Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
…
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Content provided by CorrDyn. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by CorrDyn or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
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Targeting Transcription Factors with AI, featuring Will Fondrie from Talus Bio
Manage episode 477395417 series 3526491
Content provided by CorrDyn. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by CorrDyn or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
How do you drug the undruggable? In this episode of Data in Biotech, Ross Katz sits down with Will Fondrie, Head of Data Science and Engineering at Talus Bio, to explore how machine learning, mass spectrometry, and innovative computational models are transforming drug discovery. Learn how Talus Bio is targeting transcription factors—once considered out of reach—with scalable, high-impact data science.
What You'll Learn in This Episode
- Why transcription factors are historically hard to drug and how Talus Bio is changing that
- How mass spectrometry offers high-throughput, unbiased views of protein-DNA interactions
- The role of recommender systems in prioritizing compound testing
- Strategies for balancing build vs. buy in data infrastructure at scale
- Why open-source software is essential for scientific transparency and progress
Links:
- Find out more about Talus Bio: https://talus.bio
- Connect with Ross Katz on LinkedIn: https://www.linkedin.com/in/b-ross-katz/
Connect with Will Fondrie on LinkedIn: https://www.linkedin.com/in/wfondrie/
Meet Our Guest
Will Fondrie is the Head of Data Science and Engineering at Talus Bio, a biotech company pioneering the development of small molecule drugs targeting transcription factors. With a PhD in molecular medicine and a background in proteomics, Will brings deep expertise in computational biology, machine learning, and scalable data systems.
About the Host
Ross Katz is the Principal and Data Science Lead at CorrDyn. He hosts Data in Biotech to spotlight innovative thinkers and data-driven leaders pushing the boundaries of biotechnology.
Enjoying the show? If you liked this episode, consider sharing it with a colleague and exploring more conversations at Data in Biotech. Your support helps us keep delivering expert insights on the future of biotech.
Sponsored by CorrDyn
This episode is brought to you by CorrDyn, a leader in data-driven solutions for biotech and healthcare. Learn more at CorrDyn.
46 episodes
Share
Manage episode 477395417 series 3526491
Content provided by CorrDyn. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by CorrDyn or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
How do you drug the undruggable? In this episode of Data in Biotech, Ross Katz sits down with Will Fondrie, Head of Data Science and Engineering at Talus Bio, to explore how machine learning, mass spectrometry, and innovative computational models are transforming drug discovery. Learn how Talus Bio is targeting transcription factors—once considered out of reach—with scalable, high-impact data science.
What You'll Learn in This Episode
- Why transcription factors are historically hard to drug and how Talus Bio is changing that
- How mass spectrometry offers high-throughput, unbiased views of protein-DNA interactions
- The role of recommender systems in prioritizing compound testing
- Strategies for balancing build vs. buy in data infrastructure at scale
- Why open-source software is essential for scientific transparency and progress
Links:
- Find out more about Talus Bio: https://talus.bio
- Connect with Ross Katz on LinkedIn: https://www.linkedin.com/in/b-ross-katz/
Connect with Will Fondrie on LinkedIn: https://www.linkedin.com/in/wfondrie/
Meet Our Guest
Will Fondrie is the Head of Data Science and Engineering at Talus Bio, a biotech company pioneering the development of small molecule drugs targeting transcription factors. With a PhD in molecular medicine and a background in proteomics, Will brings deep expertise in computational biology, machine learning, and scalable data systems.
About the Host
Ross Katz is the Principal and Data Science Lead at CorrDyn. He hosts Data in Biotech to spotlight innovative thinkers and data-driven leaders pushing the boundaries of biotechnology.
Enjoying the show? If you liked this episode, consider sharing it with a colleague and exploring more conversations at Data in Biotech. Your support helps us keep delivering expert insights on the future of biotech.
Sponsored by CorrDyn
This episode is brought to you by CorrDyn, a leader in data-driven solutions for biotech and healthcare. Learn more at CorrDyn.
46 episodes
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Similar to Data in Biotech
Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
…
continue reading
A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health and hosted by Kris Tatiossian and Olivia Webb, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vijay Pande, Julie Yoo, Vineeta Agarwala, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg ...
…
continue reading
DNA science. Artificial intelligence. Smartphones and 3D printers. Science and technology have transformed the world we live in. But how did we get here? It wasn’t by accident. Well, sometimes it was. It was also the result of hard work, teamwork, and competition. And incredibly surprising moments. Hosted by bestselling author Steven Johnson (“How We Got To Now”), American Innovations uses immersive scenes to tell the stories of the scientists, engineers, and ordinary people behind the great ...
…
continue reading
Come dive into one of the curiously delightful conversations overheard at National Geographic’s headquarters, as we follow explorers, photographers, and scientists to the edges of our big, weird, beautiful world. Hosted by Peter Gwin and Amy Briggs.
…
continue reading
We humans could have a bright future ahead of us that lasts billions of years. But we have to survive the next 200 years first. Join Josh Clark of Stuff You Should Know for a 10-episode deep dive that explores the future of humanity and finds dangers we have never encountered before lurking just ahead. And if we humans are alone in the universe, if we don't survive intelligent life dies out with us too.
…
continue reading
This Week in Microbiology is a podcast about unseen life on Earth hosted by Vincent Racaniello and friends. Following in the path of his successful shows 'This Week in Virology' (TWiV) and 'This Week in Parasitism' (TWiP), Racaniello and guests produce an informal yet informative conversation about microbes which is accessible to everyone, no matter what their science background.
…
continue reading
Whether the topic is popcorn or particle physics, you can count on BrainStuff to explore -- and explain -- the everyday science in the world around us.
…
continue reading
Unexplainable takes listeners right up to the edge of what we know…and then keeps on going. The Unexplainable team — Noam Hassenfeld, Julia Longoria, Byrd Pinkerton, and Meradith Hoddinott — tackles scientific mysteries, unanswered questions, and everything we learn diving into the unknown. New episodes Mondays and Wednesdays.
…
continue reading
The surprising connections in science and technology that give you the Big Picture. Astronomer Seth Shostak and science journalist Molly Bentley are joined each week by leading researchers, techies, and journalists to provide a smart and humorous take on science. Our regular "Skeptic Check" episodes cast a critical eye on pseudoscience.
…
continue reading
Going Wild with Dr. Rae Wynn Grant is a different kind of nature show about the human drama of saving animals. From a paleoanthropologist who hunts fossils in conflict zones to someone who helped save an endangered species while in prison, in season four we will hear from real-life heroes and nature advocates with widely different expertise and life experiences that led them to be champions for the natural world. Wildlife biologist and host Dr. Rae Wynn-Grant has been studying wild animals i ...
…
continue reading
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