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How Can We Trust Computational Models in Healthcare? A Framework for In Silico Clinical Trials
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Are you curious about how computer simulations are changing the way we evaluate medical devices? In this episode, we delve into the fascinating world of in silico clinical trials (ISCTs), a cutting-edge approach that uses computational models to assess the safety and effectiveness of medical interventions. We explore a recent paper that highlights the unique challenges of ensuring the credibility of ISCT results. The authors present a comprehensive workflow for assessing this credibility, drawing on various methodologies and frameworks, including those from the FDA. By reviewing a range of ISCT studies, we discuss innovative patient model generation techniques, the integration of clinical outcomes, and how these virtual trials can complement traditional clinical studies. Join us as we unpack the potential of ISCTs to revolutionize medical device evaluation, making it more cost-effective, time-efficient, and ethically sound.
Source: Pathmanathan P, Aycock K, Badal A, Bighamian R, Bodner J, Craven BA, Niederer S. Credibility assessment of in silico clinical trials for medical devices. PLoS Comput Biol. 2024 Aug 8;20(8):e1012289. doi: 10.1371/journal.pcbi.1012289.
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