Best The Knowledge Heist Podcasts (2025)

1
🔌 Power Heist in the Tumor: Neurons Fuel Cancer Spread 4:22

4d ago4:22

4:22

🚨 New insights from cancer neuroscience! 🧠🧬 A groundbreaking Nature study reveals that cancer cells can steal mitochondria from nearby neurons via tunneling nanotubes — supercharging their metabolism, stemness, and metastatic potential 🌪️💥 Using a clever tool called MitoTRACER, researchers traced this “mitochondrial hijack” across cancers (breast, …

1
💥 Beyond the Block: Cracking the Code of Chest Pain 🔬❤️ 6:09

19h ago6:09

6:09

Refractory Angina: Time to Rethink the Diagnosis 🫀💥 Chest pain that defies stents and statins? It may not be your typical obstructive CAD. This podcast unpacks the redefinition of refractory angina — spotlighting INOCA, CMD, vasospasm, and myocardial bridging 🔬⚙️ We explore PET, CMR, CFVR, and wire-based diagnostics 🔎 — and why a multidisciplinary …

1
Inflammaging: Myth, Marker, or Mismatch? 🧪❓🌐 3:46

1d ago3:46

3:46

🔬🌍 New insights from Nature Aging: Inflammaging isn’t universal! A fascinating cross-cultural study comparing Italy 🇮🇹, Singapore 🇸🇬, Bolivia 🇧🇴, and Malaysia 🇲🇾 shows that age-related inflammation—long considered a hallmark of aging—may actually be a product of industrialized environments. Populations like the Tsimane (Bolivia) and Orang Asli (Mal…

1
Is it the Greatest Comedy of All-Time? Monty Python and The Holy Grail (1975) 59:14

1d ago59:14

59:14

'Tis but a scratch! This week on Cocktails & Classics, we embark on a ridiculous quest with the legendary 1975 comedy, "Monty Python and the Holy Grail." Join us as we laugh our way through King Arthur's absurd journey, killer bunnies, and insulting Frenchmen. We'll dissect the film's unique comedic style, its quotable lines, and its enduring influ…

1
What Ravi Sharma is doing to Retire Filthy Rich with Bitcoin & Real Estate 33:05

1d ago33:05

33:05

How do you transfer your alt coins into property? Today Ted Coaldrake is joined by Ravi Sharma, the author of Retire Filthy Rich with Property and man behind the 100K+ youtube account Personal Finance with Ravi Sharma. We talk about how to pick markets that still have growth, why Gen Z are avoiding investing in shares and the strategy behind NEVER …

1
🧠❤️ Predict. Prevent. Protect: AI’s Lifesaving Role in HCM 3:54

2d ago3:54

3:54

🚨 AI vs Sudden Cardiac Death in HCM 🫀🤖 Exciting new study published in Nature Cardiovascular Research showcases MAARS, a multimodal AI model that dramatically improves risk prediction for sudden arrhythmic death in hypertrophic cardiomyopathy patients. 📊 MAARS outperformed current guidelines with AUROC of 0.89 (internal) and 0.81 (external) 🧠 Integ…

1
💡 Personalized, Precise, Powerful: The Rise of Cancer Vaccines 🧪 4:26

2d ago4:26

4:26

“Vax to the Future: Cancer Immunity Revolution 🧬💉” Cancer vaccines are no longer a promise — they’re a precision revolution. From HBV and HPV to cutting-edge mRNA-based neoantigen vaccines, we explore how tumor sequencing + AI + immune checkpoint inhibitors are reshaping oncology. 📈 Real data from trials in melanoma, ccRCC, and pancreatic cancer ⚔️…

1
🍬 Endothelium Under Attack: The Sweetener-Inflammation Link 2:58

3d ago2:58

2:58

🚨 New Findings on Aspartame & Heart Health! 🍬🫀 A groundbreaking study in Cell Metabolism reveals how aspartame, a common artificial sweetener, may worsen atherosclerosis via an insulin-triggered inflammatory pathway involving the CX3CL1-CX3CR1 axis. 🧪 Key insights from mice and monkeys: – Aspartame spikes insulin via vagus nerve stimulation – Eleva…

1
Dr RR Baliga's Philosophical Discourses: Saint Augustine of Hippo (354–430 CE) 2:57

3d ago2:57

2:57

Saint Augustine of Hippo (354–430 CE), a prominent theologian, philosopher, and bishop in Roman North Africa, profoundly influenced Western Christianity and philosophy. Known for works like Confessions, The City of God, and On Christian Doctrine, he developed doctrines on original sin, grace, just war, and ecclesiology. His thoughts shaped medieval…

1
Beats, Bytes, Brilliance 🫀💾🌟: The Rise of AI in Echocardiography 3:27

4d ago3:27

3:27

🚨 Just out in JAMA! 💡 PanEcho, a multitask AI model trained on over 1.2 million echo videos, can automate complete echocardiographic interpretation — from LVEF to valvular disease — with diagnostic AUCs up to 1.00 and MAE as low as 4.2%. 🌍 Validated across international cohorts, including point-of-care settings, this tool could redefine access, acc…

1
🧠💡 Memory Matters: A Cardiologist’s Guide to Cognitive Care 5:13

5d ago5:13

5:13

🧠💓 Cognitive decline and cardiovascular disease often go hand in hand — but they don’t have to spiral together. In our latest breakdown, we explore how cardiologists can detect, manage, and even improve cognitive impairment through smart risk factor control, lifestyle changes, and a multidisciplinary approach. From MoCA to memantine, TAVR to team-b…

1
Adjuvants & Alzheimer’s: A Shot at Prevention 💥🧬🧠 4:11

5d ago4:11

4:11

🧠💉 Can vaccines protect the mind? New research suggests that AS01-adjuvanted vaccines like Shingrix and Arexvy may reduce the risk of dementia—possibly by stimulating immune pathways like IFN-γ and TLR4, not just by preventing infection. 📊 In a large US-based EHR study, those who received the RSV or shingles vaccine had a significantly lower 18-mon…

1
💉 Pump, 📉 Pressure, ⚡ Power: Inside the STEMI Shock Solution 4:26

6d ago4:26

4:26

New Insights from the DanGer Shock Trial! 🫀💡 Can early left ventricular unloading with a microaxial flow pump (mAFP) save lives in STEMI-related cardiogenic shock? This compelling substudy shows that mAFP not only boosts cardiac output and power, but also reduces pulmonary pressures—all while using less pharmacologic support. 📉💊 🧪 Native CO improve…

1
🌐 ACHIEVE-1 Decoded: Efficacy & Safety of Orforglipron in Type 2 Diabetes 3:43

6d ago3:43

3:43

🚨 New Breakthrough in Type 2 Diabetes Care! 💊🧬 The ACHIEVE-1 trial shows that Orforglipron, a once-daily oral, nonpeptide GLP-1 receptor agonist, delivers significant reductions in HbA1c and body weight—without injections and with minimal restrictions! 🌍📉 👨‍⚕️ 559 patients across 5 countries ⏱️ 40 weeks, 3 dosing arms (3, 12, 36 mg) 📊 HbA1c ↓ by up…

1
Frailty as a Cardiovascular Compass 🧭📉🩻 4:54

7d ago4:54

4:54

🚨 Frailty matters — even in the cath lab! 🧓🫀 A new NCDR registry analysis of 1.3M+ older adults shows a clear gradient: as frailty increases, so do complications, mortality, and procedural risks during PCI. Severely frail patients faced a striking 20.3% in-hospital mortality and >50% mortality with cardiogenic shock. 🧠 It’s time to treat frailty as…

1
🧬 Amylin & GLP-1: Double Agents for Weight Loss & DM-CagriSema (Part II) 7:00

7d ago7:00

7:00

🚨 Major breakthrough in obesity pharmacotherapy! The REDEFINE-1 & REDEFINE-2 trials show that once-weekly CagriSema (Cagrilintide + Semaglutide) delivers up to 20% weight loss in people with obesity—and significant glycemic improvements in those with type 2 diabetes. 💉📉 🌍 Global, double-blind RCTs ⚖️ >90% lost ≥5% body weight 🩺 SBP ↓, QoL ↑, predia…

1
🌲 Burning Risk: How Wildfires Ignite Heart Failure 📉 4:23

8d ago4:23

4:23

🔥 New Study Alert! 🩺 Wildfire smoke isn’t just a respiratory threat — it’s taking a toll on the heart, especially in older adults. 📊 A nationwide Medicare cohort (~22M) shows that long-term exposure to wildfire-specific PM2.5 is linked to significantly higher heart failure risk — more so than urban pollution. 📍 Vulnerable groups — women, Medicaid-e…

1
🧬 Amylin & GLP-1: Double Agents for Weight Loss (Part 1) 6:10

8d ago6:10

6:10

🧠💊 Appetite Meets Its Match: The Amylin Advantage” In this episode of Got Knowledge Doc, we explore how amylin, the lesser-known hormone co-secreted with insulin, is making a comeback — this time as part of a dual receptor strategy with GLP-1. 💡 Learn how amylin: 🧠 Activates brainstem satiety centers ⏳ Delays gastric emptying 📉 Suppresses glucagon …

1
The Dads Do Disney: Snow White and The Seven Dwarfs (1937) 53:39

8d ago53:39

53:39

Hi-ho, hi-ho, it's off to Disney we go! Welcome to "The Dads Do Disney," a new series from Cocktails & Classics! For our inaugural episode, we're diving into the enchanting world of Disney's first animated feature, "Snow White and the Seven Dwarfs" (1937). Join us as we explore this groundbreaking classic, from its animation innovations to its time…

1
2% of Aussies Own Crypto - But 89% of Advisors Won’t Talk About It ft. Andrew McPhee 29:22

9d ago29:22

29:22

Australia is one of the top 10 countries globally for Crypto Adoption but so many people in the financial sector still won’t talk about it. Today Pav Hundal and Ted Coaldrake are joined by Director of Synergist, Andrew McPhee who has over 30 years of experience ranging starting way back in traditional finance as Head of Retail for E*Trade, working …

1
⏱️🩸 Timing is Brain: Early DOACs in Atrial Fibrillation 4:43

9d ago4:43

4:43

🧠💉 When should you start anticoagulation after an ischaemic stroke in atrial fibrillation? The CATALYST meta-analysis may have the answer! 📊 5,441 patients from 4 RCTs ⏱️ Early DOAC (≤4 days) reduced recurrent stroke risk at 30 days ⚖️ No increased bleeding, even in moderate stroke severity 🚫 But patients with PH2 or very severe strokes were exclud…

1
🧠 Restore, Regulate, Reimagine Type 1 Diabetes 3:18

9d ago3:18

3:18

🚨 Breakthrough in Type 1 Diabetes! 🧬💉 A new study in NEJM shows that zimislecel, a fully differentiated stem cell–derived islet therapy, restored insulin production and led to insulin independence in 83% of participants! ✅ 📉 HbA1c dropped, 📈 time-in-range soared to 93%, and ⚖️ glucose variability was dramatically reduced. This marks a major step to…

1
🧘‍♂️📉 Fitness on the Floor: Predicting Death with a Sit 3:48

10d ago3:48

3:48

🧘‍♂️ How Well Can You Sit and Rise from the Floor? 🪑⬆️ That simple motion might say more about your longevity than you think. A 12-year study of 4,282 adults found that lower Sit–Rise Test (SRT) scores predicted 3.8x higher natural death and 6x higher cardiovascular death rates. 😱 ✅ No equipment ✅ Under 2 minutes ✅ Predicts survival Why aren’t we u…

1
Dr. RR Baliga’s Philosophical Discourses: Aristotle (Greece, 384–322 BCE) – Founder of the Lyceum 2:38

10d ago2:38

2:38

Aristotle (384–322 BC), a Greek philosopher and polymath, founded the Peripatetic school and Lyceum in Athens. His extensive works spanned diverse fields, including logic, ethics, politics, biology, and metaphysics, profoundly influencing Western thought, science, and philosophy.By MasterMedFacts LLC

1
⚡Gatekeepers of Strength: Allopurinol, Calcium & the RyR Revolution 4:23

11d ago4:23

4:23

⚡Gatekeepers of Strength: Allopurinol, Calcium & the RyR Revolution”! Did you know that an old gout drug might hold the key to reversing age-related muscle weakness and heart failure? Using cryo-EM, researchers found that allopurinol and xanthine derivatives directly activate ryanodine receptors—calcium channels essential for muscle contraction. 💡 …

1
🧠🔥 Flame Within the Brain: Neuroinflammation Decoded 5:24

11d ago5:24

5:24

🧠🔥 Neuroinflammation: The Common Flame in MS, Stroke, Alzheimer’s & Parkinson’s Why do microglia flip from guardians to arsonists? How does immune cell infiltration differ between MS and AD? And which CNS-penetrant therapies show the most promise in dousing the inflammatory fire? In our latest Got Knowledge Doc podcast, we decode the science behind…

1
EF Up, Risk Still On 📈🧠⚠️: Understanding the Fragile Success of HF Recovery 6:00

12d ago6:00

6:00

🔬💓 New Insights on HFimpEF 💓🔬 Heart Failure with Improved Ejection Fraction (HFimpEF) is no longer just a transition phase—it’s a distinct, dynamic phenotype with its own risks and management needs. From biomarkers and imaging to the latest trials like PROSPER-HF and FINEARTS-HF, we’re entering an era of more personalized care for these patients. 📈…

1
🧠 🎛️💡 Master Control: Is the Brain Orchestrating Aging? 2:28

12d ago2:28

2:28

🧠 Is your brain orchestrating how fast you age? New insights suggest that aging isn’t just about wear and tear—it may be centrally coordinated by the brain through molecules like GDF15, responding to stress, senescence, and energy demands. 💬 Fascinating findings from Nature (June 2025) show how psychological stress accelerates aging at a cellular l…

1
💊❤️🔥Obesity:- Hormones, Hearts, and Hope; The Cardiologist’s New Toolkit 6:07

13d ago6:07

6:07

“Obesity Rx 💊❤️🔥: Hormones, Hearts, and Hope” The 2025 ACC guidance reframes obesity as a chronic disease—with precision therapies like GLP-1/GIP agonists now essential in cardiology. We explore NuSH therapies (semaglutide, tirzepatide), the latest trial data, clinical thresholds for risk reduction, and practical steps for de-stigmatizing care. 👉 T…

1
Ep. 32. Belisarius: The Last of the Great Roman Generals 2:00:40

13d ago2:00:40

2:00:40

Who was Belisarius—the man who nearly rebuilt the Roman Empire under Justinian I? From the deserts of North Africa to the ruins of Gothic Italy, Belisarius led brilliant campaigns that stunned both enemies and emperors. In this episode, we trace his rise from obscure origins to his legendary victories in the Vandalic and Gothic Wars, and explore wh…

1
🥗🧬💊 “Eat Less or Pop a Pill? Rapamycin vs. Metformin 3:48

13d ago3:48

3:48

🔬 New meta-analysis alert! 🧪 Researchers compared rapamycin and metformin to dietary restriction across 167 studies in 8 vertebrate species. 📈 Key finding: Rapamycin mirrors dietary restriction’s longevity benefits—but metformin falls short. ⚠️ High heterogeneity and species bias remind us: translation to human health still needs careful navigation…

1
🫀 Cells, Senescence, and Survival: How the Heart Ages 5:42

14d ago5:42

5:42

🫀 The Heart Ages—But Can We Intervene? New insights from Nature Reviews Cardiology highlight how endothelial dysfunction, inflammageing, CHIP, and senescence-associated secretory phenotypes (SASP) drive cardiovascular ageing. Promising interventions—from gerotherapeutic diets and exercise to NAD+ boosters, senolytics, and ACBP neutralization—may he…

1
🧬Genes, Clocks, and Global Gaps: UN Insights on Aging 4:05

14d ago4:05

4:05

We unpack the UN Scientific Advisory Board Brief on Aging—from telomeres and epigenetic clocks 🧫 to senolytics 💊 and AI-driven geroscience 🤖. Why does aging matter to every clinician? Because aging is the common soil of all chronic disease. 🌱 🔗 Listen now and join the longevity conversation! #Aging #UNBrief #Geroscience #Epigenetics #Healthspan #Go…

1
🧠 Brains, Beating Hearts, and Bioethics: Human Cells in Animal Bodies 💓 4:02

15d ago4:02

4:02

🚨 Game-changing breakthroughs in chimaera research! 🧬💓 From beating human hearts grown in pig embryos to human organoids integrating into mouse intestines and brains via amniotic injection—two bold advances are reshaping the future of organ transplantation and regenerative medicine. But with scientific promise comes ethical complexity. How far shou…

1
Vitamin D: Broad Hopes, Narrow Proof? 3:11

15d ago3:11

3:11

🌞 New Guidelines on Vitamin D Supplementation! 💊🧪 JAMA’s latest synopsis recommends empirical vitamin D dosing—without routine testing—for children, the elderly, pregnant women, and those with prediabetes. The evidence? Conditional, with wide confidence intervals—but the low cost and minimal harm may tip the scales. Let’s discuss: Is this the dawn …

1
The Greatest Heist Scene Ever? Mission: Impossible (1996) 52:44

15d ago52:44

52:44

Your mission, should you choose to accept it... This week on Cocktails & Classics, we're taking on the original spy thriller masterpiece, "Mission: Impossible" (1996)! Join us as we dissect Brian De Palma's masterful direction, Tom Cruise's iconic performance as Ethan Hunt, and that legendary vault heist. We'll unmask the mole, marvel at the incred…

1
He predicted the last Crypto Crash - here’s what @ASXTrader says is coming next 23:17

16d ago23:17

23:17

If you’ve been confused by the current market today’s guest has predicted the top of the market twice AND he called the covid crash before it happened. This week Pav Hundal and Ted Coaldrake are joined by David Bird (ak the ASX Trader) to talk to us about when alt-season is coming, what noise you SHOULD be paying attention to and what is actually h…

1
.📜 “The Brussels Declaration 🎯: Prevent the Preventable: The Lp(a) Revolution Begins 2:39

16d ago2:39

2:39

🚨 One in five people carry a hidden cardiovascular risk—do you? The Brussels Declaration on Lipoprotein(a) calls for global, once-in-a-lifetime Lp(a) testing to prevent premature heart disease and stroke. With strong scientific backing and health equity at its core, this is a pivotal step toward personalized cardiovascular prevention. 🧬 Let’s test …

1
Switching Gears: From Fetal Hemoglobin to Gene Therapy 3:53

16d ago3:53

3:53

From baby blood to breakthrough cures — we explore how unlocking fetal hemoglobin through gene editing (exa-cel/Casgevy) is transforming treatment for sickle cell disease and β-thalassemia. 🧬✂️ Featuring the science of BCL11A, CRISPR therapies, and what the future holds for global access 🌍💉 🎧 Tune in: “Switching Gears: From Fetal Hemoglobin to Gene…

1
Valve by Valve: Treat Early, Treat Right, Treat Once 3:47

17d ago3:47

3:47

Treat it Early. Treat it Right. Treat it Once. New Lancet comment calls for a paradigm shift in heart valve disease care—advocating early referral, multidisciplinary heart networks, and lifetime management strategies that prioritize durability over delay. Surgery isn’t the villain—delay is. #Cardiology #HeartValveDisease #PrecisionMedicine #Surgica…

1
Dr RR Baliga's Philosophical Discourses: Vasubandhu (India, c. 4th Century CE) – Co-Founder of Yogacara School 3:38

17d ago3:38

3:38

Vasubandhu was a 4th–5th century Indian Buddhist monk, philosopher, and co-founder of the Yogācāra school of Mahayana Buddhism. Renowned for his works on Abhidharma, he developed key philosophical concepts such as “consciousness-only” (vijñaptimātra) and authored texts on Buddhist metaphysics, logic, and meditation. His influential treatises, inclu…

1
Shear Genius: Clot Control, Microstructure Mastery, Revascularization 🚀🧠🔬 3:19

18d ago3:19

3:19

🧠💥 New spin on stroke care! The Milli-Spinner thrombectomy device shrinks clots by up to 95% using shear + compression — no rupture, no fragments. 🚑 Achieves revascularization in 90%+ cases, even when aspiration fails. #Stroke #Innovation #NeuroTech 🔄🩸🔬 📖 https://doi.org/10.1038/s41586-025-09049-0By MasterMedFacts LLC

1
🔥 Age, Immune, Inflamming: Cracking the Code of Aging 🧬🛡️ 6:38

18d ago6:38

6:38

🔥 Immunosenescence + Inflammaging = Aging’s hidden engines. 🧬 New studies link immune decline to frailty, dementia, and disease. 🥗💉 Sleep, diet, vaccines, and GLP-1s may slow the clock. #Healthspan > #Lifespan 💡👴🛡️ Derived from Dr. Eric Topol’s Ground Truths on Substack.By MasterMedFacts LLC

1
"The Final Showdown: Timothy McVeigh and the Tournament of Mad Men Season 1 Finale" 41:47

18d ago41:47

41:47

Send us a text You Might Be a Madman: The Tournament of Mad Men – Season 1 Finale Welcome to the season one finale of 'You Might Be a Madman,' the game show podcast where your ability to think like history's most notorious figures is put to the test. Hosted by John Zap, this episode features three contestants—Sheiby, Dave, and Emmett—as they compet…

1
Beyond the Blockage: Arrhythmias, Aging, and Aortic Storms ⏳⚡🌀 2:45

19d ago2:45

2:45

Heart attacks & strokes are down, but guess what’s rising? ⚡ Atrial fibrillation, 🫀 valve disease, & 🩸 VTE are taking the lead! It’s time to rethink prevention: from plaque to pulse to prognosis. 🧠💊📊 #CardioTwitter #HeartHealth #TheLancet https://doi.org/10.1016/S0140-6736(25)00990-0By MasterMedFacts LLC

1
Fructose, Anxiety, Fear, and the Brain 🍭😨🧠 3:35

19d ago3:35

3:35

🧠🍬 New study in Nature reveals: High-fructose exposure in early life impairs brain development by suppressing microglial phagocytosis via GLUT5 ➡️ HK2-driven metabolic rewiring. Result? 🐭 develop anxiety-like behavior. Cut the sweet talk. Think before you drink. #NeuroScience #FructoseFacts #MentalHealth 🧪🍼…

1
🏃‍♂️ Weight, Wellness, and the Weakening Heart 4:28

20d ago4:28

4:28

🚨 New 2025 ACC Statement! Obesity worsens heart failure—but weight loss changes the game. 🏃‍♂️ Lifestyle helps. 💊 Semaglutide & tirzepatide show promise in HFpEF. 🔬 Rethink BMI. ⚖️ Precision + empathy = better outcomes. 👇 Dive into key takeaways. #CardioTwitter #Obesity #HeartFailureBy MasterMedFacts LLC

1
Forks, Frailty, and Forgetfulness 🦷➡️🧠: Mapping Malnutrition in Old Age 4:01

20d ago4:01

4:01

👵🍽️ Malnutrition in aging isn’t just about food — it’s frailty, forgetfulness, and function. The DoMAP model 🧠🔺 reveals how low intake, high needs, and poor absorption collide with social, physical & mental challenges. Let’s fix the hidden hunger. 🥣❤️ #Geriatrics #Malnutrition #HealthyAgingBy MasterMedFacts LLC

1
💊 Ditch the Aspirin? 🔄 P2Y12 Prevails 🛡️ After PCI 4:30

21d ago4:30

4:30

🚨 New BMJ meta-analysis! After PCI & stopping DAPT, P2Y12 inhibitor monotherapy 💊 reduces MACCE 🧠❤️ (HR 0.77) vs aspirin — without more major bleeding 💉 🫀 MI & stroke ↓ 📊 16,117 pts, 5 trials 🧠 Smarter post-PCI strategy? #CardioTwitter #BMJ #PCI #P2Y12 #Aspirin 🚫By MasterMedFacts LLC

1
💉 T Cells, TCF7, and Time ⏱️: The Immune Key to Longevity: When transcription meets transformation 4:09

21d ago4:09

4:09

🧬 New study in Aging Cell finds immune resilience—anchored by TCF7 expression—confers a 🚀 15.5-year survival advantage! 💥 SAS-1 high / MAS-1 low = 🔑 to longevity 👵 Midlife is the window. 🧠 Age is biology, but resilience is destiny. #Longevity #Aging #Immunology #TCF7By MasterMedFacts LLC

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