Highlights from AAN 2025

Meeting Mic

In this episode of Meeting Mic, we bring you pearls and perspectives from the 2025 American Academy of Neurology Annual Meeting.

Mary A. O'Neal, MD, FAAN, and Ratna K. Bhavaraju-Sanka, MD, FAAN, discuss their efforts to address the lack of access to neurological care by partnering with primary care. :34

Merit E. Cudkowicz, MD, MSc, FAAN, speaks with Healio about being honored The American Academy of Neurology’s Lifetime Achievement Award for her extensive work in ALS research. 2:50

Read the full coverage here:

https://www.healio.com/news/neurology/20250417/partners-in-crime-neurologists-collaborate-with-pcps-to-improve-brain-health

https://www.healio.com/news/neurology/20250407/merit-e-cudkowicz-md-msc-receives-lifetime-award-for-als-research-im-not-done-yet

ACCORD-2: AXS-05 delays relapse time to Alzheimer’s disease agitation

Source: Grossberg G, et al. Efficacy and safety of AXS-05 in Alzheimer's disease agitation: Results from ACCORD-2, a phase 3 randomized withdrawal double-blind placebo-controlled study. Presented at: American Academy of Neurology Annual Meeting; April 5-9, 2025; San Diego.

Risk for ARIA driven by patient genotype, presence of hemorrhage in early Alzheimer’s

Source: Biffi A, et al. ARIA insights from the donanemab trials: Amyloid-targeted therapy in early symptomatic Alzheimer’s disease. Presented at: American Academy of Neurology Annual Meeting; April 5-9, 2025; San Diego.

Microplastics in oceans may increase disability risk among coastal populations

Source: Ganatra S, et al. Marine microplastics levels and the prevalence of neurologic disability. Presented at: American Academy of Neurology Annual Meeting; April 5-9, 2025; San Diego.

Nightmares may increase risk for early death

Source: Otaiku A, et al. Distressing dreams and risk of premature mortality: A population-based multicohort study. Presented at: American Academy of Neurology Annual Meeting; April 5-9, 2025; San Diego.

Disclosures:

Bhavaraju-Sanka reports serving as a consultant for Amgen and Argenx.

Cudkowicz reports financial relationships with AB Science, AC Immune SA, Aclipse, Annals of Neurology, Biogen, Coya Therapeutics, Cytokinetics, Eli Lilly, Immunity Pharma, InFlectis, Locust Walk, Novartis, Ono Pharmaceutical, Otsuka Pharmaceutical, Pasithea Therapeutics, Pontifax, Praxis Precision Medicine, Transposon, QurAlis, Regeneron, VectorY. She also reports receiving publishing royalties from a publication relating to health care. Her institution(s) received support from ALS Finding a Cure, ALS ONE, Biohaven, Calico, Clene Nanomedicine, Denali, ITB, Johnson & Johnson, the National Institute of Neurological Disorders and Stroke, PharmAust, Prilenia, Seelos, UCB/RA and Woolsley.

O’Neal reports serving as a consultant and excerpt witness for Circo; being an employee of Best Doctors; and receiving publishing royalties from a health care-related publication.