“Got Knowledge Doc” Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Eac ...
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Podcast by John Federico, Jeff Schoenberger, & Danielle DavisRoe
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A selection of the best talks, discussions and performances from our annual documentary festival in Belfast, Docs Ireland.
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💊 Ditch the Aspirin? 🔄 P2Y12 Prevails 🛡️ After PCI
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4:30🚨 New BMJ meta-analysis! After PCI & stopping DAPT, P2Y12 inhibitor monotherapy 💊 reduces MACCE 🧠❤️ (HR 0.77) vs aspirin — without more major bleeding 💉 🫀 MI & stroke ↓ 📊 16,117 pts, 5 trials 🧠 Smarter post-PCI strategy? #CardioTwitter #BMJ #PCI #P2Y12 #Aspirin 🚫By MasterMedFacts LLC
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💉 T Cells, TCF7, and Time ⏱️: The Immune Key to Longevity: When transcription meets transformation
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4:09🧬 New study in Aging Cell finds immune resilience—anchored by TCF7 expression—confers a 🚀 15.5-year survival advantage! 💥 SAS-1 high / MAS-1 low = 🔑 to longevity 👵 Midlife is the window. 🧠 Age is biology, but resilience is destiny. #Longevity #Aging #Immunology #TCF7By MasterMedFacts LLC
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🫀 Hearts, Hope, and Health for All: Lancet Editorial
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3:19🫀 Cardiovascular breakthroughs abound—yet millions still die needlessly. 🌍 Innovation without equity is like a heart without a pulse. 💡 From molecules to communities, it’s time to turn science into survival. #GlobalHealth #CardioCare #EquityMattersBy MasterMedFacts LLC
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Migraines: “Prodrome, Precision, Prevention 💫🧠💊”
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3:33🚨New insights from the PRODROME trial! 💊 Ubrogepant 100mg, given before the migraine hits, reduced photophobia, fatigue & brain fog—within hours! 🧠 Targets the prodrome, not just the pain. 📈 A paradigm shift in migraine care? #Migraine #CGRP #NeuroTwitter N 🔗 https://doi.org/10.1038/s41591-025-03679-7…
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💊 Big win for kidneys! In the CONFIDENCE trial, combo therapy with #Finerenone + #Empagliflozin 📉 slashed albuminuria 29–32% more than either alone in CKD + T2D patients 🧪🛡️ Safe, fast, and promising! 👥⏱️✅ #Nephrology #CardioRenal #SGLT2i #NEJM 🧬🩺By MasterMedFacts LLC
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Blindness, Breakthroughs, Biotech 🧬 From Darkness to Light via Nanoscience
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3:35👁️✨ Scientists have restored infrared vision using tellurium #nanowires implanted in the retina! 🧪 Mice and primates regained light sensitivity and behavioral vision. 🚀 A bold leap toward restoring sight without bulky tech. #VisionScience #NeuroTech #Retina #InnovationBy MasterMedFacts LLC
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🥃 Alcohol and 🫀 Heart Disease: Dose, Debate, and Disease
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5:12🍷 Is a glass of wine a heart helper or hidden hazard? The 2025 AHA Statement says: ⚠️ Moderate = uncertain 🚫 Heavy = harmful 🫀 Risks include AFib, stroke, CAD, HF & sudden death 📊 New genetic studies challenge old myths. 👇 Know your limits. Rethink the drink. #CardioTwitter #MedEd #AHA2025By MasterMedFacts LLC
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Dr RR Baliga's Philosophical Discourses: Patanjali (India, c. 200 BCE) – Compiler of Yoga Sutras
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3:15Patanjali, an ancient Indian sage, is credited with authoring foundational texts in Sanskrit grammar (Mahābhāṣya), yoga philosophy (Yoga Sutras), and possibly medicine (Patanjalatantra). Revered as a mystic and philosopher, his works laid the groundwork for classical yoga and linguistics, profoundly influencing Indian philosophical traditions. Thou…
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🏁 From Chemo to Cardio: Prescribing Steps, May Save Lives
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4:02🏃♂️💪 New NEJM study shows structured exercise after chemo boosts survival in colon cancer patients! 📈 5-yr DFS: 80.3% vs 73.9% ❤️ 8-yr OS: 90.3% vs 83.2% 🧬 Fitness = longevity 👟 Time to prescribe steps, not just scripts? #Oncology #ExerciseIsMedicine #CHALLENGEtrialBy MasterMedFacts LLC
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SGLT2 inhibitors: Safer Teens, Stronger Kidneys, Steadier Glucose
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3:44🚨 New trial alert! In youth with type 1 diabetes, adding #SGLT2i 💊 (dapagliflozin) to insulin: ✅ Reduced glomerular hyperfiltration ✅ Lowered HbA1c 📉 ✅ Boosted time-in-range ⏱️ 😌 Safe with DKA precautions in place 📄 #ATTEMPTTrial | @NatureMedicine 🔗 https://doi.org/10.1038/s41591-025-03723-6By MasterMedFacts LLC
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📉 New study alert! Patients with diabetes using GLP-1 receptor agonists had 2x higher risk of developing neovascular macular degeneration 😮 Longer use = greater risk 📈 Clinicians, keep an 👀 on ocular safety! #GLP1 #Diabetes #EyeHealth #nAMD #JAMAOphthalmologyBy MasterMedFacts LLC
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🧲 New twist in sex determination! Maternal iron levels shape whether XY embryos become male 🧬👶. Low iron ➡️ silenced Sry gene ➡️ female development 💡🧪. Epigenetics meets nutrition in utero—stay iron-clad, moms! #Epigenetics #IronMatters #SexDeterminationBy MasterMedFacts.com
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Mini Organs (Gastruloids), Major Insights, Marvelous Science 🧫🔬✨
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5:49🔬 New in @ScienceMagazine: Researchers grew mini human organs (gastruloids) with real blood vessels! ❤️🧠 Using stem cells + special cocktails, they modeled early heart & liver development in a dish. A leap for organoids & regenerative medicine! 🧪🧬 #Biotech #StemCells #OrganoidsBy MasterMedFacts LLC
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🚫 Taurine ≠ Aging Clock: The Biomarker That Wasn’t
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3:29🧬 Is taurine the secret to youth? Not quite. 📈 New study shows taurine levels 📈 with age—especially in women. 🙅♂️ Not a reliable aging biomarker: too much variability, too many mixed signals. 🧠 Context matters. Supplement wisely. #Longevity #AgingResearch #Taurine #Science 🧪By MasterMedFacts LLC
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🧠 From Burst Cells to Blocked Organs: The New Vascular Story
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2:41🧬 New vascular villain? It’s not always clots. 💥 Necroptosis of endothelial cells triggers red blood cell rupture. 🩸 Sticky RBC fragments form “endo-seals” that block blood flow—especially in COVID-19, stroke, and MI. 🎯 Targets? Think MLKL & complement, not just platelets. #MedTwitter #COVID19 #VascularBiology #Pathology…
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🛡️ Warriors, Watchers & Worn-Outs: Mapping Immune Identity
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4:58🧬 New study reveals 4 stable #Immunotypes in healthy adults! Each with unique 🔥inflammatory, 🦠CMV-driven, 💧quiet, or 🔥aging-linked immune traits. They predict LPS response better than age or sex. Welcome to the era of immune fingerprinting! 🧪🧠 #PrecisionMedicine #Immunology #MultiomicsBy MasterMedFacts LLC
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Glycemic Wisdom: 📊 Spikes, Stats & Surprises
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6:13🥖 Not all carbs are created equal — or digested the same! A new study shows glycemic responses vary wildly by individual 🍚🥔🍞🍇 Your microbiome, metabolism, and ethnicity all matter! Precision nutrition is the future 🔬🧬📊 #GlycemicResponse #CGM #NutritionScience #T2D 🍽️By MasterMedFacts LLC
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🧠💪🧬 Aging Redefined: Cracking the Epigenome with the "Intrinsic Capacity" Clock
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4:16🧬 A new epigenetic clock predicts your functional age — not just birthdays! 🕰️ Built from 91 CpGs, the IC Clock outperforms GrimAge & others at predicting mortality 💪 Linked to T-cell health, 🫁 lung function & 🐟 omega-3 intake 📖 Nature Aging: https://doi.org/10.1038/s43587-025-00883-5 #Aging #Epigenetics #Longevity #Immunosenescence Doximity…
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🎯 Nuts About Health: Daily Dose, Daily Gains?
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3:17🥜 Daily almonds = big wins for metabolic health! ✅ ↓ LDL & total cholesterol ✅ ↑ Vitamin E (α-tocopherol) ✅ ↓ Gut inflammation (calprotectin, MPO) ❌ No change in systemic inflammation or weight Crunch wisely, live heart-smart! ❤️🧠 #Nutrition #MetabolicSyndrome #RCT #Almonds #GutHealthBy MasterMedFacts LLC
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🧬 Age, Clocks, and Plasma: The Biology of Rejuvenation
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3:38🧪 Can we turn back the clock? A new RCT shows TPE + IVIG reversed biological age by 2.6 years in older adults! 🔄🧬 ✅ Boosted naïve T cells ⚠️ Small sample, no clinical endpoints 🔍 Personalized markers predict response #Aging #LongevityScience #Epigenetics 🧓📉✨By MasterMedFacts LLC
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🌈 Eat the Polyphenol Rainbow: Quantity + Variety = Longevity
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3:47🥗 New study in Nature Food: Greater diversity of flavonoid intake—not just quantity—linked to ↓ risk of death, diabetes, heart disease & more 🌈🍇🍵 Eat the rainbow daily: apples, tea, berries, citrus, greens = longevity boost 💪🧬 #Nutrition #Longevity #FlavonoidsBy www.MasterMedFacts.com
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Dr RR Baliga's Philosophical Discourses: Marcus Aurelius (Rome, 121–180 CE) – Roman Emperor and Stoic Philosopher
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3:38Marcus Aurelius (121–180 CE), a Roman emperor and prominent Stoic philosopher, ruled from 161 to 180 CE. As the last of the Five Good Emperors, his reign marked the end of the Pax Romana, a period of relative peace in the Roman Empire. Known for his military campaigns against Parthians and Germanic tribes, he also endured the devastating Antonine P…
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🩸 Tiny Messengers, Big Damage: How RBC EVs Wreck Vascular Health in Diabetes
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4:52🩸 New JCI study reveals how RBC-derived EVs 🧬 in #Type2Diabetes sneak into endothelial cells 🧫, delivering arginase-1 & sparking oxidative stress 🔥—a hidden cause of vascular dysfunction. Blocking EV uptake = 💡 new therapy? 📖 https://doi.org/10.1172/JCI180900 #CardioTwitter #Diabetes #VascularBiology…
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🧭 From Prevention to Precision of Alzheimers Disease: New Frontiers
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4:13Big shift in Alzheimer’s care! We can now predict it years in advance using 🩸 biomarkers like p-tau217, 🧬 genetic risk, & 🤖 AI-analyzed retina scans. Prevention = lifestyle 🥦🏃♂️💤, vaccines 💉, & maybe GLP-1s 💊. Why wait to treat when you can PREVENT? 🔍 #Alzheimers #PrecisionMedicine #AIBy MasterMedFacts LLC
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🩸 Fueling Inflammation: Haematometabolism & Heart Disease
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2:45🧬 Did you know your blood cell metabolism could fuel heart disease? 🔁 Disrupted haematometabolism = more inflammation, less cleanup 🧹 Efferocytosis fails → plaques grow 🧠 Aging + CHIP mutations = 🔥 risk 🥗 Fix it with fasting, fitness & future therapies! #CardioTwitter #MedEd #Haematometabolism ❤️By MasterMedFacts LLC
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Mastering the Microbiome: Bugs, Biomarkers, and Beyond 🔬
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3:38🧬 The microbiome is medicine’s next frontier! From Fecal Transplants 💩 to probiotics 🦠, diagnostics 🔍 to designer bugs 🧪—we’re decoding disease, predicting treatment, and redefining care. But challenges remain. 🎙️ Dive into the FAQs with Got Knowledge Doc! #Microbiome #GutHealth #MedTwitter 🚀By MasterMedFacts LLC
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🔄 From Injection to Ingestion: SOUL Sparks a CKM Revolution
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2:29📢 New from the SOUL trial! 💊 Oral semaglutide cuts heart attack risk in T2DM 🫀 but shows no benefit for stroke 🧠 or kidney disease 🧫. A win for adherence, a push for CKM integration! 🔄💡 #Diabetes #Cardiology #NEJM #CKM #GLP1RA @doximityBy MasterMedFacts LLC
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⛳ Pesticides, Proximity, Parkinson’s: The Hidden Risk of Golf Courses
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2:43🏌️♂️⛳ Living near golf courses may increase Parkinson’s risk! 📊 Case-control study: Risk highest within 1–3 miles 💧 Contaminated groundwater & pesticides likely culprits 🧠 aOR up to 2.98 for 6 miles! 📉 Risk ↓ 13% per mile after 3 miles 🔗 [JAMA 2025] #Neurology #Parkinsons #EnvironmentalHealth #GolfRisk @doximity…
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🌟 A New Dawn in PAH: Sotatercept’s Big Win in PAH 🧬🏔️
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4:35🚨 BREAKING: Sotatercept cuts risk by 76% in advanced #PAH! 💉 Targets activin signaling 🫁 Fewer deaths, transplants & hospitalizations 📉 HR 0.24 | Trial stopped early for efficacy ⚠️ Epistaxis, ↑Hgb, telangiectasia noted 🔬 A new era in pulmonary hypertension care! #ZENITHTrial #CardioTwitter 🫀📊 @doximity…
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🫁 Beyond the Blow: Redefining COPD Risk with CT and Symptoms 🫁💡
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3:12🚨New COPD diagnosis alert!🫁 A multidimensional schema using CT 🖼️ + symptoms 😮💨 + spirometry 📉 identified high-risk patients missed by GOLD! 📈↑Mortality (HR 1.98) 📉FEV1 decline (–7.7 mL/y) 📊 Reclassified 15% w/o obstruction as COPD! 👉CT matters. #PulmTwitter #COPD #MedTwitter @doximityBy MasterMedFacts LLC
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“🧬 One Shot, Six Months: Zilebesiran—an RNAi therapeutic Redefines BP Control”
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2:58🚨 New data! In the KARDIA-2 trial, 🧬 zilebesiran—an RNAi therapeutic—cut SBP by up to 12 mmHg when added to common antihypertensives 💊. One shot, 6 months of BP control! 📉 Promising for poor adherence. Mild AEs. #Hypertension #Cardiology #RNAi 🌍【JAMA 2025】By MasterMedFacts LLC
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🧓➡️🧒 Anti-Aging Alchemy: A Tale of Two Geroprotectors-Trametinib & Rapamycin
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4:41🧬 Big win for longevity! A Nature Aging study shows that combining 💊 trametinib + rapamycin extends lifespan, reduces tumors, and tames inflammation in mice 🐭🔥 Dual geroprotectors = additive benefits without added toxicity 🛡️🕰️ Future of anti-aging? Watch this space 👀 #Aging #Longevity #Geroprotectors #Science 🧪 @doximity…
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📉 Less is More: Light-Touch Stroke Care, Same Results
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3:13🧠💉 New Lancet study (OPTIMISTmain) shows low-intensity monitoring after thrombolysis in mild strokes may be just as safe as standard care! 💤 Less sleep disruption, 🧑⚕️ lighter nursing load, ⚖️ similar outcomes. Could this change global stroke care? 🌍🏥 #Stroke #Thrombolysis #OPTIMISTmain #NeurologyBy MasterMedFacts LLC
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⚖️🚨 The Great Sedative Showdown: No Clear Winner, Just Tough Side Effects
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3:33🚨New A2B Trial in JAMA! Can 🧪dexmedetomidine or clonidine beat 💉propofol in sedating ICU patients on ventilators? ❌ No faster extubation ⚠️ More bradycardia & agitation ⚖️ Similar mortality Verdict: No clear winner—tailor sedation to patient needs 🛌👨⚕️ #CriticalCare #ICU #SedationTrialBy MasterMedFacts LLC
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🧠➡️🩺🚀 “From Clot to Cure: Does TNK Boost EVT?”
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4:41🚨🧠 BREAKING: Tenecteplase before thrombectomy boosts chances of stroke recovery! 💉 Faster reperfusion 📈 Higher functional independence (mRS 0–2 at 90d: 52.9% vs 44.1%) ⚠️ Slight ↑ in sICH, but no major safety red flags 🧪 #BRIDGE_TNK trial rewrites the stroke playbook! #Stroke #Tenecteplase #NeuroTwitter…
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Dr RR Baliga's Philosophical Discourses: Nagarjuna (India, c. 150 CE) – Founder of Madhyamaka School
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3:52Nāgārjuna (c. 150 – c. 250 CE) was an Indian Buddhist monk and philosopher, regarded as the founder of the Madhyamaka (Middle Way) school of Mahāyāna Buddhism. His most famous work, Mūlamadhyamakakārikā (Root Verses on the Middle Way), presents the concept of śūnyatā (emptiness) and the two truths doctrine, emphasizing dependent origination and rej…
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🫀Low-Voltage Areas in AF, The SUPPRESS-AF Showdown!
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3:36📢 New RCT in Nature Medicine 🎯 Can zapping low-voltage areas (LVAs) reduce AF recurrence after PVI? 🔬 SUPPRESS-AF Trial 👥 342 pts with persistent AF 📉 1-yr AF/AT-free: 61% (PVI+LVA) vs 50% (PVI) ❌ Not statistically significant 🧠 Subgroup benefit in high-risk pts #EPeeps #AFib #CardioTwitter 🫀By MasterMedFacts LLC
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Muscles, Memory, and Molecules 🧠💪🧬: Predicting Strength Decline with Alzheimer’s Biomarkers
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3:36🧠💪 Can blood biomarkers of Alzheimer’s predict who’ll lose muscle strength with age? In a 12-year study, higher p-tau, NfL & GFAP levels forecasted faster decline in grip & leg power — even before dementia onset. 🧬🪑✊ #Aging #Alzheimers #Sarcopenia #Biomarkers #LongevityBy MasterMedFacts LLC
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🚶♂️ The Great Sit-Down: A Decade of Sitting Habits
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2:52📉 New JAMA study tracks U.S. #SedentaryBehavior from 2013–2023: 🪑 Sitting time fell from 7.1 to 5.9 hrs/day pre-COVID 🦠 But plateaued post-pandemic at 6.0 hrs/day 🚶♀️ Progress stalled—time to get moving again! #PublicHealth #NHANES #PhysicalActivity 🏃♂️📊🛋️By MasterMedFacts LLC
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🐒 No Drama, Just Mama: Wild Chimps Show Secure Attachment
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5:36🐒 New study finds no disorganized attachment in wild chimpanzees! 🧠 Only secure & avoidant types observed—just like humans, but without the trauma. 🌿 Evolution favors calm, connected bonds. 📍Taï National Park, Côte d’Ivoire 🔗 Nature knows best. #PrimateScience #AttachmentTheory #Chimpanzees
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“💡Tiny Pulse, Big Impact: Dissolving Pacemakers Powered by Light”
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2:53💡World’s tiniest pacemaker—smaller than a grain of rice! 🫀Leadless, wireless & bioresorbable 🔦 Powered by NIR light 🧬 Perfect for post-op pacing & TAVR 🌱 No wires, no scars, no removal! #MedTech #Cardiology #Bioengineering #Innovation @NatureBy MasterMedFacts LLC
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“Cut the Cysteine, Burn the Fat, Jolt the Genome 🔪🔥🧬”
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3:25Cutting cysteine = 🔥 30% weight loss in 7 days! 🧬 Triggers stress pathways (ISR/OSR) ❌ CoA & glutathione drop 🔥 Browning fat, futile cycling, energy drain 💡 Reversible & promising for obesity research! #Metabolism #Obesity #AminoAcids #Science 🧪⚖️🧠By MasterMedFacts LLC
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Battle of the Heart Valves: 🔍: Myval Matches, ACURATE Misses ❌, SAPIEN Stands Strong 💪
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5:50🚨 TAVI Trials Update! 🆚 COMPARE-TAVI 1: 🇮🇳Myval = 💪SAPIEN 3 in safety & efficacy 🆚 ACURATE IDE: ACURATE neo2 ❌not non-inferior to 💥SAPIEN/EVOLUT 📊 Valve wars intensify! #TAVI #HeartValve #Cardiology 🫀By MasterMedFacts LLC
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“Not All Heat Is Equal: Science Behind the Chili Burn 🌡️🧠🌶️”
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3:07🌶️ Not all chili heat is created equal! Scientists found hidden compounds—like capsianoside I & roseoside—that cool the burn without changing flavor 🔬❄️ Your next spicy dish might be hot… but not hurt. #FlavorScience #Capsaicin #TRPV1 #FoodTech 🍽️🧠🔥By MasterMedFacts LLC
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🚨 Tiny Twists, Big Clues: Vortices Reveal Chemotherapy’s Toll
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4:05📊 New study shows Topological Flow Data Analysis (TFDA) 🌀 detects early cardiac dysfunction in childhood cancer survivors—before LVEF or strain drop! 🔍 A game-changer in cardio-onc surveillance. #CardioOncology #TFDA #EchoRevolutionBy MasterMedFacts LLC
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📉 Mucus plugs matter! In COPD, persistent or new plugs accelerate FEV₁ decline 🫁💨 🖥️ CT imaging tracks their impact 🚬 Smoking worsens the hit 👉 Clear the plugs, preserve the lungs! #COPD #LungHealth #NEJM #FEV1 #PulmonologyBy MasterMedFacts LLC
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💥 Old Drugs, New Power: Amiloride vs Spironolactone in Resistant Hypertension
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4:24🩺 New hope for #ResistantHypertension! A 12-week RCT 🇰🇷 shows 💊 amiloride is noninferior to spironolactone in lowering SBP 📉 Fewer side effects, similar BP drop! But spironolactone may still reign 👑 for organ protection 🫀🧠 🧪 #Hypertension #Cardiology #JAMA2025By MasterMedFacts LLC
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🧪 Precision for One, Promise for Many: CRISPR Meets the Clinic--A New Era in Rare Disease Therapy
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6:43🧬✨ A baby with deadly CPS1 deficiency (which results in elevated ammonia levels) gets a custom-made gene edit—delivered by lipid nanoparticles—in just 6 months! 🚀 Ammonia levels down, no hospitalizations, and hope up. N-of-1? More like Future-of-Many. 💡👶🔬 #GeneTherapy #PrecisionMedicine #RareDiseaseBy MasterMedFacts LLC
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🔥 Smoldering Systems: Staging Systemic Metabolic Disorder Before It Ignites
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3:40🚨 New framework alert! Systemic Metabolic Disorder (SMD) gets a clinical staging makeover 🧬 From reversible risks 🌱 to systemic damage 🔥—this EAS consensus guides timely, targeted care 🎯 #MetabolicHealth #Cardiology #PrecisionMedicine #SMD 🩺📊By MasterMedFacts LLC
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Dr RR Baliga's Philosophical Discourses: Pyrrho (Greece, c. 360–270 BCE) – Founder of Pyrrhonism
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4:16Pyrrho of Elis (c. 360–270 BCE) was an ancient Greek philosopher and founder of Pyrrhonism, a school of philosophical skepticism. He advocated for epoché (suspension of judgment) as a path to ataraxia (peace of mind). Influenced by his travels to India with Alexander the Great, Pyrrho believed that nothing could be definitively known and that by re…
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