The Metabolic Approach to Glioblastoma | Episode 71

The Health Pulse

Could the deadliest form of brain cancer have a metabolic Achilles’ heel? In this episode of The Health Pulse, we explore Dr. Thomas Seyfried’s groundbreaking theory that glioblastoma multiforme (GBM) is not just a genetic disease, but fundamentally a metabolic disorder—one that can be targeted by cutting off its preferred fuel sources.

Building on Otto Warburg’s historic observation that cancer cells rely heavily on fermentation even in the presence of oxygen, Seyfried’s work reveals GBM’s metabolic inflexibility: while healthy cells can adapt to burning different fuels, GBM cells with damaged mitochondria remain dependent on glucose and glutamine. This opens the door to the PRESS-pulse strategy—a therapeutic ketogenic diet combined with fasting, glutamine restriction, and hyperbaric oxygen therapy.

We discuss compelling case studies showing extended survival and improved quality of life, why these therapies remain underutilized, and how patient advocacy is driving change. If you’ve ever wondered how nutrition and metabolism could play a role in cancer care, this conversation will challenge everything you thought you knew.

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Disclaimer: The information provided in this podcast is for informational purposes only and should not be considered medical advice. The content discussed is based on research, expert insights, and reputable sources, but it does not replace professional medical consultation, diagnosis, or treatment. We strive to present accurate and up-to-date information, medical research is constantly evolving. Listeners should always verify details with trusted health organizations, before making any health-related decisions. If you are experiencing a medical emergency, such as severe pain, difficulty breathing, or other urgent symptoms, call your local emergency services immediately. By listening to this podcast, you acknowledge that The Health Pulse and its creators are not responsible for any actions taken based on the content of this episode. Your health and well-being should always be guided by the advice of qualified medical professionals.

Chapters

1. Introduction to GBM's Challenge (00:00:00)

2. Understanding the Warburg Effect (00:05:00)

3. Cancer as a Metabolic Disease (00:08:15)

4. PRESS-Pulse Strategy Explained (00:09:55)

5. Challenges and Future of Metabolic Therapy (00:13:20)

6. Conclusion and Key Takeaways (00:17:35)