#155: Ray Dalio’s Playbook — 7 Principles for Building Scalable, Resilient Companies

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#Trading #Entrepreneur #Business #Christian Soschner #Startup #Tech #Life Sciences #Health and Well-Being

13:44

Legendary actor and mental health advocate Glenn Close is on a quest to change how we think about mental health, starting with her decision to speak out about her own family's struggles — a brave choice considering the stigma that pervades the topic. This week, we're revisiting this sweeping conversation with TEDWomen curator Pat Mitchell, where Close shares the inspiration behind the advocacy group she founded to combat the crisis, underscoring the transformative power of community and the critical need for comprehensive mental health care systems. Want to help shape TED’s shows going forward? Fill out our survey ! Hosted on Acast. See acast.com/privacy for more information.…

about a year ago 56:56

MP3•Episode home

What if your business ran like a well-designed machine—one that could evolve, self-correct, and outperform your competition over decades?

In this episode, I unpack Principles by Ray Dalio, the billionaire investor and founder of Bridgewater Associates, the world’s largest hedge fund. It’s not a traditional business book—it’s a blueprint for decision-making, culture design, and long-term scaling, rooted in clarity, transparency, and radical self-honesty.

This episode is built for venture capitalists, executives, and operators leading at scale—those who are no longer improvising but building enduring systems.

You’ll hear the 7 most actionable principles Dalio used to scale Bridgewater, reimagined for anyone building the future—from biotech to AI, from global funds to market-leading enterprises.

We cover how to engineer feedback cultures, design for evolution, and drive decisions that compound over time. And we tackle the big question: Can you be both a high-performance machine and a human-centered leader?

Key Takeaways:

Think Like a Machine: Build systems that run without your constant input.
Get the People Right: Talent isn’t enough—character and growth capacity matter most.
Radical Transparency: Trust is built by saying the hard things early and often.
Idea Meritocracy: Don’t default to consensus. Weight decisions by experience.
Shaper Thinking: Zoom out to vision, zoom in to execution—and toggle constantly.
Diagnose the Root Cause: Don’t waste time solving symptoms.
Open-Mindedness as Strategy: Challenge your thinking before reality does.

Timestamps:

(00:00) Intro: The Principles
(02:15) Why This Book Matters If You’re Building or Investing in the Future
(04:14) Who Is Ray Dalio?
(06:21) The Snapshot: What Principles Is Really About
(10:05) Build Your Company Like a Machine, Not a Hero’s Journey
(15:29) Get the People Right
(20:40) Radical Truth & Transparency Are Force Multipliers
(26:08) Build an Idea Meritocracy
(32:26) Shapers Win—They Dream Big, Think Clear, Execute Ruthlessly
(37:37) Diagnose Root Causes, Not Symptoms
(44:02) Be Radically Open-Minded
(50:12) Key Takeaways & Personal Reflection

Why Listen:

Learn how billion-dollar systems are designed and scaled
Identify blind spots in your leadership, org design, or investment theses
Equip yourself with 7 operating principles you can implement this quarter
Reframe your relationship to truth, conflict, and growth
Decide whether to build a machine—or remain the operator

If these ideas resonate, I strongly recommend reading Principles in full. Or better yet—share this episode with someone you think is ready to level up how they lead and build.

Send us a text

Support the show

Join the Podcast Newsletter: Link

200 episodes

#155: Ray Dalio’s Playbook — 7 Principles for Building Scalable, Resilient Companies

Beginner's Mind

published about a year ago

MP3•Episode home

What if your business ran like a well-designed machine—one that could evolve, self-correct, and outperform your competition over decades?

This episode is built for venture capitalists, executives, and operators leading at scale—those who are no longer improvising but building enduring systems.

You’ll hear the 7 most actionable principles Dalio used to scale Bridgewater, reimagined for anyone building the future—from biotech to AI, from global funds to market-leading enterprises.

Key Takeaways:

Think Like a Machine: Build systems that run without your constant input.
Get the People Right: Talent isn’t enough—character and growth capacity matter most.
Radical Transparency: Trust is built by saying the hard things early and often.
Idea Meritocracy: Don’t default to consensus. Weight decisions by experience.
Shaper Thinking: Zoom out to vision, zoom in to execution—and toggle constantly.
Diagnose the Root Cause: Don’t waste time solving symptoms.
Open-Mindedness as Strategy: Challenge your thinking before reality does.

Timestamps:

Why Listen:

Learn how billion-dollar systems are designed and scaled
Identify blind spots in your leadership, org design, or investment theses
Equip yourself with 7 operating principles you can implement this quarter
Reframe your relationship to truth, conflict, and growth
Decide whether to build a machine—or remain the operator

If these ideas resonate, I strongly recommend reading Principles in full. Or better yet—share this episode with someone you think is ready to level up how they lead and build.

Send us a text

Support the show

Join the Podcast Newsletter: Link

200 episodes

#Trading #Entrepreneur #Business #Christian Soschner #Startup #Tech #Life Sciences #Health and Well-Being

All episodes

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1
#159: No Rules Rules — 7 Culture Principles That Made Netflix Unstoppable 52:52

11 hours ago52:52

52:52

Most founders add layers to gain control. Reed Hastings built an empire by removing them. This episode unpacks No Rules Rules —the leadership playbook behind Netflix’s rise from a DVD mail service to a global entertainment powerhouse. Co-authored by founder Reed Hastings and INSEAD professor Erin Meyer, the book reveals how to scale not through policy, but through trust, talent density, and extreme transparency. But this isn’t just about Netflix. It’s about you—if you’re building or investing in companies between Series A and IPO, where culture either compounds performance or quietly kills it. I walk you through 7 operational principles that deep-tech teams can apply now—lessons forged in crisis, growth, and reinvention. You’ll learn how to sunshine mistakes, pay like a pirate, and lead without becoming a bottleneck. Each principle is translated into coaching prompts, ready to implement this week. Key Takeaways: Culture Outruns Capital : Don’t optimize the engine—reinvent the vehicle. Pro Team > Family : Loyalty is earned through excellence, not tenure. Candor Drives Speed : Build feedback loops that fuel progress. Pay Top of Market : Buy peace of mind. Unlock creative flow. Bet Boldly : Seek dissent. Test. Learn. Repeat. Context Beats Control : Share the why. Let them own the how. Transparency = Trust : Open up, even when it’s uncomfortable. Timestamps: (00:00) Intro – Why Netflix Scaled Faster by Removing Rules, Not Adding Them (04:30) Who Is Reed Hastings? – From Math Teacher to Global Disruptor (09:13) Book Snapshot – What Makes No Rules Rules a Real Operating System (11:35) Lesson 1: Culture Outruns Capital – How Netflix Survived 4 Disruptions, Blockbuster Didn’t Survive One (17:25) Lesson 2: Build a Pro Team, Not a Family – Talent Density Over Loyalty (22:48) Lesson 3: Radical Candor = Speed – The Feedback Model That Fuels Innovation (27:34) Lesson 4: Pay Like a Pirate – Why Netflix Pays Top of Market—No Games, Just Outcomes (32:20) Lesson 5: Bet Bold, Fail Proudly – The 4-Step Innovation Cycle That Keeps Netflix Ahead (39:12) Lesson 6: Lead with Context, Not Control – Scaling Leadership Without Becoming a Bottleneck (43:28) Lesson 7: Transparency Builds Velocity – How Truth-Telling Became Netflix’s Superpower (48:15) 7 Key Takeaways – The Culture Playbook Every Growth-Stage Founder Needs (50:15) Personal Reflection – What I Questioned, What I’ll Steal, What Gave Me Pause (52:00) Call to Action + What’s Next – Support the Show + Tease of the Next Episode Why Listen: Learn how Netflix scaled without micromanagement Get 7 principles that push your org design, talent strategy, and leadership edge Discover where you're still playing defense—when your culture should be your offense Upgrade your leadership thinking with real examples and immediate applications Found this useful? Like, share, and follow. Every signal grows the show—and brings in more elite guests ready to share the truths behind high-growth success. Send us a text Support the show Join the Podcast Newsletter: Link…

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EP 158 - Rafael Rosengarten: Why 90% of Cancer Drugs Fail — and the Radical AI Fix You’ve Never Heard Of 2:00:48

16 days ago2:00:48

2:00:48

Most cancer drugs fail. Not because the science is wrong—because we’re solving the wrong problems. The cost? Over $2 billion per failure. And for the patient waiting on a miracle—there’s no second chance. Behind the headlines of “precision medicine,” there’s a deeper story nobody’s telling. Until now. 🎯 Enter Rafael Rosengarten , the scientist-turned-founder who’s rewriting the rules of drug development. In this gripping conversation, we unpack how RNA, AI, and deep empathy could finally close the loop between biology, data, and the patient in the room. 🎧 Watch now to explore: 1️⃣ Why drug failure isn’t a tech problem—it’s a strategy problem 2️⃣ How “information companions” will guide every medicine to the right patient 3️⃣ What pharma keeps getting wrong about biomarkers—and how to fix it 4️⃣ The untold story behind turning down a chef’s job on a Mediterranean yacht 5️⃣ The real reason Genialis may one day go out of business (and why Rafael hopes it does) 👤 About Rafael Rosengarten Rafael is CEO and co-founder of Genialis, the RNA biomarker company reshaping precision oncology. From academic labs to Michelin-star kitchens, his journey is anything but linear—but his mission is clear: make medicine make sense. With partners across pharma, diagnostics, and AI, Genialis is creating a world where every patient gets the treatment they actually need. 💬 Quotes That Might Shift Your Thinking: (00:58:37) “Our AI biomarkers de-risk clinical trials, slashing costs and saving lives.” (01:54:46) “Every drug will have an information companion guiding it to the right patient.” (01:14:32) “AI should free humans for empathy and creativity, not replace them.” (00:14:13) “We now have the tools to treat every cancer as unique to each patient.” (01:31:38) “Stop selling technology; sell solutions to real problems.” 🧭 Timestamps to Explore: (00:03:52) Inside the World’s Largest Medical Center (00:10:30) How AI Is Rewiring Precision Medicine (00:13:51) Why Precision Medicine Is Scaling Now (00:17:34) Startups Must Solve Market Needs First (00:23:53) Culture First, Then Business: Startup Blueprint (00:27:57) Cancer Isn’t One Disease—It’s Thousands (00:31:44) Predicting Drug Success with AI Biology (00:36:40) Reimagining Biomarkers Using RNA and AI (00:47:45) Why Early Detection Still Saves Lives (00:57:30) Why Most Cancer Drugs Still Fail (00:58:37) AI Biomarkers That De-Risk Clinical Trials (01:09:42) Rethinking Dosage with Predictive Algorithms (01:13:33) Why Human Intuition Still Matters in Science (01:36:41) The Crystal Ball Question Pharma Can’t Ignore (01:50:19) The moment where time disappears—and the real future begins. (01:53:39) Every Drug Will Have an AI Companion 🔔 Let’s Rebuild Trust in Medicine—Together If this episode sparked a new thought—or just gave you pause—don’t let it end here. Subscribe. Share it with someone who still believes medicine can be both scientific and deeply human. Every action brings in minds like Rafael’s… and gets us one step closer to treatments that truly heal. 🎧 Watch now—and discover how medicine gets smarter, safer, and more personal. Send us a text Support the show Join the Podcast Newsletter: Link…

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EP 157 - Fabrizio Conicella: Why Europe Keeps Losing the Next Breakthroughs in Medicine 2:00:46

29 days ago2:00:46

2:00:46

Europe has the science. The talent. The breakthroughs. But when an idea feels too uncertain, our systems shut it down before it has a chance to breathe. And with every safe bet… we quietly lose the next cure, the next Car-T, the next AI that could change everything. 🚨 Risk-aversion, fragmentation, and bureaucracy are draining Europe’s innovation power—and nobody dares to name it out loud. But Fabrizio Conicella , VP of Open Innovation at Chiesi Group, isn’t holding back. 💡 In this deep, urgent conversation, Fabrizio shares how Europe can build the ecosystems we need to turn bold ideas into real-world impact—without compromising ethics, patients, or long-term value. 🎧 Watch now to explore: 1️⃣ Why uncertainty, not risk, is the true frontier of innovation 2️⃣ The hidden reasons startups leave Europe—and how to keep them 3️⃣ How Chiesi’s “The Impulse” model flips corporate R&D on its head 4️⃣ What every policymaker, CEO, and scientist must change before it’s too late 5️⃣ A bold new playbook for turning visionary science into trusted medicine 👤 About Fabrizio Conicella: As one of Europe’s leading voices in health innovation, Fabrizio is pioneering how pharma collaborates across startups, data, and ethics. His mission: create environments where the best ideas don’t get shut down—they get built. 💬 Quotes That Might Just Change Your Thinking: (01:58:01) "Be bold enough to dream, but pragmatic enough to make it real." (01:07:22) "Science is essential, but turning it into a product requires a different kind of wisdom." (01:04:35) "Visionary entrepreneurs see the future and change the game." (00:16:51) "Innovation today is no longer a race for ownership, but a journey of collaboration." (00:47:55) "If the idea is truly bold, no pharma company can replicate it without you." ⏱️ Timestamps: (03:00) Europe’s Innovation Crisis: A Wake-Up Call (08:19) Chiesi’s Bold B Corp Strategy (16:26) Building Healthcare Innovation Ecosystems (22:09) Predictive Medicine and Patient Data (29:49) Pharma vs. Startup Ecosystems Today (34:38) Why R&D Must Go External (35:06) The End of Buy-and-Wait Pharma (41:42) Ethics First: Pharma’s New Mandate (44:06) Respecting Founders, Not Just IP (47:23) Debunking the 'Pharma Steals Ideas' Myth (54:10) Why Pharma Moves Slowly—but Must Adapt (59:25) Market Acumen: Startups’ Missing Ingredient (01:04:35) What Makes a Visionary Entrepreneur (01:29:22) Embracing Failure to Spark Innovation (01:46:01) Europe’s Risk Culture is Holding Us Back 🔔 Help Us Grow the Future of Thoughtful Innovation If this conversation sparked something in you—an insight, a question, a sense of urgency—help us keep it alive. Subscribe. Leave a comment. Share it with someone who still believes bold ideas deserve a fighting chance. Every action brings in deeper minds, bigger questions, and the kind of leadership our systems so desperately need. Book mention : The Venture Mindset 🎧 Watch now—and join the movement to rebuild Europe’s innovation edge. Send us a text Support the show Join the Podcast Newsletter: Link…

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1
EP 156 - Janos Pasztor: The Most Controversial Fix for Climate Change 2:59:21

6 weeks ago2:59:21

2:59:21

What if the only way to save the planet... is to cool it? Not figuratively— literally . Because the heatwaves, floods, and fires you’ve seen so far? They’re just the beginning. 🌍 Emissions keep rising. Global cooperation is slowing. And the window to act is closing fast. Now, world leaders are quietly weighing a radical idea: Should we artificially cool Earth before it’s too late? 💥 In this explosive episode, we dive into the most controversial climate strategy on the table today: solar radiation modification . But who decides how much cooling is “enough”? What happens if we act too late—or worse, too soon? 📌 In this episode, Janos Pasztor —former UN Assistant Secretary-General for Climate Change and climate advisor to Ban Ki-moon—breaks his silence on the plans world leaders are only now beginning to confront. 🎧 Watch now to uncover: 1️⃣ Why geoengineering may soon become a global necessity—not a fringe idea. 2️⃣ What governments aren’t telling you about unilateral climate interventions. 3️⃣ The ethical, political, and scientific minefield behind planetary cooling. 4️⃣ Why some scientists say this tech could save millions—and others call it madness. 5️⃣ What it will take to govern Earth’s thermostat before someone does it alone. 👤 About Janos Pasztor: With nearly 50 years of experience in climate policy, diplomacy, and governance, Pasztor has shaped global climate strategy from inside the UN and beyond. From the 1992 Earth Summit to the corridors of the UN Security Council, he’s been advising heads of state on how to confront the world’s most complex crisis—and now, he’s sharing what’s coming next. 💡 Quotes to Challenge Your Thinking: (00:08:41) “We must ask: is it time to start cooling parts of the planet?” (01:21:07) “Stratospheric aerosol injection could cool the planet—yet we barely understand its consequences.” (01:11:03) “The real question is whether capitalism can evolve beyond its dependence on resource extraction.” (02:24:41) “Three degrees of warming is cuckoo land—it’s beyond what humanity can realistically adapt to.” (02:47:03) “Climate policy isn't just climate—it’s about everything we do as a society.” ⏱️ Timestamps: (00:04:12) Urgent Climate Crisis: Rising Emissions Explained (00:10:15) Inconvenient Truth 2.0: What We Missed (00:18:32) China’s Green Tech Revolution Unpacked (00:26:20) Can Climate Forums Deliver Real Action? (00:32:50) Designing Just, Achievable Climate Goals Globally (00:40:06) How Growth Triggers Today’s Polycrisis (00:45:08) Rethinking Economies for Sustainable Living (00:53:00) Why We Need Mixed Energy Strategies (01:17:24) Geoengineering vs Terraforming: Climate Futures Debate (01:26:20) Who Funds Carbon Removal Technologies? (01:37:06) Why We May Need to Cool Earth (01:40:41) Warming Beyond 3°C: What’s at Risk (01:48:02) How Fossil Fuels Hide True Heat (02:08:00) The Hidden Risks of Cheap Climate Fixes (02:24:41) 3 Degrees Warming: Scientifically Unmanageable? 🔔 Help Us Grow If this conversation gave you insight, urgency, or a new perspective—help us keep it going. Subscribe. Leave a comment. Share it with someone who cares. Every single action helps us invite world-class thinkers, spark deeper debates, and bring you the conversations that actually matter. 🎧 Watch now—and be part of the climate conversation no one dares to start. Send us a text Support the show Join the Podcast Newsletter: Link…

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1
#155: Ray Dalio’s Playbook — 7 Principles for Building Scalable, Resilient Companies 56:56

9 weeks ago56:56

56:56

What if your business ran like a well-designed machine—one that could evolve, self-correct, and outperform your competition over decades? In this episode, I unpack Principles by Ray Dalio , the billionaire investor and founder of Bridgewater Associates , the world’s largest hedge fund. It’s not a traditional business book—it’s a blueprint for decision-making, culture design, and long-term scaling, rooted in clarity, transparency, and radical self-honesty. This episode is built for venture capitalists, executives, and operators leading at scale—those who are no longer improvising but building enduring systems. You’ll hear the 7 most actionable principles Dalio used to scale Bridgewater, reimagined for anyone building the future—from biotech to AI, from global funds to market-leading enterprises. We cover how to engineer feedback cultures, design for evolution, and drive decisions that compound over time. And we tackle the big question: Can you be both a high-performance machine and a human-centered leader? Key Takeaways: Think Like a Machine: Build systems that run without your constant input. Get the People Right: Talent isn’t enough—character and growth capacity matter most. Radical Transparency: Trust is built by saying the hard things early and often. Idea Meritocracy: Don’t default to consensus. Weight decisions by experience. Shaper Thinking: Zoom out to vision, zoom in to execution—and toggle constantly. Diagnose the Root Cause: Don’t waste time solving symptoms. Open-Mindedness as Strategy: Challenge your thinking before reality does. Timestamps: (00:00) Intro: The Principles (02:15) Why This Book Matters If You’re Building or Investing in the Future (04:14) Who Is Ray Dalio? (06:21) The Snapshot: What Principles Is Really About (10:05) Build Your Company Like a Machine, Not a Hero’s Journey (15:29) Get the People Right (20:40) Radical Truth & Transparency Are Force Multipliers (26:08) Build an Idea Meritocracy (32:26) Shapers Win—They Dream Big, Think Clear, Execute Ruthlessly (37:37) Diagnose Root Causes, Not Symptoms (44:02) Be Radically Open-Minded (50:12) Key Takeaways & Personal Reflection Why Listen: Learn how billion-dollar systems are designed and scaled Identify blind spots in your leadership, org design, or investment theses Equip yourself with 7 operating principles you can implement this quarter Reframe your relationship to truth, conflict, and growth Decide whether to build a machine—or remain the operator If these ideas resonate, I strongly recommend reading Principles in full. Or better yet—share this episode with someone you think is ready to level up how they lead and build. Send us a text Support the show Join the Podcast Newsletter: Link…

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Suzanne Heywood | From Shipwreck to Boardroom Leadership (SPARK20 - 133) 21:26

11 weeks ago21:26

21:26

What does it take to turn extreme adversity into extraordinary leadership? Suzanne Heywood’s life reads like a novel—shipwrecked at seven, isolated at sea for a decade, forging her father’s signature to survive, and ultimately earning a place at Oxford through sheer determination. Today, she’s a top executive and investor, steering multi-billion-dollar companies with resilience, clarity, and innovation. In this episode, Suzanne shares the defining moments that shaped her, the mindset that helped her thrive in crisis, and the leadership lessons she applies in business today. Whether you’re an investor, entrepreneur, or leader, this conversation will leave you inspired and armed with valuable insights: How to stay calm under extreme pressure and make clear decisions. Why resilience isn’t about being tough—but about perspective. How diversity fuels innovation and why biases hold companies back. The ‘Critical Friend’ approach to leadership and board dynamics. At the heart of it all, Suzanne’s journey is a testament to perseverance and purpose. As she says: "You’ll learn things from adversity that people with an easier life never will." Timestamps & Topics 📌 (01:00) Overcoming Extreme Adversity – A childhood lost at sea, a future built from nothing. 📌 (03:43) Knowing Which Mountains Are Worth Climbing – How to distinguish real challenges from distractions. 📌 (06:05) Resilience Under Pressure – From shipwreck to boardroom calm. 📌 (07:51) The Dangers of Bias in Innovation – Why lack of diversity kills progress. 📌 (09:39) Creating Sustainable Innovation – What great leaders prioritize for long-term success. 📌 (13:48) The ‘Critical Friend’ in Leadership – Balancing support with hard truths. 📌 (16:43) Metallica Meets Electric Trucks – A masterclass in creative partnerships. 📌 (18:29) Education as the Ultimate Investment – How learning transformed her life. Powerful Quotes 💡 (03:43) "I picked kiwifruit… earned enough for a one-way ticket—Oxford changed my life." 💡 (06:58) "Nobody's life is in danger—we will get this sorted out." 💡 (20:39) "You’ll learn things from adversity that people with an easier life never will." This episode is more than an inspiring story—it’s a blueprint for navigating uncertainty, making tough decisions, and leading with conviction. 👉 Listen now, take notes, and if this sparks something in you, share it with someone who needs to hear it! Send us a text Support the show Join the Podcast Newsletter: Link…

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EP 154 - Kristina Levan: Why Life-Saving Therapies Aren’t Reaching Patients—And How to Fix It 1:51:29

12 weeks ago1:51:29

1:51:29

ATMPs, gene therapies, and cancer breakthroughs are here—but outdated regulations, high costs, and logistical bottlenecks are blocking access. What needs to change for hospitals to deliver these cures to patients who need them most? 💡 Here’s the harsh reality: Patients are waiting, but hospitals aren’t ready. The science exists, but regulations haven’t caught up. The treatments work, but they’re too expensive to scale. So what’s the solution? And who’s taking action? 📌 In this episode, Kristina Levan —ATMP innovation leader and biotech strategist—breaks down the challenges and opportunities shaping the future of advanced therapies. 🎧 Watch now to learn: 1️⃣ How gene therapy is curing blindness—and why it almost didn’t happen. 2️⃣ The biggest bottleneck preventing hospitals from offering life-saving treatments. 3️⃣ How AI and automation could unlock personalized medicine for everyone. 4️⃣ The real reason ATMPs are so expensive—and what must change. 5️⃣ Why healthcare leaders, policymakers, and investors must rethink how we manufacture cures. 👤 About Kristina Levan: Kristina Levan has spent years at the cutting edge of cancer research, clinical trials, and ATMP development. She’s helped shape Sweden’s national ATMP strategy , connecting industry, healthcare, and academia to push these breakthroughs forward. Now, she’s tackling the next big challenge— getting these treatments to patients faster. 💡 Quotes to Challenge Your Thinking: (00:12:05) "ATMPs don’t just treat symptoms—they have the power to cure diseases." (00:23:36) "Gene therapy is giving children a future—restoring sight and transforming their lives forever." (01:27:52) "Imagine a future where hospitals create customized gene therapies on-site for every patient." (01:43:13) "ATMPs could transform lives by treating the untreatable." (01:45:42) "If we can cure early, we don’t just save lives—we reshape them." Timestamps: (00:05:32) How ATMPs Will Reshape Global Healthcare (00:13:54) CAR-T Therapy: The Next Cancer Treatment Revolution (00:23:36) Gene Therapy Restores Sight—The Future of Medicine? (00:28:33) AI-Powered Therapies: Can Hospitals Manufacture Cures? (00:37:55) Why Cutting-Edge ATMPs Struggle to Reach Patients (00:53:36) Personalized Medicine & Real-Time Health Monitoring (01:09:02) From Research to Reality: Scaling ATMP Treatments (01:12:54) The True Cost of ATMPs—Can We Afford Innovation? (01:27:15) Cell Therapy Manufacturing: The Next Big Disruption (01:33:03) AI & Automation in Healthcare: What’s Next? 🔔 Help Us Grow If this episode gave you insight, inspiration, or a new perspective—here’s how you can help: 📢 Hit SUBSCRIBE, like, and leave a comment. It’s a small action, but it has a huge ripple effect. Every engagement helps us bring in bigger guests, deeper insights, and more industry-changing conversations. Right now, we’re in the global top 10%—let’s push for the top 1% together. 🎧 Watch now and be part of the conversation shaping the future of medicine. 🚀 Send us a text Support the show Join the Podcast Newsletter: Link…

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EP 153 - Christopher Uhde: The Biotech IPO Boom is Over. Now What? 2:02:20

14 weeks ago2:02:20

2:02:20

In 2021, biotech IPOs were soaring. Valuations hit record highs. Investors were throwing money at anything that moved. Then… the market crashed. Funding dried up. Growth stalled. Biotech founders and investors were left scrambling. So what really happened? And more importantly— how do you navigate what’s next? 📌 In this episode, Christopher Uhde —Senior Pharma & Biotech Equity Analyst at SEB—breaks down the brutal realities of biotech IPOs, investor sentiment, and the high-stakes game of survival in a post-boom world. 🎧 Watch now to learn: 1️⃣ Why valuations aren’t about science—but about demand. 2️⃣ The biggest mistake biotech founders make after going public. 3️⃣ How to raise capital before you actually need it. 4️⃣ The European biotech advantage—and how to leverage it. 5️⃣ How to attract the right investors and avoid the wrong ones. 👤 About Christopher Uhde: Christopher Uhde is a Senior Pharma & Biotech Equity Analyst at SEB , one of Europe’s leading financial institutions. With a PhD in neurodevelopmental systems biology and postdoctoral research in drug discovery, he’s spent years studying the biotech market—from billion-dollar giants to early-stage startups—analyzing their success, failures, and what separates winners from the rest. 💡 Quotes to Challenge Your Thinking: 📌 (00:16:29) "Valuation isn’t about science; it’s about demand and the right investors." 📌 (00:49:17) "The power of the right team in biotech can’t be overstated." 📌 (01:13:08) "European startups struggle not from lack of innovation, but from a lack of ownership mindset." 📌 (01:38:39) "The long-term equity story isn’t just about share price—it’s about trust and vision." 📌 (01:50:44) "Biotech isn’t just about breakthrough science—it’s about strategy, trust, and long-term vision." ⏰ Timestamps: (00:09:48) IPO Market Realities and Investor Sentiment (00:17:59) Why European biotech should think beyond US listings (00:25:15) The hidden challenges of taking a company public (00:28:45) Preparing for IPO Compliance (00:37:11) Public company leadership demands strategic communication (00:49:17) The power of the right team in biotech (00:52:48) Planning for success in biotech acquisitions (01:13:08) Incentivizing Innovation in Europe (01:23:33) Nordic IPO culture shaping biotech success (01:36:16) Realistic Communication in Biotech (01:50:44) Europe’s Biotech Global Edge 🔔 Help Us Grow If this episode gave you insight, inspiration, or a new perspective—here’s how you can help: 📢 Hit SUBSCRIBE, like, and leave a comment. It’s a small action, but it makes a huge difference. Every engagement helps us bring in more top-tier guests, deeper insights, and the conversations that keep you ahead. Right now, we’re in the global top 10% — let’s push for the top 1% together. 🎧 Watch now and make sure your biotech strategy is built to last. 🚀 Send us a text Support the show Join the Podcast Newsletter: Link…

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1
EP 152 - Alex Dang: Billion-Dollar Bets: Why VC’s Best Decisions Go Against the Crowd 2:06:51

17 weeks ago2:06:51

2:06:51

🚀 Most investors chase consensus. The best ones? They bet against it. If everyone agrees on an investment, it’s probably not bold enough. That’s why the greatest venture capitalists don’t just follow trends—they seek out the hidden outliers that redefine industries. But how do they spot the next Amazon, Google, or Tesla before anyone else? And why do so many leaders play it safe and miss out? 📌 In this episode, Alex Dang —former Amazon and McKinsey leader—breaks down how elite investors think, how to cultivate the venture mindset , and why risk isn’t the enemy—short-term thinking is. 🎧 Watch now to learn how to think like the world’s top investors. 🎙️ What’s in the Episode: 1️⃣ Conviction Over Consensus – Why the best decisions often go against the crowd. 2️⃣ The VC Playbook – How top investors filter out noise and double down on outliers. 3️⃣ Risk vs. Regret – The hidden cost of playing it safe. 4️⃣ The ‘Day One’ Mentality – How Amazon avoids stagnation and bureaucracy. 5️⃣ From Poker to Investing – The mindset shift that separates amateurs from professionals. 👤 About Alex Dang: Alex Dang has lived the venture mindset firsthand—at Amazon , where he built new businesses; at AWS , where he launched cutting-edge AI solutions; and at McKinsey , where he helped Fortune 500 leaders scale transformative innovations. A Stanford GSB graduate , he’s spent nearly two decades guiding decision-makers through high-risk, high-reward environments. 💡 Quotes to Challenge Your Thinking: 📌 (01:21:31) "Conviction beats consensus. If everyone agrees, the idea isn’t bold enough." 📌 (01:49:18) "VCs don’t fear losing money. They fear missing the next Google." 📌 (00:31:08) "Home runs matter, strikeouts do not in the venture capital game." 📌 (00:58:46) "In business, like poker, fold early or double down—there’s no in-between." 📌 (00:47:00) "The moment you abandon a Day One mentality, bureaucracy wins." ⏰ Timestamps: (00:04:58) AI's Next Big Disruption (00:20:08) Predictability vs. Innovation in Business (00:30:45) Venture Capital’s Risk Culture Explained (00:38:00) How Amazon Built a Venture Mindset (00:46:34) Day One vs. Day Two Thinking (00:53:22) Writing for High-Stakes Decision Makers (00:57:51) Poker Mindset in Venture Investing (01:11:07) Why Failure Leads to Billion-Dollar Wins (01:21:31) Conviction vs. Consensus in Investing (01:26:46) Avoiding the Crowd, Finding Outliers (01:32:47) Playing the Long Game in Venture (01:54:59) Optimism in Innovation’s Unpredictable Future 🔔 Help Us Grow If this episode challenged your thinking, hit follow, like, and share . The bigger the show gets, the bigger the guests we can bring you—so you get even more game-changing insights . 🎧 Watch now and start making billion-dollar bets like the world’s best investors. 🚀 Send us a text Support the show Join the Podcast Newsletter: Link…

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#151: Mastering Uncertainty – 7 Venture Secrets to Thriving in Chaos 46:53

19 weeks ago46:53

46:53

What if your greatest asset in business was how you think under pressure? In this episode, I dive into The Venture Mindset by Alex Dang and Ilya Strebulaev , unpacking seven transformative lessons drawn from the world of venture capital and deep-tech entrepreneurship. These principles aren’t just for investors—they’re a roadmap for anyone navigating uncertainty, from startup founders to corporate innovators. Alex Dang, a veteran innovator, and Ilya Strebulaev, a leading academic in venture capital, combine decades of hands-on experience and rigorous research. Together, they reveal how to embrace risk, think strategically, and build ventures that thrive in chaotic environments. As an entrepreneur and investor, I’ve found these lessons invaluable. This episode explores how to prepare your mind for contrarian thinking, align incentives for growth, and make bold decisions when it matters most. Whether you’re building groundbreaking technology or adapting to a disruptive market, these insights will reshape how you approach challenges. Key Takeaways: This episode covers seven critical lessons, including: 1️⃣ Home Runs Matter, Strikeouts Don’t : Embrace failure as a stepping stone to transformative success. 2️⃣ Prepare Your Mind for Contrarian Thinking : Spot opportunities others miss and thrive in uncertainty. 3️⃣ Bet on the Jockey, Not Just the Horse : Prioritize resilient founders over flashy ideas. 4️⃣ Double Down or Quit : Make disciplined decisions to invest or cut losses. 5️⃣ Get Outside the Four Walls : Source ideas from diverse networks and unexpected places. 6️⃣ Make the Pie Bigger : Align incentives to foster collaboration and shared success. 7️⃣ Great Things Take Time : Cultivate patience and a long-term vision to achieve exponential impact. While this episode highlights actionable takeaways, The Venture Mindset is packed with even more insights and strategies for anyone looking to excel in unpredictable environments. Timestamps: (00:00) - Introduction: Why This Episode Matters (01:20) - The Book’s Relevance for Entrepreneurs and Innovators (02:02) - Author Spotlight: Alex Dang and Ilya Strebulaev (04:15) - Book Overview: A Roadmap for Thriving in Uncertainty (06:56) - Key Takeaway 1: Home Runs Matter, Strikeouts Don’t (12:43) - Key Takeaway 2: Prepare Your Mind for Contrarian Thinking (19:07) - Key Takeaway 3: Bet on the Jockey, Not Just the Horse (24:00) - Key Takeaway 4: Double Down or Quit (29:22) - Key Takeaway 5: Get Outside the Four Walls (34:00) - Key Takeaway 6: Make the Pie Bigger (38:53) - Key Takeaway 7: Great Things Take Time (43:55) - Closing Reflections and Final Insights Why Listen: Embrace Bold Thinking : Learn how to thrive in uncertainty with strategies from venture capitalists and entrepreneurs. Master Decision-Making : Equip yourself with tools to adapt and act decisively in chaotic environments. Drive Innovation and Growth : Gain insights into fostering collaboration, resilience, and long-term value creation. Practical Application : Reflect on actionable coaching questions tailored to your journey. If these lessons resonate, I encourage you to explore The Venture Mindset in full. It’s more than a book—it’s your guide to navigating uncharted waters and building a futur Send us a text Support the show Join the Podcast Newsletter: Link…

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Dan Bowyer: Rethinking Venture Capital with Superseed VC (SPARK 20 – 125) 23:14

20 weeks ago23:14

23:14

What does it take to redefine venture capital while empowering founders to disrupt industries and drive meaningful change? Meet Dan Bowyer , a bold investor from Superseed VC reshaping the game with a no-nonsense approach and a passion for impactful innovation. In this episode, Dan shares his journey from entrepreneur to VC and dives deep into what’s wrong with traditional venture capital. He reveals the personality traits that define world-changing founders, the importance of customer obsession, and the stark realities of boardroom dynamics. Dan’s candid insights and thought-provoking lessons are as entertaining as they are eye-opening. Whether you’re an aspiring founder, an experienced investor, or someone intrigued by the startup world, this conversation will teach you: Why venture capital doesn’t work for 99.9% of founders —and what needs to change. The three personality traits that separate great founders from the rest. How misaligned boards and outdated practices can derail even the best startups. At the heart of it all, Dan’s passion for connecting people, products, and processes shines through. As he says, “The next wave of commercial activity is about making money and doing good—it's not just about the bottom line anymore.” Curious for more? Listen to the full episode here and dive deeper into Dan’s bold vision and unfiltered perspective. Quotes: (3:44) "Most VCs have never worked in a startup, so how can they advise one?" (9:42) "The greatest founders are not just charming—they’re determined, disagreeable, and unrelenting in disrupting the status quo." (22:02) "We've moved on from 'don’t be a dick' to 'do some good'—and that’s how we transform the future." Timestamps (01:37) Bridging the Gap: Why Venture Capital Fails 99% of Founders (03:44) Startup Struggles: The Hard Truths Founders Need to Hear (09:42) Decoding Greatness: Traits of Exceptional Founders (12:58) From Prototype to Profit: Why Customer Obsession Wins (17:01) Boardroom Battles: Misaligned Boards and Startup Success (21:02) A New Era: Making Money While Doing Good Don’t miss this chance to learn from Dan Bowyer’s dynamic journey, sharp insights, and inspiring approach to venture capital. Press play, and let’s spark some bold ideas together! Send us a text Support the show Join the Podcast Newsletter: Link…

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EP 150: 2024 in Review: 9 Bold Steps Toward a Brighter 2025 1:24:26

22 weeks ago1:24:26

1:24:26

What makes a year unforgettable? Is it the challenges conquered, the bold ideas pursued, or the connections that shaped us? As 2024 comes to a close, this special episode celebrates the lessons, breakthroughs, and visionary insights that defined the year. Through 9 remarkable stories, hear from leaders, investors, and innovators who are shaping the future. 🎙️ In This Episode: Suzanne Heywood : Discover the balance of trust and challenge that makes great leaders. Shlomo Noy : Explore how Israel transformed challenges into global innovation success. Charlie Munger : Learn why a latticework of mental models is the ultimate leadership tool. Hampus Jakobsson : Understand how empathy and diverse perspectives drive venture success. Marc Penkala : Uncover the mindset shift Europe needs to compete with U.S. venture capital. Jeff Bezos : Dive into the principles of customer-driven innovation from Invent and Wander . DC Palter : Find out why startups fail without the right mix of technical expertise and business acumen. Joe Panetta : Learn the secret sauce behind California’s thriving biotech ecosystem. Marina Schmidt : Reimagine food systems with agroforestry—a sustainable, resilient alternative to industrial farming. 💡 Key Quote Highlights: “The ideal board member is a critical friend—someone who challenges you when times are good and supports you when they’re tough.” – Suzanne Heywood "Israel’s innovation story is a testament to how bold policies and restless minds can turn challenges into a thriving tech ecosystem." – Shlomo Noy “In Europe, we focus on what could go wrong; in the U.S., they focus on what could go right.” – Marc Penkala "A great product without the right team is like a rocket without a pilot—it won’t fly far." – DC Palter "Empathy isn’t just a soft skill—it’s a leadership superpower." – Hampus Jakobsson “Agroforestry isn’t just farming—it’s nature’s blueprint for a resilient, abundant food system.” – Marina Schmidt ⏰ Timestamps: (00:00) This Was 2024 – 9 Stepping Stones into 2025 (04:34) Suzanne Heywood: How Great Leaders Build Trust and Challenge (14:36) Shlomo Noy: How Israel’s Innovation Ecosystem Transformed Challenges Into Global Success (22:54) Charlie Munger – Poor Charlie’s Almanack : The Power of Thinking Across Disciplines (29:37) Hampus Jakobsson: Empathy, Fiction, and Business Success (37:31) Marc Penkala: Europe vs. U.S.—Bridging the Venture Capital Divide (45:13) Jeff Bezos – Invent and Wander : Solving Problems, Not Selling Tech (51:58) DC Palter: Why Great Inventions Fail Without Business Expertise (01:02:13) Joe Panetta: California's Risk-Taking Culture and Biotech Success (01:10:14) Marina Schmidt: Agroforestry—A Vision for a Sustainable Food System (01:22:17) Happy New Year 2025 Step boldly into 2025, inspired by these stories of leadership, resilience, and innovation. The lessons of this year remind us that every small action today shapes a brighter tomorrow. Thank you for listening—here’s to Send us a text Support the show Join the Podcast Newsletter: Link…

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EP 149: Marina Schmidt - How Do We Feed 10 Billion People Without Destroying the Planet? 2:04:31

24 weeks ago2:04:31

2:04:31

Our global food systems are at a breaking point. Climate change, geopolitical tensions, and industrial farming are pushing us closer to food insecurity every day. Can we find a way to feed 10 billion people while safeguarding the planet? Marina Schmidt, founder of Red to Green Solutions , reveals groundbreaking ideas that reimagine how we grow, consume, and sustain food for a resilient future. 🎙️ What’s in the Episode: 1️⃣ Building Food System Resilience : How to adapt agriculture to survive droughts, floods, and supply chain disruptions. 2️⃣ Passive Impact for Lasting Change : Discover how creating systems can drive sustainable results—even while you sleep. 3️⃣ The Global Food Paradox : Why efficiency in food systems comes at a cost, and how agroforestry could be the answer. 👤 About Marina Schmidt: Marina Schmidt is the visionary Founder of Red to Green Solutions , the leading global podcast on food tech and sustainability. Ranked in the top 5% globally, Marina's work spans research, policy influence, and media, making her a trusted voice for transforming global food systems. 💡 Quotes to Inspire: (06:38) "Food is not just sustenance; it’s a gateway to health and sustainability." (01:01:50) "Globalization makes food systems efficient but at the cost of stability."(01:12:20) "Agroforestry mimics nature, creating resilient ecosystems that feed both people and biodiversity." (01:50:19) "Food system resilience is key to surviving climate disruptions."(02:01:00) "Create systems for passive impact, change while you sleep." ⏰ Timestamps: (03:34) From Health Crisis to Food Sustainability (05:50) Transforming Health Challenges into Purpose (31:30) The Surprising Global Journey of the Potato (45:28) Vibrant Plate Colors and Nutritional Benefits (58:21) Globalization’s Impact on Food Systems (01:08:55) Fixing Farming Subsidies for Sustainability (01:15:35) Agroforestry: Nature-Inspired Food Systems (01:22:26) The Monsanto Legacy and Pesticide Debate (01:27:18) Why Europe Leads in Food Safety Regulations (01:35:52) Western Diets Reshaping China’s Food Culture (01:50:19) Building Resilient Food Systems for Climate Change (02:01:00) Creating Lasting Change Through Passive Impact If you care about food security, climate resilience, and innovative solutions that can sustain future generations, this episode is for you. 🔔 Subscribe, comment, and share to help grow the show and bring more transformative ideas to leaders and changemakers like you. 👀 Watch the full episode to uncover the tools and strategies that can redefine our food future—before it’s too late. Send us a text Support the show Join the Podcast Newsletter: Link…

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Doerte Hirschberg: Investing in Climate Solutions and Transforming Industries (SPARK20 - 114) 22:11

25 weeks ago22:11

22:11

What does it take to tackle the world's biggest challenge—climate change—while driving profit and innovation? Meet Doerte Hirschberg , a visionary investor reshaping industries with bold ideas and data-driven solutions. In this episode, Doerte takes us on a journey of how her team at Climentum Capital uses measurable CO2 impact as their guiding star. She shares insights into why the future of sustainable industries lies in rethinking systems, embracing new technologies, and focusing on the bigger picture. From transforming dairy into vegan alternatives to unlocking the potential of the hydrogen economy, her lessons are as inspiring as they are actionable. Whether you're an aspiring entrepreneur, an investor, or someone passionate about sustainability, this conversation will teach you: Why CO2 is the most powerful KPI to measure climate impact. How industries like food and transport are being revolutionized with technology like precision fermentation. The secret to avoiding overhyped trends while investing in solutions that truly make a difference. At the heart of it all, Doerte’s optimism, strategic mindset, and passion for innovation make this episode a masterclass in balancing ambition with sustainability. As she says, “The world doesn’t need more overhyped investments. It needs smarter ones.” Curious for more? Listen to the full episode here and dive deeper into Doerte’s remarkable journey. Quotes: (10:40) "We need to feed 7 billion people with less land, less animals, and less CO2—this isn't just a challenge, it's an opportunity to rethink the future of food." (17:26) "Imagine a world where climate change isn’t just a problem we talk about, but a challenge we’ve conquered—with measurable impact and real change." (14:01) "Biases are everywhere—even in venture capital. The industry claims it wants women, yet the system subtly works against them. It's time for that to change." Timestamps (0:00) Can We Balance Profit with Saving the Planet? (1:08) Why CO2 is the Key Metric for Climate Impact (3:07) The Challenges and Opportunities of Climate Tech (8:10) Why LPs Should Invest in Elemental Capital (11:12) The Future of Vegan Cheese with Fermify (14:01) Breaking Biases in Venture Capital (18:46) Vision for a Sustainable Future Don't miss this chance to learn from Doerte Hirschberg's journey, her inspiring vision, and her sharp strategies to reshape the future. Press play, and let’s spark some change together! Send us a text Support the show Join the Podcast Newsletter: Link…

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#148: Think Long-Term, Thrive Always: 7 Lessons From Investing Titans 41:09

26 weeks ago41:09