Building a CDMO is a Lesson in Failing Upwards and Failing Successfully

CABTalks by Synthace

#Science #Biology #Fane Mensah & David Kirk #David Kirk #Fane Mensah

36:16

DANMMMMM…Have I got a show for you! First, a lot of Sister Wives tea - new rumors have surfaced Janelle Brown is leaving the show. Plus, Gabe Brown gives a life update after losing and tragically finding his brother Garrison dead. Sadly, Garrison took his own life in March 2024. Then we head over to discuss the new Welcome To Plathville tea. The first pictures of Micah Plath have surfaced after being beat up by his brother Issac and it doesn’t look good for the future of his modeling career. Lastly, we discuss the latest in the Justin Baldoni v Blake Lively case, Justin is back on social media and it was the perfect social media return. Timestamps: 00:00:00 - Open and new Sister Wives news 00:05:43 - Janelle Brown leaving the show? Sister Wives Closet is officially closed 00:12:45 - A new pic of Micah Plath’s broken nose has surfaced 00:18:18 - Justin Baldoni back on social media and Taylor Swifts team is pissed at Justin Baldoni MY Go Big Podcasting Courses Are Here! Purchase Go Big Podcasting and learn to start, monetize, and grow your own podcast. USE CODE: MOM15 for 15% OFF (code expires May 11th, 2025) **SHOP my Amazon Marketplace - especially if you're looking to get geared-up to start your own Podcast!!!** https://www.amazon.com/shop/thesarahfrasershow Show is sponsored by: Download Cash App & sign up! Use our exclusive referral code TSFS in your profile, send $5 to a friend within 14 days, and you’ll get $10 dropped right into your account. Terms apply Horizonfibroids.com get rid of those nasty fibroids Gopurebeauty.com science backed skincare from head to toe, use code TSFS at checkout for 25% OFF your order Nutrafol.com use code TSFS for FREE shipping and $10 off your subscription Rula.com/tsfs to get started today. That’s R-U-L-A dot com slash tsfs for convenient therapy that’s covered by insurance. SkylightCal.com/tsfs for $30 OFF your 15 inch calendar Quince.com/tsfs for FREE shipping on your order and 365 day returns Warbyparker.com/tsfs make an appointment at one of their 270 store locations and head to the website to try on endless pairs of glasses virtually and buy your perfect pair Follow me on Instagram/Tiktok: @thesarahfrasershow ***Visit our Sub-Reddit: reddit.com/r/thesarahfrasershow for ALL things The Sarah Fraser Show!!!*** Advertise on The Sarah Fraser Show: thesarahfrasershow@gmail.com Got a juicy gossip TIP from your favorite TLC or Bravo show? Email: thesarahfrasershow@gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices…

3 years ago 42:24

MP3•Episode home

In this podcast, Christa shares her experiences and deep insights on her life as a bioprocess expert. She’s spent her career navigating the tricky challenges you need to overcome in order to thrive in a fast-paced CDMO environment. She discusses what the grand vision is for biopharmas working with CDMOs and some of the ways that they're addressing pain points, like finding expertise in niche cell lines and structuring data from experimental runs.

30 episodes

Building a CDMO is a Lesson in Failing Upwards and Failing Successfully

CABTalks by Synthace

published 3 years ago

MP3•Episode home

30 episodes

#Science #Biology #Fane Mensah & David Kirk #David Kirk #Fane Mensah

All episodes

CABTalks by Synthace

1
The Evolution of Today’s Lab Automation Scientist 40:00

3 years ago40:00

40:00

Emilie Fritsch, Principal Scientist at Syngenta, joins Fane to talk about her journey from scientist to lab automation specialist. As her career evolved, so did her understanding of the automation needs of science. She went from molecular biology to the perfect blend of science and automation learning the best of both worlds to shape better science. The podcast is filled with nuggets of wisdom to take away, here’s what you can expect: (3:00 mins) Being thrown into the deep end of lab automation (7:30 mins) Three users of new technology: early adopters, watchers and skeptics (11:40 mins) Communicate reassurance. Look after those that are resisting new technologies and they will become your champions (14:11 mins) The “Eureka” moment of a skeptic adopting new technology feels really good (15:43 mins) The key learning from automation: not one size fits all (21:43 mins) Understand your problem so you know when to use automation (23:05 mins) Biologists need to spend less time pipetting and more time on the things they’re good at: the science (27:50 mins) Scientists need to be good communicators to thrive in a diverse environment filled with opportunities and challenges (31:43 mins) Women can become lab automation specialists, your study doesn’t define your scientific future Listen to the podcast to follow the conversation. If you have questions about this podcast - hello@synthace.com is only an email away…

CABTalks by Synthace

1
Adopting Lab Automation Starts In Academia 41:43

3 years ago41:43

41:43

Mario Antonio Torres Acosta,Postdoctoral Research Fellow at UCL, joins us to talk about his lab automation journey as an academic, specifically teaching others how to use lab automation. There’s plenty to cover in this episode, but you can look forward to hearing about: The shift to lab automation post-pandemic (5:25 mins) Automation and expertize is fluid, so should be the approach to adopting it and to think in the long term (11:30 mins to 16:21mins) Commitment is a big barrier to adopting lab automation (21:19 mins) Assessing how comfortable a person is with automation is to say nothing, see what they do and use this as a measure for your adoption (25:59 mins) Addressing the automation skills shortage in life sciences starts in academia (32:50 mins) Mario and Fane delve into the deep nitty-gritty of automation in an academic setting with lessons that apply to those on their automation journey. Listen to the podcast to follow the conversation. If you have questions about this podcast - hello@synthace.com is only an email away!…

CABTalks by Synthace

1
People Are The Key To Lab Automation 50:01

3 years ago50:01

50:01

Bob Gantzer , Director of Lab Automation at Beam Therapeutics joins us to talk about his trials and tribulations across his lab automation journey. Here are some of the many golden threads of wisdom he speaks to: How he became a lab automation guru by being a “flunky scientist” Taking the hard lessons of automating in a large company and raising it to a fledgling biotech company Why you must prioritize automation in your R&D Lab automation is not a technical problem, it’s a people problem, and you have to sell the dream to scientists who aren’t trained with highly integrated robotics. There’s a ton of helpful things Bob said about lab automation and how he learned to be successful at implementing it. Listen to the podcast to follow the conversation. If you have any questions about this podcast - hello@synthace.com is only an email away!…

CABTalks by Synthace

1
Shaping Your Career Starts With You And The Science You Want To Do 41:22

3 years ago41:22

41:22

Gintarė Bučaitė is a Senior Scientist at Benevolent AI, and she’s carved out her career working in academia, big pharma and small biotech doing what she does best - enabling scientists to do the science they want to do. But it’s not always been easy. In this podcast, she talks about her journey of actively shaping her career and the science she wants to achieve. From the uncertainty of her post-doc career to her forays in data science to enable scientists to do the science they want, Gintarė shares her journey with the hope that others learn from her successes and challenges.…

CABTalks by Synthace

1
Design Of Experiments Is The Future, And Scientists Are At The Heart of It 39:56

3 years ago39:56

39:56

Phil Kay is a Learning Manager at JMP with over 16 years of practical experience working with a multitude of companies across industries championing Design of Experiments (DOE) and the marvels of this transformational methodology. In this podcast, he talks about how DOE in life sciences has been a fascinating evolution to watch. How it’s transformed the way biopharma companies get drugs to market faster, how it’s helped improve the productivity and predictability of R&D teams, and how it has impacted a person’s career. Design of Experiments is the future, the future is already here with scientists and automation at the heart of this.…

CABTalks by Synthace

1
The Lab of the Future Starts Outside the Lab 50:24

3 years ago50:24

50:24

Markus Gershater is the Chief Science Officer of Synthace and has over 15 years of experience working with biopharma and life sciences companies to enable better experimentation for scientists. He’s also a champion for Design of Experiments (DOE) as the way forward for experimentation. In this podcast, Markus goes into the framing of “Lab of the Future”. He shares his own personal experiences to dig into this adage and why he feels the framing “isn’t quite right”. He says “the lab is more than just the room itself, it’s the technologies, people, and science involved”. He also goes into deep detail about the importance of metadata and why scientists need to take care better of their data.…

CABTalks by Synthace

1
Building a CDMO is a Lesson in Failing Upwards and Failing Successfully 42:24

3 years ago42:24

42:24

Christa Short, VP for Process Sciences at Wheeler Bio, is a master in navigating bioprocessing. She’s spent over 20 years working with biopharma companies to develop their drugs as quickly and as scalably as possible. In this podcast, Christa shares her experiences and deep insights on her life as a bioprocess expert. She’s spent her career navigating the tricky challenges you need to overcome in order to thrive in a fast-paced CDMO environment. She discusses what the grand vision is for biopharmas working with CDMOs and some of the ways that they're addressing pain points, like finding expertise in niche cell lines and structuring data from experimental runs.…

CABTalks by Synthace

1
Cloud Computing in R&D - If You’re Not Using It, You’re Already 5 Years Behind 49:28

3 years ago49:28

49:28

John Conway is a cloud lab evangelist and founder of 20/15 Visioneers and has over 30 years of experience working with biopharma companies tackle their R&D challenges in a multitude of capacities to drive forward changes through technology, strategy and change management. In this podcast, Jon talks about the R&D journey he has taken in the last 30 years, change management over the decades, the changes that we as an industry need to make and ultimately - the bright future that awaits us. He shares his insight on biopharma’s approach to data environments, utilizing computer-aided biology technologies and what biopharma culture needs to change in order to realize the ideal standard of data environments - “that anybody in the field should be able to take it and completely understand the data set and do what they want to do with it.”…

CABTalks by Synthace

1
Change Management for Adopting Advanced Technologies and Automation in R&D (Part 2) 28:41

3 years ago28:41

28:41

Traci Howard is a Management Consultant with Attainment Consulting Services and has over seven years of experience working with the unique challenges facing biotech companies - among them, managing change. Following on from Part 1, which looked at the broader industry, Fane Mensah and Traci Howard take a closer look at life science organizations. Traci shares her tips and tools to introduce new technologies into an organization, and how to encourage the successful adoption of computer-aided biology technologies whether that's top-down from the management team, or from the research team upwards. Traci takes us through the Change Journey - how to make a case for change within an organization and what the important questions that need answering are to help people sit up and take notice.…

CABTalks by Synthace

1
Change Management for Adopting Advanced Technologies and Automation in R&D (Part 1) 28:57

3 years ago28:57

28:57

Traci Howard is a Management Consultant with Attainment Consulting Services and has over seven years of experience working with the unique challenges facing biotech companies - among them, managing change. In Part 1 of this special two-part episode of CABTalks by Synthace, Fane Mensah and Traci Howard discuss the broad industry challenge of implementing the appropriate technologies in the appropriate organizations at the appropriate time, as well as how vendors and tech developers should engage in conversations with their prospective clients. We talk about how vendors and technology developers can segment their audience and tailor their approach to help individual clients meet their research goals. The conversation continues in Part 2, taking a closer look at changes like introducing new technologies can be managed within a life science organization.…

CABTalks by Synthace

1
Challenges and Solutions in Bioprocessing 30:09

4 years ago30:09

30:09

Alexandre Super is a Data Scientist in upstream process sciences at UCB , a global biopharma company focusing on neurology and immunology. In this episode of CABTalks by Synthace, Alexandre and Fane discuss bioprocessing and data management. What are the challenges in moving from R&D to a scaled-up process? And how are Computer-Aided Biology tools helping tackle bioprocesses’ biggest challenge of all: capturing high-quality data. Listen in to learn how Automation, Miniaturization, and Digitalization play key roles in 21st Century bioprocessing.…

CABTalks by Synthace

1
CABTalk S2E8: Scaling Biotech with Jesse Johnson 44:59

4 years ago44:59

44:59

Jesse Johnson is head of Data Science and Data Engineering at Dewpoint Therapeutics , an R&D-stage biotech startup, and the author of the Scaling Biotech blog where he pursues his goal to find ways to scale biotech research platforms through better software and organizational design. In this episode of CAB Talk, we discuss Jesse's framework for scaling biotech, explore the three big trade-offs of Cost vs Reliability, Immediacy vs Generality, and Flexibility vs Consistency, and touch on how we can better communicate the need for computer-aided biology. FYI - the book Jesse mentions is Data-Centric Biology: A Philosophical Study by Sabina Leonelli…

CABTalks by Synthace

1
CABTalk S2E7: AI, Life Science, and Wraparound Care with Mike Fero COO of TeselaGen 43:39

4 years ago43:39

43:39

With advancements in artificial intelligence and cloud computing technologies, there are a growing number of solutions in Computer-Aided Biology. But what exactly are the problems? We speak with Dr Mike Fero, the former CEO and current COO of TeselaGen - one of the first big AI companies in the Computer-Aided Biology, on the problems facing scientists and how CAB companies should be articulating that problem. We also chat about Mike's journey from Physics into Computer-Aided Biology, the challenges facing CAB companies and CEOs today, as well as his personal challenge of balancing work with life and providing "wraparound care" for his grandchild.…

CABTalks by Synthace

1
CABTalk S2E6: Design of Experiments in Biology with Shama Chilakwad 40:27

4 years ago40:27

40:27

Biology is a notoriously difficult research area, especially for replicating results. To paraphrase from a film that has inspired thousands of people to get into this field: life finds a way (of behaving unexpectedly). Because everything is so interconnected in biology, the one-factor-at-a-time (OFAT) approach is usually taken to investigate biological systems. But what if there were a better way to gain insights into the holistic nature of biology and explore the interconnectedness of various factors while maintaining scientific accuracy? Well there is, it’s called Design of Experiments (DOE). When we say DOE we are talking about a branch of applied statistics that can be applied to experimental design to explore the relationships between factors in an experiment as well as the effect of the factors themselves. Compared to other experimental approaches, such as the OFAT approach, DOE can save time and resources in performing experiments while providing deeper insights. In CABTalk this month, EngD student Shama Chilakwad explains how her studies are entirely based on exploring the possibilities of DOE in studying transaminases.…

CABTalks by Synthace

1
CABTalk S2E5: The Future of Research with Melissa Sterry 31:55

4 years ago31:55