Fixing the Scales - How Re-Balancing Agents Work

Ask The Expert Presents Hemophilia on Balance

In this episode of Ask the Experts, host Amy Board breaks down one of the most exciting developments in bleeding disorders treatment — rebalancing agents. Think of your body’s clotting system like a seesaw: when everything’s working right, it’s balanced. But in bleeding disorders, the scale tips. Instead of adding what’s missing (like clotting factors), rebalancing agents work by removing what’s getting in the way — helping to restore that balance in a totally new way.

Amy is joined by Dr. Ben Samuelson Jones, Dr. Patrick Ellsworth, and Dr. Tami Singleton for a deep dive into how these therapies work, how they were inspired by what’s already happening naturally in the body, and what makes them so promising. From TFPI antibodies to small interfering RNA treatments like Fitusiran, these cutting-edge approaches could transform care for many.

The experts also discuss the crucial role of patient participation in ongoing studies and why your voice matters in shaping the future of treatment. It’s a hopeful, eye-opening conversation about how innovation is changing the game for bleeding disorders — and what comes next.

Presenting Sponsor:

Presented by Sanofi

For too long, women and girls who bleed have been dismissed. Left out of the narrative. Ignored by the system. But not anymore.

In our new film, “Dismissed,” meet Isabelle—a 15-year-old with hemophilia who’s using her voice to uplift the unheard. Alongside her are four powerful stories of women challenging what’s "normal" and demanding recognition, care, and justice.

This is more than a film. It’s a movement.

📽️ Watch and share the trailer now. Learn more at http://dismissedfilm.com/

Sanofi’s Global Hemophilia Survey uncovers significant care gaps and emotional challenges faced by patients and caregivers. Learn how improving health literacy and fostering better patient-provider communication are essential to addressing these inequities. Explore the findings and see how Sanofi is driving health equity for the hemophilia community. Explore the survey findings here: Global Hemophilia Survey Page.

Show Notes:

Ask the Expert is produced by Believe Limited, and is found only on the BloodStream Media Podcast Network.

Presented by Sanofi

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