Best IMD Podcasts (2025)

1
IMD Research Round-Up: Methylmalonic Aciduria 34:17

19d ago34:17

34:17

Dr Sabine Fuchs, Professor of Metabolic diseases and innovative therapies at the UMC Utrecht, and Dr Sean Froese, a Principal Investigator in the Metabolism Division at University Children’s Hospital Zürich, join Rodrigo and Silvia to discuss new insights and some of their favourite papers on Methylmalonic Aciduria. Authors opinions are their own a…

1
Managing Metabolic Emergencies - Intoxication type disorders 26:35

5d ago26:35

26:35

Treatment is available for most intoxication-type disorders, but would you know what to do in an emergency. In this podcast, Dr Dexter Tarr discusses the acute management when these conditions cause encephalopathy, seizures, stroke-like episodes, thromboses, liver failure, cardiac failure, arrhythmias and rhabdomyolysis. Emergency Management of Int…

1
IEMs in Adult Metabolic Centres: 10 Years Later 22:50

12d ago22:50

22:50

Michel Tchan and Mirjam Langeveld join the podcast to look at changes to adult IMD services over the last decade and consider the challenge to develop services to meet the needs of growing patient numbers over the next 10 years.The Frequencies of Different Inborn Errors of Metabolism in Adult Metabolic Centres: 10 Years Later, Another Report From t…

1
How do deans lead when the world turns upside down? 38:28

13d ago38:28

38:28

Global deans on leading through turbulence — and why optimism, not certainty, is the real power in today’s business education. In today’s episode, IMD President David Bach discusses how the rapid global shifts of the moment impact leadership education, with two of his peers: – Catherine Duggan, Dean of the University of Cape Town Graduate School of…

1
Shortcast: Sleep quality in children with hepatic GSDs, a prospective observational pilot study 8:38

26d ago8:38

8:38

Lucas Agnoletto and Dr Rebecca Halligan report work looking at sleep quality in children with hepatic GSDs, considering whether sleep is impacted by poor glycemic control or our efforts to improve this through overnight feeding.Sleep quality in children with hepatic glycogen storage diseases, a prospective observational pilot studyLucas Agnoletto, …

1
David Bach: Why we all benefit from America’s top universities 35:45

1M ago35:45

35:45

In the latest episode, IMD President David Bach explains the vital importance of the partnership between the US government and the elite research universities, what we can learn from the vibrancy of the Middle East, and why Ted Lasso is a better leadership role model than Elon Musk. “The US built its global edge by attracting the world’s best. Now,…

1
NAXD deficiency 32:57

1M ago32:57

32:57

Dr Carole Linster and Dr Nicole van Bergen explain why metabolism isn't perfect and how disorders of enzyme repair present their own challenges. In an episode that explores Niacin and longevity, we also hear why NAXD deficiency is an important differential in acute cardiomyopathy and provides an aetiology that could be highly amenable to treatment.…

1
Imaging readiness in the gene therapy era 22:54

1M ago22:54

22:54

Asthik Biswas, Spyros Batzios, and Kshitij Mankad expand on their recent letter to the editor to explain why ushering in the new era of gene therapy treatments requires not just clinical but also imaging readiness. Imaging readiness in the gene therapy era-exploring standardized protocols for response assessmentAsthik Biswas, et alhttps://doi.org/1…

1
Episode 3: David Bach with Stuart DeCew and Geraldine Matchett 38:23

2M ago38:23

38:23

Welcome to the third episode of Leaders Unplugged, presented by IMD, and hosted by IMD's president David Bach, together with Remote Daily's founder Felix Zeltner. Leaders Unplugged is real talk with the impactful – candid, honest, and fresh from behind the scenes. Today, we take you behind the scenes of a recent gathering led by the World Business …

1
IMD Research Round-Up: Congenital Disorders of Glycosylation 39:58

2M ago39:58

39:58

Dr Matthew Wilson, Postdoctoral Fellow at the Centre for Human Genetics, KU Leuven, joins hosts Silvia Radenkovic and Rodrigo Starosta to discuss a scintillating selection of CDG papers in our first ever research round-up. Authors opinions are their own and do not represent their institutions.The papers discussed include:A pseudoautosomal glycosyla…

1
Exploring the disease burden in Arginase 1 deficiency 27:51

2M ago27:51

27:51

It's an Arg1 extravaganza as Reena Sharma, Sara Olofsson, Karolina Stepien and Alison Woodall discuss three separate papers looking at the Salford Royal experience of a cohort of adults with Arginase 1 deficiency and the wider health and societal cost of the condition. Retrospective analysis of arginase 1 deficiency progression in adults over 5 yea…

1
The Interview: Jim Pulcrano speaks with Ruchita Sinha of AV8 Ventures 17:54

2M ago17:54

17:54

This interview with Ruchita Sinha, partner at AV8 Ventures, explores her journey from science to venture capital and her approach to early-stage investing. She discusses AV8’s focus on AI-driven innovation in healthcare, enterprise tech, and financial services, and shares insights on evaluating founders, what distinguishes a good company builder, n…

1
Episode 2: David Bach and UBS CEO Sergio Ermotti 32:34

2M ago32:34

32:34

Welcome to the second episode of Leaders Unplugged, a bi-weekly podcast by IMD, hosted by IMD President David Bach with Felix Zeltner. In this wide-ranging chat, David goes from the global to the personal with one of the world’s most prominent bankers: UBS CEO Sergio Ermotti. At a recent event in Lausanne, Sergio Ermotti joined Bach on stage and pu…

1
Shortcast: D,L-3-hydroxybutyrate in the treatment of glucose transporter 1 deficiency syndrome (Glut1DS) 5:12

2M ago5:12

5:12

In this Shortcast, Dr Aya Amer presents the New Zealand experience of using ketone (D,L-3-HB) supplementation in 12 patients (aged 10-50 years) with GLUT1DS.D,L-3-hydroxybutyrate in the treatment of glucose transporter 1 deficiency syndrome (Glut1DS)Aya Amer, et alhttps://doi.org/10.1002/jmd2.12461By Journal of Inherited Metabolic Disease

1
Can biodiversity credits alter the landscape for nature conservation? 25:49

2M ago25:49

25:49

IMD Senior Researcher Adrian Dellecker is joined in the latest I by IMD podcast by Mariana Sarmiento, Founder and CEO of Terrasos, a company developing innovative solutions for environmental conservation and restoration. In this episode, you will learn about the business opportunities in the new market for voluntary biodiversity credits and more. F…

1
Can eDNA revolutionize biodiversity monitoring? 31:43

2M ago31:43

31:43

IMD Senior Researcher Adrian Dellecker is joined in the latest I by IMD podcast by Kristy Deiner, a well-respected academic and entrepreneurial figure in Environmental DNA (eDNA) science. She was a professor on the subject at ETH Zurich, and in 2021 she co-founded SimplexDNA, where she is now CEO. In this episode, you will learn some fundamentals o…

1
Citrulline: beyond the urea cycle 26:29

2M ago26:29

26:29

Marshall Summar explains why common polymorphisms and basic physiology mean that L-citrulline may have a role in sickle cell disease, bronchopulmonary dysplasia and even asthma.Potential therapeutic uses of L-citrulline beyond genetic urea cycle disordersMarshall Summarhttps://doi.org/10.1002/jimd.12810…

1
The Interview: Howard Yu speaks with Julie Linn Teigland of EY 32:57

2M ago32:57

32:57

Leaders are under pressure to project certainty and to know all the answers. In this interview podcast, Julie Linn Teigland, a Managing Partner at EY, tells IMD’s Howard Yu why it’s better to admit you’re unsure and collaborate to find a solution. ***** Read our magazine, I by IMD, here: https://www.imd.org/ibyimd/ Discover IMD's leadership program…

1
Welcome to Leaders Unplugged! 30:49

2M ago30:49

30:49

Welcome to the inaugural episode of Leaders Unplugged, presented by IMD and hosted by IMD President David Bach and Felix Zeltner. To kick things off, David and Felix discuss the key learnings from David's recent travels that took him from the World Economic Forum to the World Government Summit, to business school conferences in Las Vegas and Lisbon…

1
Metabolic mysteries: Hypoglycemia? Don't forget the urine 6:11

2M ago6:11

6:11

Dr Ashlee Stiles discusses the work-up of a 13-month-old girl with hypoglycaemia and discusses the need to balance prompt metabolic work-up with managing the acutely unwell patient in front of you. Critical sample collection is key and don't forget the urine. Read the report here: https://www.sciencedirect.com/science/article/pii/S2214426924000156?…

1
Metabolic mysteries: New weakness, poor balance and paresthesia at 55 years of age 7:00

2M ago7:00

7:00

In this Metabolic Mystery, Dr Eamon McCarron unravels an unexpected diagnosis in a 55-year-man with a 2-year history of dragging his legs, poor balance, and paresthesia along the outer aspect of his right thigh. He underwent various assessments and investigations over the next 3 years before a diagnosis was made. https://onlinelibrary.wiley.com/doi…

1
Transition & executive function in MSUD 16:30

3M ago16:30

16:30

Dr Jessica Gold discusses observations around executive function in early treated MSUD patients and how this impacts on outcomes around transition to adulthood. Executive and adaptive function impacts long-term outcomes for adults with maple syrup urine diseaseJessica I. Gold, et alhttps://doi.org/10.1002/jimd.12827…

1
The future of agritech investing, with Jim Pulcrano & Rob Trice 22:40

3M ago22:40

22:40

Rob Trice is an established international venture capital investor. He is currently leveraging his background in telecom, mobile and internet investing to fund companies that apply IT to the food and agriculture sectors via Better Food Ventures, a seed stage investment entity established in 2013. Jim Pulcrano is Adjunct Professor of Entrepreneurshi…

1
The Trump effect on tech 20:49

3M ago20:49

20:49

Michael Wade is a Professor of Innovation and Strategy and Director of the IMD Global Center for Digital Business Transformation. He also holds the Cisco Chair in Digital Business Transformation. An expert in digital transformation, he has published 10 books and more than 100 case studies, as well as articles on topics such as digital business tran…

1
Shortcast: TFP deficiency caused by a deep intronic deletion leading to aberrant splicing 3:05

3M ago3:05

3:05

Dr Thomas Cassini explains how the Undiagnosed Diseases Network group used advanced sequencing techniques to clarify the genotype in a child with an unusual phenotype for mitochondrial trifunctional protein deficiency.Mitochondrial trifunctional protein deficiency caused by a deep intronic deletion leading to aberrant splicingThomas Cassini, et alh…

1
CBS Deficiency in the E-HOD Registry 15:58

3M ago15:58

15:58

Dr Andrew Morris joins the podcast to discuss insights from 311 patients with CBS deficiency (classical homocystinuria), their response to treatment and clinical outcomes. Cystathionine β-Synthase Deficiency in the E-HOD Registry—Part II: Dietary and Pharmacological TreatmentAndrew A. M. Morris, Jitka Sokolová, Markéta Pavlíková, Florian Gleich, St…

1
Beyond the obvious: quiet predictors of VC fund performance with Michael Kim 36:07

4M ago36:07

36:07

Cendana Capital is a San Francisco-based fund of funds investing in early-stage venture capital ventures. The firm was launched in 2010 and has over $2B in assets. Cendana has invested in many VC teams that have gone on to enjoy great success, like Forerunner Ventures, K9 Ventures, and IA Ventures. In this episode, the founder of Cendana, Michael K…

1
Velmanase alfa for alpha-mannosidosis 25:34

4M ago25:34

25:34

Nathalie Guffon joins the podcast to discuss alpha-mannosidosis and the long term efficacy of enzyme replacement therapy with velmanse alfa.Extended long-term efficacy and safety of velmanase alfa treatment up to 12 years in patients with alpha-mannosidosisNathalie Guffon, et alhttps://doi.org/10.1002/jimd.12799…

1
The Treatabolome: Don't miss the chance to treat! 22:40

4M ago22:40

22:40

Eva Hoytema van Konijnenburg and Clara van Karnebeek tell the podcast about the treatabolome an epic project to include all current IMD treatments and add them to the IEMbase. The Metabolic Treatabolome and Inborn Errors of Metabolism Knowledgebase therapy tool: Do not miss the opportunity to treat!Bibiche den Hollander, et alhttps://doi.org/10.100…

1
Alternative Exit Options for VC Funds, with Liz Campbell 32:32

4M ago32:32

32:32

Liz Campbell, CIO at Portfolio Advisors, discusses the challenges of realising returns in an increasingly sophisticated VC market. Founded in 1994, Portfolio Advisors is an experienced private markets manager with dedicated primary, secondary, co-investment, real estate and direct credit teams. In 2023, Portfolio Advisors combined with FS Investmen…

1
The rules of VC, with David Clark CIO at VenCap International 22:20

5M ago22:20

22:20

Since its inception, VenCap has committed $2.9 billion to over 450 venture capital funds in the US, Europe, China and India. As CIO David Clark has decades of experience and access to unparalleled data, and in this episode of Capital Conversations he explores the cycles, metrics and misconceptions associated with VC. *** Through our research, thoug…

1
An update on autophagy disorders 49:08

5M ago49:08

49:08

It seems everyone is talking about autophagy but what is it and what happens when it goes wrong? Hormos Salimi Dafsari, Carlo Dionisi-Vici, and Heinz Jungbluth join the podcast to answer these questions, discuss their experience across 3 (or 2.5) generations of clinical practice and why you never see an obese 100-year-old.An update on autophagy dis…

1
Models in Leigh Syndrome 41:32

5M ago41:32

41:32

Marie-Thérèse Henke, Alessandro Prigione, and Markus Schuelke get 2025 off to an informative start discussing why so many models exist for Leigh Syndrome, why we need them and how insights from disease models have led to Sildenafil being used in some patients. Disease models of Leigh syndrome: From yeast to organoidsMarie-Thérèse Henke, Alessandro …

1
KAMPER: Kuvan (BH4) in phenylketonuria 25:38

5M ago25:38

25:38

Dr François Feillet returns to the podcast to discuss the final results of the KAMPER study, evaluating the long-term safety of sapropterin in phenylketonuria (phenylalanine hydroxylase deficiency).Long-term safety of sapropterin in paediatric and adult individuals with phenylalanine hydroxylase deficiency: Final results of the Kuvan® Adult Materna…

1
Didier Cossin: High performance boards 30:31

5M ago30:31

30:31

Didier Cossin discusses the latest edition of his book "High Performance Boards," a comprehensive guide to transforming boards and achieving best-practice governance in any organisation. **** Didier Cossin is Chaired Professor of Governance and Finance at IMD, and Founder and Director of the IMD Global Board Center. He works with owners, boards, an…

1
What is the impact of technology on K-12 education? 20:56

6M ago20:56

20:56

***** Michael Wade is a Professor of Innovation and Strategy and Director of the IMD Global Center for Digital Business Transformation. He also holds the Cisco Chair in Digital Business Transformation. An expert in digital transformation, he has published 10 books and more than 100 case studies, as well as articles on topics such as digital busines…

1
Sia Houchangnia on building relationships that empower founders 30:13

6M ago30:13

30:13

Sia Houchangia joined Seedcamp as an intern in 2014 and became a partner in 2017. Seedcamp is a leading European seed fund that has backed over 500 tech-driven startups, including Sorare, Revolut, UiPath, Wise, and Synthesia. **** Through our research, thought leadership, and annual program, IMD’s Venture Asset Management Initiative aims to demysti…

1
Dietary management in GSD type 3a 19:08

6M ago19:08

19:08

Dr Sema Kalkan Uçar joins the podcast to discuss the merits of a high protein, high fat diet for the management of patients with Glycogen Storage Disease type 3a.Long-term personalized high-protein, high-fat diet in pediatric patients with glycogen storage disease type IIIa: Evaluation of myopathy, metabolic control, physical activity, growth, and …

1
Footprints of IMD: Psychiatric presentations... with Gabriella Horvath 13:34

6M ago13:34

13:34

Dr Gabriella Horvath returns for her second visit to the podcast, joining Eva Morava to discuss psychiatric presentations of Inherited Metabolic Disease.Read the referenced paper here: https://doi.org/10.1016/j.ymgme.2020.02.007Find IMDs associated with psychiatric presentations at: http://iembase.org/gamuts/store/docs/Psychiatric_IMD_gamuts.pdf…

1
David Bach: The first 90 days as IMD President 32:52

6M ago32:52

32:52

Michael Watkins, Professor of Leadership and Organizational Change and author of the international bestseller The First 90 Days, speaks to IMD President David Bach about how he has found the transition to his new role. Also available as a video on imd.org here **** David Bach began his term as IMD President in September 2024, and is focused on maki…

1
Shortcast: Two successful pregnancies in patients taking Volanesorsen for FCS 8:09

6M ago8:09

8:09

In this Shortcast Antonio Ochoa-Ferraro and Dr Charlotte Dawson share their experience using the medication Volanesorsen with two pregnant women diagnosed with familial chylomicronemia syndrome.Two successful pregnancies in patients taking Volanesorsen for familial chylomicronemia syndromeSubadra Wanninayake, et alhttps://doi.org/10.1002/jmd2.12435…

1
RNA based therapies in Urea Cycle Disorders 15:03

6M ago15:03

15:03

In the latest podcast, Dr Lourdes Desviat provides an overview of the different RNA based therapeutic approaches including how they work and which are showing promise for the management of Urea Cycle Disorders. Exploring RNA therapeutics for urea cycle disordersEva Richard, Ainhoa Martínez-Pizarro, Lourdes R. Desviathttps://doi.org/10.1002/jimd.128…

1
Bpifrance: How a government initiative can support domestic venture capital 19:13

6M ago19:13

19:13

France's national investment bank, led by Nicolas Dufourc, finances businesses at every stage of development through loans, guarantees, and equity investments. In this week's episode, we explore its pivotal role in fostering entrepreneurship through a grassroots approach to innovation and commitment to supporting diverse communities. Dufourc discus…

1
The launch of the AI safety clock 17:44

7M ago17:44

17:44

The IMD AI Safety Clock is a tool designed to evaluate the risks of Uncontrolled Artificial General Intelligence (UAGI) – autonomous AI systems that operate without human oversight and could potentially cause significant harm. Our mission is to evaluate and communicate these risks to the public, policymakers, and business leaders, helping ensure th…

1
Brain changes in infantile Pompe disease 21:50

7M ago21:50

21:50

Dr Hannerieke van den Hout of Erasmus MC joins the podcast to discuss observations from two decades of early treated infantile onset Pompe disease and the evolving nature of the neurological phenotype.Long term survival in patients with classic infantile Pompe disease reveals a spectrum with progressive brain abnormalities and changes in cognitive …

1
Shortcast: Metabolic management of a successful pregnancy in FBPase deficiency 6:40

7M ago6:40

6:40

Callie Ferguson discusses her group's care for a young woman with FBPase deficiency during pregnancy and beyond. Metabolic management of a successful pregnancy and postpartum complications in fructose-1,6-bisphosphatase deficiencyCallie Ferguson, Anita Madison, Ada Hamosh, Celide Koernerhttps://doi.org/10.1002/jmd2.12453…

1
Europe's Untapped Venture Capital Potential, with Nathaniel Gunn Arnold and Jan-Martin Frie from the IMF 33:07

7M ago33:07

33:07

Over the past decade, American VCs have outraised their European counterparts by hundreds of billions of dollars. But why? Nathaniel Arnold and Jan-Martin Frie say several factors are at play, including fragmented markets, a disparity in private capital, and Europe's comparative absence of institutional investors. The result has been a "scale-up ga…

1
Gene therapy for mitochondrial disorders 26:07

7M ago26:07

26:07

Professor Shamima Rahman and Dr Nandaki Keshavan take us on a whistle stop tour of the different approaches taken to gene therapy in mitochondrial disease and why some may work better than others. Gene therapy for mitochondrial disordersNandaki Keshavan, Michal Minczuk, Carlo Viscomi, Shamima Rahmanhttps://doi.org/10.1002/jimd.12699…

1
Part 2: Exploring the craft of fund sizing and modelling, with Daniel Keiper-Knorr 20:33

8M ago20:33

20:33

How do investors strike the delicate balance between fund size, investment strategy, and portfolio construction to maximize returns? In today's markets, that's a tricky question. VCs need to keep one eye on waning IPO activity and intensifying competition while also grappling with unpredictable market dynamics. One firm that has done this successfu…

1
Adult outcomes in classic galactosemia 35:05

8M ago35:05

35:05

Olivia Garrett, Jared Druss, Estela Rubio-Gozalbo, Gerard Berry, and Judith Fridovich-Keil discuss outcomes in classic galactosemia drawn from patient surveys of 92 adults.Health and well-being of maturing adults with classic galactosemiaOlivia S. Garrett, Jared J. Druss, E. Naomi Vos, Yu-Ting Debbie Fu, Stephanie Lucia, Patricia E. Greenstein, Ann…

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