HemaSphere is the official online, open access journal of the European Hematology Association (EHA). HemaSphere publishes exciting basic, translational, and clinical research in hematology. We are pleased to introduce our new podcast series where our host and guest speakers exchange ideas about select HemaSphere publications. Spend some time with us and enjoy casual and insightful discussions about hematology research. Listen to the stories behind the papers. HemaSphere is always accessible; ...
…
continue reading

1
Metabolism in hematology - Ep 3.4, Part 2
28:52
28:52
Play later
Play later
Lists
Like
Liked
28:52In this second part of a 2-part episode, Dr Charles De Bock engages with Prof Dr Petya Apostolova and Dr Jörg Büscher to explore the intricate relationship between metabolism and hematology, particularly focusing on #AML. They discuss the challenges and advancements in metabolomics, the importance of integrating multi-omics approaches, and the futu…
…
continue reading

1
Metabolism in hematology - Episode 3.4, Part 1
29:51
29:51
Play later
Play later
Lists
Like
Liked
29:51In this 2-part episode of the HemaSphere podcast, host Dr Charles de Bock and guests Dr Jörg Büscher and Prof Dr Petya Apostolova discuss the critical role of metabolism in cellular function, particularly in the context of hematology and cancer research. The discussion highlights the technological advancements in metabolic analysis and their impact…
…
continue reading

1
Machine learning for AML-MRD - Episode 3.3
29:24
29:24
Play later
Play later
Lists
Like
Liked
29:24In this episode of the HemaSphere podcast, host Charles de Bock and guest Tim Mocking, PhD, discuss the role of machine learning in the assessment of measurable residual disease (MRD) in acute myeloid leukemia (AML). They explore the challenges of MRD detection, the potential of machine learning to improve accuracy and efficiency, and the importanc…
…
continue reading

1
Navigating Neutropenia: New Guidelines Explained - Episode 3.2
28:05
28:05
Play later
Play later
Lists
Like
Liked
28:05In this episode of the HemaSphere podcast, host Dr Charles De Bock discusses the newly published Guidelines on the treatment of neutropenias with co-authors Dr. Francesca Fioredda and Dr. Eleni Papadaki. They explore the importance of these international guidelines, the challenges faced in gathering evidence, and the consensus-building process amon…
…
continue reading

1
Single‐cell DNA and surface protein - Episode 3.1
34:17
34:17
Play later
Play later
Lists
Like
Liked
34:17In this episode of the HemaSphere podcast, host Charles De Bock engages with HemaSphere Editor in Chief Professor Jan Cools, Professor Heidi Segers, and Doctor Margo Aertgeerts to discuss their recent study on acute lymphoblastic leukemia (ALL). They explore the advancements in treatment, particularly for high-hyperdiploid ALL, the challenges of re…
…
continue reading

1
Two distinct fetal-type signatures characterize JMML - Episode 2.8
36:59
36:59
Play later
Play later
Lists
Like
Liked
36:59In this episode of the HemaSphere podcast, host Charles de Bock engages with Professor Hélène Cavé and Dr. Marion Strullu to discuss their recent study on juvenile myelomonocytic leukemia (JMML). They delve into the complexities of diagnosing JMML, the genetic mutations associated with the disease, and the prognostic factors that influence patient …
…
continue reading

1
Revolutionizing Pediatric Cancer Research with PDXs - Episode 2.7
35:54
35:54
Play later
Play later
Lists
Like
Liked
35:54In this episode of the HemaSphere podcast, host Dr Charles de Bock discusses the critical role of mouse models in understanding leukemogenesis and hematopoiesis with Prof Richard Lock. They explore the significance of patient-derived xenografts (PDXs) in preclinical testing, the challenges faced in generating PDXs for acute myeloid leukemia (AML), …
…
continue reading

1
Episode 2.6 - High 5hmC predicts worse OS
25:15
25:15
Play later
Play later
Lists
Like
Liked
25:15In this episode of the HemaSphere podcast, host Charles de Bock discusses the latest research on myelodysplastic syndrome (MDS) with Dr Francesca Tiso and Dr Florentien in 't Hout from Radboud University Medical Center, co-authors of a recent paper published in HemaSphere. The conversation covers the clinical presentation of MDS, treatment options,…
…
continue reading

1
Episode 2.5 - Informed consent is almost impossible
39:11
39:11
Play later
Play later
Lists
Like
Liked
39:11This podcast episode delves into the complexities of informed consent in healthcare, particularly in the context of hematology. The discussion with host Dr Charles de Bock features insights from Dr Stephen Hibbs and Dr Louise Caldwell, authors of the HemaTopics "Informed consent is almost impossible” and guest Mark Dawson, a patient family member, …
…
continue reading

1
Episode 2.4 - Best of Pediatric Hematology from EHA2024
42:24
42:24
Play later
Play later
Lists
Like
Liked
42:24In the latest episode, Dr Charles de Bock talks with Prof H. Josef Vormoor and Dr Maria Ester Bernardo, Chair and Co-Chair of EHA’s Pediatric Hematology Specialized Working Group. They discuss highlights from the EHA 2024 Congress in Madrid, including key lectures, new insights and what they could mean for clinicians, researchers, patients and thei…
…
continue reading
Authors of this recent HemaSphere published paper discovered a high-risk subgroup of pediatric T-LBL, defined by NOTCH1 gene fusions. This finding will have an important impact on newly diagnosed children with T-LBL globally, listen to two of the co-authors, Dr Jan Loeffen and Professor Roland Kuipers discuss their findings with Dr Charles de Bock,…
…
continue reading

1
Episode 2.2 - A transcriptional cofactor‐mediated dependency module
24:48
24:48
Play later
Play later
Lists
Like
Liked
24:48In this newest podcast episode, Dr Charles de Bock hosts Dr Thomas Mercher and Dr Alexandre Fagnan. This episode is based on their recent paper, “The ETO2 transcriptional co-factor maintains acute leukemia by driving a MYB/EP300-dependent stemness program”, highlighting ETO2 activated gene transcription and how this affects erythroleukemia. The dis…
…
continue reading

1
Episode 2.1 - Unraveling the secrets of thrombopoiesis
25:20
25:20
Play later
Play later
Lists
Like
Liked
25:20Welcome to Season 2 of our podcast! In this episode, Dr. Francesca Vinchi interviews Professor Alessandra Balduini about thrombopoiesis. They explore Prof. Balduini's journey into research, her intuition that led to silk scaffolding, and her hopes on future results. "Unraveling the secrets of thrombopoiesis", is on our website and all major podcast…
…
continue reading

1
Episode 1.8 - What’s so Great About the P-value? A Statistician’s Point of View
30:24
30:24
Play later
Play later
Lists
Like
Liked
30:24Dr Stephen Hibbs invites HemaSphere Associate Editor Prof Robert K Hills to discuss statistics in scientific writing in an entertaining and informative episode: What’s so Great About the P-value? A Statistician’s Point of View. This discussion covers the overlap of statistics and hematology with themes like the importance of P value and the use of …
…
continue reading

1
Episode 1.7 - This Is Going to Hurt: Revisiting the Patient Experience of Bone Marrow Biopsies
24:16
24:16
Play later
Play later
Lists
Like
Liked
24:16Dr Stephen Hibbs invites Dr Joseph Taylor to a discussion based on Dr Hibbs popular HemaTopics article, This Is Going to Hurt: Revisiting the Patient Experience of Bone Marrow Biopsies. The conversation ranges from the type of training providers receive, how to talk to patients about these bone marrow biopsies, and some of the outstanding questions…
…
continue reading

1
Episode 1.6 - Part 1: The European Guidelines on Diagnosis and Management of Neutropenia in Adults and Children
27:29
27:29
Play later
Play later
Lists
Like
Liked
27:29Though many advances have been made in neutropenias, diagnosis and management are still based on physicians’ experience or local practices. Prof Francesca Fioredda and Prof Helen Papadaki, two co-authors of the HemaSphere published article The European Guidelines on Diagnosis and Management of Neutropenia in Adults and Children: A Consensus Between…
…
continue reading

1
Episode 1.4, Part 1 - Comprehensive Diagnosis and Management of POEMS Syndrome
23:23
23:23
Play later
Play later
Lists
Like
Liked
23:23POEMS syndrome (Polyneuropathy Organomegaly, Endocrinopathy, M-protein and Skin changes) is rare, and systemic manifestations are commonly overlooked initially. Diagnosis is often delayed 12-16 months, during which patients can be severely disabled. No established treatment guidelines exist for POEMS. A recent HemaSphere published article, Comprehe…
…
continue reading

1
Episode 1.5, Part 2 - Comprehensive Diagnosis and Management of POEMS Syndrome
24:32
24:32
Play later
Play later
Lists
Like
Liked
24:32POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein and Skin changes) is rare, and systemic manifestations are commonly overlooked initially. Diagnosis is often delayed 12-16 months, during which patients can be severely disabled. No established treatment guidelines exist for POEMS. A recent HemaSphere published article Comprehe…
…
continue reading

1
Machine Learning Improves Risk Stratification in Myelofibrosis: An Analysis of the Spanish Registry of Myelofibrosis - Episode 1.3
34:01
34:01
Play later
Play later
Lists
Like
Liked
34:01Machine Learning is a subsection in the field of Artificial Intelligence. How can this be used as a tool in hematology-oncology for advanced disease prognostification and beyond? Adrián Mosquera-Orgueira and Juan Carlos Hernández-Boluda, two co-authors of the HemaSphere published article Machine Learning Improves Risk Stratification in Myelofibrosi…
…
continue reading

1
EHA Guidelines on Management of Antithrombotic Treatments in Thrombocytopenic Patients With Cancer - Episode 1.2
24:32
24:32
Play later
Play later
Lists
Like
Liked
24:32As the overall cancer death rate has declined over past decades and cancer survival has increased, unforeseen challenges are emerging. Thrombocytopenia, often associated with cancer disease or anticancer therapy, will be more present in thrombotic cancer patients, but evidence on how to treat these patients is lacking. Prof Anna Falanga discusses t…
…
continue reading

1
Long COVID-19” of Researchers: What to Do Next? - Episode 1.1
20:07
20:07
Play later
Play later
Lists
Like
Liked
20:07What to do next for “Long COVID-19” of researchers? A survey from scientists to scientists led by the Young European Hematology Association (Young EHA)committee led to this discussion about how COVID-19 impacted researchers, especially earlier in their career and without a network. What tools did they discover to get through it? Find it on the Hema…
…
continue reading