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NAD Wars: NMN vs NR in the Aging Battle
Manage episode 484350580 series 3635277
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In this episode of Daily Value, we look inside the NAD+ wars - breaking down the science, the hype, and the controversy surrounding Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN). These two molecules have been promoted as keys to longevity, but the story is far more complex. We’ll look at the biochemistry of NAD+ metabolism, compare what the research really says about NR and NMN, and dig into the regulatory drama that’s shaped their (NMN’s) availability. Most importantly, we’'ll look at a bigger-picture strategy for restoring NAD+, one that goes beyond precursors alone.
00:00 the NAD Wars
01:02 Understanding NAD+ and Its Importance
01:52 The Role of NR and NMN in NAD+ Replenishment
02:29 Biochemical Pathways of NAD+ Production
04:14 Challenges and Regulatory Issues with NMN and NR
05:44 Clinical Research and Safety Profiles
07:13 Complexities in Boosting NAD+ Levels
09:04 Multi-Targeted Strategies for NAD+ Restoration
13:25 Conclusion: Embracing Complexity in Aging
PMID: 35134387
PMID: 39026037
doi:10.1002/fft2.511
Chapters
1. The Molecular Battle of Aging (00:00:00)
2. NAD+ Fundamentals and Age-Related Decline (00:00:42)
3. NMN vs NR: Metabolic Pathways Explained (00:02:15)
4. Regulatory Challenges and Clinical Safety (00:04:24)
5. Beyond Precursors: NAD+ Restoration Complexity (00:07:25)
6. Multi-Target Strategy for NAD+ Optimization (00:09:06)
7. Practical Recommendations and Conclusion (00:11:40)
45 episodes
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