Elliot, Eric, and Jeff look at every movie in franchises that went on and on.
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A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health and hosted by Kris Tatiossian and Olivia Webb, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vijay Pande, Julie Yoo, Vineeta Agarwala, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg ...
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Engaging the Unengaged at Home with Max Cohen and Cameron Behar
22:32
22:32
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22:32In this episode, Sprinter Health co-founders Max Cohen and Cameron Behar sit down with Julie Yoo to unpack how their home-based care model reaches underserved populations and reintegrates “the unengaged” into the healthcare system. From starting with blood draws in living rooms to scaling a high-complexity, tech-enabled logistics platform, they sha…
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By Elliot, Eric, and Jeff
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A new season of All Things Being Sequel is here! Each year, three brothers visit their grandfather for the summer. He is highly skilled in ninjutsu, and for years he has trained the boys in his techniques. We’re starting the 3 Ninjas season here on All Things Being Sequel. Was Elliot wrong for picking this series? Probably. He was trying something …
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Bonus episodes! A delicious, mysterious goo that oozes from the earth is marketed as the newest dessert sensation, but the tasty treat rots more than teeth when zombie-like snackers who only want to consume more of the strange substance at any cost begin infesting the world. This week, the boys are drooling with anticipation to talk about 1985’s hi…
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Streamlining the Patient Referrals Chain with Trey Holterman
19:53
19:53
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19:53In this episode, Tennr cofounder and CEO Trey Holterman sits down with a16z’s David Haber and Jay Rughani to unpack one of healthcare’s most overlooked pain points: patient referral logistics. When a patient is referred to a specialist and told that the specialist will follow up with them, what happens next? A convoluted system sometimes involving …
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From Chaos to Clarity in Data with Malinka Walaliyadde
23:23
23:23
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23:23What if one of healthcare’s most complex administrative challenges—revenue cycle management—was reframed as a data science problem? In this episode, Malinka Walaliyadde, cofounder and CEO of AKASA, joins Julie Yoo to unpack how large language models have the potential to transform hospital revenue by automating highly nuanced coding and billing wor…
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A baby born to a human couple turns out to be a mutant monster with an appetite to kill when scared. It the 2009 remake It’s Alive. Woof. Is it our first remake? Eric thinks it might be, Jeff believes there may have been one before, having not much else to talk about, he makes the argument. Elliot Casually mentions some time theft at his job, Eric …
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What if we stopped trying to cure disease and started preventing it instead? In this episode, Eric Topol, founder and director of the Scripps Research Translational Institute and a cardiologist, scientist, and author, joins a16z general partner Vijay Pande to unpack the future of aging, prevention, and precision health—as explored in Eric's new boo…
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The monster babies have been placed by court order on a deserted island so that they can live out their lives as far away from normal humans as possible without killing them. Enraged by the cynicism toward, and the exploitation of, the monster babies by both the legal system and the media, the man who is responsible for them leads an expedition to …
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Fueling Innovation with Data with Arif Nathoo
24:46
24:46
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24:46Arif Nathoo, cofounder and CEO of Komodo Health, joins Jorge Conde and Jay Rughani to explore the transformative potential of healthcare data in reshaping biotech and healthcare innovation. Arif reflects on a decade-long journey of unlocking the power of fragmented healthcare data, delving into Komodo Health’s “full-stack thesis” — a strategy that …
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An epidemic of monster babies sweeps across America. Hidden gem? Just ok? The boys are back this week, talking about 1978’s It Lives Again, or It’s Alive two, depending on which box set you pick up to watch. Murder babies here, murder babies there, murder babies everywhere. Where do you fall in the argument of what to do with these genetic anomalie…
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The Paradox of U.S. Healthcare with Marc Andreessen
33:32
33:32
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33:32Join a16z general partners Marc Andreessen, Julie Yoo, and Vijay Pande for an incisive exploration of what's driving—and stalling—transformation in healthcare. With the industry now consuming nearly 20% of U.S. GDP yet delivering poor outcomes relative to other developed countries, is technology the remedy or a red herring? This episode, cross-post…
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The Davises are expecting a baby, which turns out to be a monster with a nasty habit of killing people whenever it is scared. And it is easily scared. It’s a season of new beginnings here on All Things Being Sequel. This time we’re jumping into a new trilogy of films, starting with 1974’s It’s Alive. First off, I know the audio isn’t loud enough. U…
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The time has come. The end of our first era of All Things Being Sequel is here, and folks, we are going out with a bang. And there’s no way to celebrate then by introducing a new segment, Bold Statements. Listen to us gush over how unbelievable it is that Leprechaun Returns might be the best movie of the entire franchise. We spent a large portion o…
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The (Epic) Arc of a Patient Journey with Seth Hain
26:00
26:00
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26:00Seth Hain, SVP of R&D at Epic, joins a16z Bio + Health general partner Julie Yoo to explore technology in healthcare. Reflecting on over two decades of industry shifts, Seth shares how Epic has transitioned from enabling integrated systems within health systems to driving cross-ecosystem collaboration and rapid innovations like generative AI. They …
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Building for the Healthcare Consumer with Elliot Cohen
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26:01
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26:01Elliot Cohen, cofounder of PillPack, joins Julie Yoo, a16z Bio + Health general partner. Together, they discuss Elliot's experience designing and building a consumer-first pharmacy alongside TJ Parker. Elliot's journey with PillPack began when he noticed his father struggling with a mail-order pharmacy that couldn’t get the simplest thing right: th…
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Not related to the previous Leprechaun films. Two young couples backpacking through Ireland discover that one of Ireland's most famous legends is a terrifying reality. We have arrived at 2014’s Leprechaun: Origins. Looking back, I am surprised by how much I disliked this one. In hindsight, I don’t think it is the worst film we’ve watched. We diverg…
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When Emily Woodrow and her friends happen on a treasure chest full of gold coins, they fail to heed the warnings of a wise old psychic, who had foretold that they would encounter trouble with a very nasty and protective Leprechaun. This week, we are talking about Warwick Davis’ final Leprechaun film, Leprechaun: Back 2 tha Hood. As they say, he sav…
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Scaling Mental Health Access through AI with Neil Parikh and Daniel Cahn
25:40
25:40
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25:40In this episode, Slingshot AI cofounders Daniel Cahn and Neil Parikh join a16z Bio + Health general partner Julie Yoo to explore how their mission to transform mental health care with AI took shape. Drawing from their unique journeys—Daniel as the son of a psychologist and Neil as a former medical student-turned-entrepreneur—they discuss the challe…
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When three rappers want to get even with a pimp, they accidentally unleash a leprechaun who goes on a killing rampage in tha 'hood. This week, we are talking about the 2000s’ Leprechaun 5: In the Hood. If you listen closely, you can almost hear Jeff's audible sigh as we go off script repeatedly this week. Which Star Trek series can be skipped entir…
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An Ironman Suit for Doctors with Muthu Alagappan
23:33
23:33
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23:33Dr. Muthu Alagappan, MD, founder and CEO of Counsel Health, joins Julie Yoo, a16z Bio + Health general partner, to dive deep into the company's vision for revolutionizing healthcare through AI-powered asynchronous care. Together, they unpack how Counsel enables on-demand access to real doctors for instant medical guidance, lessening patient relianc…
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Our deadly leprechaun is in space to woo a beautiful princess who is impressed with his gold and desires to separate him from it. Looking back, it’s funny to see how little the tagline has to do with 1996’s Leprechaun 4: In Space. Jeff argues that the Leprechaun is the most powerful slasher villain to exist. Elliot brings up a Home Improvement tie-…
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Voice AI: Solving Healthcare's Workforce Challenges with Ankit Jain
30:03
30:03
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30:03Ankit Jain, CEO and cofounder of Infinitus Systems, Inc, joins Julie Yoo, a16z Bio + Health general partner, to discuss Infinitus's work in solving one of healthcare's most pressing challenges: workforce shortages. Leveraging LLMs and AI voice agents, Infinitus automates repetitive tasks, such as benefits verification and prior authorization, freei…
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An evil leprechaun finds himself in Las Vegas, where he proceeds to cause mischief by killing people, granting twisted wishes, and infecting a young man with his green blood. It can be no other than 1995’s Leprechaun 3, starring Warwick Davis, John Gatins, Lee Armstrong, and directed by Brian Trenchard-Smith. This week, the boys debate on why it ta…
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Transforming Clinical Trials with Alexander Saint-Amand
24:53
24:53
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24:53Alexander Saint-Amand, cofounder and CEO of Topography, reflects on his journey from leading Gerson Lehrman Group (GLG), a pioneer in expert networks, to tackling systemic barriers in clinical trials at his current company, Topography. Inspired by personal experiences, Alexander’s mission centers on democratizing access to clinical research by tran…
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On his one-thousandth birthday, an evil leprechaun selects the descendant of one of his slaves to have as his bride, leaving it up to the girl's boyfriend to save her. We are once again trudging through the Leprechaun series, this time with just the regular cast of Eric, Jeff, and Elliot, looking at the 1994 sequel. What new lore awaits? What fresh…
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Scaling Medicaid Innovation with Afia Asamoah, Rajaie Batniji, and Sanjay Basu
33:45
33:45
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33:45Rajaie Batniji, MD, PhD, Afia Asamoah, JD, and Sanjay Basu, MD, PhD, cofounders of Waymark, join Vineeta Agarwala, MD, PhD, a16z Bio + Health general partner, to discuss their transformative approach to Medicaid care delivery. This episode dives into their rising risk signal prediction framework, where cutting-edge machine learning predicts patient…
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Super Staffing in Healthcare with Munjal Shah
24:36
24:36
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24:36Hippocratic AI cofounder and CEO Munjal Shah joins a16z Bio + Health general partner Julie Yoo to explore the incredible potential of generative AI in transforming healthcare delivery. Together, they discuss the emerging "voice renaissance" in healthcare, the nuances of designing safe and empathetic AI interactions, and how Hippocratic AI is addres…
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Here it is. All Things Being Sequel. Join Eric, Elliot, and Jeff as they take a look at all the Leprechaun films. This episode is a cross over with The Movie Draft House. Eric on Youtube. Check out Gaming Nexus Jeff can also be found on The Movie Draft House Listen to the Children of the Corn season over on the Chronologically podcast feed.…
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Lessons from Healthcare Infrastructure Pioneers with Jeff Margolis
23:26
23:26
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23:26Jeff Margolis, founder of TriZetto, joins Julie Yoo, a16z Bio + Health general partner, to share the journey of building an iconic company in healthcare infrastructure. From the early days of managed care to creating a three-pronged platform uniting computing power, software, and data analytics, Jeff reflects on TriZetto’s groundbreaking model that…
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Rare Disease, Big Impact with Matt Wilsey
23:08
23:08
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23:08In this episode, Matt Wilsey joins Jorge Conde to share the profound personal story of his daughter Grace's diagnosis with NGLY1 deficiency and how it catalyzed his journey to founding a biotech startup, Grace Science, aimed at developing a cure for his daughter’s condition. Matt emphasizes the importance of strategic partnerships, like his collabo…
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Bioorthogonal Chemistry with Carolyn Bertozzi
31:02
31:02
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31:02Nobel laureate Carolyn Bertozzi joins Jorge Conde to unravel the concept of bioorthogonal chemistry. Carolyn traces her pioneering path from early studies in carbohydrate chemistry to how her lab developed the revolutionary ability to manipulate chemical reactions inside the human body. Together, they highlight the intersection of cutting-edge acad…
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Chronologically presents All Things Being Sequel. New episodes start Jan 6th.By Elliot, Eric, and Jeff
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Mastering Data with Sajith Wickramasekara
26:45
26:45
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26:45In this episode, a16z partners Jorge Conde and Jay Rughani sit down with Sajith Wickramasekara, CEO and cofounder of Benchling, to unpack the evolution of Benchling from idea to transformative software platform. Saji discusses his journey from software engineer to building Benchling and digitizing biotech workflows for industry giants like Sanofi. …
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Build Your Own Provider Network with Dan Rosenthal
24:41
24:41
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24:41Join healthcare expert Dan Rosenthal and a16z Bio + Health general partner Julie Yoo in a deep dive into the evolution of provider networks and their strategic importance in the health insurance ecosystem. Dan discusses how networks are built, managed, and optimized for both cost and quality—including the complexities of payor-provider contracts, t…
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The Freedom to Choose Your Own Insurance with Chris Ellis and Adam Stevenson
27:54
27:54
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27:54Chris Ellis, CEO and Adam Stevenson, president, both cofounders of Thatch, join Julie Yoo and Jay Rughani of a16z Bio + Health. In early 2020, a new policy called ICHRA altered the insurance market, which had remained largely unchanged for decades. As you’ll hear in the episode, it’s been slow to catch on — but the cofounders of Thatch think it’s a…
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From Surgeon to Biotech CEO with Jonathan Lim
27:36
27:36
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27:36Jonathan Lim is the CEO of Erasca, but his career path took him on a fascinating journey from practicing as a surgeon to leading life science companies. In a recent conversation, Lim shared valuable insights about his transition to the biotech world, his leadership experiences, and the lessons he's learned while founding and guiding organizations t…
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In this episode, Vijay Pande and Daisy Wolf of a16z Bio + Health join a16z Podcast host Steph Smith to make a provocative case for why technologists—not just medical professionals—are key to reinventing healthcare. They argue that to transform a sector representing 20% of U.S. GDP, innovation must move beyond curing diseases toward tackling healthc…
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Marta Bralic Kerns, founder and CEO of Pomelo Care, joins Will Shrank, MD, a16z Bio + Health venture partner. Together, they talk about the innovator’s dilemma with building in the Medicaid space, how Pomelo partners with managed care plans, and the opportunity to potentially lower costs through providing additional support to pregnant women. This …
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Nikita Singareddy, cofounder and CEO of Fortuna Health, joins Will Shrank, MD, a16z Bio + Health venture partner. Together, they discuss building a useful and convenient platform for Medicaid enrollees, listening to patient feedback to improve, and the complexities of different states’ Medicaid processes. This is the second episode in our Medicaid …
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Over the next three episodes, we’re going to talk about why Medicaid matters, and the potential for technology to make it easier for enrollees to access and utilize the program. Our first guest is Mark Smith, MD, Clinical Professor of Medicine at UCSF. He was the founding President and former CEO of the California HealthCare Foundation from 1996-20…
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Vijay Pande, PhD, founding partner of a16z Bio + Health, joins Derrick Harris, host of the AI + a16z podcast. Together, they discuss how computer science has subsumed biotech.By a16z
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Good Energy, Better Health with Casey Means
29:07
29:07
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29:07Casey Means, MD, a Stanford-trained physician, cofounder of Levels, and author of the new book Good Energy, joins Vijay Pande, PhD, founding partner of a16z Bio + Health. Together, they discuss the downsides of physician specialization, the rising tide of chronic illness in the U.S., and how tracking biomarkers might allow people to determine the b…
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Adapting Biopharma to AI: A 2024 Update with Greg Meyers
25:55
25:55
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25:55Greg Meyers, EVP and Chief Digital and Technology Officer at Bristol Myers Squibb, or BMS, joins Jorge Conde, general partner at a16z. This is a follow-up to their 2023 episode, where they discussed how biopharma can adapt to AI. Now, they revisit the conversation to see what’s changed and what hasn’t. Together, they chat through tech as a competit…
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Harnessing Water Dynamics for Drug Design with Michael Crackower and Jason Burch
37:24
37:24
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37:24Michael Crackower, PhD, Chief Scientific Officer of Ventus Therapeutics, and Jason Burch, PhD, join Vineeta Agarwala, MD, PhD, general partner at a16z Bio + Health. Together, they talk about how Ventus approaches drug discovery and why they believe we’re in the early stages of small molecule innovation. Specifically, we’ll hear about the ReSOLVE pl…
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AI at the Intersection of Bio with Vijay Pande, Surya Ganguli, and Bowen Liu
30:08
30:08
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30:08Bowen Liu, PhD, investing partner, and Surya Ganguli, PhD, venture partner, join Vijay Pande, PhD, general partner of a16z Bio + Health. Together, they detail different methods through which AI could assist drug development, the opportunity for AI to flag new targets and compounds for scientists to investigate, and the science fiction-sounding noti…
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The History and Future of CAR T with Bruce Levine
31:26
31:26
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31:26Bruce Levine, PhD, the Barbara and Edward Netter Professor in Cancer Gene Therapy at the University of Pennsylvania, joins Jorge Conde, general partner, and Ginger Liau, partner at a16z Bio + Health. Bruce talks about how his time working in a lab at the Children’s Hospital of Philadelphia inspired him to work on translational therapies. Together, …
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Implementation, Data, Impact of Healthcare AI with Vijay Pande and Julie Yoo
35:28
35:28
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35:28In this episode, a follow-up to our episode Grand Challenges in Healthcare AI, Julie Yoo and Vijay Pande, a16z general partners, answer audience questions about AI applications in healthcare. Together, they dive into cost and implementation challenges, the data landscape, and what the patient experience might look like. If you liked this episode, l…
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Protecting the Golden Age of Medicine with John Crowley
30:33
30:33
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30:33John Crowley, President and CEO of Biotechnology Innovation Organization (BIO), joined Jorge Conde, general partner at a16z Bio + Health. Together, they talk about John’s entry into biotech and his time as a founder, all motivated by his determination to discover and develop a treatment for his children, who have Pompe disease. They also talk about…
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A Fatal Inheritance with Lawrence Ingrassia
28:05
28:05
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28:05Lawrence Ingrassia, author and journalist, joins Vineeta Agarwala, general partner, and Kris Tatiossian, editorial lead at a16z Bio + Health. Together, they discuss Larry's recently published book, A Fatal Inheritance: How A Family Misfortune Revealed A Deadly Medical Mystery. In the book, Larry recounts the story of the p53 cancer suppressor gene,…
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