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🤰🔬Exploring pregnancy’s power to suppress autoimmune disease: Insights from multiple sclerosis research
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Keywords
Multiple Sclerosis, Pregnancy, Autoimmune Diseases, Immune Tolerance, GDF15, Neuroimmune Crosstalk, Reproductive Immunology, Maternal Health, Research Challenges, MS Treatment
Summary
In this episode of the Young Immunologist podcast, Nóra Balzer interviews Jana Sonner, a postdoc at the University Medical Center in Hamburg, discussing the intersection of multiple sclerosis (MS) and pregnancy. They explore how autoimmune diseases typically affect women during their reproductive years, the unique immunological changes that occur during pregnancy, and the implications for maternal and fetal health. The conversation delves into the mechanisms of maternal immune tolerance, the role of GDF15, and the latest research findings on MS and pregnancy. Jana emphasizes the need for more research in reproductive immunology and the importance of including pregnant women in clinical trials to improve treatment outcomes.
Takeaways
- Pregnancy can suppress disease activity in autoimmune diseases.
- Autoimmune diseases often onset during women's reproductive years.
- MS does not typically affect fertility or pregnancy outcomes.
- Disease-modifying therapies may pose risks during pregnancy.
- Maternal immune tolerance is crucial for pregnancy success.
- GDF15 plays a role in immune regulation during pregnancy.
- Peripheral immune system adapts significantly during pregnancy.
- Exclusive breastfeeding may lower postpartum relapse risk in MS.
- Research in reproductive immunology is still underfunded and underexplored.
- Inclusion of pregnant women in clinical trials is essential for better treatment.
Please find some links to work both on MS in general and pregnancy and MS
- https://www.nejm.org/doi/10.1056/NEJM199807303390501?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.gov
- https://link.springer.com/article/10.1007/s00281-016-0584-y
- https://www.nature.com/articles/s41583-024-00823-z
- https://www.nature.com/articles/s41577-022-00718-z
Contact details
- Contact: Dr. Jana Sonner, [email protected],de
- Webpage Institute of Neuroimmunology and Multiple Sclerosis (INIMS): https://www.inims.de
The Podcast is hosted by Nóra Balzer -
https://www.instagram.com/balzernora/
https://www.linkedin.com/in/n%C3%B3ra-balzer-253a767b/?originalSubdomain=de
The podcast is supported by the German Association of Immunology (DGfI) - Young Immunologists (YI)
https://dgfi.org/
https://dgfi.org/young-immunologists/
https://www.linkedin.com/company/dgfi-yi/
https://twitter.com/YI_dgfi
Become a member today! --> https://dgfi.org/dgfi-en/dgfi-membership/?noredirect=en_US
https://www.yefis.org/
Chapters
1. Introduction to MS and Pregnancy (00:00:00)
2. Understanding Autoimmune Diseases (00:02:55)
3. Impact of Autoimmune Diseases on Pregnancy (00:05:44)
4. Exploring Multiple Sclerosis (00:09:09)
5. Maternal Immune Tolerance During Pregnancy (00:11:52)
6. Peripheral Immune System Adaptations (00:15:02)
7. The Role of GDF15 in Pregnancy (00:17:46)
8. Neuroimmune Crosstalk and MS (00:21:06)
9. Latest Research Findings on MS and Pregnancy (00:23:53)
10. Future Directions in Reproductive Immunology (00:27:03)
11. Challenges in Reproductive Medicine Research (00:30:03)
12. Advice for Aspiring Researchers in Reproductive Immunology (00:32:52)
15 episodes
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