Ep. 24: This Ex-Surgeon Is Reprogramming Aging with AI and Systems Science

Precision Medicine Made Simple

We’re living in the age of health data overload—but how do you turn all those insights into real-life transformation? This episode of Precision Medicine Made Simple features Dr. Daniel Stickler, former vascular surgeon turned systems medicine pioneer, who’s leading the charge in longevity, AI-powered diagnostics, and cutting-edge clinical tools.

In this candid conversation with hosts Dr. Stanford and Taylor, Dr. Stickler opens up about the moment he walked away from surgery for good—and how it led to building an entirely new model of medicine. From continuous glucose monitors to full genome sequencing, from peptides to personalized AI agents, Dr. Stickler shares the emerging tools that are empowering both doctors and patients to move from disease management to proactive health optimization.

Whether you're a healthcare provider, tech innovator, or simply a wellness-curious listener, this episode will challenge your assumptions and give you a vision for the future of truly personalized care.

Key Takeaways

• Why most modern medicine is built around postponing death, not optimizing life
• How wearables like Garmin and UltraHuman reveal individual patterns (and change behavior fast)
• The overlooked power of epigenetics—and why lifestyle still rules your genes
• What peptides like BPC-157 and GLP-1 analogs are doing for healing, inflammation, and gut health
• How Dr. Stickler uses AI to process patient data and create 50-page system-based care plans in minutes
• Why “root cause” medicine might be an outdated myth—and what’s next

In This Episode

• [00:00] Introduction
• [00:14] Guest introduction: Dr. Daniel Stickler
• [01:00] Dr. Stickler's journey into medicine
• [03:19] Integrating wearable technology in medicine
• [05:39] The impact of wearables on patient care
• [12:38] Genetics and epigenetics in medicine
• [22:21] Systems-based medicine explained
• [27:08] The role of peptides in modern medicine
• [30:58] Introduction to GLP-1 peptides
• [31:30] Benefits and fine-tuning of semaglutide
• [32:35] Exploring BPC-157 for recovery
• [33:51] Oral vs. injectable BPC-157
• [35:05] Potential downsides of BPC-157
• [36:44] Wearable technology and recovery
• [38:19] The future of medicine: AI and personalized care
• [56:17] The role of physicians in the AI era
• [57:17] Concerns about over-reliance on technology
• [58:46] Recommended resources for providers and patients
• [01:01:19] FDA's role in approving medical advancements
• [01:03:42] Exosomes and young plasma therapy potential

Our Guest

Dr. Daniel Stickler is the Co-Founder and Chief Medical Officer of Apeiron Zoh and Mosaic Biodata, where he integrates wearable tech, AI, peptides, genetics, and systems thinking into personalized healthcare. A former high-volume surgeon, he now trains clinicians globally in longevity and performance medicine. He's also an advisor to Google and a recognized thought leader in human enhancement and optimization.

Resources and Links

Dr. Daniel Stickler

• Apeiron Center
• LinkedIn
• Substack

Taylor Cu

• Captivate.FM
• LinkedIn
• Instagram

Dr. William Stanford

• LinkedIn

Sponsored by: Biography Health

This episode is sponsored by Biography Health — where DNA-powered healthcare is designed just for you. Biography Health is a HIPAA-compliant precision medicine platform that equips providers with AI-driven recommendations powered by your genetics, health history, and clinical insights — all while keeping data private, secure, and independent from large EHR systems.

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.