315. Lepidext: Dr. Bruce Webb and Dr. Mary Wallace on Solving a $2B Pest Problem Without Chemicals

Middle Tech

Lepidext is a Lexington-based biotech company developing a natural, non-chemical solution to control one of agriculture’s most damaging pests - the corn earworm. Founded by Dr. Bruce Webb, a University of Kentucky professor emeritus and virus researcher, Lepidext uses a modified virus to sterilize pest populations without harming the environment.The technology originated from research into a major equine reproductive crisis in Kentucky and evolved into a scalable product with the potential to replace traditional pesticides in the field. With a regulatory decision pending from the EPA, Lepidext is preparing for commercial rollout with a focus on farmer partnerships and sustainable impact.In this episode, Bruce and research scientist Dr. Mary Wallace share the journey from university research to ag-tech startup, the science behind their approach, and what’s next for Lepidext as they bring biological pest control to market.Expect to learn how a virus discovered in nature became the foundation for a new kind of pest management, what the EPA approval process really looks like, and why timing, team structure, and field trials matter when scaling a startup in agriculture.Middle Tech is proudly supported by:KY Innovation → kyinnovation.com