MOTS-c Vs. SS-31 | Which Mitochondria Peptide Is Right For You?

The Hunter Williams Podcast

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In today’s video, I’m diving deep into the world of mitochondrial optimization, breaking down the key differences between two powerhouse peptides—MOTSc and SS31. I get questions about these peptides all the time, and there’s a lot of confusion out there. I’m here to clear it all up and give you a practical guide for using them effectively.
We’ll explore how MOTSc and SS31 target mitochondrial function in different yet complementary ways. Think of MOTSc as the “software upgrade” for your cells—it acts as a powerful signaling molecule enhancing metabolic flexibility, insulin sensitivity, and fat burning. On the other hand, SS31 is more like a “hardware upgrade,” stabilizing the mitochondrial structure, reducing oxidative stress, and protecting your cells during acute stress events.
Whether you’re trying to combat aging, enhance your athletic performance, or simply maintain optimal metabolic health, understanding the unique roles of these peptides is crucial. I’ll also cover precise dosing strategies, the best scenarios for each peptide, and whether or not you should combine them.
If you’re looking for a comprehensive comparison of MOTSc vs. SS31, you’re in the right place. Don’t forget to download my Peptide Cheat Sheet linked below for quick reference on dosages, mixing, and cycling strategies. And join Fully Optimized Health—the best private peptide community out there!
Timestamps:
0:00 - Intro: MOTSc vs. SS31 Overview
1:42 - Understanding Mitochondrial Dysfunction
2:16 - What is SS31? (Elamipretide)
2:41 - What is MOTSc? (Mitochondrial Peptide)
3:19 - How SS31 Works: The Hardware Upgrade
8:30 - How MOTSc Works: The Software Upgrade
9:55 - MOTSc & AMPK Activation: Metabolic Master Switch
11:17 - Hormesis: Why MOTSc Mimics Exercise
13:43 - MOTSc’s Role in Gene Expression
16:28 - Direct Comparison: MOTSc vs. SS31
18:21 - SS31 Preclinical Findings (Heart & Neuroprotection)
23:03 - MOTSc Preclinical Findings (Fat Loss & Exercise Performance)
29:40 - Human Clinical Trials: SS31
32:07 - Human Clinical Trials: MOTSc & Analogues
33:35 - Safety & Side Effects
35:38 - Synergies: Should You Combine MOTSc and SS31?
41:03 - My Recommended Dosing Protocols
42:20 - Final Summary & Practical Takeaways