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Breathwork: Asthma Biologic Therapies with Mr. Stephen Shelly (Part 2)
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Description
This week we speak to Mr Stephen Shelly again about the exciting but sometimes mysterious world of asthma biologics. We speak about the different biologics, going about getting approval to start an asthma biologic, training, and treatment response.
We speak about the potential impact that asthma biologics are going to have on the future of asthma (and hopefully COPD!), the cost benefit analysis and the limitations of these new wonder drugs.
Chapters
0.42min Intro to Biologics
1.00min Rapid fire round
1.52min Severe asthma & biologic eligibility
3.50min Available biologics
6.50min Which biologic?
7.30min Journey to asthma biologic
13.55min Asthma biologic administration
15.30min Monitoring while on asthma biologic
16.40min Training for asthma biologic admin at home
18.50min Assessing treatment response
21:10min Patient expectations
24:50min Are inhalers still needed?
26:12min Pitfalls in treatment with asthma biologics
28:54min Cost-benefit analysis
31.30min Take-home points
Show notes
Dupilumab https://www.nejm.org/doi/10.1056/NEJMoa1804092
Mepolizumab https://www.nejm.org/doi/10.1056/NEJMoa1403290
Omalizumab https://www.jacionline.org/article/S0091-6749(01)65945-1/fulltext
Benralizumab https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)31322-8/abstractTezepelumab
https://doi.org/10.1164/rccm.202210-2005OC
Difficult to treat asthma (GINA) https://ginasthma.org/wp-content/uploads/2024/11/GINA-Severe-Asthma-Guide-2024-WEB-WMS.pdf
Asthma compliance programmes Ireland https://www.rcsi.com/dublin/research-and-innovation/innovation/investors-entrepreneurs-and-spin-outs/phyxiom
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