#103: Can epigenetic research transform MS treatment? Insights into DNA methylation and MS progression with Dr. Majid Pahlevan Kakhki

MS-Perspektive - The Multiple Sclerosis Podcast

Discover how epigenetic research is transforming multiple sclerosis treatment by uncovering the role of DNA methylation, gene regulation, and potential new therapies for MS progression.

You can read through all questions and answers on my blog: https://ms-perspektive.com/103-majid

Have you ever wondered how epigenetic mechanisms influence multiple sclerosis (MS) progression and why some people experience rapid disease worsening while others have a milder course? Could there be hidden biological switches beyond genetics affecting MS? In this deep dive, I explore the fascinating world of epigenetics with Dr. Majid Pahlevan Kakhki, uncovering how factors like DNA methylation shape MS progression and treatment outcomes.

Join me as we discuss groundbreaking research on how lifestyle, environment, and molecular modifications influence MS. Could epigenetic therapies hold the key to slowing or even reversing disease progression? Read on to find out how this cutting-edge science is paving the way for more personalized and effective MS treatments.

Table of Contents

• Introduction – Who is Dr. Majid Pahlevan Kakhki?
• Introduction to Epigenetics and MS
• Genetic Factors and MS Progression
• Clinical Implications for MS Patients
• Epigenetic Therapies and Future Prospects
• Broader Impact of Epigenetic Research
• Quickfire Q&A Session
• Farewell

Introduction – Who is Dr. Majid Pahlevan Kakhki?

Sure! My name is Majid Pahlevan Kakhki, and I’m originally from Iran, specifically from the Khorasan province in the northeast of the country. My childhood was closely tied to agriculture, as I spent a lot of time working in the saffron fields alongside my parents. As I grew older, I wanted to support my education and gain independence, so I learned tailoring and became quite skilled at it. This allowed me to finance my studies while remaining self-sufficient. I pursued a Ph.D. in Molecular Genetics in Iran, and after completing my doctorate, I moved to Karolinska Institutet as a postdoctoral researcher. Since then, I have been working there, focusing on cutting-edge research in my field.

Finally, what message of hope or encouragement would you like to share with the listeners?

„Don’t give up. I know that some days can be tough, but please remember that researchers around the world, including myself, are working hard to find better treatments and solutions for you. I truly believe that one day, we will hear the news that MS is cured, and we’ll be able to focus our research on curing other diseases.“

How and where can interested people follow your research activities?

I have a LinkedIn profile (https://www.linkedin.com/in/majid-pahlevan-kakhki) and also the Karolinska Institute (https://ki.se/en/people/majid-pahlevan-kakhki) webpage where our research is reported.

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Many thanks to Majid and his colleagues for all the valuable research they are doing and the insights provided into it today.

See you soon and try to make the best out of your life, Nele

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