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Spatial Proteomics with Fiona Ginty Ph.D.
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On this episode of Translating Proteomics, host Parag Mallick discusses spatial proteomics with special guest Fiona Ginty Ph.D. Fiona is a Senior Principal Scientist in Precision Diagnostics at the GE Healthcare Technology & Innovation Center. She is a leader in the development of spatial proteomics technologies and their application in precision diagnostics and medicine.
Their discussion covers:
· How Fiona began working in spatial proteomics
· Why spatial biology is important
· What the future holds for spatial biology
Chapters:
00:00 – Introduction
01:54 – Fiona’s journey to biology
05:26 – Fiona’s transition to tool development
07:20 – Working at GE Research
11:26 – Identifying the importance of spatial biology
14:43 – How Cell DIVETM works
18:25 – The importance of single cell
23:01 - When Fiona realized the technology worked
28:04 – Spatial biology projects Fiona is excited about
30:08 – Fiona’s role in HuBMAP
36:50 – Learnings from HuBMAP so far
38:35 – The future of spatial proteomics in the clinic
46:56 – Current limits on spatial proteomics
49:56 – Current and future uses of AI in spatial proteomics
53:30 – The most exciting thing Fiona learned in her spatial proteomics journey
56:08 – Outro
Resources:
Method of the Year 2024: Spatial Proteomics
Paper covering the spatial proteomics technology Fiona worked on at GE Healthcare
HubMAP – Human BioMolecular Atlas Program
Cell DIVE Multiplex Imaging Solution
Papers discussing what makes colorectal cancer cells undergo apoptosis in response to chemotherapy
- An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution
- Integrated multiplex analysis of cell death regulators in stage II colorectal cancer suggests patients with ‘persister’ cell profiles fail to benefit from adjuvant chemotherapy
Paper discussing how the distance between tumor cells and cytotoxic t-cells correlates to caspase level
Paper showing it takes 3 hits from cytotoxic t-cells to kill cancer cells
Paper focused on generating new pathology image patches using AI
Acknowledgements
Dr. Ginty wanted to acknowledge the many people she’s worked with on Cell DIVE and as part of HuBMAP. She stresses that these are highly collaborative projects, and just some of the many great team members she's worked with are listed below.
Cell DIVE:
Anup Sood, Sean Dinn, Yunxia Sui, Sanghee Cho, John Graf , Kathleen Bove, Musodiq Bello, Sudeshna Adak, Michael Lazare, Anirban Bhaduri, Thomas Treynor, Dileep Vangasseri, Alberto Santamaria-Pang, Maureen Bresnahan, Micheal Gerdes, Megan Rothman, Colin McCullough, Chris Sevinsky, Liz McDonough, Christine Surrette, Max Seel, Alex Corwin, Bob Filkins, Kevin Kenny, Brion Sarachan, Mike Montalto, Christoph Hergersberg, John Burczak, Jens Rittscher, Steve Zingelewicz, Dr. Sunil Badve (Emory U), Dr. Yesim Gokmen Polar (Emory U), Eli Lilly collaborators
HuBMAP:
Lou Falo (U. Pitt), Arivarasan Karunamurthy (U. Pitt), John Hickey (Duke), Chenchen Zhu (Stanford), Ioannis Vlachos (BIDMC), Liz McDonough (GE HealthCare Technology and Innovation Center [HTIC]), Sammi Abate (GE HealthCare Technology and Innovation Center [HTIC]), Soumya Ghose (GE HealthCare Technology and Innovation Center [HTIC]), Christine Surrette (GE HealthCare Technology and Innovation Center [HTIC]), Dr. Katy Borner (Indiana U)
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