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Episode 33 - CAR-T and Chromothripsis | Multiple Myeloma Review with Dr Christian Bryant
Manage episode 462391658 series 3596833
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Myeloma beware, it's time to bring out the big guns. We are incredibly thankful to be joined by a peak predator of plasma cells, Dr. Christian Bryant. He is a consultant Haematologist at RPA in Sydney, has a PhD on the immunology of myeloma and is driven by a passion to improve the treatment and understanding of all things myeloma.
TIMESTAMPS
2:18 - Intro to Christian Bryant
3:05 - Why Haematology?
5:31 - Why (oh god why) myeloma?
7:28 - Heavy metal, heavy chains
9:28 - Chromothripsis - The Cause That Breaks The Camel's Back?
13:45 - In praise of plasma cells
18:38 - Genomics to risk-stratify precursor states - should we bother?
20:32 - Predicting response and high risk disease
21:43 - IMS Criteria - High Genomic Risk
28:22 - Response Kinetics - When are you nervous?
31:31 - Balancing maintenance Len vs. secondary malignancies
39:34 - Other agents for maintenance?
44:44 - CAR-T - A New Hope?
49:10 - T cell exhaustion
50:21 - What are the CAR-T target molecules for MM?
53:27 - Any hope for a cure?
57:35 - MRD Matters
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
Chapters
1. Episode 33 - CAR-T and Chromothripsis | Multiple Myeloma Review with Dr Christian Bryant (00:00:00)
2. Intro to Christian Bryant (00:02:18)
3. Why Haematology? (00:03:05)
4. Why (oh god why) myeloma? (00:05:31)
5. Heavy metal, heavy chains (00:07:28)
6. Chromothripsis - The Cause That Breaks The Camel's Back? (00:09:28)
7. In praise of plasma cells (00:13:45)
8. Genomics to risk-stratify precursor states - should we bother? (00:18:38)
9. Predicting response and high risk disease (00:20:32)
10. IMS Criteria - High Genomic Risk (00:21:43)
11. Response Kinetics - When are you nervous? (00:28:22)
12. Balancing maintenance Len vs. secondary malignancies (00:31:31)
13. Other agents for maintenance? (00:39:34)
14. CAR-T - A New Hope? (00:44:44)
15. T cell exhaustion (00:49:10)
16. What are the CAR-T target molecules for MM? (00:50:21)
17. Any hope for a cure? (00:53:27)
18. MRD Matters (00:57:35)
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