A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health and hosted by Kris Tatiossian and Olivia Webb, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vijay Pande, Julie Yoo, Vineeta Agarwala, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg ...
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Similar to The Chain: Protein Engineering Podcast
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Episode 44: Structure Forward: Using Structural Biology Pipelines to Achieve Favorable Antibody Responses
Manage episode 352120998 series 2967424
Content provided by Cambridge Healthtech Institute. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Cambridge Healthtech Institute or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
Over the last two decades, cryogenic electron microscopy (cryo-EM) has transformed from what Dr. Andrew Ward calls the “outcast of structural biology” to one of the most promising technologies in the field. Ward, professor of integrative structural and computational biology at Scripps Research Institute, speaks with moderator Brandon DeKosky, assistant professor of chemical engineering at the Massachusetts Institute of Technology, about the evolution of cryo-EM and how its direct detector transformative technology enables scientists to craft favorable antibody responses.
Ward also talks about cryo-EM’s technological advantages when working with proteins, sterilizing immunity, and designing accurate structural biology pipelines that lead to next-generation vaccines. Finally, Ward offers his predictions about the immunological breakthroughs he thinks structural biologists will accomplish in the very near future.
Links from this episode:
Scripps Research Institute
PepTalk Conference
Discovery on Target Conference
75 episodes
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Manage episode 352120998 series 2967424
Content provided by Cambridge Healthtech Institute. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Cambridge Healthtech Institute or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
Over the last two decades, cryogenic electron microscopy (cryo-EM) has transformed from what Dr. Andrew Ward calls the “outcast of structural biology” to one of the most promising technologies in the field. Ward, professor of integrative structural and computational biology at Scripps Research Institute, speaks with moderator Brandon DeKosky, assistant professor of chemical engineering at the Massachusetts Institute of Technology, about the evolution of cryo-EM and how its direct detector transformative technology enables scientists to craft favorable antibody responses.
Ward also talks about cryo-EM’s technological advantages when working with proteins, sterilizing immunity, and designing accurate structural biology pipelines that lead to next-generation vaccines. Finally, Ward offers his predictions about the immunological breakthroughs he thinks structural biologists will accomplish in the very near future.
Links from this episode:
Scripps Research Institute
PepTalk Conference
Discovery on Target Conference
75 episodes
All episodes
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The Chain: Protein Engineering Podcast
1 Episode: 72 - Pamela Barney on HR Lessons to Meet the Needs of Biotech 35:23
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Play Later Play Later Lists Like LikedIn this episode of The Chain, host Tariq Ghayur, PhD, Tariq Ghayur Consulting, LLC, talks with Pamela Barney, former associate director of HR, AbbVie, about her career within biotech/pharma organizations and some key lessons learned, such as taking advantage of your contacts and network, managing diverse workforces, and HR’s role in creating an engaged team. Barney also discusses why she entered the HR field and the challenges of culture changes when transitioning from a small organization to a large company. AbbVie: https://www.abbvie.com/…
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The Chain: Protein Engineering Podcast
1 PEGS Young Scientist Keynote Jessica Stark on the Role of Glycans in Cancer Research 28:38
28:38 Play Later Play Later Lists Like Liked28:38
Play Later Play Later Lists Like LikedIn this episode of The Chain, host Brandon DeKosky, associate professor, speaks with MIT colleague Jessica Stark, Underwood-Prescott career development professor, about glycans and why they are important in cancer research. Stark discusses how she became interested in immunology, what her PhD and post-doctoral training was like, her thoughts on singlets operating as part of a network of checkpoint molecules, and what’s currently going on in glycobiology. She also talks about her keynote presentation at PEGS 2025 and what her new lab is working on. LINKS: MIT Department of Chemical Engineering MIT Department of Biological Engineering MIT…
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The Chain: Protein Engineering Podcast
1 Episode: 70 - Views on Machine Learning and AI in the Antibody and Protein Engineering Space 49:36
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Play Later Play Later Lists Like LikedMarch 11, 2025 | In this episode of The Chain, host Andrew Buchanan, principal scientist at AstraZeneca, and Andreas Plückthun, professor and head of biochemistry at the University of Zurich, discuss AI/ML technologies in the antibody and protein engineering space. Plückthun shares his perspectives on what technologies show promise and success, why the definition of epitope is important when developing a drug, and what aspects he expects to improve in the ML field in the future.…
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The Chain: Protein Engineering Podcast
1 Episode: 69 - Conversation with Sir Greg Winter on the 50th Anniversary of the Milstein and Köhler Paper 50:36
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Play Later Play Later Lists Like LikedFebruary 21, 2025 | This episode marks the 50th anniversary of one of the most influential papers in biomedical science—the 1975 Milstein and Köhler paper on hybridoma technology, which paved the way for monoclonal antibodies. Ralph Minter, Biotech CSO/CTO, discusses this important milestone with a true pioneer in the field, Sir Greg Winter, Nobel Laureate and one of the key figures in the development of therapeutic antibodies.…
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The Chain: Protein Engineering Podcast
1 Episode: 68 - Changing the Game of Protein-Protein Interactions With Randolph Lopez 46:00
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Play Later Play Later Lists Like LikedIn this episode of The Chain, host Andrew Bradbury, CSO of Specifica, an IQVIA business, speaks with Randolph Lopez, CTO and co-founder of A-Alpha Bio, about how A-Alpha Bio is changing the game of protein-protein interactions with their platform AlphaSeq. Lopez delves into the origins, the process, the successes, and the possibilities of the company’s platform and how it can help with epitope mapping, affinity predictions, and off-target binding. With the data the platform generates, Lopez also discusses how this affects the potential of AI and ML. LINKS: Bionavigen A-Alpha Bio Specifica…
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The Chain: Protein Engineering Podcast
1 Episode: 67 - Anthony Tolcher Discusses Oncology, Dual-Payload Technology, and the ADC Field 42:34
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Play Later Play Later Lists Like LikedNovember 12, 2024 | In this episode of The Chain, host Rakesh Dixit, PhD, DABT, president and founder of Bionavigen Oncology and Regio Biosciences, speaks with Anthony Tolcher, M.D., FRCPC, cofounder of NEXT Oncology, about antibody drug conjugates (ADCs) including the role of the bystander effect, approaching targets in oncology, dual-payload technologies, the potency of new payloads, and bispecific targeting. Tolcher also shares what inspired him to pursue oncology, how he came across ADCs, and where he sees ADCs heading in the future. LINKS: Bionavigen NEXT Oncology…
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The Chain: Protein Engineering Podcast
1 Episode: 66 - John Lambert on Antibody Drug Conjugates Then, Now, & Beyond 39:43
39:43 Play Later Play Later Lists Like Liked39:43
Play Later Play Later Lists Like LikedOctober 15, 2024 | In this month’s episode of The Chain, host Rakesh Dixit, PhD, DABT, president and founder of Bionavigen Oncology and Regio Biosciences, and John Lambert, PhD, consultant, about antibody drug conjugates (ADCs) then, now, and beyond. Lambert shares his experiences from his decades-long career at ImmunoGen, why ADCs are more successful now compared to in the past, and where he sees ADCs going forward. He also discusses his thoughts on the half-life of diffusible payloads, the toxicity of the bystander effect, and more. LINKS: Bionavigen ImmunoGen…
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The Chain: Protein Engineering Podcast
1 Episode 65- Tariq Ghayur on the Renaissance of Bispecifics and ADCs, AI, and More 31:55
31:55 Play Later Play Later Lists Like Liked31:55
Play Later Play Later Lists Like LikedSeptember 10, 2024 | In this episode of The Chain, host Nimish Gera speaks with Tariq Ghayur, of Tariq Ghayur Consulting, LLC and Entrepreneur in Residence, FairJourney Biologics (and a fellow host of the podcast), about the current renaissance of bispecifics and ADCs, the impact of AI in pharmaceuticals, and what to watch out for in the biopharma space in the next few years. Ghayur also shares his journey from BASF Pharma to AbbVie, what it was like when the industry shifted its focus from small molecules to biologics, and the major differences between doing a postdoc in academia versus in the industry.…
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The Chain: Protein Engineering Podcast
1 Episode: 64 - Peyton Greenside on AI’s Role in Antibody Engineering, Optimization, and More 32:31
32:31 Play Later Play Later Lists Like Liked32:31
Play Later Play Later Lists Like LikedIn this episode of The Chain, host Nimish Gera, Ph.D., vice president of biologics at Mythic Therapeutics, speaks with Peyton Greenside, CSO and co-founder of BigHat Biosciences, about the role of AI and machine learning in antibody engineering and targeting complex modalities, including bispecifics and ADCs. Greenside also discusses the work her organization does, what BigHat is doing to ensure the quality of data to train their AI models with, the methods of approaching harder targets such as GPCRs, and certain properties that AI can optimize better.…
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The Chain: Protein Engineering Podcast
1 Episode: 63 - Discussing Protein Signaling and Structural Biology With Andrew Kruse 38:18
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Play Later Play Later Lists Like LikedIn this episode of The Chain, host Brandon DeKosky, associate professor at MIT, speaks with Andrew Kruse, PhD, professor of biological chemistry and molecular pharmacology at Harvard University, about protein signaling and structural biology. Kruse explains what exactly bias signaling is and discusses the problems he and his team are working to resolve, as well as the tools they use to work out the dynamics of structures. He also shares the findings in signaling receptors and biology that he’s most excited about, recent advancements that have caught his attention, and the new directions for him and his lab.…
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The Chain: Protein Engineering Podcast
1 Episode: 62 - AI/ML in Antibody Discovery and Engineering: Reality, Hope, Future, and Hype 1:03:57
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Play Later Play Later Lists Like Likedhis special episode of The Chain features a panel of industry experts who discussed AI and ML in antibody discovery and engineering at this year’s PEGS Boston event. Peter Tessier, professor at the University of Michigan; Andrew Bradbury, CSO at Specifica; Andrew Waight, Senior Director of Machine Learning, Discovery Biologics & Protein Sciences at Merck Research Labs; Peyton Greenside, Co-Founder & CSO of BigHat Biosciences; and Paolo Marcatili, Director of Antibody Design at Novo Nordisk take on where AI/ML has the biggest impact, what the hype is in the use of AI/ML in antibody discovery, how new AI/ML methods are being benchmarked against traditional discovery methods, and what controls should be used in an AI/ML discovery or optimization campaign.…
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The Chain: Protein Engineering Podcast
1 Episode: 61 - Tomoyuki Igawa Discusses Leadership and His Experiences in Discovery and Development 55:04
55:04 Play Later Play Later Lists Like Liked55:04
Play Later Play Later Lists Like LikedIn this episode of The Chain, host Tariq Ghayur, PhD, consultant and entrepreneur in residence, FairJourney Biologics, speaks with Tomoyuki Igawa, PhD, chief executive officer, Chugai Pharmabody Research in Singapore, about his 20+ years of experience in drug discovery and development. Igawa possesses a unique perspective that has allowed him and his team to develop innovative concepts, such as recycling sweeping antibodies and bispecific platforms. He discusses how the discovery and development organizations work together to provide a steady supply of products, how he builds the right team when starting a new project, and how to keep team members engaged and motivated. He also offers advice for young scientists on the importance of enjoying their work and how to maintain work-life balance.…
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The Chain: Protein Engineering Podcast
1 Episode: 60 - Lesley Millar-Nicholson on Technology Licensing, Navigating Patents, and Building Teams 48:14
48:14 Play Later Play Later Lists Like Liked48:14
Play Later Play Later Lists Like LikedThis month The Chain shares a recent episode of the Lab Rats to Unicorns podcast. Lab Rats to Unicorns, hosted by John Flavin, aims to demystify the process of creating a great company in the life sciences, biotech, medtech, clean energy, and beyond. In this episode, Flavin speaks with Lesley Millar-Nicholson, executive director of MIT’s Technology Licensing Office (TLO). Millar-Nicholson discusses the role of the TLO, what happens after a patent is filed and licensed to a company or start-up, how she got her start in the field, and her journey from Scotland to the U.S. She also delves into finding the right people for the best team, the importance of a diverse workforce and awareness, and being around science as a non-scientist.…
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The Chain: Protein Engineering Podcast
1 Episode: 59 - Gabriel Rocklin on Protein Biophysics and Protein Design 33:10
33:10 Play Later Play Later Lists Like Liked33:10
Play Later Play Later Lists Like LikedIn this month’s episode of The Chain, host Ben Hackel, professor of Chemical Engineering & Materials Science at the University of Minnesota, speaks with Gabriel Rocklin, assistant professor of Pharmacology at Northwestern University, about two recently published papers from Rocklin’s lab: one on advancing the ability to design challenging typologies and one on developing and leveraging a new technique on high-throughput protein biophysics. Rocklin shares the journey from ideation to realization of the research process, the inspiration that motivated the work, and interesting results and technological advancements discovered along the way. He also talks about the opportunities emerging from his team’s research and the challenges that still need overcoming, as well as offers advice for future scientists interested in protein biophysics.…
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The Chain: Protein Engineering Podcast
1 Episode: 58 - Janine Schuurman Reflects on the Key Lessons and Accomplishments of Her 20-Year Career 55:05
55:05 Play Later Play Later Lists Like Liked55:05
Play Later Play Later Lists Like LikedHow does one maintain innovation in the antibody industry? In this episode of The Chain, host Tariq Ghayur, PhD, consultant and entrepreneur in residence, FairJourney Biologics, talks with Janine Schuurman, PhD, president of The Antibody Society, independent biotech consultant and founder of Lust for Life Sciences, about her inspiration to get into antibody engineering, her impressive career at Genmab, advice for a productive work environment, and her current work. Dr. Schuurman also shares insights on staying innovative, how to deal with the challenges of the industry, why young scientists should not be afraid to fail, as well as her plans as the new president of The Antibody Society. Links: Lust for Life Sciences: https://www.lustforlifescience.com/ The Antibody Society: https://www.antibodysociety.org/ FairJourney Biologics: https://fjbio.com/…
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Similar to The Chain: Protein Engineering Podcast
A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health and hosted by Kris Tatiossian and Olivia Webb, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vijay Pande, Julie Yoo, Vineeta Agarwala, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg ...
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continue reading
Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
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