Revolutionizing organ preservation and transplantation by mimicking antifreeze proteins of Arctic fish

Lab to Startup

Xiaoxi Wei, Ph.D (CEO) and Mark Kline, Ph.D. (CTO) are the cofounders of X-Therma, a biotechnology startup developing a breakthrough technology for regenerative medicine and organ preservation. In this episode of lab to startup, we talk about the challenges around organ preservation and transplantation; and how a technology they developed at Lawrence Berkeley National laboratory is being used to increase the life of organs to up to a week.We will talk about the inspiration to launch the startup, unique success around raising non-dilutive funding; creating a culture, and the importance of freedom to take decisions not driven by investors; Last but not the least, we will also get into their personal life briefly, as Xaoxi and Mark are unique co-founders on that front. Show notes - https://x-therma.com - Peptoid research originally developed for a DARPA project formed the basis for the underlying technology - Biomimicking chemistry in nature (fishes) to overcome freezing problems - Solid organ transplant still very inefficient due to limited amount of time to transport and transplant an organ - Product evolution - Determining the first product to develop, timing and timelines - SBIR grants and VC funding - Building the startup as an outsider (non-cryobiology experts) & role of KOLs - Turning down term sheets - The power of freedom while building startups by taking in the right money - Challenges in the organ preservation space - X-Therma assisting cell and gene therapy. - FDA Breakthrough device status - Culture and lessons learnt from hiring - Being partners at work and at home - Careers: https://x-therma.com/join-us/