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⏱️🩸 Timing is Brain: Early DOACs in Atrial Fibrillation

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Manage episode 490809069 series 2740117
Content provided by MasterMedFacts LLC and RR Baliga MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC and RR Baliga MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.

🧠💉 When should you start anticoagulation after an ischaemic stroke in atrial fibrillation? The CATALYST meta-analysis may have the answer!

📊 5,441 patients from 4 RCTs

⏱️ Early DOAC (≤4 days) reduced recurrent stroke risk at 30 days

⚖️ No increased bleeding, even in moderate stroke severity

🚫 But patients with PH2 or very severe strokes were excluded

Individual Participant Data Meta-Analysis allowed detailed subgroup analysis and minimized bias

💡 Clinical Takeaway: In most mild-to-moderate strokes, don’t delay—start DOACs early!

📄 #Stroke #AtrialFibrillation #CATALYST #DOAC #Neurology #Cardiology #MetaAnalysis #IPDMA #ClinicalTrials #PrecisionMedicine #StrokePrevention

  continue reading

540 episodes

Artwork
iconShare
 
Manage episode 490809069 series 2740117
Content provided by MasterMedFacts LLC and RR Baliga MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by MasterMedFacts LLC and RR Baliga MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.

🧠💉 When should you start anticoagulation after an ischaemic stroke in atrial fibrillation? The CATALYST meta-analysis may have the answer!

📊 5,441 patients from 4 RCTs

⏱️ Early DOAC (≤4 days) reduced recurrent stroke risk at 30 days

⚖️ No increased bleeding, even in moderate stroke severity

🚫 But patients with PH2 or very severe strokes were excluded

Individual Participant Data Meta-Analysis allowed detailed subgroup analysis and minimized bias

💡 Clinical Takeaway: In most mild-to-moderate strokes, don’t delay—start DOACs early!

📄 #Stroke #AtrialFibrillation #CATALYST #DOAC #Neurology #Cardiology #MetaAnalysis #IPDMA #ClinicalTrials #PrecisionMedicine #StrokePrevention

  continue reading

540 episodes

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