Are the extinct dire wolves really back?

In Focus by The Hindu

The world of science was rocked early last month when U.S. company Colossal Biosciences announced that it had resurrected the dire wolf—a species that went extinct more than 10,000 years ago. Three pups, named Remus, Romulus, and Khaleesi are now living on a 2,000-acre enclosure in a secret location. Videos of the wolf pups howling went viral across the internet, as did photographs of their snowy white fur.

How did Colossal achieve this? Through genetic editing. After first extracting DNA from an ancient dire wolf skull and tooth and studying its genome, the company claims it then took the genome of a grey wolf, the closest living ancestor of the dire wolf, and made precise edits at 20 locations across 14 genes. Most of these edits were cosmetic changes—to do with fur colour and size. The modified genome was then implanted in embryos, and surrogate dog mothers gave birth to the wolf pups.

While the science sounds immensely exciting, several experts have contested the claim that these pups are dire wolves. Can a few edits in a genome truly recreate a lost species? Can these wolves behave just as the real dire wolves did, given that the ecology and environment that the dire wolves existed in no longer exist? The company claims that it wants to secure the health and biodiversity of our planet’s future—its next project is to ‘de-extinct’ the woolly mammoth. Is this the right way to go about conservation, and can it even work?

Guest: Kartik Shanker, Professor & Chairperson, Centre for Ecological Studies, Indian Institute of Science, Bengaluru

Host: Zubeda Hamid

Produced by Sharmada Venkatasubramanian