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Episode 43 - When your number’s not up | Platelet Refractoriness
Manage episode 478600743 series 3596833
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Have you ever looked at your wallet after a big night out and seen that all your dollars have been conjugated to alloantibodies and phagocytosed by macrophages? Then you know what it’s like to transfuse a platelet refractory patient! Join us as we take a tour of platelet refractoriness and do our best to find some HLA-matched dollars for rent this week.
Timestamps
00:52 - Bashar lives near a nuclear reactor
2:03 - Clinical case
5:38 - Defining platelet refractoriness
7:46 - Calculating platelet increments
12:42 - Causes of refractoriness
18:10 - Immune mechanisms of refractoriness
21:23 - HLA in detail
25:03 - HPA antigens
27:39 - Testing
31:46 - The Luminex assay
34:00 - Managing immune refractoriness
43:26 - Take home messages
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
Chapters
1. Episode 43 - When your number’s not up | Platelet Refractoriness (00:00:00)
2. Bashar lives near a nuclear reactor (00:00:52)
3. Clinical case (00:02:03)
4. Defining platelet refractoriness (00:05:38)
5. Calculating platelet increments (00:07:46)
6. Causes of refractoriness (00:12:42)
7. Immune mechanisms of refractoriness (00:18:10)
8. HLA in detail (00:21:23)
9. HPA antigens (00:25:03)
10. Testing (00:27:39)
11. The Luminex assay (00:31:46)
12. Managing immune refractoriness (00:34:00)
13. Take home messages (00:43:26)
45 episodes
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