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What Happens in the Brain to Cause Depression?

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Content provided by Quanta Magazine, Steven Strogatz, and Janna Levin. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Quanta Magazine, Steven Strogatz, and Janna Levin or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.

For decades, the best drug therapies for treating depression, like SSRIs, have been based on the idea that depressed brains don’t have enough of the neurotransmitter serotonin. Yet for almost as long, it’s been clear that simplistic theory is wrong. Recent research into the true causes of depression is finding clues in other neurotransmitters and the realization that the brain is much more adaptable than scientists once imagined. Treatments for depression are being reinvented by drugs like ketamine that can help regrow synapses, which can in turn restore the right brain chemistry and improve whole body health.

In this episode, John Krystal, a neuropharmacologist at the Yale School of Medicine, shares the new findings in mental health research that are revolutionizing psychiatric medication.

Listen on Apple Podcasts, Spotify, TuneIn or your favorite podcasting app, or you can stream it from Quanta.

  continue reading

60 episodes

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Fetch error

Hmmm there seems to be a problem fetching this series right now. Last successful fetch was on June 26, 2025 13:40 (5d ago)

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Manage episode 419823198 series 3328067
Content provided by Quanta Magazine, Steven Strogatz, and Janna Levin. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Quanta Magazine, Steven Strogatz, and Janna Levin or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.

For decades, the best drug therapies for treating depression, like SSRIs, have been based on the idea that depressed brains don’t have enough of the neurotransmitter serotonin. Yet for almost as long, it’s been clear that simplistic theory is wrong. Recent research into the true causes of depression is finding clues in other neurotransmitters and the realization that the brain is much more adaptable than scientists once imagined. Treatments for depression are being reinvented by drugs like ketamine that can help regrow synapses, which can in turn restore the right brain chemistry and improve whole body health.

In this episode, John Krystal, a neuropharmacologist at the Yale School of Medicine, shares the new findings in mental health research that are revolutionizing psychiatric medication.

Listen on Apple Podcasts, Spotify, TuneIn or your favorite podcasting app, or you can stream it from Quanta.

  continue reading

60 episodes

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