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How loneliness and purpose determine your wellbeing | Leo Pruimboom | #011 Master Change
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“Genes don’t control your life – your life controls your genes,” says Dr. Leo Pruimboom in the eleventh episode of Mastering Change. A clinical psychoneuroimmunologist, researcher and pioneer in systems-based medicine, Dr. Pruimboom is challenging everything we think we know about trauma, disease, genes, psychology and mental health.
In this episode we discuss:
- Why most autoimmune diseases are misnamed (and aren’t autoimmune diseases at all)
- How loneliness rewires our organs
- The power of purpose – and how purpose of life intervention can shrink tumour size by 50%
- That genes do nothing on their own: it’s our environment or choice that activate or silence them
- The importance of spontaneous neural activity – and how doing nothing is medicine
“You can take a human being out of nature, but you can’t take nature out of the human being.”
Dr. Pruimboom makes a compelling case for the role of environment, connection, and behavioural agency in reversing modern illness. As he explains, we’re currently living in – and desperately trying to adapt to – a world we’re not made for. But thankfully, we have the capability to adapt: he reports the research showing that 120mins in nature per week can down regulate our blood pressure.
Find out more by listening the whole conversation.
PS. You can watch Dr. Pruimboom live at this year’s Transform Trauma Oxford by Masters Events – Europe's largest trauma conference. His talk, Everything is Everywhere at the Same Time will explore how the intricate connections between cells, organs and the environment shape mental health, emphasising the importance of relationships at every level of life in maintaining wellbeing.
More info and Early Bird Tickets are here: https://mastersevents.com/oxford-2025/
Moment of Care: This episode discusses sensitive episodes related to trauma, mental health and potential distressing experiences. If you feel triggered at any point, please take a moment to check in with yourself and seek support.
Watch this episode on Youtube: https://tinyurl.com/masteringchangepodcast
Follow us on instagram: www.instagram.com/masterseventsltd
Visit mastersevents.com/oxford-2025 for more details.
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