DNA methylation & epigenetic reprogramming during development with Dr Maxim Greenberg

The Genomics Lab

Greenberg M.V.C. (2021) Get Out and Stay Out: New Insights Into DNA Methylation Reprogramming in Mammals. Frontiers in Cell and Developmental Biology

32:48

America’s Sweethearts: Dallas Cowboys Cheerleaders is back for its second season! Kay Adams welcomes the women who assemble the squad, Kelli Finglass and Judy Trammell, to the Netflix Sports Club Podcast. They discuss the emotional rollercoaster of putting together the Dallas Cowboys Cheerleaders. Judy and Kelli open up about what it means to embrace flaws in the pursuit of perfection, how they identify that winning combo of stamina and wow factor, and what it’s like to see Thunderstruck go viral. Plus, the duo shares their hopes for the future of DCC beyond the field. Netflix Sports Club Podcast Correspondent Dani Klupenger also stops by to discuss the NBA Finals, basketball’s biggest moments with Michael Jordan and LeBron, and Kevin Durant’s international dominance. Dani and Kay detail the rise of Coco Gauff’s greatness and the most exciting storylines heading into Wimbledon. We want to hear from you! Leave us a voice message at www.speakpipe.com/NetflixSportsClub Find more from the Netflix Sports Club Podcast @NetflixSports on YouTube, TikTok, Instagram, Facebook, and X. You can catch Kay Adams @heykayadams and Dani Klupenger @daniklup on IG and X. Be sure to follow Kelli Finglass and Judy Trammel @kellifinglass and @dcc_judy on IG. Hosted by Kay Adams, the Netflix Sports Club Podcast is an all-access deep dive into the Netflix Sports universe! Each episode, Adams will speak with athletes, coaches, and a rotating cycle of familiar sports correspondents to talk about a recently released Netflix Sports series. The podcast will feature hot takes, deep analysis, games, and intimate conversations. Be sure to watch, listen, and subscribe to the Netflix Sports Club Podcast on YouTube, Spotify, Tudum, or wherever you get your podcasts. New episodes on Fridays every other week.…

4 years ago 1:13:50

M4A•Episode home

Today we discuss several of Maxims publications (linked below), the function of DNA methylation and the process of DNA methylation deposition and removal. Maxim also gives us an interesting insight into the details of how his lab aim to better understand epigenetic reprogramming in development.

Connect with Maxim on twitter

Maxims Lab website

Publications discussed in todays episode are linked below:

The diverse roles of DNA methylation in mammalian development and disease.

34 episodes

#Science #Biology #Olivia Grant and Eleanor Watson #Eleanor Watson #Olivia Grant

DNA methylation & epigenetic reprogramming during development with Dr Maxim Greenberg

The Genomics Lab

published 4 years ago

M4A•Episode home

Connect with Maxim on twitter

Maxims Lab website

Publications discussed in todays episode are linked below:

Greenberg M.V.C. (2021) Get Out and Stay Out: New Insights Into DNA Methylation Reprogramming in Mammals. Frontiers in Cell and Developmental Biology

The diverse roles of DNA methylation in mammalian development and disease.

34 episodes

#Science #Biology #Olivia Grant and Eleanor Watson #Eleanor Watson #Olivia Grant

All episodes

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59:35

Our second guest from the Garvan Institute of Medical Research in Sydney, is DrOzren Bogdanovic. We are so privileged to talk today to Ozren about his work in developmental epigenetics which covers how DNA methylation participates in diverse developmental processes, and how deposition and removal of the methylation mark impacts upon embryonic and germline integrity. We discuss his recent publication on non-CG methylation at satellite DNA repeats - something a little different this week! Widespread non-CG methylation occurs in mammalian embryonic stem cells and in the brain. In mammals, it is found at CAC trinucleotides in the nervous system, and is associated with transcriptional repression. It is found at CAG trinucleotides in embryonic stem cells, and CAC methylation is a known conserved feature of adult vertebrate brains. However, in his recent work, Ozren describes how, as opposed to any of these established methylation signatures, a novel form of non-CG methylation occurs in the TGCT context within zebrafish mosaic satellite repeats. TGCT methylation is inherited from both male and female gametes, and is critical for development. Ozren also discusses enzymes responsible for this observed novel methylation mark. We hope you enjoy listening as much as we enjoyed talking to Ozren. Ozren's recent publication we discuss can be found here . If you want to find out more, contact Ozren on Twitter or via email .…

The Genomics Lab

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The Genomics Lab

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The Genomics Lab

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The Genomics Lab

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The Genomics Lab

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1:13:50

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The Genomics Lab

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The Genomics Lab

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The Genomics Lab

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The Genomics Lab

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The Genomics Lab

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4 years ago51:34

51:34

Don't miss today's episode, as we are joined by Nicky Hales, who runs a Genomics Core Facility in Texas! This episode is a little different to usual, as we are focusing more on a genomics based career path, and excitingly, it's a career path we did not know much about - so it was a real learning curve to talk to Nicky. Nicky explains to us how she found herself in this position, what a Core Facility is (we had no idea before chatting to Nicky!), the significance of core facilities, and what a typical day looks like for Nicky. We discuss some of the techniques that Nicky runs at her facility, how she learnt all about how to perform each technique, and her favourite techniques (as well as the ones she doesn't enjoy quite so much..!). If you have any further questions, don't hesitate to contact Nicky: Google Scholar: Nicole Hales Twitter: @nicky_rosemarie IG: @nicky.rosemarie Email: nicole.hales@unths…

The Genomics Lab

1
Social media in academia and networking as a PhD student - Joseph Festa and Brad Richardson (Bonus Ep1) 1:09:53

4 years ago1:09:53

1:09:53

Something a little different - our first BONUS episode. Today we talk to Brad and Joe about our experience of using social media as a networking an science communications tool. Brad and Joe briefly introduce their research (for once, not genomics......) and we then discuss the pros and cons of a number of social media platforms, as well as the power of social media as a networking and opportunities tool. We had so much fun filming this episode, so we hope you enjoy listening to something a little more relaxed than the usual hardcore science! Contact Joe: Twitter @festafitness or Instagram @festa.science or listen to his podcast The Research Lounge! Contact Brad: @Twitter B_D_Richardson or Instagram @the.neuro.scientist…

The Genomics Lab

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Using explainable AI to understand the enhancer histone modification code - Jareth Wolfe 58:42

4 years ago58:42

58:42

Welcome to Episode 5 of The Genomics Lab! On today's episode we talk to Jareth Wolfe who is a final year PhD student at the University of Essex. We talk to Jareth today about his work on using explainable artificial intelligence models in order to identify enhancers in DNA. Jareth explores the link between histone modifications and enhancers, explains the importance of enhancers, and gives us an insight into how his model was developed and trained to identify these enhancers. We also discuss with Jareth what benefit his model brings over other methods of identifying enhancers. Contact Jareth: jw18713@essex.ac.uk Twitter: @jareth_wolfe…

The Genomics Lab

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Epigenetic biomarkers of exposure to tobacco smoke : A biosocial approach - Alexandria Andrayas 59:18

4 years ago59:18

59:18

Welcome to Episode 6 of The Genomics Lab! On today's episode we talk to Alexandria Andrayas who is a PhD candidate in the Soc-B Centre for doctoral training which is a new and unique programme in biosocial research. The programme is funded by the Economic and Social Research Council and the Biotechnology & Biological Sciences Research Council. It combines the strengths of the University of Essex, Manchester and UCL. The impact of smoking on health can be mediated through several biological pathways and it is well documented that smoking can be linked to large differences in DNA methylation as Alex discusses today. We also discuss the need and importance of giving consideration to the role that society may play in studies such as these. Stay tuned to find out more about epigenetics, DNA methylation and biosocial research. Contact alex here: https://www.iser.essex.ac.uk/people/aandra…

The Genomics Lab

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Identifying genetic variants for inherited retinal disease - Laura Whelan 56:49

5 years ago56:49

56:49

Welcome to Episode 3 of The Genomics Lab! On today's episode we talk to Laura Whelan, who is a PhD researcher at the School of Genetics & Microbiology at the Trinity College Dublin. Laura is part of the Target 5000 programme; the first large-scale study to apply next generation sequencing to the Irish inherited retinal diseases (IRD) patient population. Laura discusses with us some of the causes of IRDs, the different types of IRD, the kind of inheritance involved in these diseases, and how her lab and the Target 5000 initiative use sequencing techniques to both discover novel genetic variants, and validate previous findings of genetic variants involved in the cause of IRDs. Laura discusses the impact of IRD on quality of life, the scale of the problem and the future of this work in terms of improving the diagnostics of IRDs. Laura's twitter: https://twitter.com/ PhD_With_Laura Laura's research paper: https://www.mdpi.com/2073-4425/11/1/105/htm Laura's Instagram: https://www.instagram.com/phd_with_laura/…

The Genomics Lab

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How neuroepigenetics can help us to better understand spinal cord injury -Jess Chadwick 49:05

5 years ago49:05