Developing non-opioid pain drugs

Beyond Biotech - the podcast from Labiotech

Brixton Biosciences, a clinical-stage life sciences company spun out from Massachusetts General Brigham, has been awarded $2m from the NIH HEAL Initiative to support the development of non-opioid, injectable pain relief solutions.

As part of the NIH's efforts to tackle the U.S. opioid crisis, the funding will advance research into safer, drug-free alternatives to opioid pain management. Brixton’s Neural Ice is an injectable, drug-free pain management technology designed to provide long-lasting relief from chronic and post-operative pain.

On the podcast this week, we have a conversation with Sameer Sabir, CEO and co-founder of Brixton Biosciences, to dive deeper into pain treatment, the opioid crisis, and Brixton’s mission.

01:05-02:47: About Brixton Biosciences
02:47-03:39: Brixton’s pipeline
03:39-07:46: The opioid crisis
07:46-08:41: The extent of the crisis
08:41-12:00: Current alternatives to opioids
12:00-12:40: Managing pain
12:40-17:19: How was Neural ice developed?
17:19-18:33: Duration of treatment
18:33-21:01: Suitability for different levels of pain
21:01-21:31: Speed of effect
21:31-22:37: Side effects
22:37-24:18: Opioids vs. non-opioids
24:18-25:33: Are there different responses to Neural Ice?
25:33-26:29: Standardized doses
26:29-27:42: Pricing
27:42-28:49: Other work on alternatives to opioids
28:49-30:45: Challenges to developing new pain treatments
30:45-31:57: Other priorities at Brixton
31:57-32:16: Timeline for Neural Ice

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Chapters

1. Developing non-opioid pain drugs (00:00:00)

2. About Brixton Biosciences (00:01:05)

3. Brixton’s pipeline 
 (00:02:47)

4. The opioid crisis
 (00:03:39)

5. The extent of the crisis
 (00:07:46)

6. Current alternatives to opioids
 (00:08:41)

7. Managing pain
 (00:12:00)

8. How was Neural ice developed?
 (00:12:40)

9. Duration of treatment
 (00:17:19)

10. Suitability for different levels of pain
 (00:18:33)

11. Speed of effect
 (00:21:01)

12. Side effects
 (00:21:31)

13. Opioids vs. non-opioids
 (00:22:37)

14. Are there different responses to Neural Ice?
 (00:24:18)

15. Standardized doses
 (00:25:33)

16. Pricing
 (00:26:29)

17. Other work on alternatives to opioids
 (00:27:42)

18. Challenges to developing new pain treatments
 (00:28:49)

19. Other priorities at Brixton
 (00:30:45)

20. Timeline for Neural Ice (00:31:57)