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The Tumultuous Tale of Th17-and the IL23/IL17 immune axis

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Manage episode 491721437 series 3560282
Content provided by Healio, Adam J. Brown, and MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Healio, Adam J. Brown, and MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.

In this episode, we dive into a two-part story of intrigue starting from a paradigm shift in understanding of T cell biology because of a mouse model of post-measles encephalopathy, to the eventual recognition of the IL-23/17 immune axis.

• Intro 0:01 • In this episode 0:12 • Interleukin-17 (IL-17) is a relatively recent discovery 1:34 • The beginning of TH-17 2:20 • Looking at autoimmune encephalopathy: A story of measles 03:30 • 1790’s woman with post measles inflammatory process in the brain 10:26 • What is causing post-infection encephalitis? 12:00 • Acute disseminated encephalomyelitis 12:30 • How did we find out the immune system was behind this - The rabies vaccine 13:09 • Similarity between the rabies vaccine and infections like measles 16:04 • T-cell lymphocytes 17:12 • The forgotten thymus 18:00 • What’s the function of T-cells? 19:35 • How do you tell T-cells apart? 21:14 • The Human Leukocyte Differentiation Antigens Party 24:05 • The godfather of T-cells 24:45 • The TH-1 and TH-2 axis 27:30 • Experimental Autoimmune Encephalomyelitis model screwed everything up 29:16 • Interferon gamma 32:32 • What’s missing? IL-23 surprise 33:40 • IL-17 in the 1990’s 36:44 • The world is introduced to TH-17 39:12 • Let’s recap what we learned 40:30 • That is the end! 42:30 • Thanks for listening 42:39

We’d love to hear from you! Send your comments/questions to Dr. Brown at [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

References:

Bashyam H. J Exp Med. 2007;doi:10.1084/jem.2042fta

Bennetto L, et al. J Neurol Neurosurg Psychiatry. 2004;doi:10.1136/jnnp.2003.034256

Berche P. Presse Med. 2022;doi:10.1016/j.lpm.2022.104149

El-behi M, et al. J Neuroimmune Pharmacol. 2010;doi:10.1007/s11481-009-9188-9

Gooderham MJ, et al. J Eur Acad Dermatol Venereol. 2018;doi:10.1111/jdv.14868

Hawkes JE, et al. J Immunol. 2018;doi:10.4049/jimmunol.1800013

Rogozynski N, et al. Immunol Lett. 2024;doi:10.1016/j.imlet.2024.106870

Sospedra M, et al. Annu Rev Immunol. 2005;doi:10.1146/annurev.immunol.23.021704.115707

Steinman L. Nat Med. 2007;doi:10.1038/nm1551

Disclosures: Brown reports no relevant financial disclosures.

  continue reading

91 episodes

Artwork
iconShare
 
Manage episode 491721437 series 3560282
Content provided by Healio, Adam J. Brown, and MD. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Healio, Adam J. Brown, and MD or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.

In this episode, we dive into a two-part story of intrigue starting from a paradigm shift in understanding of T cell biology because of a mouse model of post-measles encephalopathy, to the eventual recognition of the IL-23/17 immune axis.

• Intro 0:01 • In this episode 0:12 • Interleukin-17 (IL-17) is a relatively recent discovery 1:34 • The beginning of TH-17 2:20 • Looking at autoimmune encephalopathy: A story of measles 03:30 • 1790’s woman with post measles inflammatory process in the brain 10:26 • What is causing post-infection encephalitis? 12:00 • Acute disseminated encephalomyelitis 12:30 • How did we find out the immune system was behind this - The rabies vaccine 13:09 • Similarity between the rabies vaccine and infections like measles 16:04 • T-cell lymphocytes 17:12 • The forgotten thymus 18:00 • What’s the function of T-cells? 19:35 • How do you tell T-cells apart? 21:14 • The Human Leukocyte Differentiation Antigens Party 24:05 • The godfather of T-cells 24:45 • The TH-1 and TH-2 axis 27:30 • Experimental Autoimmune Encephalomyelitis model screwed everything up 29:16 • Interferon gamma 32:32 • What’s missing? IL-23 surprise 33:40 • IL-17 in the 1990’s 36:44 • The world is introduced to TH-17 39:12 • Let’s recap what we learned 40:30 • That is the end! 42:30 • Thanks for listening 42:39

We’d love to hear from you! Send your comments/questions to Dr. Brown at [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

References:

Bashyam H. J Exp Med. 2007;doi:10.1084/jem.2042fta

Bennetto L, et al. J Neurol Neurosurg Psychiatry. 2004;doi:10.1136/jnnp.2003.034256

Berche P. Presse Med. 2022;doi:10.1016/j.lpm.2022.104149

El-behi M, et al. J Neuroimmune Pharmacol. 2010;doi:10.1007/s11481-009-9188-9

Gooderham MJ, et al. J Eur Acad Dermatol Venereol. 2018;doi:10.1111/jdv.14868

Hawkes JE, et al. J Immunol. 2018;doi:10.4049/jimmunol.1800013

Rogozynski N, et al. Immunol Lett. 2024;doi:10.1016/j.imlet.2024.106870

Sospedra M, et al. Annu Rev Immunol. 2005;doi:10.1146/annurev.immunol.23.021704.115707

Steinman L. Nat Med. 2007;doi:10.1038/nm1551

Disclosures: Brown reports no relevant financial disclosures.

  continue reading

91 episodes

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