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Genetic Causes of ALS/FTD with Prof. Isaacs
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Manage episode 468693090 series 3381775
Content provided by Neuro Podcases. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Neuro Podcases or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
In this episode of our Neuroscience Research series, hosts Filippo Dall'Armellina and Michael Cearns welcome Professor Adrian Isaacs (UCL), who investigates the molecular and cellular mechanisms underlying FTD and ALS. Research Highlights: - Paper 1: Mizielinska S, et al. C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins. Science, 2014. [PMID: 25103406] - Paper 2: Kempthorne L, et al. Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo. Nat Commun., 2025. [PMID: 39779704] - Paper 3: Giblin A, et al. Neuronal polyunsaturated fatty acids are protective in ALS/FTD. Nat Neurosci., 2025. [PMID: 40000803]
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78 episodes
MP3•Episode home
Manage episode 468693090 series 3381775
Content provided by Neuro Podcases. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Neuro Podcases or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
In this episode of our Neuroscience Research series, hosts Filippo Dall'Armellina and Michael Cearns welcome Professor Adrian Isaacs (UCL), who investigates the molecular and cellular mechanisms underlying FTD and ALS. Research Highlights: - Paper 1: Mizielinska S, et al. C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins. Science, 2014. [PMID: 25103406] - Paper 2: Kempthorne L, et al. Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo. Nat Commun., 2025. [PMID: 39779704] - Paper 3: Giblin A, et al. Neuronal polyunsaturated fatty acids are protective in ALS/FTD. Nat Neurosci., 2025. [PMID: 40000803]
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