A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health and hosted by Kris Tatiossian and Olivia Webb, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vijay Pande, Julie Yoo, Vineeta Agarwala, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg ...
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1 Richard (Kudo) Couto: The Hidden Horror Behind a Billion-Dollar Brand 42:18
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Liked“I used to be the largest dairy consumer on the planet. I used to eat so much dairy and meat. The more that I looked into the dairy industry, the more that I saw that it was the singular, most inhumane industry on the planet, that we've all been lied to, including myself, for years. I always believed that the picture on the milk carton, the cow standing next to her calf in the green field with the red barn in the back was true. It’s certainly the complete opposite.” – Richard (Kudo) Couto Richard (Kudo) Couto is the founder of Animal Recovery Mission (ARM), an organization solely dedicated to investigating extreme animal cruelty cases. ARM has led high-risk undercover operations that have resulted in the shutdown of illegal slaughterhouses, animal fighting rings, and horse meat trafficking networks. Recently, they released a damning investigation into two industrial dairy farms outside of Phoenix, Arizona supplying milk to Coca-Cola’s Fairlife brand. What they uncovered was systemic animal abuse, environmental violations, and a devastating betrayal of consumer trust. While Fairlife markets its products as being sourced "humanely," ARM’s footage tells a very different story—one of suffering, abuse, and corporate complicity. Despite the evidence, this story has been largely ignored by mainstream media—likely due to Coca-Cola’s massive influence and advertising dollars.…
‘Neuroprosthesis for decoding speech in a paralyzed person with anarthria’ with David Moses and Jessie Liu
Manage episode 299323378 series 2863266
Content provided by Stephen M. Wilson. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Stephen M. Wilson or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
In this episode, I talk with David Moses and Jessie Liu about their recent NEJM paper ‘Neuroprosthesis for decoding speech in a paralyzed person with anarthria’, in which they decoded intended utterances from the brain of an individual with anarthria using an electrode array implanted of sensorimotor cortex and machine learning.
Moses DA, Metzger SL, Liu JR, et al. Neuroprosthesis for decoding speech in a paralyzed person with anarthria. N Eng J Med 2021; 385: 217-27. [doi]
Related papers:
Bouchard KE, Mesgarani N, Johnson K, Chang EF. Functional organization of human sensorimotor cortex for speech articulation. Nature 2013; 495: 327-32. [doi]
Chartier J, Anumanchipalli GK, Johnson K, Chang EF. Encoding of articulatory kinematic trajectories in human speech sensorimotor cortex. Neuron 2018; 98: 1042-54. [doi]
Anumanchipalli GK, Chartier J, Chang EF. Speech synthesis from neural decoding of spoken sentences. Nature 2019; 568: 493-8. [doi]
Moses DA, Leonard MK, Makin JG, Chang EF. Real-time decoding of question-and-answer speech dialogue using human cortical activity. Nat Commun 2019; 10: 3096. [doi]
Makin JG, Moses DA, Chang EF. Machine translation of cortical activity to text with an encoder–decoder framework. Nat Neurosci 2020; 23: 575-82. [doi]
32 episodes
ShareManage episode 299323378 series 2863266
Content provided by Stephen M. Wilson. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Stephen M. Wilson or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://ppacc.player.fm/legal.
In this episode, I talk with David Moses and Jessie Liu about their recent NEJM paper ‘Neuroprosthesis for decoding speech in a paralyzed person with anarthria’, in which they decoded intended utterances from the brain of an individual with anarthria using an electrode array implanted of sensorimotor cortex and machine learning.
Moses DA, Metzger SL, Liu JR, et al. Neuroprosthesis for decoding speech in a paralyzed person with anarthria. N Eng J Med 2021; 385: 217-27. [doi]
Related papers:
Bouchard KE, Mesgarani N, Johnson K, Chang EF. Functional organization of human sensorimotor cortex for speech articulation. Nature 2013; 495: 327-32. [doi]
Chartier J, Anumanchipalli GK, Johnson K, Chang EF. Encoding of articulatory kinematic trajectories in human speech sensorimotor cortex. Neuron 2018; 98: 1042-54. [doi]
Anumanchipalli GK, Chartier J, Chang EF. Speech synthesis from neural decoding of spoken sentences. Nature 2019; 568: 493-8. [doi]
Moses DA, Leonard MK, Makin JG, Chang EF. Real-time decoding of question-and-answer speech dialogue using human cortical activity. Nat Commun 2019; 10: 3096. [doi]
Makin JG, Moses DA, Chang EF. Machine translation of cortical activity to text with an encoder–decoder framework. Nat Neurosci 2020; 23: 575-82. [doi]
32 episodes
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The Language Neuroscience Podcast
1 What's going on with the NIH? with Julius Fridriksson 45:44
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Play Later Play Later Lists Like LikedIn the episode, I talk with Julius Fridriksson, Professor of Communication Sciences and Vice President for Research at the University of South Carolina, about what's going on with the NIH since the recent change of administration.
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The Language Neuroscience Podcast
1 ‘A mountain of small things’ with Masud Husain 38:28
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Play Later Play Later Lists Like LikedIn this episode, I talk with Masud Husain, Professor of Neurology and Cognitive Neuroscience at the University of Oxford, about his recent editorial ‘A mountain of small things’. Husain website Husain M. A mountain of small things. Brain 2024; 147: 739. [ doi ]
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The Language Neuroscience Podcast
1 Developmental dyslexia and neuroplasticity in aphasia with Maaike Vandermosten 1:03:12
1:03:12 Play Later Play Later Lists Like Liked1:03:12
Play Later Play Later Lists Like LikedIn this episode, I talk with Maaike Vandermosten, Associate Professor in the Department of Neurosciences at KU Leuven, about the neural basis of developmental dyslexia, and neuroplasticity in recovery from aphasia. Vandermosten website Vanderauwera J, Wouters J, Vandermosten M, Ghesquière P. Early dynamics of white matter deficits in children developing dyslexia. Dev Cogn Neurosci 2017; 27: 69-77. [ doi ] Beelen C, Vanderauwera J, Wouters J, Vandermosten M, Ghesquière P. Atypical gray matter in children with dyslexia before the onset of reading instruction. Cortex 2019; 121: 399–413. [ doi ] Phan TV, Sima D, Smeets D, Ghesquière P, Wouters J, Vandermosten M. Structural brain dynamics across reading development: A longitudinal MRI study from kindergarten to grade 5. Hum Brain Mapp 2021; 42: 4497-509. [ doi ] Clercq PD, Gonsalves AR, Gerrits R, Vandermosten M. Individualized functional localization of the language and multiple demand network in chronic post-stroke aphasia. bioRxiv 2024; 2024.01.12.575350. [ doi ]…
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The Language Neuroscience Podcast
1 Developmental language disorder and its neural basis with Dorothy Bishop 1:23:18
1:23:18 Play Later Play Later Lists Like Liked1:23:18
Play Later Play Later Lists Like LikedIn this episode, I talk with Dorothy Bishop, Emeritus Professor of Developmental Neuropsychology at the University of Oxford, about her work on developmental langauge disorder and its neural basis. Bishop website Bishop DVM. Comprehension in developmental language disorders. Dev Med Child Neurol. 1979;21:225-38. [ doi ] Bishop DVM, Snowling MJ, Thompson PA, Greenhalgh T, CATALISE consortium. CATALISE: A multinational and multidisciplinary Delphi consensus study: Identifying language impairments in children. PLoS One. 2016;11:e0158753. [ doi ] Bishop DVM, Snowling MJ, Thompson PA, Greenhalgh T, CATALISE‐2 consortium. Phase 2 of CATALISE: a multinational and multidisciplinary Delphi consensus study of problems with language development: Terminology. J Child Psychol Psychiatry. 2017;58:1068-80. [ doi ] Wilson AC, Bishop DVM. Resounding failure to replicate links between developmental language disorder and cerebral lateralisation. PeerJ. 2018;6:e4217. [ doi ] Bishop D. Rein in the four horsemen of irreproducibility. Nature. 2019;568:435. [ doi ]…
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The Language Neuroscience Podcast
1 ‘Determinants of multilevel discourse outcomes in anomia treatment for aphasia’ with Rob Cavanaugh 1:15:14
1:15:14 Play Later Play Later Lists Like Liked1:15:14
Play Later Play Later Lists Like LikedIn this episode, I talk with Rob Cavanaugh, Research Data Analyst at the Observational Health Data Sciences and Informatics Center at Northeastern University, about his dissertation ‘Determinants of multilevel discourse outcomes in anomia treatment for aphasia’. Cavanaugh website Cavanaugh, R. Determinants of multilevel discourse outcomes in anomia treatment for aphasia. Doctoral dissertation, University of Pittsburgh. [ dissertation ]…
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The Language Neuroscience Podcast
1 Deep learning algorithms, natural language processing, and the brain, with Jean-Rémi King 1:35:15
1:35:15 Play Later Play Later Lists Like Liked1:35:15
Play Later Play Later Lists Like LikedIn the episode, I talk with Jean-Rémi King, Research scientist and team leader at Meta AI, and Associate Researcher at CNRS, École Normale Supérieure, about three recent papers from his lab on deep learning algorithms, natural language processing, and the brain. King website Millet J, Caucheteux C, Orhan P, Boubenec Y, Gramfort A, Dunbar E, Pallier C, King J-R. Toward a realistic model of speech processing in the brain with self-supervised learning. In Advances in Neural Information Processing Systems (NeurIPS) 2022. [ doi ] Caucheteux C, King JR. Brains and algorithms partially converge in natural language processing. Commun Biol. 2022;5:134. [ doi ] Caucheteux C, Gramfort A, King JR. Evidence of a predictive coding hierarchy in the human brain listening to speech. Nat Hum Behav. 2023;7:430-41. [ doi ]…
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The Language Neuroscience Podcast
1 ‘Neural dynamics of phoneme sequences reveal position-invariant code for content and order’ with Laura Gwilliams 1:21:51
1:21:51 Play Later Play Later Lists Like Liked1:21:51
Play Later Play Later Lists Like LikedIn this episode, I talk with Laura Gwilliams, soon-to-be Assistant Professor of Psychology, Neuroscience, and Data Science at Stanford University, about her recent paper ‘Neural dynamics of phoneme sequences reveal position-invariant code for content and order’. Gwilliams lab website Gwilliams L, King JR, Marantz A, Poeppel D. Neural dynamics of phoneme sequences reveal position-invariant code for content and order. Nat Commun 2022; 13: 6606. [ doi ]…
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The Language Neuroscience Podcast
1 Encoding and decoding semantic representations with Alexander Huth 1:49:12
1:49:12 Play Later Play Later Lists Like Liked1:49:12
Play Later Play Later Lists Like LikedIn this episode, I talk with Alexander Huth, Assistant Professor of Neuroscience and Computer Science at the University of Texas, Austin, about his work using functional imaging and advanced computational methods to model how the brain processes language and represents meaning. Huth lab website Huth AG, Nishimoto S, Vu AT, Gallant JL. A continuous semantic space describes the representation of thousands of object and action categories across the human brain. Neuron 2012; 76: 1210-24. [ doi ] Huth AG, de Heer WA, Griffiths TL, Theunissen FE, Gallant JL. Natural speech reveals the semantic maps that tile human cerebral cortex. Nature 2016; 532: 453-8. [ doi ] Jain S, Huth AG. Incorporating context into language encoding models for fMRI. Proceedings of the 32nd International Conference on Neural Information Processing Systems 2018, pp. 6629-38. [ doi ] Tang J, LeBel A, Jain S, Huth AG. Semantic reconstruction of continuous language from non-invasive brain recordings. Nat Neurosci in press. [ doi ]…
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The Language Neuroscience Podcast
1 ‘Disentangling Semantic Composition and Semantic Association in the Left Temporal Lobe’ with Liina Pylkkänen 1:04:12
1:04:12 Play Later Play Later Lists Like Liked1:04:12
Play Later Play Later Lists Like LikedIn this episode, I talk with Liina Pylkkänen, Professor of Linguistics and Psychology at NYU, about her research program, and in particular her recent paper ‘Disentangling semantic composition and semantic association in the left temporal lobe’. Pylkkänen lab website Li J, Pylkkänen L. Disentangling semantic composition and semantic association in the left temporal lobe. J Neurosci 2021; 41: 6526-38. [ doi ]…
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The Language Neuroscience Podcast
1 ‘Speech computations of the human superior temporal gyrus’ with Eddie Chang 1:22:10
1:22:10 Play Later Play Later Lists Like Liked1:22:10
Play Later Play Later Lists Like LikedIn this episode, I talk with Eddie Chang, Professor of Neurological Surgery at the University of California, San Francisco, about his recent paper ‘Speech computations of the human superior temporal gyrus’. Chang lab website Bhaya-Grossman I, Chang EF. Speech computations of the human superior temporal gyrus. Annu Rev Psychol 2022; 73: 79-102. [ doi | pdf ] Chang EF, Rieger JW, Johnson K, Berger MS, Barbaro NM, Knight RT. Categorical speech representation in human superior temporal gyrus. Nat Neurosci 2010; 13: 1428-33. [ doi ] Sjerps MJ, Fox NP, Johnson K, Chang EF. Speaker-normalized sound representations in the human auditory cortex. Nat Commun 2019; 10: 2465. [ doi ] Leonard MK, Baud MO, Sjerps MJ, Chang EF. Perceptual restoration of masked speech in human cortex. Nat Commun 2016; 7: 13619. [ doi ] Hamilton LS, Edwards E, Chang EF. A spatial map of onset and sustained responses to speech in the human superior temporal gyrus. Curr Biol 2018; 28: 1860-71. [ doi ] Oganian Y, Chang EF. A speech envelope landmark for syllable encoding in human superior temporal gyrus. Sci Adv 2019; 5: eaay6279. [ doi ]…
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The Language Neuroscience Podcast
1 Awake craniotomy for a brain tumor surrounded by language areas, with Olivia Leow 57:01
57:01 Play Later Play Later Lists Like Liked57:01
Play Later Play Later Lists Like LikedIn this episode, I talk with Olivia Leow, who experienced an awake craniotomy for resection of a brain tumor surrounded by language areas in her left posterior temporal lobe. Vanderbilt Brain Cancer Patient Assistance Fund, established by Olivia Leow Diachek E, Morgan VL, Wilson SM. Adaptive language mapping paradigms for presurgical language mapping. AJNR Am J Neuroradiol 2022; in press. [ pdf ] Wilson SM, Yen M, Eriksson DK. An adaptive semantic matching paradigm for reliable and valid language mapping in individuals with aphasia. Hum Brain Mapp 2018; 39: 3285-307. [ doi ] Yen M, DeMarco AT, Wilson SM. Adaptive paradigms for mapping phonological regions in individual participants. NeuroImage 2019; 189: 368-79. [ doi ] Wilson SM, Lam D, Babiak M, Perry D, Shih T, Hess CP, Berger MS, Chang EF. Transient aphasias after left hemisphere resective surgery. J Neurosurg 2015; 123: 581-93. [ doi ] McCarron A, Chavez A, Babiak MC, Berger MS, Chang EF, Wilson SM. Connected speech in transient aphasias after left hemisphere resective surgery. Aphasiology 2017; 31: 1266-81. [ doi ] Penfield W, Roberts L. Speech and Brain-Mechanisms . Princeton University Press; 1959. [ book ] Long Monday by John Prine Clay Pigeons by John Prine…
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The Language Neuroscience Podcast
1 Generative linguistics and the neural basis of language, with Noam Chomsky 1:02:30
1:02:30 Play Later Play Later Lists Like Liked1:02:30
Play Later Play Later Lists Like LikedIn this episode, I talk with Noam Chomsky, Institute Professor and Emeritus Professor of Linguistics at MIT and Laureate Professor of Linguistics at the University of Arizona. After starting with a discussion of the early development of Chomsky’s key ideas, our conversation is centered on the relationship between generative linguistics and the neuroscience of language. Grodzinsky Y, Finkel L. The neurology of empty categories: Aphasics’ failure to detect ungrammaticality. J Cogn Neurosci 1998; 10: 281-92. [ doi ] Chomsky N. Linguistics and brain science. In: Marantz A, Miyashita Y, O’Neil W, editors. Image, language, brain: Papers from the first mind articulation project symposium . MIT Press; 2000. p. 13-28. [ pdf ] Musso M, Moro A, Glauche V, Rijntjes M, Reichenbach J, Büchel C, Weiller C. Broca’s area and the language instinct. Nat Neurosci 2003; 6: 774-81. [ doi ] Chomsky N. Language and mind . Cambridge University Press; 2006. [ doi ] Friederici AD, Chomsky N, Berwick RC, Moro A, Bolhuis JJ. Language, mind and brain. Nat Hum Behav 2017; 1: 713-22. [ doi ] Chomsky N. Linguistics then and now: Some personal reflections. Annu Rev Linguist 2021; 7: 1-11. [ doi ] Chomsky website…
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The Language Neuroscience Podcast
1 Cortical myeloarchitecture, tonotopy, and spectrally directed attention, with Fred Dick 1:04:36
1:04:36 Play Later Play Later Lists Like Liked1:04:36
Play Later Play Later Lists Like LikedIn this episode, I talk with Fred Dick, Professor of Auditory Cognitive Neuroscience in the Department of Psychological Sciences at Birkbeck, University of London, about his work, with a focus on his recent paper ‘Extensive tonotopic mapping across auditory cortex is recapitulated by spectrally directed attention and systematically related to cortical myeloarchitecture’. Dick F, Bates E, Wulfeck B, Utman JA, Dronkers N, Gernsbacher MA. Language deficits, localization, and grammar: evidence for a distributive model of language breakdown in aphasic patients and neurologically intact individuals. Psychol Rev 2001; 108: 759-88. [ doi ] Dick F, Tierney AT, Lutti A, Josephs O, Sereno MI, Weiskopf N. In vivo functional and myeloarchitectonic mapping of human primary auditory areas. J Neurosci 2012; 32: 16095-105. [ doi ] Lutti A, Dick F, Sereno MI, Weiskopf N. Using high-resolution quantitative mapping of R1 as an index of cortical myelination. NeuroImage 2014; 93: 176-88. [ doi ] Dick FK, Lehet MI, Callaghan MF, Keller TA, Sereno MI, Holt LL. Extensive tonotopic mapping across auditory cortex is recapitulated by spectrally directed attention and systematically related to cortical myeloarchitecture. J Neurosci 2017; 37: 12187-201. [ doi ] Dick faculty webpage Transcript…
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The Language Neuroscience Podcast
1 Anatomy and neuropathology of progressive speech and language disorders, with Keith Josephs 1:01:44
1:01:44 Play Later Play Later Lists Like Liked1:01:44
Play Later Play Later Lists Like LikedIn this episode, I talk with Keith Josephs, Professor of Neurology at the Mayo Clinic in Rochester, Minnesota, about his work on the anatomy and neuropathology of progressive speech and language disorders. Josephs KA, Duffy JR, Strand EA, Whitwell JL, Layton KF, Parisi JE, et al. Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech. Brain 2006; 129: 1385-98. [ doi ] Josephs KA, Hodges JR, Snowden JS, Mackenzie IR, Neumann M, Mann DM, et al. Neuropathological background of phenotypical variability in frontotemporal dementia. Acta Neuropathol 2011; 122: 137-53. [ doi ] Josephs KA, Duffy JR, Strand EA, Machulda MM, Senjem ML, Master AV, et al. Characterizing a neurodegenerative syndrome: primary progressive apraxia of speech. Brain 2012; 135: 1522-36. [ doi ] Josephs KA, Duffy JR, Strand EA, Machulda MM, Senjem ML, Lowe VJ, et al. Syndromes dominated by apraxia of speech show distinct characteristics from agrammatic PPA. Neurology 2013; 81: 337-45. [ doi ] Graff-Radford J, Jones DT, Strand EA, Rabinstein AA, Duffy JR, Josephs KA. The neuroanatomy of pure apraxia of speech in stroke. Brain Lang 2014; 129: 43-6. [ doi ] Josephs KA, Duffy JR, Clark HM, Utianski RL, Strand EA, Machulda MM, et al. A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech. Nat Commun 2021; 12: 3452. [ doi ] Josephs faculty webpage…
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The Language Neuroscience Podcast
1 Imaging the language network, with Cathy Price 1:07:44
1:07:44 Play Later Play Later Lists Like Liked1:07:44
Play Later Play Later Lists Like LikedIn this episode, I talk with Cathy Price, Professor of Cognitive Neuroscience and Director of the Wellcome Trust Centre for Neuroimaging at University College London, about her pioneering work on functional neuroimaging of the language network, whether there are really such things as “language regions”, degeneracy, predicting and explaining language outcomes after stroke, and more. Price C, Wise R, Ramsay S, Friston K, Howard D, Patterson K, Frackowiak R. Regional response differences within the human auditory cortex when listening to words. Neurosci Lett 1992; 146: 179-82. [ doi ] Price CJ, Wise RJS, Warburton EA, Moore CJ, Howard D, Patterson K, Frackowiak R, Friston K. Hearing and saying. Brain 1996; 119: 919-31. [ doi ] Price CJ, Friston KJ. Degeneracy and cognitive anatomy. Trends Cogn Sci 2002; 6: 416-21. [ doi ] Crinion J, Price CJ. Right anterior superior temporal activation predicts auditory sentence comprehension following aphasic stroke. Brain 2005; 128: 2858-71. [ doi ] Price CJ, Seghier ML, Leff AP. Predicting language outcome and recovery after stroke: the PLORAS system. Nat Rev Neurol 2010; 6: 202-10. [ doi ] Price CJ. A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. NeuroImage 2012; 62: 816-47. [ doi ] Hope TMH, Seghier ML, Leff AP, Price CJ. Predicting outcome and recovery after stroke with lesions extracted from MRI images. NeuroImage Clin 2013; 2: 424-33. [ doi ] Seghier ML, Price CJ. Interpreting and utilising intersubject variability in brain function. Trends Cogn Sci 2018; 22: 517-30. [ doi ] Price lab website Transcript…
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A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health and hosted by Kris Tatiossian and Olivia Webb, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vijay Pande, Julie Yoo, Vineeta Agarwala, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg ...
…
continue reading
Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
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This Week in Microbiology is a podcast about unseen life on Earth hosted by Vincent Racaniello and friends. Following in the path of his successful shows 'This Week in Virology' (TWiV) and 'This Week in Parasitism' (TWiP), Racaniello and guests produce an informal yet informative conversation about microbes which is accessible to everyone, no matter what their science background.
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Each week we bring you a new, in-depth exploration of the space where science and society collide. We’re committed to the idea that making an effort to understand the world around you though science and critical thinking can benefit everyone—and lead to better decisions. We want to find out what’s true, what’s left to discover, and why it all matters.
…
continue reading
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