# 82 Dr Thomas Clausen: Understanding the new science of the glycocalyx

Neuroveda Podcast for Complex Health

Thomas Mandel Clausen completed his PhD in Clinical Cancer Research at the University of Copenhagen and postdoc at the University of California in San Diego and has spent the bulk of his career thus far focused on cancer biology, malariavaccine development, and more recently COVID-19. His special focus was & remains cell & glycobiology which will be the focus of our discussion today. He’s presented at conferences all around the world and has over 40 published articles within the field of glycobiology focused on various molecular structures and functions and how they relate to human disease. He is currently matriculated at the University of Hawaii to gain his medical doctorate degree with estimated completion in 2026.

We discuss:

The endothelial glycocalyx is a specialized extracellular matrix that covers the apical side of vascular endothelial cells, projecting into the lumen of blood vessels. The composition of the glycocalyx has been studied in greatdetail, and it is known to be composed of a mixture of proteoglycans, glycosaminoglycans, and glycoproteins. Although this structure was once believed to be a passive physical barrier, it is now recognized as a multifunctional and dynamic structure that participates in many vascularprocesses, including but not limited to vascular permeability, inflammation, thrombosis, Mechan transduction, and cytokine signaling

Because vascular dysfunction is associated with a wide variety of diseases and because of the crucial role of the glycocalyx in maintaining proper vascular function,the significance of the glycocalyx in disease has become a topic of intensive investigation.