Disease with Life Insurance and Data Featuring Jeremy Shane 1:00:25

6 weeks ago1:00:25

1:00:25

Entrepreneur Jeremy Shane joins host Ross Katz to discuss Life for Health, a revolutionary framework aiming to tackle chronic disease through the integration of life insurance, longitudinal data, and preventative care. From drug discovery feedback loops to outcomes-based pricing, Shane outlines a bold new path for biotech and healthcare convergence. What You'll Learn in This Episode: Why today's healthcare system fails chronic disease patients and how Life for Health aims to fix it. How longitudinal data and life insurance can realign healthcare incentives for better outcomes. The economic logic behind outcomes-based annuity pricing for breakthrough drugs like GLP-1s. What biotech companies gain from a proactive, participant-driven health model. How clinical trials could transform through pre-qualified data-rich populations. Meet Our Guest Jeremy Shane, Venture Partner at NextGen Venture Partners, is a healthcare innovator focused on chronic disease. With leadership experience at HealthCentral, WebMD, and 2U, he now pioneers Life for Health, blending life insurance with preventative care to realign incentives and extend health span. Life for Health, the book, will be released in July 2025. To learn more about Life For Health or get involved, go to www.lifeforhealth.com About The Host Ross Katz is Principal and Data Science Lead at CorrDyn. Ross specializes in building intelligent data systems that empower biotech and healthcare organizations to extract insights and drive innovation. Connect with Our Guest: Sponsor: CorrDyn, a data consultancy Connect with Jeremy Shane on LinkedIn or on Twitter @jeremylshane Connect with Us: Follow the podcast for more insightful discussions on the latest in biotech and data science. Subscribe and leave a review if you enjoyed this episode! Sponsored by… This episode is brought to you by CorrDyn, the leader in data-driven solutions for biotech and healthcare. Discover how CorrDyn is helping organizations turn data into breakthroughs at CorrDyn .…

Data in Biotech

1
How Etiome Is Redefining Preemptive Medicine with Scott Lipnick 58:54

8 weeks ago58:54

58:54

In this episode of Data in Biotech, host Ross Katz sits down with Scott Lipnick, Co-Founder and President of Etiome, to explore how preemptive medicine is changing the way biotech approaches therapeutic modeling and intervention. Discover how Etiome’s recently launched, AI-driven platform is built to detect disease earlier, identify precise biomarkers, and create stage-specific treatments—all before symptoms arise. It’s a visionary approach to healthcare focused on preserving health, not just managing illness. What You'll Learn in This Episode: Why Scott Lipnick believes the future of medicine lies in preemptive care. How Etiome uses AI to map disease progression at the cellular level. The role of biomarkers in identifying disease before symptoms surface. How Etiome applies its Temporal Biodynamics platform across diseases. What venture creation looks like at Flagship Pioneering. Meet Our Guest Scott Lipnick is the Co-founder and President of Etiome. At the forefront of preemptive medicine, Scott’s work focuses on predicting disease progression and delivering personalized, early-stage interventions using cutting-edge AI and molecular tools. About The Host Ross Katz is Principal and Data Science Lead at CorrDyn. Ross specializes in building intelligent data systems that empower biotech and healthcare organizations to extract insights and drive innovation. Connect with Our Guest: Sponsor: CorrDyn , a data consultancy Find out more about Etiome Connect with Scott on LinkedIn Connect with Us: Follow the podcast for more insightful discussions on the latest in biotech and data science. Subscribe and leave a review if you enjoyed this episode! Sponsored by… This episode is brought to you by CorrDyn, the leader in data-driven solutions for biotech and healthcare. Discover how CorrDyn is helping organizations turn data into breakthroughs at CorrDyn .…

Data in Biotech

1
Transforming Houseplants with Synthetic Biology with Patrick Torbey 47:17

10 weeks ago47:17

47:17

In this episode of Data in Biotech , host Ross Katz speaks with Patrick Torbey, CEO and Co-Founder of Neoplants, about using genetic engineering and microbiome innovation to tackle indoor air pollution. Patrick explains how Neoplants is turning everyday houseplants into powerful air purifiers using synthetic biology, offering insights into VOC degradation, enzyme pathways, and data-driven R&D. What You'll Learn in This Episode: How genetically modified plants and microbiomes can reduce indoor air pollution by targeting VOCs like formaldehyde and benzene The scientific and engineering challenges of modifying indoor plants at the genomic level Why data-driven testing and simulation are critical to optimizing plant function and user impact The role of synthetic biology in creating sustainable, scalable biotech products Patrick’s vision for solving climate challenges through engineered plant ecosystems Meet Our Guest: Patrick Torbey is the CEO and Co-Founder of Neoplants, a Paris-based biotech startup engineering plants to purify indoor air. With a PhD in genetic editing and deep expertise in synthetic biology, Patrick leads Neoplants in building functional, aesthetically unique, and sustainable plant systems for the future. About The Host: Ross Katz is the Principal Data Scientist at CorrDyn. He brings decades of experience across biotech, energy, and non-profit sectors, with a focus on building smarter data systems, machine learning pipelines, and actionable insights for complex industries. Connect with Our Guest: Sponsor: CorrDyn, a data consultancy Find out more about Neoplants Connect with Patrick Torbey on LinkedIn Connect with Us: Follow the podcast for more insightful discussions on the latest in biotech and data science. Subscribe and leave a review if you enjoyed this episode!…

Data in Biotech

1
How Phage Therapy is Scaling to Meet Antibiotic Resistance with Jessica Sacher 59:02

12 weeks ago59:02

59:02

Phage therapy is stepping into the spotlight as antibiotic resistance rises - and Jessica Sacher is helping lead the charge. In this episode, Ross Katz speaks with Jessica, Co-Founder of Phage Directory and Staff Scientist at Stanford, about sourcing phages, operationalizing therapy, and predicting efficacy through data. This conversation explores how personalized phage therapy works, its scalability, and the data challenges shaping its future. What You'll Learn in This Episode: Why phage therapy is a promising solution to antibiotic-resistant infections How Phage Directory connects researchers and clinicians to accelerate treatment What operational hurdles exist in scaling personalized phage production How data science is being applied to predict effective phage-bacteria matches Why building infrastructure and awareness is essential to adoption in clinical care Connect with Our Guest: Sponsor: CorrDyn, a data consultancy Find out more about Phage Directory Connect with Jessica on LinkedIn Connect with Us: Follow the podcast for more insightful discussions on the latest in biotech and data science. Subscribe and leave a review if you enjoyed this episode! Resources Mentioned: Why Language Itself Might Be Holding Back AI – by Ross Katz: https://www.linkedin.com/pulse/why-language-itself-might-holding-back-ai-ross-katz-rcl9e/?trackingId=Y6%2FH45W%2BxImfl%2By2geB6%2Bg%3D%3D Bacteriophage Therapy for Multidrug-Resistant Infections – PubMed: https://pubmed.ncbi.nlm.nih.gov/40026251/ Cystic Fibrosis Australia and Phage Australia Survey – medRxiv: https://www.medrxiv.org/content/10.1101/2024.05.14.24307275v1 Phage Directory: https://phage.directory/…

Data in Biotech

1
Targeting Transcription Factors with AI, featuring Will Fondrie from Talus Bio 46:54

14 weeks ago46:54

46:54

How do you drug the undruggable? In this episode of Data in Biotech, Ross Katz sits down with Will Fondrie, Head of Data Science and Engineering at Talus Bio, to explore how machine learning, mass spectrometry, and innovative computational models are transforming drug discovery. Learn how Talus Bio is targeting transcription factors—once considered out of reach—with scalable, high-impact data science. What You'll Learn in This Episode Why transcription factors are historically hard to drug and how Talus Bio is changing that How mass spectrometry offers high-throughput, unbiased views of protein-DNA interactions The role of recommender systems in prioritizing compound testing Strategies for balancing build vs. buy in data infrastructure at scale Why open-source software is essential for scientific transparency and progress Links: Find out more about Talus Bio: https://talus.bio Connect with Ross Katz on LinkedIn: https://www.linkedin.com/in/b-ross-katz/ Connect with Will Fondrie on LinkedIn: https://www.linkedin.com/in/wfondrie/ Meet Our Guest Will Fondrie is the Head of Data Science and Engineering at Talus Bio, a biotech company pioneering the development of small molecule drugs targeting transcription factors. With a PhD in molecular medicine and a background in proteomics, Will brings deep expertise in computational biology, machine learning, and scalable data systems. About the Host Ross Katz is the Principal and Data Science Lead at CorrDyn. He hosts Data in Biotech to spotlight innovative thinkers and data-driven leaders pushing the boundaries of biotechnology. Enjoying the show? If you liked this episode, consider sharing it with a colleague and exploring more conversations at Data in Biotech . Your support helps us keep delivering expert insights on the future of biotech. Sponsored by CorrDyn This episode is brought to you by CorrDyn, a leader in data-driven solutions for biotech and healthcare. Learn more at CorrDyn .…

Data in Biotech

1
Decoding the Dark Proteome: Biological Insights for Pharma with Dr. Jonathan Usuka from Sapient 46:45

16 weeks ago46:45

46:45

In this episode of the Data and Biotech Podcast, host Ross Katz sits down with Dr. Jonathan Usuka to discuss Usuka’s extensive background in bioinformatics and genomics, leading to his current role as CEO of Sapient. The conversation dives into the importance of deep molecular characterization of diseases, the role of proteomics and metabolomics in drug discovery, and the gaps between real-world data and clinical trial data. As a leader with a small but impactful team, Jonathan discusses the complexities of the dark proteome and metabolites, emphasizing the opportunity for deeper biological insights in pharmaceutical research using repeated, deep profiling of the same cohorts of patients. Jonathan also explores how advancements in computational approaches allow Sapient to build a robust data foundation for insight generation in biopharma. What You'll Learn in This Episode: The significance of longitudinal patient sampling Why we need robust conclusions in biotechnology How the role of the FDA is evolving for drug approval and personalized medicine applications Connect with Our Guest: Sponsor: CorrDyn, a data consultancy Find out more about Sapient Connect with Dr. Jonathan Usuka on LinkedIn Connect with Us: Follow the podcast for more insightful discussions on the latest in biotech and data science. Subscribe and leave a review if you enjoyed this episode!…

Data in Biotech

1
How AI Can Increase Clinical Trial Efficiency with Patrick Leung from Faro Health 39:02

18 weeks ago39:02

39:02

How can AI improve clinical trials and accelerate drug development? In this episode of Data in Biotech, Ross Katz sits down with Patrick Leung, CTO of Faro Health, to explore how AI-driven tools are reshaping clinical trial design. Patrick shares insights into document generation, patient burden analysis, and AI governance in biotech. Learn how Faro Health is developing clinical protocols and leveraging AI to optimize trial success while ensuring regulatory compliance. Whether you're in biotech or healthcare, this conversation offers valuable takeaways on the future of AI in increasing clinical trial efficiency. What You'll Learn in This Episode: How AI is used to generate clinical trial protocols and reduce inefficiencies. The role of AI in assessing patient burden and optimizing trial designs. How data model development enables specialized biomedical AI workflows. How large language models (LLMs) support clinical trial automation. Future trends in AI-driven clinical trial optimization. Links: Find out more about Faro Health: https://www.farohealth.com Connect with Ross Katz on LinkedIn: https://www.linkedin.com/in/b-ross-katz/ Connect with Patrick Leung on LinkedIn: https://www.linkedin.com/in/puiwah/ Meet Our Guest: Patrick Leung is the Chief Technology Officer at Faro Health, where he leads AI-driven innovations in clinical trial design. With a background in data science and software engineering from companies like Google and Two Sigma, Patrick brings a fresh perspective to life sciences, focusing on optimizing clinical trials through AI and structured data models. About the Host: Ross Katz is the Principal and Data Science Lead at CorrDyn, specializing in applying data science to biotech and healthcare. As the host of Data in Biotech, Ross explores the latest trends and innovations shaping the industry. Enjoying the Show? Visit Faro Health to learn more about AI-driven clinical trial optimization. Don’t forget to rate and review Data in Biotech on Apple Podcasts! Sponsored by CorrDyn This episode is brought to you by CorrDyn, a leader in data-driven solutions for biotech and healthcare. Learn more at CorrDyn .…

Data in Biotech

1
Organoids and Active Learning for Chronic Disease with Naren Tallapragada 50:25

20 weeks ago50:25

50:25

In this episode of Data In Biotech, Ross Katz interviews Naren Tallapragada, CEO and Co-founder of Tessel Bio, about his background in electrical engineering and physics and how personal circumstances led to him pivoting his focus to enter biotech and start Tessel Bio. Naren breaks down Tessel Bio’s unique approach to drug discovery, which involves "reverse engineering" chronic diseases. Instead of starting with a potential drug and testing its effects, they begin with a clear picture of the disease itself—specifically, how it appears and behaves in the body. A key part of their method is using human organoids—tiny, lab-grown versions of human tissues—to closely replicate real diseases and see how different treatments interact with them. This “small data” approach is made substantially more efficient with the addition of active learning. Join us for a fascinating conversation about Tessel Bio’s approach to finding cures for chronic diseases that impact hundreds of thousands of people every day. What You'll Learn in This Episode: Naren’s journey into biotech and personal motivation Understanding Tessel Bio's approach to drug discovery The role of organoids in disease modeling Data gathering and target identification strategies Active learning in drug discovery at Tessel Bio Connect with Our Guest: Sponsor: CorrDyn, a data consultancy Find out more about Tessel Bio Connect with Naren on LinkedIn Connect with Us: Follow the podcast for more insightful discussions on the latest in biotech and data science. Subscribe and leave a review if you enjoyed this episode!…

Data in Biotech

1
How Alex Junge from amass is Speeding Up Scientific Breakthroughs with AI 52:25

22 weeks ago52:25

52:25

In this episode of the Data and Biotech Podcast , host Ross Katz sits down with Alexander Junge, Co-Founder and CTO of amass , to break down how AI is reshaping scientific research in life sciences. Alex walks us through how his platform is creating professional tools for researchers, biotech companies, and venture firms to navigate the (rapidly!) growing breadth and depth of scientific knowledge by leveraging artificial intelligence - and what this will look like in the future. Alex also shares insights into his company’s work with Nordic Bio Ventures and how amass delivers reliability and builds trust in its platform. What You'll Learn in This Episode: What challenges researchers face in formulating questions and retrieving relevant answers from the breadth of scientific knowledge. The importance of design and user experience in life sciences, and how the company adopts a rigorous approach to information retrieval. How amass helps life sciences professionals navigate complex scientific domains by building trust in answers generated by AI. A real-world case study of how amass is assisting Nordic BioVentures a venture firm to build a biotech company. Alex’s predictions for AI's impact on scientific discovery over the next decade. Connect with Our Guest: Sponsor: CorrDyn, a data consultancy Find out more about amass Connect with Alex on LinkedIn Connect with Us: Follow the podcast for more insightful discussions on the latest in biotech and data science. Subscribe and leave a review if you enjoyed this episode!…

Data in Biotech

1
Advancing Therapeutic Design in Gene and Cell Therapy with Dipen Sangurdekar 40:34

23 weeks ago40:34

40:34

In this episode of Data in Biotech, Ross sits down with Dipen Sangurdekar, VP of Data Sciences at KSQ Therapeutics, to discuss the role of data-driven approaches in therapeutic design and development. The conversation explores the intersection of computational biology, machine learning, and bioinformatics in advancing personalized medicine and improving patient outcomes. Dipen shares his journey in the industry, emphasizing the importance of integrating data science with biological research and the challenges associated with working in the rapidly evolving field of cell therapies. From hypothesis-driven research to leveraging multimodal data for actionable insights, this episode explores the nuances of using statistical methods and AI to enhance drug development. Key Takeaways: Successful data science in therapeutics requires a deep understanding of both statistical methods and biological processes. High-dimensional but low-sample-size data demands a guided hypothesis-driven approach to avoid false positives. Data integration and collaboration between computational and biological teams are critical for generating meaningful insights. Emerging AI and machine learning tools are enhancing productivity but must be carefully applied in therapeutic research. Picking a problem you’re passionate about and going deep into it is crucial for long-term success in the field. Connect with Our Guest: Sponsor: CorrDyn, a data consultancy Find out more about KSQ Therapeutics Connect with Dipen on LinkedIn Connect with Us: Follow the podcast for more insightful discussions on the latest in biotech and data science. Subscribe and leave a review if you enjoyed this episode!…

Data in Biotech

1
Democratizing Therapeutic Discovery for Neglected Diseases using AI with Timothy Jenkins of DTU Bioengineering 50:39

26 weeks ago50:39

50:39

This week on Data in Biotech, we welcome Timothy Jenkins, the Head of Data Science and Associate Professor at DTU Bioengineering, a leading scientific community dedicated to advancing areas of biotechnology, food technology, and health through innovative teaching and research. Timothy starts the conversation by walking us through his background and early career beginnings, from the first time he expressed interest in zoology and venomous snakes to now leading a research group focused on AI-guided drug discovery for snake antivenom. He and our host, Ross Katz, dive into one of DTU’s most exciting recent publications about "de novo" designed proteins to neutralize lethal snake venom toxins. Inspired by Nobel Prize winner David Baker’s groundbreaking paper and in collaboration with the Baker Lab on computational design methodology, this project holds great promise in therapeutic discovery and drug development. Tim explains how computational protein design and protein structure prediction are revolutionizing his field, highlighting compelling examples and milestones from his research on antivenom. He also provides an overview of the process used to discover new antivenoms, including the sourcing of biological data, model training, and integration of experimental feedback. Finally, we get Tim’s perspective on the future of AI-powered therapeutic discovery, and his take on the integration of quantum computing into protein design. Data in Biotech is a fortnightly podcast exploring how companies leverage data innovation in the life sciences. Useful Links Nature - De novo designed proteins neutralize lethal snake venom toxins Timothy’s LinkedIn DTU Bioengineering Website UW Institute for Protein Design “ de novo” designed proteins project Information on Nobel Prize winner David Baker…

Data in Biotech

1
Revolutionizing Drug Discovery with AI: Fred Manby of Iambic Therapeutics 38:19

28 weeks ago38:19

38:19

In this episode, Ross Katz sits down with Fred Manby, Co-Founder and Chief Technology Officer of Iambic Therapeutics, to explore how cutting-edge AI technologies are reshaping the landscape of drug discovery. From building advanced machine learning platforms to designing user-friendly interfaces for scientists, Fred shares insights into the company’s approach to tackling some of the biggest challenges in biotech. Fred dives into the unique capabilities of Iambic’s Enchant multi-modal transformer model, its differentiation from other biological foundation models, and the importance of aligning model architecture with data creation and acquisition in modern drug discovery. We also discuss Iambic’s data-driven approach to developing oncology drugs, the exciting possibilities of incorporating new modalities like imaging, and the recent breakthroughs in protein-ligand structure prediction with NeuralPLexer3. Highlights: Enchant Multi-Modal Transformer Model : How it systematically surpasses state-of-the-art molecular AI technologies. Uncertainty Quantification : The role of probabilities and predictions in streamlining drug discovery. Interface Design for Scientists : Iambic’s approach to integration between AI platforms and experimental workflows. Connect with Our Guest: Sponsor: CorrDyn, a data consultancy Find out more about Iambic’s work on their website Connect with Fred Manby on LinkedIn…

Data in Biotech

1
Unlocking the Power of AI in Microscopy with Ilya Goldberg and Reese Findley 47:32

32 weeks ago47:32