How SpineDAO Is Redefining DeSci - From Back Pain to Blockchain

The DeSci Podcast

21:38

Burnout Recovery works better with support. UNFRIED is our small group (5 people max!) coaching program to help guide you through your recovery. Apply now! [ http://bit.ly/unfried ] Burnout quietly hijacks your focus, your memory, your sleep, and eventually, your sense of self. In this #straightfromcait episode, Cait Donovan unpacks the results of a burnout symptoms survey answered by over 150 listeners. What shows up again and again? Brain fog. Forgetfulness. Sleep issues. That heavy, unshakable sense of dread. She walks through the patterns in these responses with honesty and insight, weaving in what we know about how burnout affects the brain and what it feels like to lose your ability to think clearly or remember what used to bring you joy. Have you ever found yourself feeling disconnected from who you are? Struggling to rest even when you finally have time? Wondering why everything feels harder than it used to? Cait gets it. She’s been there, and she knows how isolating it can feel. This episode offers language for what you’ve been living through and a reminder that self-abandonment doesn’t have to be your default setting. Healing starts when you begin listening to yourself again. Episode Breakdown: 00:00 Introduction 01:30 How the Burnout Survey Was Conducted 02:33 Why Burnout Impacts Your Brain 07:26 The Emotional Weight of Dread 10:39 When You Can’t Think, Plan, or Remember 13:50 How Burnout Disrupts Sleep and Fuels Anxiety 16:22 Shame, Guilt, and the Struggle to Rest 18:29 Burnout and the Loss of Self 21:02 Reclaiming Compassion in the Healing Process Links Connect with Cait: Initial Call with Cait: bit.ly/callcait Initial Call with Sarah: bit.ly/callsarahv Burnout Recovery works better with support. UNFRIED is our small group (5 people max!) coaching program to help guide you through your recovery. Apply now! [ http://bit.ly/unfried ] Podcast production and show notes provided by HiveCast.fm…

about a year ago 58:48

MP3•Episode home

What if your next spine surgery was coordinated by a DAO?

In Episode 48 of the Molecule Podcast, we’re joined by Vincent Challier, spine surgeon and co-founder of SpineDAO, and Virginie Lafage, medical strategist and Core Team member, to explore how decentralized science can transform a field as specialized and critical—as spinal health.

SpineDAO is building one of the first focused medical DAOs on the Bio Launchpad. In this episode, we cover:

• Why spinal health is overlooked in innovation

• The power of patient and clinician-led DAOs

• Challenges of onboarding medical professionals into DeSci

• Real-world use cases for DAOs in healthcare

• Why Solana? Technical decisions behind the DAO’s design

Whether you’re into biotech, DAOs, or the future of decentralized medicine, this conversation bridges science, surgery, and Web3 in a way you’ve never heard before.

⏱️ Timestamps

0:00 – Intro: Meet Vincent & Virginie from SpineDAO

2:10 – How they met and started the DAO

5:18 – From spine surgery to decentralization: Why this field?8:50 – Building a community around spine health

12:42 – Why spinal innovation is long overdue

17:20 – Challenges patients face in current medical systems

24:10 – How DAOs can unlock patient-centric research

29:45 – Engaging surgeons and clinicians in DeSci

36:30 – Building accessibility into Web3 onboarding

40:00 – Why SpineDAO chose Solana

44:23 – The Bio Launchpad auction and what’s next

49:04 – A message to their future community

52:10 – The real-world use case for SpineDAO

______

🔔 Subscribe to stay updated: https://www.youtube.com/@Molecule_dao/?sub_confirmation=1

______

If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.

If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to

_________

Special thanks to:

Vincent Challier : https://x.com/challaire

Virginie Lafage : https://x.com/VirginieLafage

Ella McCarthy-Page :https://x.com/EMcCarthyPage

______

Let's connect:

Website: https://bit.ly/3d6nh2C

Twitter: https://twitter.com/Molecule_dao

Discord: https://discord.gg/ZHGpJQzeTq

Molecule - The future of medicine belongs to everyone

50 episodes

#Science #Molecule

How SpineDAO Is Redefining DeSci - From Back Pain to Blockchain

The DeSci Podcast

15 subscribers

published about a year ago

MP3•Episode home

What if your next spine surgery was coordinated by a DAO?

SpineDAO is building one of the first focused medical DAOs on the Bio Launchpad. In this episode, we cover:

• Why spinal health is overlooked in innovation

• The power of patient and clinician-led DAOs

• Challenges of onboarding medical professionals into DeSci

• Real-world use cases for DAOs in healthcare

• Why Solana? Technical decisions behind the DAO’s design

Whether you’re into biotech, DAOs, or the future of decentralized medicine, this conversation bridges science, surgery, and Web3 in a way you’ve never heard before.

⏱️ Timestamps

0:00 – Intro: Meet Vincent & Virginie from SpineDAO

2:10 – How they met and started the DAO

5:18 – From spine surgery to decentralization: Why this field?8:50 – Building a community around spine health

12:42 – Why spinal innovation is long overdue

17:20 – Challenges patients face in current medical systems

24:10 – How DAOs can unlock patient-centric research

29:45 – Engaging surgeons and clinicians in DeSci

36:30 – Building accessibility into Web3 onboarding

40:00 – Why SpineDAO chose Solana

44:23 – The Bio Launchpad auction and what’s next

49:04 – A message to their future community

52:10 – The real-world use case for SpineDAO

______

🔔 Subscribe to stay updated: https://www.youtube.com/@Molecule_dao/?sub_confirmation=1

______

If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.

If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to

_________

Special thanks to:

Vincent Challier : https://x.com/challaire

Virginie Lafage : https://x.com/VirginieLafage

Ella McCarthy-Page :https://x.com/EMcCarthyPage

______

Let's connect:

Website: https://bit.ly/3d6nh2C

Twitter: https://twitter.com/Molecule_dao

Discord: https://discord.gg/ZHGpJQzeTq

Molecule - The future of medicine belongs to everyone

50 episodes

#Science #Molecule

All episodes

The DeSci Podcast

1
Human Trials for Anti-Aging Drugs! 0:38

21 days ago0:38

0:38

What if we stopped treating aging as “natural” and started treating it like a disease? In this episode of the Molecule Podcast, Ella McCarthy-Page (Sci Comms Lead at Molecule)and Alana Tara Singh (Behavioural Strategist) unpack a seismic shift in how governments are approaching longevity science. The German National Academy of Sciences has officially defined aging as a disease target, opening the door for clinical trials, new drug development, and the first regulatory frameworks focused on reversing age-related decline. They’re joined by Michael Torres (co-founder, R10 Bio & VITA RNA), who shares why he’s launching a human clinical trial targeting post-chemo aging in Abu Dhabi, a country now fast-tracking longevity drugs under radical new trial standards. You’ll learn: * Why aging wasn’t treatable (until now) * What Germany’s new policy really means * How Rapamycin exposed the flaws in current regulation * Why Abu Dhabi is leading the longevity race * The role of DeSci in decentralized drug development * How R10 Bio used Molecule’s IP-NFT model to raise funds * The real story behind Michael’s anti-aging therapy Welcome to the future of proactive medicine! Let’s reimagine aging before it redefines us. Timestamps: 00:00 – Intro with Ella & Alana 00:34 – Germany now targets aging as a disease 01:30 – Why regulators blocked anti-aging drugs 02:40 – Rapamycin and the loophole problem 04:00 – Why off-label drugs are risky 05:20 – Germany’s surprise leadership in longevity 06:00 – Abu Dhabi’s radical trial reforms 09:15 – Raves, cappuccinos & Gen Z health trends 10:00 – Can we prevent cancer by targeting aging? 10:50 – What is R10 Bio’s therapy actually doing? 12:00 – The DeSci fundraising journey with Molecule 13:10 – From mutation suppression to clinical readiness 14:00 – Why Abu Dhabi was chosen for trials 14:40 – Michael Torres on aging post-chemo 16:00 – Defining a huge market with aging-related outcomes 17:00 – Why rare disease trials don’t scale 18:00 – How Abu Dhabi is implementing FDA “guidance”…

The DeSci Podcast

1
The Real Story Behind Pump Science! 1:27:09

22 days ago1:27:09

1:27:09

What if your healthspan was backed by a token? What if trading fees funded science? And what if longevity wasn’t just about “not dying”, but about living better for the ones you love? In this episode of the Molecule Podcast, we dive deep with Jillian and Benji, the team behind Pump Science, a protocol that combines crypto markets with open scientific experimentation to find real longevity compounds. But this episode isn’t just technical. It’s deeply human. From bonding curves and tokenomics to holding your child longer, this is what decentralized science looks like when purpose meets protocol. We cover: * The emotional “why” behind longevity research * How crypto markets fund real scientific experiments * Testing pipeline: from worms to flies to mice to humans * The design of the Pump Science game, and how it rewards curiosity * How you can submit your own idea for a longevity compound * What’s next for Pump Science This is more than a podcast, it’s a thesis on how the future of health could be fun, fair, and radically open. — Timestamps: 0:00 – Intro: Do you want to live for tomorrow? 1:45 – A mother’s promise: holding her son longer 5:35 – Longevity as emotional responsibility 8:12 – Why crypto is the only viable engine 10:10 – Pump Science protocol explained from first principles 14:42 – Launching a compound via bonding curve 17:55 – Who are the players? Drug devs & gem hunters 24:18 – What happens when a token “migrates” 29:34 – How token trading fees fund real experiments 32:20 – The buyback & burn mechanic 37:02 – The new standard for supplement + data 39:15 – Why not wait for human data? Worms, flies & predictive efficiency 48:04 – Pump Science vs other longevity efforts (Brian Johnson, etc.) 50:25 – How much has actually been studied in longevity? 55:00 – Why this system must exist, or nothing will change 57:02 – Making science fun again: designing a game people want to play 1:00:00 – Fly racing & the next experimental features 1:02:30 – Launching more tokens, testing more ideas 1:04:05 – How you can submit your own compound 1:05:40 – Final vision: best products, open data, real change 🔔 Subscribe to stay updated: https://www.youtube.com/@Molecule_dao/?sub_confirmation=1 ______ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to Special thanks to: ______ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.gg/ZHGpJQzeTq Molecule - The future of medicine belongs to everyone…

The DeSci Podcast

1
The Future of Cancer Therapy: Modular, Safe & Open! 41:51

8 weeks ago41:51

41:51

What if your immune cells came with a smart upgrade?In this episode of the DeSci Podcast, we speak with Dr. Henry Erdlei, medical doctor, cancer researcher, and founder of GoCart, a new cell therapy platform building safer, modular CAR-T therapies through decentralized science.Henry breaks down:* How CAR-T cell therapies work* The real-world risks of immune overactivation* Why cancer is hard to distinguish from healthy tissue* The problem with existing logic gates in cell therapies* His own innovation: an external AND-gate adapter system* Why DeSci and IP-NFTs are the right path for early-stage therapeutics🔔 Subscribe to stay updated: https://www.youtube.com/@Molecule_dao/?sub_confirmation=1______If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.toTimestamps0:00 – Intro: What is CAR-T therapy?2:00 – Henry’s background & journey into cancer research4:20 – What T-cells do and why they fail in cancer7:30 – CAR-T vs chemotherapy: cost, complexity, and potential11:00 – Which cancers are eligible for CAR-T treatment?13:10 – Risks: cytokine storms, immune cascades, suicide switches17:30 – Emily Whitehead: the first CAR-T success story20:30 – Current limitations of approved CAR-Ts (CD19, BCMA)23:00 – Introducing GoCart and their “AND gate” design26:00 – Why tumor targeting needs precision logic29:00 – Modular CAR-Ts and the future of personalized medicine32:00 – Why GoCart is building in public with Molecule34:30 – Can DeSci unlock truly customizable cell therapies?37:00 – From research to startup: bridging the valley of death40:00 – How to follow GoCart and get involved______Let's connect: Website: https://bit.ly/3d6nh2CTwitter: https://twitter.com/Molecule_daoDiscord: https://discord.gg/ZHGpJQzeTqMolecule - The future of medicine belongs to everyone…

The DeSci Podcast

1
The Hidden Quantum World Inside Your Body! 58:00

9 weeks ago58:00

58:00

What if you were told that your body is secretly responding to Wi-Fi signals you can't even feel?In episode 49 of the Molecule Podcast we meet Dr. Geoff Anders (Founder, Leverage) and Dr. Clarice D. Aiello (Quantum Engineer), to explore the cutting-edge field where quantum physics meets biology, revealing how the smallest particles in the universe might be controlling the largest processes in life itself. Whether you're a scientist, technologist, or simply curious about the quantum world around us, this deep dive into quantum biology will change how you think about life, technology, and the future of medicine. • Quantum biology explained in simple terms• Weak magnetic field effects on cellular processes• The radical pair mechanism and quantum sensing in nature• Space exploration and magnetic field implications• DeSci (Decentralized Science) and crypto funding for research• The future of quantum-controlled medicine• Open science and radical transparency in researchTake a leap into the never ending world of science and imagination with this podcast.Timestamps:00:00:02 - Introduction to Quantum Biology00:02:31 - Quantum Physics in Everyday Life00:04:34 - Understanding the Micro to Macro Connection00:08:11 - Weak Magnetic Fields and Cellular Response00:10:31 - Space Exploration and Magnetic Fields00:14:10 - Mars Colonization Challenges00:15:10 - Future Applications00:16:57 - Personal Backgrounds00:18:36 - From Quantum Sensors to Biology00:20:16 - The DeSci Connection00:27:07 - Real-World Applications Vision00:31:09 - Multiple Flavors of Quantum Biology00:35:45 - Music and Plant Growth00:43:19 - The Consciousness Question00:54:06 - Radical Open Science00:55:15 - How to Get Involved00:56:39 - Final Thoughts🔔 Subscribe to stay updated: https://www.youtube.com/@Molecule_dao/?sub_confirmation=1______If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.toSpecial thanks to: ______Let's connect: Website: https://bit.ly/3d6nh2CTwitter: https://twitter.com/Molecule_daoDiscord: https://discord.gg/ZHGpJQzeTqMolecule - The future of medicine belongs to everyone…

The DeSci Podcast

1
If Einstein Was Born Today, He Would Have Chosen DeSci! 44:39

12 weeks ago44:39

44:39

What if science wasn’t locked in labs or universities? In episode 47 of the Molecule Podcast, we meet Juan Keymer, Assistant Professor, Shenzhen X-Institute who enlightens us on the existing academic pipeline and how it can be made more flexible with the advancement in AI, DeSci (Decentralized Science), Blockchain Innovation, Open Credentials and more. • Reimagining the future of Science with DeSci. • This is a deep, thoughtful, and radically hopeful conversation about the future of learning, research, and planetary collaboration. • Indulge in a world of Science with Juan Keymer and Ella McCarthy-Page (SciComms Lead at Molecule) away from textbooks and traditional academic systems. In this fascinating episode, we dive deep into reimagining the infrastructure of science away from elite institutions and toward decentralized, gamified systems that anyone can engage in. Timestamps 00:00:00 – Introduction: A New Vision for Science 00:03:15 – The Problem with Academia & Closed Scientific Systems 00:10:47 – Open Degrees & Scope for Open Credentials 00:15:20 – The New Scientific Interface 00:20:34 – Biotic Games: How Living Systems Become Game Mechanics 00:28:45 – Open Hardware and Decentralized Labs 00:35:06 – Rewiring Academia: Parallel Programming & Self-Credentialing 00:37:00 – Metaverse & Blockchain-Powered Ecosystems 00:41:00 – Fun First, Research Second 00:43:00 – Final Reflections: The Power of Play in Scientific Discovery 🔔 Subscribe to stay updated: https://www.youtube.com/@Molecule_dao/?sub_confirmation=1 ______ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to ______ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.gg/ZHGpJQzeTq Molecule - The future of medicine belongs to everyone…

The DeSci Podcast

1
$2.2B in Research Grants Frozen: Can DeSci Save Research? 43:45

13 weeks ago43:45

43:45

Over $2.2 billion in NIH research grants are frozen. Labs are going dark. What happens now? In Episode 46 of the Molecule Podcast, we speak with Aaron Weaver, Chief Commercial Officer at Molecule, about the ongoing NIH funding crisis, its global impact, and how decentralized science (DeSci) is becoming a critical alternative. Aaron brings a unique vantage point from the intersection of venture capital, biotech, and public science funding. This episode unpacks: • The real story behind the NIH funding freeze • Why the budget cuts on indirect costs are threatening university research • What happens when academia loses funding momentum • How DeSci offers new models for sustainability and collaboration • How to get involved — even if you’re not a researcherIf you care about the future of scientific discovery, this episode is essential. Timestamps- 0:00 – Intro: The NIH funding crisis 1:30 – What’s actually frozen? Why $2.2B is stalled 2:50 – Meet Aaron Weaver: CCO of Molecule & DeSci advocate 5:00 – Why indirect costs are at the center of the issue 9:00 – How operational freezes threaten lab survival 11:30 – The fragility of foundational science 13:45 – NIH’s critical role in FDA-approved drugs 17:00 – Academic research vs. commercialization pipelines 20:15 – Who’s affected most? Young researchers & labs 23:00 – Global ripple effects & talent displacement 27:00 – Why traditional VC can’t fill the gap 30:10 – DeSci as a market structure for resilient funding 32:45 – Are universities ready for DeSci? 35:20 – Connecting scientists with global communities 37:10 – Science as public purpose and personal mission 40:00 – How you can get involved in the DeSci movement 🔔 Subscribe to stay updated: https://www.youtube.com/@Molecule_dao/?sub_confirmation=1______If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.toSpecial thanks to: Aaron Weaver : https://x.com/RealAaronWeaverJillian Casalini : https://x.com/JillianCasalini______Let's connect: Website: https://bit.ly/3d6nh2CTwitter: https://twitter.com/Molecule_daoDiscord: https://discord.gg/ZHGpJQzeTqMolecule - The future of medicine belongs to everyone…

The DeSci Podcast

1
How SpineDAO Is Redefining DeSci - From Back Pain to Blockchain 58:48

14 weeks ago58:48

58:48

What if your next spine surgery was coordinated by a DAO? In Episode 48 of the Molecule Podcast, we’re joined by Vincent Challier, spine surgeon and co-founder of SpineDAO, and Virginie Lafage, medical strategist and Core Team member, to explore how decentralized science can transform a field as specialized and critical—as spinal health. SpineDAO is building one of the first focused medical DAOs on the Bio Launchpad. In this episode, we cover: • Why spinal health is overlooked in innovation • The power of patient and clinician-led DAOs • Challenges of onboarding medical professionals into DeSci • Real-world use cases for DAOs in healthcare • Why Solana? Technical decisions behind the DAO’s design Whether you’re into biotech, DAOs, or the future of decentralized medicine, this conversation bridges science, surgery, and Web3 in a way you’ve never heard before. ⏱️ Timestamps 0:00 – Intro: Meet Vincent & Virginie from SpineDAO 2:10 – How they met and started the DAO 5:18 – From spine surgery to decentralization: Why this field?8:50 – Building a community around spine health 12:42 – Why spinal innovation is long overdue 17:20 – Challenges patients face in current medical systems 24:10 – How DAOs can unlock patient-centric research 29:45 – Engaging surgeons and clinicians in DeSci 36:30 – Building accessibility into Web3 onboarding 40:00 – Why SpineDAO chose Solana 44:23 – The Bio Launchpad auction and what’s next 49:04 – A message to their future community 52:10 – The real-world use case for SpineDAO ______ 🔔 Subscribe to stay updated: https://www.youtube.com/@Molecule_dao/?sub_confirmation=1 ______ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to _________ Special thanks to: Vincent Challier : https://x.com/challaire Virginie Lafage : https://x.com/VirginieLafage Ella McCarthy-Page :https://x.com/EMcCarthyPage ______ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.gg/ZHGpJQzeTq Molecule - The future of medicine belongs to everyone…

The DeSci Podcast

1
The Solution to Science's BIGGEST PROBLEM | Kevin Noessler 39:44

15 weeks ago39:44

39:44

What if we could reinvent intellectual property for science? In this episode of Molecule’s DeSci Podcast, Kevin Noessler - Product Head at Molecule - joins us to talk about the next frontier of DeSci Science: Proof of Invention. Kevin unpacks how Molecule is building infrastructure for decentralized IP creation, ownership, and attribution. This episode zooms in on how DeSci tools can validate and tokenize early-stage scientific ideas—before patents or papers. We cover: • Kevin’s background and his role in shaping Molecule’s product roadmap • What “Proof of Invention” really means—and how it works onchain • Rethinking IP and scientific reputation through cryptographic primitives • UX challenges when designing for biotech DAOs • The difference between building SaaS vs protocols in DeSci • How open-source values translate into credible scientific infrastructure Whether you’re an innovator, researcher, or builder—this episode is a roadmap for the future of intellectual property in science.⏱ Timestamps: 00:00 - Intro 01:10 - Kevin’s background & journey to Molecule 05:00 - What does a Product Head do in a decentralized org?09:20 - SaaS vs Protocol: Rethinking product building 13:00 - Contributors, not customers: the shift in stakeholder models 17:15 - UX challenges for onchain science tools 21:40 - What makes a product work in DeSci? 26:00 - Building with researchers in mind 30:30 - Kevin’s long-term vision for Molecule 35:00 - Advice for builders entering DeSci 39:20 - Outro ________ 🔔 Subscribe to stay updated: https://www.youtube.com/@Molecule_dao/?sub_confirmation=1______ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to ______ Special thanks to: - Kevin Noessler: https://x.com/Noesslek - Ella McCarthy-Page: https://x.com/EMcCarthyPage ______ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.gg/ZHGpJQzeTq Molecule - The future of medicine belongs to everyone…

The DeSci Podcast

1
IP, DAOs & Cultural Ownership: Jesse Hudson Reveals the FUTURE of DeSci 1:00:49

19 weeks ago1:00:49

1:00:49

What if the future of science and biotech was built on legal frameworks that empower communities, not corporations? In Episode 44 of the Molecule Podcast, we sit down with Jesse Hudson — lawyer, anthropologist, and Chief Legal Architect at Molecule. Jesse is a pioneer in building legal infrastructure for decentralized science (DeSci), DAOs, and intellectual property (IP) tokenization. This episode dives deep into: - The failure of the current global IP system - IP as cultural infrastructure - IP tokenization and why it matters for DAOs - Licensing, enforcement, and the problem of patent trolls - How indigenous IP and cultural property are being reclaimed through blockchain - New models for governance, dispute resolution, and community-owned IP Jesse’s unique experience working with Amazonian tribes, biotech DAOs, and legal DAOs brings one of the most profound and ethical perspectives to the DeSci conversation. Timestamps:0:00 – Intro: Why IP matters2:13 – Meet Jesse Hudson: Legal architect & anthropologist5:05 – From anthropology to biotech DAOs7:44 – IP in the digital age: Why it’s grown 70x11:02 – How IP impacts individuals: NIL rights & personal brands15:10 – IP basics: Trademark, copyright, patents20:05 – Patent trolls & the licensing problem27:01 – Is the IP system serving the public?30:10 – Tesla & IP strategy: When to share vs protect33:42 – DAOs as IP holders: SideDAO & decentralized licensing36:10 – IP tokens & collective governance38:18 – Indigenous cultural IP: Working with the Shipibo tribe44:20 – NFT royalties & licensing for indigenous art48:52 – IP ethics: Alternative models beyond Western frameworks53:22 – DAO-based dispute resolution & legal evolution59:50 – Closing thoughts: Cultural values driving IP systems🔗 Learn more at https://molecule.xyz…

The DeSci Podcast

1
Graham Pechenik Reveals The FUTURE of Psychedelic Patents | The DeSci Podcast 1:47:56

20 weeks ago1:47:56

1:47:56

The psychedelic industry is booming, but a major battle is unfolding: Who will control the future of these powerful medicines? Will open science prevail, or will corporations dominate through patents? In this episode, we sit down with Graham Pechenik, a leading expert in psychedelic patent law, to unravel the complexities of intellectual property in the space.Graham Pechenik is the founder of Calyx Law, a law firm specializing in psychedelic and cannabis patents. With a background in neuroscience and law, he provides deep insights into the legal landscape shaping the future of psychedelic medicine.Topics Discussed:• The role of patents in psychedelic research• Controversies around corporate control and monopolization• How open-source models could challenge big pharma• What legal battles mean for researchers, startups, and patients• The future of psychedelic accessibilityTune in to get expert insights from one of the leading voices in psychedelic IP law.______If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.toSpecial thanks to: Ella McCarthy-Page - https://x.com/EMcCarthyPageGraham Pechenik - https://x.com/calyxlaw______Let's connect: Website: https://bit.ly/3d6nh2CTwitter: https://twitter.com/Molecule_daoDiscord: https://discord.gg/ZHGpJQzeTqMolecule - The future of medicine belongs to everyone…

The DeSci Podcast

1
The Future of Biotech: AI, Patents, and the Innovation Battle 1:30:09

21 weeks ago1:30:09

1:30:09

Biotech is at a crossroads—AI, intellectual property, and startups are reshaping the future. But who really controls the breakthroughs? In this episode, Sara Holland, an IP advisor, explores how patents impact biotech, the challenges startups face against big pharma, and whether AI will change everything.What You’ll Learn in This Episode:- The hidden barriers to biotech innovation- How AI is transforming drug discovery and synthetic biology- The role of patents in protecting—or stifling—progress- Why decentralized science (DeSci) could be the key to the future ______Special Thanks To: Ella McCarthy-Page : https://x.com/EMcCarthyPage Sara HollandChris Brynes Mark Nichols ______ Let's connect: Website: https://bit.ly/3d6nh2C Twitter: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao ______ Molecule - The future of medicine belongs to everyone…

The DeSci Podcast

1
Decentralized Science vs. Rare Diseases: A Game-Changer? | Ethan Perlstein 1:00:56

22 weeks ago1:00:56

1:00:56

Welcome to another episode of the DeSci Podcast. Today, we are discussing a critical issue that affects over 30 million people in the United States—Rare Diseases. Despite being more prevalent than cancer and HIV combined, rare diseases remain underfunded, overlooked by Big Pharma, and trapped in a broken system.Our Guest: This episode features Ethan Perlstein, founder of CureTopia, an initiative using Decentralized Science (DeSci) and blockchain to revolutionize rare disease research. Why does the current system fail millions of patients, and how can decentralized models change that?What You’ll Learn in This Episode:-The reality of rare diseases and why the term "rare" is misleading-How patients and parents are taking control of scientific research-Why Big Pharma does not prioritize rare diseases and the funding challenges involved-How DeSci and blockchain can disrupt traditional biotech and accelerate drug development-The vision behind CureTopia and how it is reshaping research for rare disease treatmentsResources Mentioned:CureTopia: https://curetopia.xyzDeSci Podcast: https://www.molecule.xyzFeel free to navigate through any of the topics discussed in the podcast using the timestamps below.___⭐ Timestamps:0:00 - Introduction: The Rare Disease Crisis2:14 - Why Rare Diseases Are More Common Than People Think5:13 - Challenges in Rare Disease Advocacy9:25 - How Parents Become Scientific Experts in Their Child’s Disease13:50 - Why Big Pharma Ignores Rare Diseases17:16 - The Role of Decentralized Science (DeSci) in Drug Development22:41 - The Funding Challenges in Rare Disease Research27:34 - How Blockchain and Smart Contracts Can Help Rare Disease Research33:04 - The Power of Community in Rare Disease Advocacy38:26 - What Is CureTopia and How Does It Work?43:57 - The Future of Rare Disease Research and Biotech Innovation49:14 - Ethan Perlstein’s Vision for CureTopia54:10 - Closing Thoughts and Where to Learn More______If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below.If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.toSpecial thanks to:Jillian Casalini: https://x.com/JillianCasaliniEthan Perlstein: https://x.com/eperlste____Let's connect: Website: https://bit.ly/3d6nh2CX: https://twitter.com/Molecule_daoDiscord: https://discord.com/invite/moleculedaoMolecule - The future of medicine belongs to everyone!…

The DeSci Podcast

1
Knowledge as a Public Good: Joshua Bate on DeSciWorld's Proof of Knowledge Protocol 34:26

50 weeks ago34:26

34:26

Welcome to another episode of the DeSci Podcast! Today, we’re excited to host Joshua Bate, Founder of DeSciWorld. DeSciWorld is a community-driven initiative dedicated to facilitating the onboarding of individuals into the Decentralized Science (DeSci) space. It provides users with the tools to view, engage with, and understand everything happening in the world of decentralized science. In this episode, Joshua shares the vision behind DeSciWorld and its role as a global hub for the decentralized science community. We touch on Joshua's frank thoughts on the DeSci movement and how open discussion and unadultered knowledge transfer, alongside powerful incentives, are necessary to grow the space. We also discuss the “Proof of Knowledge protocol”, DeSciWorld's upcoming technical product where users can upload data and receive incentives whenever their contributions are utilized. Joshua addresses concerns about spam and low-quality dataset submissions, as well as potential technical approaches to ensure that the data used to train AI remains high-quality and reliable. DeSci World: https://desci.world/ SynapseDAO: https://synapse-dao.webflow.io/ Feel free to navigate through any of the topics discussed in the podcast using the timestamps below. ___ ⭐ Timestamps: 0:00 Intro 1:28 Overview of DeSci World 04:24 About “Proof of Knowledge” protocol 7:07 Ensuring high-quality datasets 14:04 Common misconceptions about DeSci 16:28 How incentives can drive DeSci adoption in Academia 20:10 Underappreciated aspects of Decentralized Science 22:10 Recommendations for getting started in DeSci 24:23 Competition vs. collaboration in the Web3 space 25:48 Scope of biotech 30:59 The future of of Decentralized Science 33:55 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to Special thanks to Lea: https://twitter.com/lealeata Joshua: https://twitter.com/jb87ua ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao…

The DeSci Podcast

1
Democratizing Early-Stage Research Funding: Inside Catalyst, Molecule’s DeSci Funding Machine 1:18:16

1 year ago1:18:16

1:18:16

In this episode, we're diving deep into Molecule's Catalyst, an incentive-driven funding system for basic research. We begin by exploring the significant challenges posed by traditional funding models. We then touch on the "Valley of Death"—a critical juncture where many groundbreaking ideas fail often due to a lack of financial support. We discuss why early-stage research often struggles to gain traction and the barriers that prevent innovative ideas from reaching their full potential. Catalyst is at the forefront of addressing these issues with its decentralized approach. By realigning incentives and democratizing access to research funding, Catalyst fosters collaboration and makes science more inclusive and inviting. We also explore the role of IP tokens (IPTs) in decentralized science and how they democratize access to and control over scientific advancements. Additionally, we explain Catalyst’s bonding curve, which features dynamic pricing that rewards early backers with lower token prices and ensures fair pricing as more tokens are minted. This system not only incentivizes early support but also maintains a transparent and equitable funding environment. Tune in to discover the potential of decentralized funding in science and how you can get involved. Whether you're a researcher, an investor, or simply curious about the future of science, this episode is packed with insights you won't want to miss. ___ ⭐ Timestamps: 0:00 Intro 18:04 Challenges of traditional funding models 19:47 The valley of death; how it impacts research 24:30 Difficulty in getting involved in early-stage ideas 31:20 Using IP as a tool to realign incentives 35:01 Why IP is the ideal use case for bringing ideas on-chain 42:05 Decentralized funding in science 48:44 Introduction to Catalyst 55:26 How Catalyst works 59:36 Catalyst bonding curve explained 1:03:22 The negotiation period in Catalyst fundraising 1:09:22 Final remarks ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at podcast@molecule.to Special thanks to Jillian: https://twitter.com/JillianCasalini Benji: https://twitter.com/benjileibo Kevin: https://www.linkedin.com/in/kevin-noessler Learn more about Catalyst here: https://catalyst.molecule.xyz/ ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao…

The DeSci Podcast

1
Revolutionizing Drug Development for Rare Diseases Through AI | Alok Tayi 49:57

1 year ago49:57