PsychNews Special Report: Clozapine Revisited—Updates to the Gold Standard

The Medical Mind

In this episode of PsychNews Special Report, we explore the evolving landscape of clozapine therapy, reaffirming its role as the gold standard for treatment-resistant schizophrenia and examining its unique benefits in reducing suicidality. We examine key insights from the Psychiatric News article by Gemma Espejo, M.D., and Farah Khorassani, Pharm.D., which highlights challenges in clozapine utilization—including blood monitoring requirements and clinician hesitancy—alongside updates to monitoring protocols and side effect management.

The episode also touches on augmentation strategies, the potential of pharmacogenomics, and promising innovations in psychiatric treatment.

Read the full article in Psychiatric News here: https://www.psychiatryonline.org/doi/10.1176/appi.pn.2025.05.5.10

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PsychNews Special Report” is a production of Psychiatric News, a media platform dedicated to serving as the primary and most trusted source of information for APA members, other psychiatrists and physicians, health professionals, and the public about developments in the field of psychiatry and mental health that impact clinical care and professional practice. Learn more at psychiatryonline.org/journal/pn.